{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:11:55Z","timestamp":1785161515284,"version":"3.55.0"},"reference-count":114,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2504803"],"award-info":[{"award-number":["2022YFC2504803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304037"],"award-info":[{"award-number":["82304037"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangxi Key Laboratory of Oncology","award":["2024SSY06041"],"award-info":[{"award-number":["2024SSY06041"]}]},{"name":"Research Project of Changning District Health Commission","award":["20234Y039"],"award-info":[{"award-number":["20234Y039"]}]},{"name":"Research Foundation of Shanghai Changzheng Hospital","award":["2023YJBF-FH03"],"award-info":[{"award-number":["2023YJBF-FH03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Meyerozyma guilliermondii represents an opportunistic pathogen complex threatening immunocompromised patients, notably those with cancer, leading to candidemia characterized by increasing incidence and high mortality risk. However, understanding of candidemia in cancer patients is limited. This study aims to elucidate the epidemiological and clinical features of candidemia by the M. guilliermondii species complex (MGSC) in cancer patients, thereby enhancing disease diagnosis and treatment. A systematic review was performed, analyzing cases from 1967 to 2024 documented in PubMed, Scopus, Embase, and Web of Science using specific terms related to M. guilliermondii and cancer. Additionally, two cancer-related invasive candidiasis cases by M. guilliermondii sensu stricto from Jiangxi Cancer Hospital were included. The review identified 282 cases, with 225 specifying tumor types: 114 hematologic malignancies and 111 solid tumors. A significant increase in cases was noted over the last two decades (92.2%). Predominantly, adults were affected, with a male-to-female ratio of 97:53. Among the precisely identified species in recent years, M. guilliermondii sensu stricto was the most recorded species (83.6%), with nine cases of candidemia due to M. caribbica in cancer patients. The overall mortality was 33.0%. Common factors included central venous catheter (CVC) placement (75.8%), prior broad-spectrum antibiotics (68.5%), and parenteral nutrition (46.1%). Timely CVC removal is crucial for cancer patients with prolonged CVC placement to prevent MGSC-related candidemia. Cancer patients with multiple risk factors are highly susceptible to MGSC-caused candidemia, which is increasing in incidence and mortality risk. Prompt antifungal therapy is essential for improving prognosis.<\/jats:p>","DOI":"10.1093\/mmy\/myaf087","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:56:01Z","timestamp":1758282961000},"source":"Crossref","is-referenced-by-count":3,"title":["Candidemia caused by\n                    <i>Meyerozyma guilliermondii<\/i>\n                    species complex in patients with cancer: A systematic review of case reports"],"prefix":"10.1093","volume":"63","author":[{"given":"Jingchen","family":"Tang","sequence":"first","affiliation":[{"name":"Naval Medical University Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Shanghai Changzheng Hospital, , Shanghai ,","place":["China"]},{"name":"The Center for Fungal Infectious Diseases Basic Research and Innovation of Medicine and Pharmacy, Ministry of Education , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuyang","family":"Cai","sequence":"additional","affiliation":[{"name":"Naval Medical University Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Shanghai Changzheng Hospital, , Shanghai ,","place":["China"]},{"name":"The Center for Fungal Infectious Diseases Basic Research and Innovation of Medicine and Pharmacy, Ministry of Education , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6203-5490","authenticated-orcid":false,"given":"Haiyang","family":"He","sequence":"additional","affiliation":[{"name":"Naval Medical University Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Shanghai Changzheng Hospital, , Shanghai ,","place":["China"]},{"name":"The Center for Fungal Infectious Diseases Basic Research and Innovation of Medicine and Pharmacy, Ministry of Education , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health, Jiangxi Medical College, Nanchang University , Nanchang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqin","family":"Liang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Nanchang Medical College, Jiangxi Cancer Institute Department of Hepatobiliary Tumor Surgery, Department of Interventional Therapy, Jiangxi Cancer Hospital, , Nanchang ,","place":["China"]},{"name":"Gannan Medical University , Ganzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Naval Medical University Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Shanghai Changzheng Hospital, , Shanghai ,","place":["China"]},{"name":"The Center for Fungal Infectious Diseases Basic Research and Innovation of Medicine and Pharmacy, Ministry of Education , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Xue","sequence":"additional","affiliation":[{"name":"Naval Medical University Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Shanghai Changzheng Hospital, , Shanghai ,","place":["China"]},{"name":"The Center for Fungal Infectious Diseases Basic Research and Innovation of Medicine and Pharmacy, Ministry of Education , Shanghai ,","place":["China"]},{"name":"905th Hospital