{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:14:17Z","timestamp":1790835257129,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Institute of Neurologic Diseases","award":["R01NS086312"],"award-info":[{"award-number":["R01NS086312"]}]},{"name":"National Institute of Neurologic Diseases","award":["R21NS065713"],"award-info":[{"award-number":["R21NS065713"]}]},{"name":"National Institute of Neurologic Diseases","award":["K23NS122601"],"award-info":[{"award-number":["K23NS122601"]}]},{"name":"National Institute of Neurologic Diseases","award":["K01TW010268"],"award-info":[{"award-number":["K01TW010268"]}]},{"name":"National Institute of Neurologic Diseases","award":["R25TW009345"],"award-info":[{"award-number":["R25TW009345"]}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U01AI089244"],"award-info":[{"award-number":["U01AI089244"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32AI055433"],"award-info":[{"award-number":["T32AI055433"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K23AI073192"],"award-info":[{"award-number":["K23AI073192"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K23AI138851"],"award-info":[{"award-number":["K23AI138851"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["M007413\/1"],"award-info":[{"award-number":["M007413\/1"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Given extensive improvements in access to antiretroviral therapy (ART) over the past 12 years, the HIV and cryptococcal meningitis landscapes have dramatically changed since 2010. We sought to evaluate changes in clinical presentation and clinical outcomes of people presenting with HIV-associated cryptococcal meningitis between 2010 and 2022 in Uganda. We analyzed three prospective cohorts of HIV-infected Ugandans with cryptococcal meningitis during 2010\u20132012, 2013\u20132017, and 2018\u20132022. We summarized baseline demographics, clinical characteristics at presentation, and 2-week and 16-week mortality. Overall, 2022 persons had confirmed cryptococcal meningitis between 2010 and 2022. In the most recent 2018\u20132022 cohort, 48% presented as ART-na\u00efve, and the median CD4 cell count was 26 cells\/\u00b5l. Participants in the 2018\u20132022 cohort had the lowest cerebrospinal fluid (CSF) opening pressure (median 22 cmH2O) and the highest percentage with sterile CSF quantitative cultures (21%) compared with earlier cohorts (P\u00a0&amp;lt;\u00a0.001 for both), signifying a less severely ill population presenting with cryptococcal meningitis. Two-week mortality was lowest among participants with cryptococcal meningitis enrolled in a clinical trial in the 2018\u20132022 cohort at 13% compared to 26% in both 2010\u20132012 and 2013\u20132017 (P\u00a0&amp;lt;\u00a0.001). While AIDS-related deaths have dramatically declined over the past 12 years, cryptococcosis persists, presenting challenges to HIV program implementation. Two-week mortality has improved in the most recent cohort, likely due to the establishment of cryptococcal screening programs, better supportive care including scheduled lumbar punctures, and the availability of flucytosine\u2014an essential component of antifungal therapy.<\/jats:p>","DOI":"10.1093\/mmy\/myae115","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T02:27:41Z","timestamp":1736389661000},"source":"Crossref","is-referenced-by-count":7,"title":["The evolution of HIV-associated cryptococcal meningitis in Uganda from 2010 to 2022"],"prefix":"10.1093","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5361-4076","authenticated-orcid":false,"given":"Stewart","family":"Walukaga","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Minnesota , Minneapolis, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Fieberg","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Health Science Data, School of Public Health, University of Minnesota , Minneapolis, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdu","family":"Musubire","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, College of Health Sciences, Makerere University , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian","family":"Tugume","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, College of Health Sciences, Makerere University , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8125-0698","authenticated-orcid":false,"given":"Kenneth","family":"Ssebambulidde","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, College of Health Sciences, Makerere University , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0291-651X","authenticated-orcid":false,"given":"Enock","family":"Kagimu","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, College of Health Sciences, Makerere University , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7252-4052","authenticated-orcid":false,"given":"John","family":"Kasibante","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, College of Health Sciences, Makerere University , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morris K","family":"Rutakingirwa","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, College of Health Sciences, Makerere University , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Mpoza","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, College of Health Sciences, Makerere University , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0150-4887","authenticated-orcid":false,"given":"Jane","family":"Gakuru","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, College of Health Sciences, Makerere University , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Akampurira","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, College of Health Sciences, Makerere University , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Jjunju","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, College of Health Sciences, Makerere University , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Mwesigye","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mbarara University of Science and Technology , Mbarara ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrad","family":"Muzoora","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mbarara University of Science and Technology , Mbarara ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Nuwagira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mbarara University of Science and Technology , Mbarara ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0062-9434","authenticated-orcid":false,"given":"Ananta S","family":"Bangdiwala","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Health Science Data, School of Public Health, University of Minnesota , Minneapolis, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darlisha A","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Minnesota , Minneapolis, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Rhein","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Minnesota , Minneapolis, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B","family":"Meya","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, College of Health Sciences, Makerere University , Kampala ,","place":["Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R","family":"Boulware","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Minnesota , Minneapolis, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2754-3473","authenticated-orcid":false,"given":"Kathy Huppler","family":"Hullsiek","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Health Science Data, School of Public Health, University of Minnesota , Minneapolis, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5531-0231","authenticated-orcid":false,"given":"Radha","family":"Rajasingham","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Minnesota , Minneapolis, Minnesota ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ASTRO team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Francis","family":"Ndyetukira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Ahimbisibwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Kugonza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyne","family":"Namuju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisat","family":"Sadiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Namudde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Mwesigye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona V","family":"Cresswell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadeo Kiiza","family":"Kandole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kirumira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Okirwoth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Luggya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kwizera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane","family":"Mukaremera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M","family":"Lofgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Stadelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bozena","family":"Morawski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A","family":"Rolfes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darin L","family":"Wiesner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Najjuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Nanteza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhina","family":"Mushagara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Bahr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Namawejje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ssennono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Kiragga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kabanda","family":"Taseera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry W","family":"Nabeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"2025021015300064300_bib1","article-title":"Full