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When the medical records of 22 patients at one site were reviewed, only 14 (63.6%) with positive EIA IgG tests were associated with clinically active coccidioidomycosis. These results support not using EIA IgG OD as a substitute for CF titer and that an isolated positive EIA IgG may be falsely positive.<\/jats:p>","DOI":"10.1093\/mmy\/myag047","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:41:13Z","timestamp":1778586073000},"source":"Crossref","is-referenced-by-count":0,"title":["Enyzme immunoassay compared to immunodiffusion complement-fixation to assess the IgG serological response in coccidioidomycosis"],"prefix":"10.1093","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-5833","authenticated-orcid":false,"given":"Chinh T","family":"Nguyen","sequence":"first","affiliation":[{"name":"From the Southern Arizona Veterans Affairs Health Care System (SAVAHCS) and the University of Arizona , Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil M","family":"Ampel","sequence":"additional","affiliation":[{"name":"From the Southern Arizona Veterans Affairs Health Care System (SAVAHCS) and the University of Arizona , Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"2026052304261034800_bib1","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1128\/CMR.3.3.247","article-title":"Serology of coccidioidomycosis","volume":"3","author":"Pappagianis","year":"1990","journal-title":"Clin Microbiol Rev"},{"key":"2026052304261034800_bib2","doi-asserted-by":"publisher","first-page":"e0158122","DOI":"10.1128\/jcm.01581-22","article-title":"Review of clinical and laboratory diagnostics for coccidioidomycosis","volume":"61","author":"McHardy","year":"2023","journal-title":"J Clin Microbiol"},{"key":"2026052304261034800_bib3","first-page":"1","article-title":"Serological tests in the diagnosis and prognosis of coccidioidomycosis","volume":"52","author":"Smith","year":"1950","journal-title":"Am J Hyg"},{"key":"2026052304261034800_bib4","doi-asserted-by":"publisher","first-page":"4967","DOI":"10.1128\/iai.64.12.4967-4975.1996","article-title":"Cloning and expression of the complement fixation antigen-chitinase of Coccidioides immitis","volume":"64","author":"Zimmermann","year":"1996","journal-title":"Infect Immun"},{"key":"2026052304261034800_bib5","doi-asserted-by":"publisher","first-page":"e01318","DOI":"10.1128\/JCM.01318-18","article-title":"Coccidioidomycosis complement fixation titer trends in the age of antifungals","volume":"56","author":"McHardy","year":"2018","journal-title":"J Clin Microbiol"},{"key":"2026052304261034800_bib6","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1128\/jcm.18.3.529-534.1983","article-title":"Comparison of immunodiffusion techniques with standard complement fixation assay for quantitation of coccidioidal antibodies","volume":"18","author":"Wieden","year":"1983","journal-title":"J Clin Microbiol"},{"key":"2026052304261034800_bib7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-1-4612-3730-3_6","article-title":"Epidemiology of coccidioidomycosis","volume":"2","author":"Pappagianis","year":"1988","journal-title":"Curr Top Med Mycol"},{"key":"2026052304261034800_bib8","doi-asserted-by":"publisher","DOI":"10.62186\/001c.125154","article-title":"Determining a meaningful R-squared value in clinical medicine","author":"Gupta","year":"2024","journal-title":"Academic Medicine & Surgery"},{"key":"2026052304261034800_bib9","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1093\/cid\/ciad619","article-title":"Endemic Mycoses Diagnostic Algorithm Subject Matter Expert G, et al. 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