of People\u2019s Liberation Army Navy Department of Pharmacy, , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"Jiangxi Key Laboratory of Oncology, JXHC Key Laboratory of Tumour Metastasis, Jiangxi Cancer Hospital, The Second Affiliated Hospital of Nanchang Medical College, Jiangxi Cancer Institute , Nanchang ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Pan","sequence":"additional","affiliation":[{"name":"Naval Medical University Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Shanghai Changzheng Hospital, , Shanghai ,","place":["China"]},{"name":"The Center for Fungal Infectious Diseases Basic Research and Innovation of Medicine and Pharmacy, Ministry of Education , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"issue":"1","key":"2026052212164018200_bib1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/pathogens5010006","article-title":"How chemotherapy increases the risk of systemic candidiasis in cancer patients: current paradigm and future directions","volume":"5","author":"Teoh","year":"2016","journal-title":"Pathogens"},{"key":"2026052212164018200_bib2","doi-asserted-by":"crossref","first-page":"11786337211026927","DOI":"10.1177\/11786337211026927","article-title":"Candida bloodstream infections: changes in epidemiology and increase in drug resistance","volume":"14","author":"Kotey","year":"2021","journal-title":"Infect Dis (Auckl)"},{"key":"2026052212164018200_bib3","doi-asserted-by":"crossref","first-page":"988708","DOI":"10.3389\/fimmu.2022.988708","article-title":"Lung and gut microbiomes in pulmonary aspergillosis: exploring adjunctive therapies to combat the disease","volume":"13","author":"Cai","year":"2022","journal-title":"Front Immunol."},{"issue":"1","key":"2026052212164018200_bib4","doi-asserted-by":"crossref","first-page":"9304","DOI":"10.1038\/s41467-024-53693-5","article-title":"Affinity molecular assay for detecting Candida albicans using chitin affinity and RPA-CRISPR\/Cas12a","volume":"15","author":"Shen","year":"2024","journal-title":"Nat Commun"},{"issue":"3","key":"2026052212164018200_bib5","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0749-0704(05)70198-6","article-title":"Infectious morbidity in critically ill patients with cancer","volume":"17","author":"Safdar","year":"2001","journal-title":"Crit Care Clin"},{"key":"2026052212164018200_bib6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.immunol.25.022106.141609","article-title":"Immunosuppressive strategies that are mediated by tumor cells","volume":"25","author":"Rabinovich","year":"2007","journal-title":"Annu Rev Immunol"},{"issue":"5","key":"2026052212164018200_bib7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41591-018-0014-x","article-title":"Understanding the tumor immune microenvironment (TIME) for effective therapy","volume":"24","author":"Binnewies","year":"2018","journal-title":"Nat Med."},{"issue":"1","key":"2026052212164018200_bib8","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.surge.2010.07.011","article-title":"Surgery induced immunosuppression","volume":"9","author":"Hogan","year":"2011","journal-title":"The Surgeon"},{"issue":"1","key":"2026052212164018200_bib9","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12967-018-1389-7","article-title":"Effects of surgery and anesthetic choice on immunosuppression and cancer recurrence","volume":"16","author":"Kim","year":"2018","journal-title":"J Transl Med"},{"issue":"5","key":"2026052212164018200_bib10","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1007\/s00210-023-02781-2","article-title":"Effects of chemotherapy on the immune system: implications for cancer treatment and patient outcomes","volume":"397","author":"Sharma","year":"2024","journal-title":"Naunyn Schmiedebergs Arch Pharmacol."},{"issue":"1","key":"2026052212164018200_bib11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s40121-017-0146-1","article-title":"Infections in cancer patients with solid tumors: a review","volume":"6","author":"Rolston","year":"2017","journal-title":"Infect Dis Ther"},{"issue":"12","key":"2026052212164018200_bib12","first-page":"1387","article-title":"Risk factors for infections, antibiotic therapy, and its impact on cancer therapy outcomes for patients with solid tumors","volume":"11","author":"Kube\u010dek","year":"2021","journal-title":"Life (Basel)"},{"issue":"20","key":"2026052212164018200_bib13","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1016\/j.cell.2022.09.015","article-title":"A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors","volume":"185","author":"Dohlman","year":"2022","journal-title":"Cell"},{"key":"2026052212164018200_bib14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2147\/TCRM.S40160","article-title":"Epidemiology and risk factors for invasive candidiasis","volume":"10","author":"Yapar","year":"2014","journal-title":"Ther Clin Risk Manag"},{"issue":"2","key":"2026052212164018200_bib15","doi-asserted-by":"crossref","first-page":"e01811","DOI":"10.1128\/JCM.01811-20","article-title":"Name changes for fungi of medical importance, 2018 to 2019","volume":"59","author":"Borman","year":"2021","journal-title":"J Clin Microbiol"},{"issue":"4","key":"2026052212164018200_bib16","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1007\/s42770-022-00813-2","article-title":"Me y erozyma guilliermondii species complex: review of current epidemiology, antifungal resistance, and mechanisms","volume":"53","author":"Ghasemi","year":"2022","journal-title":"Braz J Microbiol."