report \u2014 in danger: UNAIDS global AIDS pdate","author":"UNAIDS","year":"2022"},{"key":"2025021015300064300_bib2","first-page":"ofz419","volume-title":"The Changing Epidemiology of HIV-Associated Adult Meningitis, Uganda 2015\u20132017","author":"Ellis","year":"2019"},{"issue":"12","key":"2025021015300064300_bib3","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/S1473-3099(22)00499-6","article-title":"The global burden of HIV-associated cryptococcal infection in adults in 2020: a modelling analysis","volume":"22","author":"Rajasingham","year":"2022","journal-title":"Lancet Infect Dis"},{"key":"2025021015300064300_bib4","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.ijid.2022.07.035","article-title":"Cytomegalovirus viremia as a risk factor for mortality in HIV-associated cryptococcal and tuberculous meningitis","volume":"122","author":"Skipper","year":"2022","journal-title":"Int J Infect Dis"},{"issue":"1","key":"2025021015300064300_bib5","doi-asserted-by":"crossref","first-page":"e25416","DOI":"10.1002\/jia2.25416","article-title":"Mortality from HIV-associated meningitis in sub-Saharan Africa: a systematic review and meta-analysis","volume":"23","author":"Tenforde","year":"2020","journal-title":"J Int AIDS Soc"},{"issue":"2","key":"2025021015300064300_bib6","doi-asserted-by":"crossref","first-page":"ofx077","DOI":"10.1093\/ofid\/ofx077","article-title":"Evolving failures in the delivery of Human immunodeficiency virus care: lessons from a Ugandan meningitis cohort 2006\u20132016","volume":"4","author":"Flynn","year":"2017","journal-title":"Open Forum Infect Dis"},{"issue":"8","key":"2025021015300064300_bib7","doi-asserted-by":"crossref","first-page":"ofy122","DOI":"10.1093\/ofid\/ofy122","article-title":"Detrimental outcomes of unmasking cryptococcal meningitis with recent ART initiation","volume":"5","author":"Rhein","year":"2018","journal-title":"Open Forum Infect Dis"},{"issue":"4","key":"2025021015300064300_bib8","doi-asserted-by":"crossref","first-page":"e0284165","DOI":"10.1371\/journal.pone.0284165","article-title":"Adherence of health workers to guidelines for screening and management of cryptococcal meningitis in Uganda","volume":"18","author":"Namuju","year":"2023","journal-title":"PLoS One"},{"issue":"1","key":"2025021015300064300_bib9","doi-asserted-by":"crossref","first-page":"e0210105","DOI":"10.1371\/journal.pone.0210105","article-title":"Evaluation of a national cryptococcal antigen screening program for HIV-infected patients in Uganda: a cost-effectiveness modeling analysis","volume":"14","author":"Rajasingham","year":"2019","journal-title":"PLoS One"},{"issue":"3","key":"2025021015300064300_bib10","doi-asserted-by":"crossref","first-page":"e759","DOI":"10.1093\/cid\/ciac599","article-title":"Outpatient cryptococcal antigen screening is associated with favorable baseline characteristics and improved survival in persons with cryptococcal meningitis in Uganda","volume":"76","author":"Levin","year":"2022","journal-title":"Clin Infect Dis"},{"key":"2025021015300064300_bib11","volume-title":"Uganda Clinical Guidelines","author":"Uganda Ministry of Health","year":"2016"},{"issue":"11","key":"2025021015300064300_bib12","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1056\/NEJMoa1710922","article-title":"Antifungal combinations for treatment of cryptococcal meningitis in Africa","volume":"378","author":"Molloy","year":"2018","journal-title":"N Engl J Med"},{"key":"2025021015300064300_bib13","article-title":"Guidelines for the diagnosis, prevention and management of cryptococcal disease in HIV-infected adults, adolescents and children","author":"WHO"},{"issue":"26","key":"2025021015300064300_bib14","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1056\/NEJMoa1312884","article-title":"Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis","volume":"370","author":"Boulware","year":"2014","journal-title":"N Engl J Med"},{"issue":"8","key":"2025021015300064300_bib15","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S1473-3099(19)30127-6","article-title":"Adjunctive sertraline for HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial","volume":"19","author":"Rhein","year":"2019","journal-title":"Lancet Infect Dis"},{"issue":"7","key":"2025021015300064300_bib16","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S1473-3099(16)00074-8","article-title":"Efficacy of adjunctive sertraline for the treatment of HIV-associated cryptococcal meningitis: an open-label dose-ranging study","volume":"16","author":"Rhein","year":"2016","journal-title":"Lancet Infect Dis"},{"issue":"12","key":"2025021015300064300_bib17","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1093\/cid\/ciad440","article-title":"Oral lipid nanocrystal amphotericin B for cryptococcal meningitis: a randomized clinical trial","volume":"77","author":"Boulware","year":"2023","journal-title":"Clin Infect