{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T09:19:32Z","timestamp":1778145572761,"version":"3.51.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Clinical High-tech"},{"name":"Characteristic Technology Projects in Guangzhou","award":["2026P-TS053"],"award-info":[{"award-number":["2026P-TS053"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This retrospective cohort study compared the efficacy and safety of lipid-based amphotericin B formulations (amphotericin B colloidal dispersion [ABCD] and liposomal amphotericin B [L-AmB]) versus conventional amphotericin B deoxycholate (AmB-d) for the treatment of non-human immunodeficiency virus (HIV)-associated cryptococcal meningitis (CM). Data from 199 patients were analyzed, divided into three groups based on induction therapy: AmB-d (n\u00a0=\u00a0110), ABCD (n\u00a0=\u00a044), and L-AmB (n\u00a0=\u00a045). At baseline, a higher proportion of patients in the lipid-based groups presented with altered mental status. After 2 weeks, the ABCD and L-AmB groups showed significantly better clinical improvement (as measured by British Medical Research Council Stage 1) compared to the AmB-d group (63.6% and 77.8% vs. 35.5%; P\u00a0&amp;lt;\u00a0.001), and experienced substantially lower rates of renal impairment (54.5% and 53.3% vs. 79.1%; P\u00a0=\u00a0.001). Early fungicidal activity was similar across all groups. Multivariate analysis at 10 weeks indicated that both lipid-based formulations were associated with a lower risk of unsuccessful outcomes compared to AmB-d. Furthermore, 1-year survival analysis for clinical cure demonstrated a significantly higher cumulative incidence in the lipid-based AmB groups (Log-rank test, P\u00a0=\u00a0.016). In conclusion, induction regimens based on ABCD or L-AmB were associated with better outcomes than AmB-d for non-HIV-associated CM, offering better long-term outcomes and a more favorable safety profile, particularly regarding kidney toxicity.<\/jats:p>","DOI":"10.1093\/mmy\/myag033","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T11:39:02Z","timestamp":1776253142000},"source":"Crossref","is-referenced-by-count":0,"title":["Lipid-based amphotericin B formulations (ABCD\/L-AmB) were associated with better outcomes than deoxycholate (AmB-d) in non-HIV-associated cryptococcal meningitis: A retrospective cohort study"],"prefix":"10.1093","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8291-9720","authenticated-orcid":false,"given":"Junyu","family":"Liu","sequence":"first","affiliation":[{"name":"Third Affiliated Hospital of Sun Yat-sen University Department of Neurology, , Guangzhou, Guangdong 510630 ,","place":["PR 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of Neurology, , Guangzhou, Guangdong 510630 ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajie","family":"Chen","sequence":"additional","affiliation":[{"name":"Third Affiliated Hospital of Sun Yat-sen University Department of Neurology, , Guangzhou, Guangdong 510630 ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhai","family":"Zeng","sequence":"additional","affiliation":[{"name":"Third Affiliated Hospital of Sun Yat-sen University Department of Neurology, , Guangzhou, Guangdong 510630 ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheqi","family":"Li","sequence":"additional","affiliation":[{"name":"Third Affiliated Hospital of Sun Yat-sen University Department of Neurology, , Guangzhou, Guangdong 510630 ,","place":["PR 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