},{"key":"2026052212164018200_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/615958","article-title":"Non-albicans Candida infection: an emerging threat","volume":"2014","author":"Deorukhkar","year":"2014","journal-title":"Interdiscip Perspect Infect Diseas"},{"issue":"10","key":"2026052212164018200_bib18","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1128\/JCM.00865-06","article-title":"Candida guilliermondii, an opportunistic fungal pathogen with decreased susceptibility to fluconazole: geographic and temporal trends from the ARTEMIS DISK Antifungal Surveillance Program","volume":"44","author":"Pfaller","year":"2006","journal-title":"J Clin Microbiol."},{"issue":"5","key":"2026052212164018200_bib19","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1439-0507.2010.01960.x","article-title":"What do we know about Candida guilliermondii? A voyage throughout past and current literature about this emerging yeast","volume":"54","author":"Savini","year":"2011","journal-title":"Mycoses"},{"issue":"3","key":"2026052212164018200_bib20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00294-013-0391-0","article-title":"Candida guilliermondii: biotechnological applications, perspectives for biological control, emerging clinical importance and recent advances in genetics","volume":"59","author":"Papon","year":"2013","journal-title":"Curr Genet"},{"issue":"3","key":"2026052212164018200_bib21","first-page":"7","article-title":"Non albicans Candida species: a review of epidemiology, pathogenicity and antifungal resistance","volume":"7","author":"Deorukhkar","year":"2015","journal-title":"Pravara Medical Review"},{"issue":"7","key":"2026052212164018200_bib22","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s10096-020-04147-5","article-title":"Expect the unexpected: fungemia caused by uncommon Candida species in a Turkish University Hospital","volume":"40","author":"Alp","year":"2021","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"1","key":"2026052212164018200_bib23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.diagmicrobio.2007.07.014","article-title":"Fungemia due to Candida guilliermondii in a pediatric and adult population during a 12-year period","volume":"60","author":"Pem\u00e1n","year":"2008","journal-title":"Diagn Microbiol Infect Dis."},{"issue":"11","key":"2026052212164018200_bib24","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.3201\/eid2111.150404","article-title":"Uncommon Candida species fungemia among cancer patients, Houston, Texas, USA","volume":"21","author":"Jung","year":"2015","journal-title":"Emerg Infect Dis"},{"issue":"6","key":"2026052212164018200_bib25","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s11046-023-00765-7","article-title":"Epidemiology and outcomes of non-albicans Candida bloodstream infections in transplant recipients and cancer patients","volume":"188","author":"Otto","year":"2023","journal-title":"Mycopathologia"},{"issue":"5","key":"2026052212164018200_bib26","doi-asserted-by":"crossref","first-page":"e0511522","DOI":"10.1128\/spectrum.05115-22","article-title":"Emergence of cryptic species and clades of Meyerozyma guilliermondii species complex exhibiting limited in vitro susceptibility to antifungals in patients with candidemia","volume":"11","author":"Francisco","year":"2023","journal-title":"Microbiol Spectr"},{"issue":"6","key":"2026052212164018200_bib27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1567-1364.2011.00731.x","article-title":"Drug-resistant cassettes for the efficient transformation of Candida guilliermondii wild-type strains","volume":"11","author":"Millerioux","year":"2011","journal-title":"FEMS Yeast Res"},{"issue":"6","key":"2026052212164018200_bib28","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1473-3099(22)00872-6","article-title":"Guideline adherence and survival of patients with candidaemia in Europe: results from the ECMM Candida III multinational European observational cohort study","volume":"23","author":"Hoenigl","year":"2023","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"2026052212164018200_bib29","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13054-016-1313-6","article-title":"Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy","volume":"20","author":"Calandra","year":"2016","journal-title":"Critical Care"},{"key":"2026052212164018200_bib30","first-page":"100117","article-title":"Prognostic factors of Candida spp. Bloodstream infection in adults: a nine-year retrospective cohort study across tertiary hospitals in Brazil and Spain","volume":"6","author":"Agnelli","year":"2022","journal-title":"Lancet Reg Health Am."},{"issue":"5","key":"2026052212164018200_bib31","doi-asserted-by":"crossref","first-page":"e280","DOI":"10.1016\/S1473-3099(24)00749-7","article-title":"Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM","volume":"25","author":"Cornely","year":"2025","journal-title":"Lancet Infect Dis."},{"issue":"4","key":"2026052212164018200_bib32","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/civ933","article-title":"Clinical Practice Guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America","volume":"62","author":"Pappas","year":"2016","journal-title":"Clin Infect Dis."