Dis"},{"key":"2025021015300064300_bib18","first-page":"14","article-title":"Integrated management of cryptococcal meningitis and concurrent opportunistic infections to improve outcomes in advanced HIV disease: a randomised strategy trial","volume-title":"Wellcome Open Res","author":"Ellis","year":"2024"},{"issue":"12","key":"2025021015300064300_bib19","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1056\/NEJMoa2111904","article-title":"Single-dose liposomal amphotericin B treatment for cryptococcal meningitis","volume":"386","author":"Jarvis","year":"2022","journal-title":"N Engl J Med"},{"issue":"6","key":"2025021015300064300_bib20","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/infdis\/jiy602","article-title":"HIV-associated cryptococcal meningitis occurring at relatively higher CD4 counts","volume":"219","author":"Tugume","year":"2019","journal-title":"J Infect Dis"},{"issue":"9","key":"2025021015300064300_bib21","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1212\/01.wnl.0000242704.60275.e9","article-title":"CSF opening pressure: reference interval and the effect of body mass index","volume":"67","author":"Whiteley","year":"2006","journal-title":"Neurology"},{"issue":"9","key":"2025021015300064300_bib22","doi-asserted-by":"crossref","first-page":"ofac416","DOI":"10.1093\/ofid\/ofac416","article-title":"Therapeutic lumbar punctures in human immunodeficiency virus-associated cryptococcal meningitis: should opening pressure direct management?","volume":"9","author":"Kagimu","year":"2022","journal-title":"Open Forum Infect Dis"},{"issue":"Suppl 1","key":"2025021015300064300_bib23","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.4103\/sja.SJA_543_18","article-title":"The STROBE guidelines","volume":"13","author":"Cuschieri","year":"2019","journal-title":"Saudi J Anaesth"},{"issue":"11","key":"2025021015300064300_bib24","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1093\/cid\/ciu596","article-title":"The effect of therapeutic lumbar punctures on acute mortality from cryptococcal meningitis","volume":"59","author":"Rolfes","year":"2014","journal-title":"Clin Infect Dis Off Publ Infect Dis Soc Am"},{"issue":"2","key":"2025021015300064300_bib25","doi-asserted-by":"crossref","first-page":"ofu070","DOI":"10.1093\/ofid\/ofu070","article-title":"Standardized electrolyte supplementation and fluid management improves survival during amphotericin therapy for cryptococcal meningitis in resource-limited settings","volume":"1","author":"Bahr","year":"2014","journal-title":"Open Forum Infect Dis"},{"issue":"1","key":"2025021015300064300_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3201\/eid2001.130906","article-title":"Multisite validation of cryptococcal antigen lateral flow assay and quantification by laser thermal contrast","volume":"20","author":"Boulware","year":"2014","journal-title":"Emerg Infect Dis"},{"issue":"1","key":"2025021015300064300_bib27_723_194924","doi-asserted-by":"publisher","first-page":"e25416","DOI":"10.1002\/jia2.25416","article-title":"Mortality from HIV-associated meningitis in sub-Saharan Africa: a systematic review and meta-analysis","volume":"23","author":"Tenforde","year":"2020","journal-title":"J Int AIDS Soc"},{"issue":"9","key":"2025021015300064300_bib28_482_195024","doi-asserted-by":"publisher","first-page":"2054270416654859","DOI":"10.1177\/2054270416654859","article-title":"Patterns and trends in mortality among HIV-infected and HIV-uninfected patients in a major Internal Medicine Unit in Yaound\u00e9, Cameroon: a retrospective cohort study","volume":"7","author":"Mbuagbaw","year":"2016","journal-title":"JRSM Open"},{"issue":"8","key":"2025021015300064300_bib29_741_195224","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.3390\/v16081333","article-title":"Trends in clinico-epidemiological profile and outcomes of patients with HIV-associated cryptococcal meningitis in Shanghai, China, 2013-2023","volume":"16","author":"Zhao","journal-title":"Viruses"}],"container-title":["Medical Mycology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mmy\/advance-article-pdf\/doi\/10.1093\/mmy\/myae115\/61382476\/myae115.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mmy\/article-pdf\/63\/1\/myae115\/61382476\/myae115.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mmy\/article-pdf\/63\/1\/myae115\/61382476\/myae115.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T15:30:22Z","timestamp":1739201422000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mmy\/article\/doi\/10.1093\/mmy\/myae115\/7945793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,27]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12,27]]}},"URL":"https:\/\/doi.org\/10.1093\/mmy\/myae115","relation":{},"ISSN":["1369-3786","1460-2709"],"issn-type":[{"value":"1369-3786","type":"print"},{"value":"1460-2709","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,1]]},"published":{"date-parts":[[2024,12,27]]},"article-number":"myae115"}}