{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:07:48Z","timestamp":1788883668612,"version":"build-2803163510"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Mayo Clinic Clinical and Translational Science","award":["UL1TR002377"],"award-info":[{"award-number":["UL1TR002377"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although candidemia is among the most common invasive fungal infections in hospitalized patients, the persistence of bloodstream infection despite antifungal therapy remains poorly characterized.<\/jats:p>\n                  <jats:p>We performed a retrospective, matched case-control study of persistent candidemia (PC) across three tertiary care centers in the United States over a 7-year period (2018\u20132025). PC was defined as at least 72 h of positive blood cultures with the same Candida species from the start of active antifungal therapy. Cases were matched 1:2 to controls with non-PC by diagnosis date. Associations were evaluated using conditional logistic regression within matched strata.<\/jats:p>\n                  <jats:p>The cohort included 47\u00a0PC cases and 94 matched controls. Compared with controls, cases were more likely to have a central venous catheter (CVC) at candidemia onset and be in the intensive care unit at diagnosis. Intra-abdominal sources were more common with PC. In multivariable analyses, CVC presence (adjusted odds ratio (aOR) 4.58, 95% CI 1.39\u201315.09) and ICU status (aOR 3.10, 95% CI 1.10\u20138.72) were associated with persistence, while male sex was inversely associated (aOR 0.21, 95% CI 0.08\u20130.60; P = .004). PC was associated with longer duration of hospitalization (median 36 vs 19 days;\u00a0P &amp;lt; .001) and higher 30-day all-cause mortality (40.4% vs 22.3%;\u00a0P = .040).<\/jats:p>\n                  <jats:p>In summary, PC was associated with higher mortality and longer hospital stays than non-PC. CVC presence and intensive care unit status were independently associated with persistence.<\/jats:p>","DOI":"10.1093\/mmy\/myag090","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:22:34Z","timestamp":1788780154000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical profile and outcomes of persistent candidemia: A matched case-control study"],"prefix":"10.1093","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8837-1044","authenticated-orcid":false,"given":"David R","family":"Bayless","sequence":"first","affiliation":[{"name":"Department of Medicine, Mayo Clinic , Rochester, MN 55905 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar M Abu","family":"Saleh","sequence":"additional","affiliation":[{"name":"Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic , Rochester, MN 55905 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