},{"key":"2026052212164018200_bib33","article-title":"Performance standards for antifungal susceptibility testing of yeasts","volume-title":"In CLSI supplement M27M44S","author":"Clinical and Laboratory Standards Institute U","year":"2022"},{"key":"2026052212164018200_bib34","article-title":"Epidemiological cutoff values for antifungal susceptibility testing","volume-title":"In CLSI supplement M57S","author":"Clinical and Laboratory Standards Institute U","year":"2022"},{"issue":"3","key":"2026052212164018200_bib35","doi-asserted-by":"crossref","first-page":"e59373","DOI":"10.1371\/journal.pone.0059373","article-title":"Epidemiology of candidemia in Latin America: a laboratory-based survey","volume":"8","author":"Nucci","year":"2013","journal-title":"PLoS One"},{"issue":"9","key":"2026052212164018200_bib36","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.3201\/eid2509.190040","article-title":"Epidemiologic shift in candidemia driven by Candida auris, South Africa, 2016\u201320171","volume":"25","author":"van\u00a0Schalkwyk","year":"2019","journal-title":"Emerg Infect Dis."},{"issue":"7","key":"2026052212164018200_bib37","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1093\/infdis\/jiaa502","article-title":"Invasive candidiasis species distribution and trends, United States, 2009\u20132017","volume":"223","author":"Ricotta","year":"2021","journal-title":"J Infect Dis."},{"issue":"1","key":"2026052212164018200_bib38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3390\/jof4010027","article-title":"Non-culture diagnostics for invasive candidiasis: promise and unintended consequences","volume":"4","author":"Clancy","year":"2018","journal-title":"J Fungi (Basel)"},{"issue":"3","key":"2026052212164018200_bib39","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1080\/21505594.2016.1141161","article-title":"Bloodstream infections in patients with solid tumors","volume":"7","author":"Gudiol","year":"2016","journal-title":"Virulence"},{"issue":"2","key":"2026052212164018200_bib40","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3390\/jof8020116","article-title":"Increasing incidence and shifting epidemiology of candidemia in Greece: results from the first nationwide 10-year survey","volume":"8","author":"Mamali","year":"2022","journal-title":"J Fungi (Basel)"},{"issue":"6","key":"2026052212164018200_bib41","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s11046-010-9278-5","article-title":"Pan-azole-resistant Candida guilliermondii from a leukemia patient\u2019s silent funguria","volume":"169","author":"Savini","year":"2010","journal-title":"Mycopathologia"},{"issue":"7","key":"2026052212164018200_bib42","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1185\/03007995.2010.487796","article-title":"Candidemia in children","volume":"26","author":"Zaoutis","year":"2010","journal-title":"Curr Med Res Opin"},{"issue":"11","key":"2026052212164018200_bib43","first-page":"B4698","article-title":"Candida and candidaemia. Susceptibility and epidemiology","volume":"60","author":"MC","year":"2013","journal-title":"Dan Med J"},{"issue":"10","key":"2026052212164018200_bib44","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1099\/ijsem.0.002232","article-title":"Meyer o zyma amylolytica sp. nov. from temperate deciduous trees and the transfer of five Candida species to the genus Meyerozyma","volume":"67","author":"Yurkov","year":"2017","journal-title":"Int J Syst Evol Microbiol"},{"issue":"3","key":"2026052212164018200_bib45","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1534\/g3.117.300316","article-title":"The genomes of four Meyerozyma caribbica isolates and novel insights into the Meyerozyma guillie r mondii species complex","volume":"8","author":"De\u00a0Marco","year":"2018","journal-title":"G3 (Bethesda)"},{"issue":"4","key":"2026052212164018200_bib46","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cmi.2014.11.009","article-title":"Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for the rapid identification of yeasts causing bloodstream infections","volume":"21","author":"Ghosh","year":"2015","journal-title":"Clin Microbiol Infect"},{"issue":"1","key":"2026052212164018200_bib47","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jmii.2021.01.009","article-title":"Species identification and antifungal susceptibility of uncommon blood yeast isolates","volume":"55","author":"Li","year":"2022","journal-title":"J Microbiol Immunol Infect."},{"key":"2026052212164018200_bib48","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejim.2016.06.029","article-title":"Candidemia and invasive candidiasis in adults: a narrative review","volume":"34","author":"Antinori","year":"2016","journal-title":"Eur J Intern Med"},{"issue":"5","key":"2026052212164018200_bib49","doi-asserted-by":"crossref","first-page":"e0511522","DOI":"10.1128\/spectrum.05115-22","article-title":"Emergence of cryptic species and clades of Meyerozyma guilliermondii species complex exhibiting limited in vitro susceptibility to antifungals in patients with candidemia","volume":"11","author":"Francisco","year":"2023","journal-title":"Microbiol Spectr"},{"issue":"1","key":"2026052212164018200_bib50","doi-asserted-by":"crossref","first-page":"e12634","DOI":"10.1111\/tid.12634","article-title":"Breakthrough fungemia due to Candida fermentati with fks1p mutation under micafungin treatment in a cord blood transplant recipient","volume":"19","author":"Konuma","year":"2017","journal-title":"Transpl Infect Dis"},{"issue":"7","key":"2026052212164018200_bib51","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.jiac.2017.12.015","article-title":"Three cases of Candida fermentati fungemia following hematopoietic stem cell transplantation","volume":"24","author":"Morita","year":"2018","journal-title":"J Infect Chemother"},{"issue":"3","key":"2026052212164018200_bib52","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/mmy\/myaa044","article-title":"A case-series of bloodstream infections caused by the Meyerozyma guilliermondii species complex at a reference center of oncology in Brazil","volume":"59","author":"Chaves","year":"2021","journal-title":"Med Mycol."