{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T23:34:48Z","timestamp":1772494488216,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The anthropophilic dermatophyte Trichophyton interdigitale and its counterpart Trichophyton mentagrophytes are phylogenetically closely related species. In India, the most common endemic dermatophyte species belong to the T. indotineae. The internal transcribed spacer (ITS) genotype VIII within this species complex was recently renamed as Trichophyton indotineae based on its rapid emergence in India and its elevated virulence and terbinafine resistance. While humans are considered a source of T. interdigitale infection, animals are considered a source of T. mentagrophytes. For T. indotineae it is not known whether infections occur anthropophilic or zoonotic, as there is very little data on its origin and transmission. Additionally, the environmental source of T. indotineae is unknown. In the current study, we have performed the molecular typing method amplified fragment length polymorphism (AFLP) on 24 T. indotineae isolates to determine the genetic diversity among animal and human origin isolates and compare it to related species. Additionally, we performed antifungal susceptibility testing by standard microbroth dilution methods against common antifungals. In contrast to the T. interdigitale which showed significant genetic variability between isolates from different cities, T. indotineae isolates demonstrate minimal genetic variability, also between samples from animals and humans, highlighting the possibility of zoonotic transmission of this virulent dermatophyte. Reduced susceptibility was found for terbinafine and griseofulvin.<\/jats:p>","DOI":"10.1093\/mmy\/myaf020","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T20:51:13Z","timestamp":1741121473000},"source":"Crossref","is-referenced-by-count":3,"title":["Amplified fragment length polymorphism genotyping of <i>Trichophyton indotineae<\/i> indicates possible zoonotic transmission"],"prefix":"10.1093","author":[{"given":"Sheetal","family":"Thakur","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research , Chandigarh 160012 ,","place":["India"]},{"name":"Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research , Chandigarh 160012 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6734-361X","authenticated-orcid":false,"given":"Bram","family":"Spruijtenburg","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Canisius-Wilhelmina Hospital (CWZ)\/Dicoon , Nijmegen ,","place":["The Netherlands"]},{"name":"Radboudumc-CWZ Center of Expertise for Mycology , Nijmegen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Abhishek","sequence":"additional","affiliation":[{"name":"Division of Bacteriology and Mycology, ICAR- Indian Veterinary Research Institute , Izatnagar, Bareilly \u2013 243122, Uttar Pradesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theun","family":"de Groot","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Canisius-Wilhelmina Hospital (CWZ)\/Dicoon , Nijmegen ,","place":["The Netherlands"]},{"name":"Radboudumc-CWZ Center of Expertise for Mycology , Nijmegen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eelco F J","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Canisius-Wilhelmina Hospital (CWZ)\/Dicoon , Nijmegen ,","place":["The Netherlands"]},{"name":"Radboudumc-CWZ Center of Expertise for Mycology , Nijmegen ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarun","family":"Narang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research , Chandigarh 160012 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9912-0085","authenticated-orcid":false,"given":"Sunil","family":"Dogra","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research , Chandigarh 160012 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamini","family":"Walia","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research , New Delhi ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1555-3807","authenticated-orcid":false,"given":"Arunaloke","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Doodhdhari Burfani Hospital and Research Institute , Bhupatwala, Haridwar, Uttarakhand ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3253-6080","authenticated-orcid":false,"given":"Jacques F","family":"Meis","sequence":"additional","affiliation":[{"name":"Radboudumc-CWZ Center of Expertise for Mycology , Nijmegen ,","place":["The Netherlands"]},{"name":"Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Excellence Center for Medical Mycology (ECMM), University of Cologne , Cologne ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9097-9253","authenticated-orcid":false,"given":"Shivaprakash M","family":"Rudramurthy","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research , Chandigarh 160012 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,2,26]]},"container-title":["Medical Mycology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mmy\/advance-article-pdf\/doi\/10.1093\/mmy\/myaf020\/62178702\/myaf020.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mmy\/advance-article-pdf\/doi\/10.1093\/mmy\/myaf020\/62178702\/myaf020.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T20:51:13Z","timestamp":1741121473000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mmy\/advance-article\/doi\/10.1093\/mmy\/myaf020\/8043259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/mmy\/myaf020","relation":{},"ISSN":["1369-3786","1460-2709"],"issn-type":[{"value":"1369-3786","type":"print"},{"value":"1460-2709","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,26]]},"article-number":"myaf020"}}