{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T23:15:26Z","timestamp":1784934926584,"version":"3.55.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T00:00:00Z","timestamp":1737763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Candidemia can lead to ocular complications, including endophthalmitis and chorioretinitis. Management of candidemia traditionally included ophthalmic exams. However, due to concerns regarding the utility of performing ophthalmic exams in all patients, there is a need for prognostic factors suggestive of ocular complications. We sought to evaluate if positive follow-up blood cultures (FUBC) are associated with ocular involvement in candidemia.<\/jats:p>\n               <jats:p>We conducted a single-center, retrospective review of candidemia cases at an academic medical center (2017\u20132022). Data on demographics, risk factors, ophthalmic exams, eye infection, and mortality outcomes were collected. Data was analyzed using descriptive statistics, \u03c72 tests, and multivariate logistic regression.<\/jats:p>\n               <jats:p>A total of 238 episodes of candidemia among 199 patients were included. FUBC were obtained for 97% of cases and were positive in 35%. Ophthalmic exams were performed in 82% of cases and identified 10 endophthalmitis and 11 chorioretinitis cases. There was no significant association between positive FUBC and endophthalmitis or chorioretinitis. Ocular infections were associated with presence of any visual symptom (P\u00a0&amp;lt;\u00a0.001), Candida albicans (P\u00a0=\u00a0.02), C. dubliniensis (P\u00a0=\u00a0.003), and length of antifungal regimen (P\u00a0=\u00a0.007). Hospital mortality was associated with age (P\u00a0&amp;lt;\u00a0.001), C. lusitaniae (P\u00a0=\u00a0.056), acquisition of FUBC (P =\u00a0.03), completion of an ophthalmic exam (P =\u00a0.046), vasopressor use (P\u00a0&amp;lt;\u00a0.001), and length of antifungal regimen (P =\u00a0.009).<\/jats:p>\n               <jats:p>While positive FUBC did not correlate with ocular candidiasis, specific Candida species were associated with endophthalmitis and chorioretinitis. C. lusitaniae infections, acquisition of FUBC, and ophthalmic exam were predictors of hospital mortality. Other indications for ophthalmic evaluations and further identification of mortality risk factors need to be investigated.<\/jats:p>","DOI":"10.1093\/mmy\/myaf010","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T01:46:11Z","timestamp":1738719971000},"source":"Crossref","is-referenced-by-count":1,"title":["Evaluating predictors of ocular complications and mortality in candidemia: Are repeat blood cultures key?"],"prefix":"10.1093","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3156-3845","authenticated-orcid":false,"given":"Hamail","family":"Iqbal","sequence":"first","affiliation":[{"name":"Cooper Medical School of Rowan University , Camden, New Jersey, 08103 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejan","family":"Nikolic","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cooper University Hospital , Camden, New Jersey, 08103 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Foppiano\u00a0Palacios","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Cooper University Hospital , Camden, New Jersey, 08103 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"issue":"5","key":"2025030418400601200_bib1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s15010-018-1163-z","article-title":"Prevalence of, and risk factors for, hematogenous fungal endophthalmitis in patients with Candida bloodstream infection","volume":"46","author":"Kato","year":"2018","journal-title":"Infection"},{"issue":"3","key":"2025030418400601200_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3109\/02713683.2010.533810","article-title":"Ocular fungal infections","volume":"36","author":"Kalkanci","year":"2011","journal-title":"Curr Eye Res"},{"issue":"4","key":"2025030418400601200_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cid\/civ933","article-title":"Clinical Practice Guideline for the management of Candidiasis: 2016 update by the Infectious Diseases Society of America","volume":"62","author":"Pappas","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2025030418400601200_bib4","first-page":"1853","article-title":"Prevalence and factors predictive of intraocular fungal infection in patients with fungemia at an academic urban tertiary care center","volume":"9","author":"Geraymovych","year":"2015","journal-title":"Clin Ophthalmol"},{"issue":"12","key":"2025030418400601200_bib5","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1016\/j.ophtha.2014.06.042","article-title":"Outcomes, impact on management, and costs of fungal eye disease consults in a tertiary care setting","volume":"121","author":"Ghodasra","year":"2014","journal-title":"Ophthalmology"},{"issue":"1","key":"2025030418400601200_bib6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ophtha.2021.07.015","article-title":"American Academy of Ophthalmology recommendations on screening for endogenous Candida endophthalmitis","volume":"129","author":"Breazzano","year":"2022","journal-title":"Ophthalmology."},{"issue":"7","key":"2025030418400601200_bib7","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.ophtha.2014.01.010","article-title":"Adult ophthalmology inpatient consults at a tertiary care teaching hospital","volume":"121","author":"Grewal","year":"2014","journal-title":"Ophthalmology"},{"issue":"9","key":"2025030418400601200_bib8","doi-asserted-by":"crossref","first-page":"e0222356","DOI":"10.1371\/journal.pone.0222356","article-title":"Risk factors and outcomes of patients with ocular involvement of candidemia","volume":"14","author":"Son","year":"2019","journal-title":"PLoS One"},{"issue":"7","key":"2025030418400601200_bib9","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/S0161-6420(94)31175-4","article-title":"Intraocular candidiasis in patients with candidemia. 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