},{"issue":"10","key":"2026052212164018200_bib53","doi-asserted-by":"crossref","first-page":"806","DOI":"10.3390\/jof7100806","article-title":"A reference laboratory surveillance on fungal isolates from patients with haematological malignancy in Japan","volume":"7","author":"Hino","year":"2021","journal-title":"J Fungi"},{"issue":"3","key":"2026052212164018200_bib54","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/cid\/civ293","article-title":"Epidemiology and outcome of fungemia in a cancer cohort of the Infectious Diseases Group (IDG) of the European Organization for Research and Treatment of Cancer (EORTC 65031)","volume":"61","author":"Cornely","year":"2015","journal-title":"Clin Infect Dis."},{"issue":"8","key":"2026052212164018200_bib55","first-page":"1068","article-title":"The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study","volume":"91","author":"Pagano","year":"2006","journal-title":"Haematologica"},{"issue":"4","key":"2026052212164018200_bib56","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/PAP.0000000000000016","article-title":"Fungal infections of the gastrointestinal tract in the immunocompromised host: an update","volume":"21","author":"Lamps","year":"2014","journal-title":"Adv Anat Pathol."},{"key":"2026052212164018200_bib57","doi-asserted-by":"crossref","first-page":"216302","DOI":"10.1016\/j.canlet.2023.216302","article-title":"Gut fungal mycobiome: a significant factor of tumor occurrence and development","volume":"569","author":"Li","year":"2023","journal-title":"Cancer Lett"},{"issue":"4","key":"2026052212164018200_bib58","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/clinids\/18.4.525","article-title":"Risk factors for fungal infection in patients with malignant hematologic disorders: implications for empirical therapy and prophylaxis","volume":"18","author":"Guiot","year":"1994","journal-title":"Clin Infect Dis."},{"issue":"2","key":"2026052212164018200_bib59","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1365-2141.2007.06906.x","article-title":"Considerations in the approach to invasive fungal infection in patients with haematological malignancies","volume":"140","author":"Bow","year":"2007","journal-title":"Br J Haematol"},{"issue":"3","key":"2026052212164018200_bib60","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3390\/jof4030097","article-title":"Treatment of invasive candidiasis: a narrative review","volume":"4","author":"Ben-Ami","year":"2018","journal-title":"J Fungi (Basel)"},{"issue":"6","key":"2026052212164018200_bib61","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s11046-020-00485-2","article-title":"Clinical characteristics and outcomes of candidemia caused by Meyerozyma guilliermondii complex in cancer patients undergoing surgery","volume":"185","author":"Chen","year":"2020","journal-title":"Mycopathologia"},{"issue":"10","key":"2026052212164018200_bib62","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1007\/s10096-020-03912-w","article-title":"Mechanism of Candida pathogenesis: revisiting the vital drivers","volume":"39","author":"Mba","year":"2020","journal-title":"Eur J Clin Microbiol Infect Dis."},{"issue":"6","key":"2026052212164018200_bib63","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.ccell.2015.10.012","article-title":"Immunological effects of conventional chemotherapy and targeted anticancer agents","volume":"28","author":"Galluzzi","year":"2015","journal-title":"Cancer Cell"},{"issue":"7","key":"2026052212164018200_bib64","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.chom.2022.04.013","article-title":"Long-term antibiotic exposure promotes mortality after systemic fungal infection by driving lymphocyte dysfunction and systemic escape of commensal bacteria","volume":"30","author":"Drummond","year":"2022","journal-title":"Cell Host Microbe"},{"issue":"9","key":"2026052212164018200_bib65","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1631\/jzus.B1500005","article-title":"Invasive fungal infection in allogeneic hematopoietic stem cell transplant recipients: single center experiences of 12 years","volume":"16","author":"Shi","year":"2015","journal-title":"J Zhejiang Univ Sci B"},{"issue":"4","key":"2026052212164018200_bib66","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.hemonc.2017.05.013","article-title":"Complications of hematopoietic stem transplantation: fungal infections","volume":"10","author":"Omrani","year":"2017","journal-title":"Hematol Oncol Stem Cell Ther"},{"issue":"10","key":"2026052212164018200_bib67","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41571-019-0222-4","article-title":"Tumour-associated neutrophils in patients with cancer","volume":"16","author":"Shaul","year":"2019","journal-title":"Nat Rev Clin Oncol"},{"issue":"8","key":"2026052212164018200_bib68","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1093\/cid\/cis021","article-title":"Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: a patient-level quantitative review of randomized trials","volume":"54","author":"Andes","year":"2012","journal-title":"Clin Infect Dis."