{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:07:01Z","timestamp":1792786021379,"version":"4.5.0"},"reference-count":97,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Mayo Foundation for Education and Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Candida auris is an emerging fungal pathogen with high rates of multidrug resistance, posing a significant global health threat. Immunosuppressed patients are particularly vulnerable to multidrug-resistant (MDR) C. auris infections. This systematic review and meta-analysis (SR-MA) aimed to assess the global prevalence of MDR-C. auris isolates in humans and their resistance to antifungal drugs, primarily fluconazole (FLZ), voriconazole (VOR), and amphotericin B (AmB). A comprehensive search was conducted in PubMed, Scopus, and ScienceDirect databases on published studies regarding clinical C. auris isolates and the use of antifungal susceptibility testing assay from 17 March 2015 to 1 February 2024. Meta-analysis was conducted using random-effects models to determine the estimated pooled prevalence of MDR-C. auris isolates and their antifungal resistance profiles from immunosuppressed humans. A total of 81 research studies were included in the final analysis, with the overall pooled prevalence of the three most important antifungal drugs; FLZ (92.5% | 95% CI: 89.5\u201394.7), VOR (49.0% | 95% CI: 37.6\u201360.4), and AmB (51.0% | 95% CI: 42.3\u201359.7). According to the subgroup analyses, FLZ-resistant C. auris was the most prevalent isolate observed in the five continents reporting compared to the VOR- and AmB-resistant C. auris having lower pooled prevalence. Further, higher pooled prevalence of MDR-C. auris isolates were observed from males (68.2%, n\u00a0=\u00a0578) compared to females (37.1%, n\u00a0=\u00a0283). Finally, the global pooled prevalence for mortality in immunosuppressed patients with MDR-C. auris from 13 research studies was 41.5% (95% CI: 29.9\u201354.2). This SR-MA study establishes the variation of MDR-C. auris resistance patterns observed from different continents and the importance to conduct further research studies using potent antifungal drugs. Accordingly, it is imperative to establish stringent surveillance on the increasing prevalence of antifungal resistance particularly in low-income regions with limited research resources to prevent increasing prevalence of MDR-C. auris.<\/jats:p>","DOI":"10.1093\/mmy\/myaf107","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:32:24Z","timestamp":1763645544000},"source":"Crossref","is-referenced-by-count":16,"title":["Global prevalence of multidrug-resistant\n                    <i>Candida auris<\/i>\n                    in humans between 2015 and 2024: A systematic review and meta-analysis"],"prefix":"10.1093","volume":"63","author":[{"given":"Conrad C","family":"Achilonu","sequence":"first","affiliation":[{"name":"Mayo Clinic Thoracic Diseases Research Unit, Departments of Medicine and Biochemistry, , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Will J","family":"Barwatt","sequence":"additional","affiliation":[{"name":"Mayo Clinic Thoracic Diseases Research Unit, Departments of Medicine and Biochemistry, , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0364-3311","authenticated-orcid":false,"given":"Theodore J","family":"Kottom","sequence":"additional","affiliation":[{"name":"Mayo Clinic Thoracic Diseases Research Unit, Departments of Medicine and Biochemistry, , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1488-3345","authenticated-orcid":false,"given":"Rita O","family":"Oladele","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Lagos Department of Medical Microbiology and Parasitology, , Idi\u2013Araba 10254 ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsepo","family":"Ramatla","sequence":"additional","affiliation":[{"name":"Central University of Technology Department of Life Sciences, , Bloemfontein 9301, Free State ,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5671-6874","authenticated-orcid":false,"given":"Andrew H","family":"Limper","sequence":"additional","affiliation":[{"name":"Mayo Clinic Thoracic Diseases Research Unit, Departments of Medicine and Biochemistry, , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"2025120804564363200_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/mmy\/myy054","article-title":"Candida auris: the recent emergence of a multidrug-resistant fungal 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