{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:10:41Z","timestamp":1789139441772,"version":"build-2803163510"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>COVID-19-associated pulmonary aspergillosis (CAPA) is a recognized fungal superinfection, but diagnosis remains difficult due to non-specific clinical and radiological findings. While anti-Aspergillus spp. IgG antibodies (AspAb) are used for chronic aspergillosis diagnosis, their role in this context is unclear. We described AspAb kinetics in CAPA patients hospitalized in intensive care unit (ICU).<\/jats:p>\n                  <jats:p>We performed a retrospective study at Lille University Hospital from February 2020 to December 2021, enrolling ICU SARS-CoV-2 patients. Patients were included if they had at least one positive mycological marker\u2014direct examination, culture, galactomannan antigen (GM) or Aspergillus fumigatus qPCR in bronchoalveolar lavage and\/or serum\u2014along with clinical and radiological findings consistent with CAPA, as defined by the 2020 European Confederation of Medical Mycology and the International Society for Human and Animal Mycology consensus criteria.<\/jats:p>\n                  <jats:p>Among 898 patients, 95 (10.6%) had at least one positive mycological marker; 47 fulfilled CAPA criteria (5.2%), and 43 had at least one AspAb measurement. One-quarter of CAPA patients (23.3%, 10 patients) had at least one positive AspAb measurement (one of whom had only one measurement). Among AspAb-positive patients, seven (70.0%) seroconverted a mean of 8.3 days (standard deviation, 8.5) after CAPA diagnosis; one had documented positivity prior to hospitalization. Seven patients (70.0%) reached AspAb rate \u2265 80\u202fAU\/ml.<\/jats:p>\n                  <jats:p>These results are the first observed in CAPA patients and need to be confirmed in a larger cohort of non-neutropenic patients hospitalized in ICU with viral pneumonia.<\/jats:p>","DOI":"10.1093\/mmy\/myag089","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T15:05:13Z","timestamp":1788015913000},"source":"Crossref","is-referenced-by-count":0,"title":["Kinetics of anti-\n                    <i>Aspergillus<\/i>\n                    spp. IgG antibodies in COVID-19-associated pulmonary aspergillosis"],"prefix":"10.1093","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8923-8764","authenticated-orcid":false,"given":"Camille","family":"Cordier","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lille, Inserm U1285, Centre Hospitalier Universitaire de Lille, Laboratoire de Parasitologie-Mycologie , CNRS, UMR 8576 - UGSF - Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00eb","family":"Lemaire","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie-Mycologie, Centre de Biologie Pathologie G\u00e9n\u00e9tique, Centre Hospitalier Universitaire de Lille , F-59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3908-7655","authenticated-orcid":false,"given":"Fanny","family":"Vuotto","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses, Centre Hospitalier Universitaire de Lille , F-59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6544-9795","authenticated-orcid":false,"given":"Mahdi","family":"Ouafi","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie-Mycologie, Centre de Biologie Pathologie G\u00e9n\u00e9tique, Centre Hospitalier Universitaire de Lille , F-59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Loridant","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, Inserm U1285, Centre Hospitalier Universitaire de Lille, Laboratoire de Parasitologie-Mycologie , CNRS, UMR 8576 - UGSF - Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetan","family":"Piga","sequence":"additional","affiliation":[{"name":"P\u00f4le de M\u00e9decine Intensive-R\u00e9animation, Centre Hospitalier Universitaire de Lille , F-59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Leroy","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, Inserm U1285, Centre Hospitalier Universitaire de Lille, Laboratoire de Parasitologie-Mycologie , CNRS, UMR 8576 - UGSF - Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Poissy","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, Inserm U1285, Centre Hospitalier Universitaire de Lille , P\u00f4le de M\u00e9decine Intensive-R\u00e9animation, CNRS, UMR 8576 - UGSF - Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boualem","family":"Sendid","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lille, Inserm U1285, Centre Hospitalier Universitaire de Lille, Laboratoire de Parasitologie-Mycologie , CNRS, UMR 8576 - UGSF - Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille 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