{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T17:29:29Z","timestamp":1786382969562,"version":"build-2736575974"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Secretar\u00eda de Ciencias, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nakaseomyces glabratus (formerly Candida glabrata) is an emerging and opportunistic fungal pathogen that possesses a set of virulence attributes allowing it to survive and colonize new niches within its host. The objective of this study is to determine patterns of phenotypic and genotypic variation in clonal clinical isolates from different patients that occur during an infection. We analyzed 35 clonal clinical isolates of N. glabratus from 10 patients, which we first identified with species-specific primers and genotyped with six polymorphic molecular markers. We characterized the susceptibility to three classes of antifungals, the ability to adhere and form biofilms on polystyrene, the response to thermal stress and oxidative stress caused by different oxidizing agents, and the enzymatic activity of the catalase. We found that the\u00a0N. glabratus clinical isolates analyzed from each patient share a clonal origin but differ from isolates from other patients. We found that the isolates can grow in a wide range of temperatures and acute and chronic stress conditions such as oxidative stress. Isolates from patient 9 displayed higher resistance to acute exposure to H2O2 in stationary-phase cells than the standard laboratory strain BG14, and this correlates with a higher activity of the only catalase enzyme of N. glabratus. In addition, we identified a case of phenotypic variation among clonal isolates derived from the same patient.<\/jats:p>","DOI":"10.1093\/mmy\/myag077","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:17:45Z","timestamp":1785323865000},"source":"Crossref","is-referenced-by-count":0,"title":["Phenotypic and genotypic analysis of clonal clinical isolates of\n                    <i>Nakaseomyces glabratus<\/i>\n                    (\n                    <i>Candida glabrata<\/i>\n                    )"],"prefix":"10.1093","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3457-5799","authenticated-orcid":false,"given":"Ana L","family":"L\u00f3pez-Marmolejo","sequence":"first","affiliation":[{"name":"Divisi\u00f3n de Biolog\u00eda Molecular. IPICYT. Instituto Potosino de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica , San Luis Potos\u00ed ,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8262-9010","authenticated-orcid":false,"given":"Marco J","family":"Hern\u00e1ndez-Ch\u00e1vez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Biolog\u00eda Molecular. IPICYT. Instituto Potosino de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica , San Luis Potos\u00ed ,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7204-5142","authenticated-orcid":false,"given":"Guadalupe","family":"Guti\u00e9rrez-Escobedo","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Biolog\u00eda Molecular. IPICYT. 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Instituto Potosino de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica , San Luis Potos\u00ed ,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1878-1792","authenticated-orcid":false,"given":"R Areli","family":"Mart\u00ednez-Gamboa","sequence":"additional","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda Cl\u00ednica, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n\u201d , Mexico City ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0292-3442","authenticated-orcid":false,"given":"Mar\u00eda F","family":"Gonz\u00e1lez-Lara","sequence":"additional","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda Cl\u00ednica, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n\u201d , Mexico City ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9584-1360","authenticated-orcid":false,"given":"Jos\u00e9","family":"Sifuentes-Osornio","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n General, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n \u201cSalvador Zubir\u00e1n\u201d , Mexico City ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2933-2856","authenticated-orcid":false,"given":"Alejandro De Las","family":"Pe\u00f1as","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Biolog\u00eda Molecular. 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