},{"issue":"1","key":"2026052212164018200_bib69","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1186\/s12879-017-2636-x","article-title":"Evaluation of candidemia in epidemiology and risk factors among cancer patients in a cancer center of China: an 8-year case-control study","volume":"17","author":"Li","year":"2017","journal-title":"BMC Infect Dis"},{"issue":"7","key":"2026052212164018200_bib70","doi-asserted-by":"crossref","first-page":"e00099","DOI":"10.1128\/AAC.00099-17","article-title":"Candida guilliermondii complex is characterized by high antifungal resistance but low mortality in 22 cases of candidemia","volume":"61","author":"Marcos-Zambrano","year":"2017","journal-title":"Antimicrob Agents Chemother."},{"issue":"7","key":"2026052212164018200_bib71","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1128\/JCM.00356-06","article-title":"Candida guilliermondii fungemia in patients with hematologic malignancies","volume":"44","author":"Girmenia","year":"2006","journal-title":"J Clin Microbiol"},{"issue":"1","key":"2026052212164018200_bib72","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1186\/s12879-025-11021-2","article-title":"Epidemiological characteristics, antifungal susceptibility, and mortality factors of candidemia in adults at a tertiary teaching hospital in Zunyi, China (2016\u20132023)","volume":"25","author":"Chen","year":"2025","journal-title":"BMC Infect Dis"},{"issue":"5","key":"2026052212164018200_bib73","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1007\/s15010-025-02513-z","article-title":"Epidemiology and outcomes of Candida spp. bloodstream infections in cancer patients: a comparative retrospective study from a German tertiary cancer center","volume":"53","author":"Wolf","year":"2025","journal-title":"Infection"},{"key":"2026052212164018200_bib74","first-page":"552","article-title":"Clinical features, antifungal susceptibility, and outcome of Candida guilliermondii fungemia: an experience in a tertiary hospital in mid-Taiwan","volume-title":"J Microbiol Immunol Infect.","author":"Tseng","year":"2018"},{"issue":"1","key":"2026052212164018200_bib75","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1128\/CMR.12.1.40","article-title":"Current and emerging azole antifungal agents","volume":"12","author":"Sheehan\u00a0CAH","year":"1999","journal-title":"Clin Microbiol Rev"},{"issue":"4","key":"2026052212164018200_bib76","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/2047-783X-16-4-159","article-title":"Pharmacology and metabolism of anidulafungin, caspofungin and micafungin in the treatment of invasive candidosis\u2014review of the literature","volume":"16","author":"Kofla","year":"2011","journal-title":"Eur J Med Res"},{"key":"2026052212164018200_bib77","first-page":"441","article-title":"Current perspectives on Echinocandin class drugs","volume-title":"Future Microbiology","author":"Perlin","year":"2011"},{"key":"2026052212164018200_bib78","first-page":"3264","article-title":"Specific substitutions in the Echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates","volume-title":"Antimicrob Agents Chemother","author":"Park","year":"2005"},{"issue":"5","key":"2026052212164018200_bib79","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/jac\/dkq053","article-title":"Candidaemia in adult cancer patients: risks for fluconazole-resistant isolates and death","volume":"65","author":"Slavin","year":"2010","journal-title":"J Antimicrob Chemother."},{"issue":"11","key":"2026052212164018200_bib80","doi-asserted-by":"crossref","first-page":"e344","DOI":"10.1016\/S1473-3099(17)30304-3","article-title":"Candida and invasive mould diseases in non-neutropenic critically ill patients and patients with haematological cancer","volume":"17","author":"Colombo","year":"2017","journal-title":"Lancet Infect Dis"},{"issue":"5","key":"2026052212164018200_bib81","doi-asserted-by":"crossref","first-page":"492.e491","DOI":"10.1016\/j.cmi.2015.01.013","article-title":"Antifungal stewardship in a tertiary-care institution: a bedside intervention","volume":"21","author":"Valerio","year":"2015","journal-title":"Clin Microbiol Infect"},{"issue":"5","key":"2026052212164018200_bib82","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1007\/s12185-013-1449-y","article-title":"Reduced-intensity conditioning regimen with low-dose ATG-F for unrelated bone marrow transplant is associated with lower non-relapse mortality than a regimen with low-dose TBI: a single-center retrospective analysis of 103 cases","volume":"98","author":"Fuji","year":"2013","journal-title":"Int. J. Hematol."},{"issue":"Suppl 7","key":"2026052212164018200_bib83","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/1469-0691.12039","article-title":"ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients","volume":"18","author":"Cornely","year":"2012","journal-title":"Clin Microbiol Infect."},{"issue":"6","key":"2026052212164018200_bib84","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1473-3099(22)00872-6","article-title":"Guideline adherence and survival of patients with candidaemia in Europe: results from the ECMM Candida III multinational European observational cohort study","volume":"23","author":"Hoenigl","year":"2023","journal-title":"Lancet Infect Dis."