{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T17:29:34Z","timestamp":1786382974240,"version":"build-2736575974"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The epidemiology of candidemia changed during the COVID-19 pandemic, but direct comparisons of episodes with and without coronavirus disease 2019 (COVID-19) remain limited. We performed a retrospective cohort study of consecutive adult patients with candidemia diagnosed from February 2020 through February 2023 at a Brazilian tertiary-care teaching hospital. Demographic, clinical, microbiological, treatment, and outcome variables were compared according to COVID-19 status, and predictors of 30-day mortality were evaluated among treated patients. Among 106 episodes in 103 patients, 36 (34.0%) occurred in patients with COVID-19. The overall incidence was 4.41 episodes per 1000 admissions (95% confidence interval [CI], 3.61\u20135.33), and the incidence among COVID-19 admissions was 20.97 per 1000 (95% CI, 14.69\u201329.03). Episodes with COVID-19 were associated with intensive care, mechanical ventilation, corticosteroid exposure, higher Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, hypotension, and vasopressor use. Thirty-day survival was lower with COVID-19 (19.4% vs. 48.6%; P\u00a0=\u00a0.003). Among treated episodes, APACHE II score and vasopressor use were independently associated with 30-day mortality. Candidemia associated with COVID-19 occurred in a setting of substantially greater acute illness severity, and severity markers rather than COVID-19 itself appeared to drive excess mortality.<\/jats:p>","DOI":"10.1093\/mmy\/myag079","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:49:23Z","timestamp":1785498563000},"source":"Crossref","is-referenced-by-count":0,"title":["Candidemia during the COVID-19 pandemic in a Brazilian tertiary care hospital: Comparison of episodes with and without COVID-19"],"prefix":"10.1093","volume":"64","author":[{"given":"Debora Otero Britto Passos","family":"Pinheiro","sequence":"first","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, HUCFF CH-UFRJ HUBrasil Departments of Internal Medicine and Infectious Diseases, , Rio de Janeiro CEP 21941-913 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Carla","family":"Casti\u00f1eiras","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, HUCFF CH-UFRJ HUBrasil Departments of Internal Medicine and Infectious Diseases, , Rio de Janeiro CEP 21941-913 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Felipe de Abreu","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, HUCFF CH-UFRJ HUBrasil Departments of Internal Medicine and Infectious Diseases, , Rio de Janeiro CEP 21941-913 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Barreiros","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, HUCFF CH-UFRJ HUBrasil Departments of Internal Medicine and Infectious Diseases, , Rio de Janeiro CEP 21941-913 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique Leandro Reis","family":"Rocha","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, HUCFF CH-UFRJ HUBrasil Departments of Internal Medicine and Infectious Diseases, , Rio de Janeiro CEP 21941-913 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4867-0014","authenticated-orcid":false,"given":"Marcio","family":"Nucci","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, HUCFF CH-UFRJ HUBrasil Departments of Internal Medicine and Infectious Diseases, , Rio de Janeiro CEP 21941-913 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone A","family":"Nou\u00e9r","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, HUCFF CH-UFRJ HUBrasil Departments of Internal Medicine and Infectious Diseases, , Rio de Janeiro CEP 21941-913 ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"issue":"5","key":"2026081012460647400_bib1","doi-asserted-by":"publisher","first-page":"e280","DOI":"10.1016\/S1473-3099(24)00749-7","article-title":"Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM","volume":"25","author":"Cornely","year":"2025","journal-title":"Lancet Infect Dis"},{"issue":"4","key":"2026081012460647400_bib2","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/civ933","article-title":"Clinical Practice Guideline for the Management of Candidiasis: 2016 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