},{"issue":"2","key":"2026052212164018200_bib85","doi-asserted-by":"crossref","first-page":"e0007423","DOI":"10.1128\/cmr.00074-23","article-title":"Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease","volume":"37","author":"Hoenigl","year":"2024","journal-title":"Clin Microbiol Rev"},{"key":"2026052212164018200_bib86","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/1471-2334-6-173","article-title":"Fluconazole for empiric antifungal therapy in cancer patients with fever and neutropenia","volume":"6","author":"Yu","year":"2006","journal-title":"BMC Infect Dis"},{"issue":"3","key":"2026052212164018200_bib87","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1001\/archinte.1967.00290210079004","article-title":"Fungemia caused by \u201cnonpathogenic\u201d yeasts","volume":"119","author":"Louria","year":"1967","journal-title":"Arch Intern Med"},{"issue":"4","key":"2026052212164018200_bib88","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/mpo.2950160417","article-title":"Skin rash associated with Candida guilliermondii","volume":"16","author":"Booth","year":"1988","journal-title":"Med Pediatr Oncol"},{"issue":"6","key":"2026052212164018200_bib89","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0190-9622(88)70273-X","article-title":"Use of touch preparation for rapid diagnosis of disseminated candidiasis","volume":"19","author":"Held","year":"1988","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"2026052212164018200_bib90","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/0002-9343(88)90059-9","article-title":"Amphotericin B-resistant yeast infection in severely immunocompromised patients","volume":"84","author":"Powderly","year":"1988","journal-title":"Am J Med"},{"issue":"Suppl 1","key":"2026052212164018200_bib91","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1093\/clinids\/14.Supplement_1.S120","article-title":"Candidemia in immunocompromised patients","volume":"14","author":"Meunier","year":"1992","journal-title":"Clin Infect Dis"},{"issue":"6","key":"2026052212164018200_bib92","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1093\/clind\/15.6.1003","article-title":"Evolving role of flucytosine in immunocompromised patients: new insights into safety, pharmacokinetics, and antifungal therapy","volume":"15","author":"Francis","year":"1992","journal-title":"Clin Infect Dis"},{"issue":"2","key":"2026052212164018200_bib93","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1023\/A:1006951619245","article-title":"Fungemia in cancer patients in Brazil: predominance of non-albicans species","volume":"141","author":"Nucci","year":"1998","journal-title":"Mycopathologia"},{"issue":"1","key":"2026052212164018200_bib94","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s101560050010","article-title":"Candida guilliermondii fungemia in cancer patients: report of three cases","volume":"5","author":"Krcmery","year":"1999","journal-title":"J. Infect Chemother"},{"issue":"1","key":"2026052212164018200_bib95","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s101560170033","article-title":"Nosocomial fungemia due to amphotericin B-resistant Candida spp. in three pediatric patients after previous neurosurgery for brain tumors","volume":"7","author":"Kovacicova","year":"2001","journal-title":"J Infect Chemother"},{"issue":"11","key":"2026052212164018200_bib96","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1007\/s10096-003-1013-4","article-title":"Nosocomial cluster of Candida guillermondii fungemia in surgical patients","volume":"22","author":"Masala","year":"2003","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"7","key":"2026052212164018200_bib97","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1128\/JCM.00356-06","article-title":"Candida guilliermondii fungemia in patients with hematologic malignancies","volume":"44","author":"Girmenia","year":"2006","journal-title":"J Clin Microbiol."},{"issue":"3","key":"2026052212164018200_bib98","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1590\/S0036-46652006000300002","article-title":"Candida guilliermondii as the aetiology of candidosis","volume":"48","author":"Pasqualotto","year":"2006","journal-title":"Rev Inst Med Trop Sao Paulo"},{"issue":"4","key":"2026052212164018200_bib99","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3324\/haematol.11149","article-title":"Breakthrough C. parapsilosis andC. guilliermondii blood stream infections in allogeneic hematopoietic stem cell transplant recipients receiving long-term caspofungin therapy","volume":"93","author":"Kabbara","year":"2008","journal-title":"Haematologica"},{"issue":"1","key":"2026052212164018200_bib100","doi-asserted-by":"crossref","first-page":"O50","DOI":"10.1111\/1469-0691.12312","article-title":"A prospective, cohort, multicentre study of candidaemia in hospitalized adult patients with haematological malignancies","volume":"20","author":"Gamaletsou","year":"2014","journal-title":"Clin Microbiol Infect."},{"key":"2026052212164018200_bib101","doi-asserted-by":"crossref","first-page":"v89","DOI":"10.1093\/annonc\/mdu436.65","article-title":"Therapy related leukemia during adjuvant chemotherapy for pancreatic cancer developed after adjuvant for breast cancer","volume":"25","author":"Muta","year":"2014","journal-title":"Ann Oncol"},{"issue":"4","key":"2026052212164018200_bib102","first-page":"340","article-title":"High infection-related mortality in pediatric acute myeloid leukemia without preventive antibiotics and antifungals: retrospective cohort study of a single center from a middle-income country","volume":"34","author":"Zengin","year":"2017","journal-title":"Turk J Hematol."},{"issue":"4","key":"2026052212164018200_bib103","doi-asserted-by":"crossref","first-page":"e01791","DOI":"10.1128\/AAC.01791-16","article-title":"Clinical and microbiological characteristics of breakthrough candidemia in allogeneic hematopoietic stem cell transplant recipients in a Japanese hospital","volume":"61","author":"Kimura","year":"2017","journal-title":"Antimicrob Agents Chemother."},{"key":"2026052212164018200_bib104","first-page":"S156","article-title":"Clinical manifestations of candidemia caused by uncommon Candida species and antifungal susceptibility of the isolates in a regional hospital in Taiwan, 2007\u20132014","volume":"50","author":"Liu","year":"2017","journal-title":"Int J Antimicrob Agents."},{"issue":"4","key":"2026052212164018200_bib105","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/s12288-016-0768-6","article-title":"Increasing non-albicans Candida in hematological patients with fluconazole prophylaxis: a case series","volume":"33","author":"Siddiqui","year":"2017","journal-title":"Indian J Hematol Blood Transfus"},{"issue":"4","key":"2026052212164018200_bib106","doi-asserted-by":"crossref","first-page":"e12922","DOI":"10.1111\/tid.12922","article-title":"Breakthrough Candida guilliermondii (Meyerozyma guilliermondii) fungemia after cord blood transplantation for extranodal NK-cell lymphoma with azole prophylaxis","volume":"20","author":"Nakazawa","year":"2018","journal-title":"Transpl Infect Dis."},{"issue":"10","key":"2026052212164018200_bib107","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1093\/cid\/ciy406","article-title":"Breakthrough fungal infections in patients with leukemia receiving isavuconazole","volume":"67","author":"Rausch","year":"2018","journal-title":"Clin Infect Dis"},{"issue":"1","key":"2026052212164018200_bib108","first-page":"32","article-title":"Candidemia due to Candida guilliermondii in an immuno-compromised infant: a case report and review of literature","volume":"5","author":"Ahangarkani","year":"2019","journal-title":"Curr Med Mycol."},{"issue":"3","key":"2026052212164018200_bib109","doi-asserted-by":"crossref","first-page":"105886","DOI":"10.1016\/j.ijantimicag.2020.105886","article-title":"Itraconazole vs. posaconazole for antifungal prophylaxis in patients with acute myeloid leukemia undergoing intensive chemotherapy: a retrospective study","volume":"55","author":"Copley","year":"2020","journal-title":"Int J Antimicrob Agents"},{"issue":"3","key":"2026052212164018200_bib110","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41409-019-0541-1","article-title":"Nutritional risk index as a risk factor for breakthrough candidemia in allogeneic hematopoietic stem cell transplantation","volume":"55","author":"Kaito","year":"2020","journal-title":"Bone Marrow Transplant."},{"issue":"4","key":"2026052212164018200_bib111","doi-asserted-by":"crossref","first-page":"15","DOI":"10.32598\/CMM.2023.1372","article-title":"Evaluation of Candida colonization index, molecular identification, and antifungal susceptibility pattern of Candida species isolated from critically ill pediatric patients: a single-center study in Iran","volume":"8","author":"Davari","year":"2022","journal-title":"Curr Med Mycol."},{"key":"2026052212164018200_bib112","doi-asserted-by":"crossref","first-page":"e935911","DOI":"10.12659\/AJCR.935911","article-title":"Thrombotic thrombocytopenic purpura triggered by acute myeloid leukemia: a case report","volume":"23","author":"Adimora","year":"2022","journal-title":"Am J Case Rep"},{"issue":"6","key":"2026052212164018200_bib113","doi-asserted-by":"crossref","first-page":"myad056","DOI":"10.1093\/mmy\/myad056","article-title":"Breakthrough candidemia with hematological disease: results from a single-center retrospective study in Japan, 2009\u20132020","volume":"61","author":"Nishida","year":"2023","journal-title":"Med Mycol"},{"key":"2026052212164018200_bib114","first-page":"7806235","article-title":"Diagnosis and treatment challenges of Candida guilliermondii in immunocompromised patients: a case study in a neutropenic AML patient","volume":"2024","author":"Modi","year":"2024","journal-title":"Case Rep Infect Dis"}],"container-title":["Medical Mycology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mmy\/advance-article-pdf\/doi\/10.1093\/mmy\/myaf087\/64345817\/myaf087.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mmy\/article-pdf\/63\/10\/myaf087\/64345817\/myaf087.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mmy\/article-pdf\/63\/10\/myaf087\/64345817\/myaf087.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T16:17:04Z","timestamp":1779466624000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mmy\/article\/doi\/10.1093\/mmy\/myaf087\/8261521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,22]]},"references-count":114,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,9,30]]}},"URL":"https:\/\/doi.org\/10.1093\/mmy\/myaf087","relation":{},"ISSN":["1369-3786","1460-2709"],"issn-type":[{"value":"1369-3786","type":"print"},{"value":"1460-2709","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,9,22]]},"article-number":"myaf087"}}