{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:05:25Z","timestamp":1789229125254,"version":"build-2803163510"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006013","name":"United Arab Emirates University","doi-asserted-by":"publisher","award":["G00004532"],"award-info":[{"award-number":["G00004532"]}],"id":[{"id":"10.13039\/501100006013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AJF-NIH-13-UAEU"],"award-info":[{"award-number":["AJF-NIH-13-UAEU"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Microsporum canis complex infections remain a major cause of pediatric dermatophytosis, yet molecular epidemiologic and antifungal susceptibility data from the Arabian Gulf are scarce, with no contemporary regional assessment since 1981\u20131988. We characterized the clinical, molecular, and antifungal susceptibility profiles of M. canis complex isolates in Abu Dhabi and assessed concordance between phenotypic and ITS-based identification. Fifty-two clinical dermatophyte isolates collected through passive surveillance at the UAEU Fungal Reference Laboratory (September 2024\u2013December 2025) underwent phenotypic identification, ITS sequencing, and antifungal susceptibility testing (CLSI M38). Clinical data were available for 48 patients. ITS sequencing identified 47 isolates (90.4%) as M. canis and 5 (9.6%) as the M. audouinii clade, with phenotypic discordance in 9.6% of isolates (including one M. canis misidentified as Trichophyton rubrum). The cohort was predominantly pediatric (79.2% \u226412 years; 54.2% female). Tinea capitis predominated (60.4%), followed by tinea corporis (20.8%) and multifocal disease (16.7%). Cat exposure was reported in 50% and infected household contact in 27.1%. All isolates showed low minimum inhibitory concentrations (MICs ; terbinafine MIC\u2085\u2080\/\u2089\u2080 0.015\/0.03; itraconazole \u2264 0.03\/0.06; voriconazole \u2264 0.03\/\u22640.03; griseofulvin 0.125\/0.25; fluconazole 4\/8 \u00b5g\/ml). Despite this, 81.2% (26\/32) of patients with follow-up experienced treatment failure or recurrence, with no clear MIC\u2013outcome association. This first molecular and antifungal characterization of M. canis complex infections in the UAE over three decades showed that ITS sequencing corrected phenotypic identification in nearly 10% of cases. High recurrence despite low MICs suggests limited predictive value of in vitro susceptibility, supporting species-directed management, molecular confirmation, species-directed management, and One Health strategies.<\/jats:p>","DOI":"10.1093\/mmy\/myag091","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T15:06:13Z","timestamp":1788015973000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>Microsporum canis<\/i>\n                    complex infections in the United Arab Emirates: Clinical, molecular, and antifungal susceptibility profiles"],"prefix":"10.1093","volume":"64","author":[{"given":"Febin","family":"Anes","sequence":"first","affiliation":[{"name":"College of Medicine and Health Sciences Department of Pediatrics and Department of Medical Microbiology and Immunology, , Al Ain, Abu Dhabi 15551 ,","place":["United Arab Emirates"]},{"name":"Zayed Bin Sultan Centre for Health Sciences, United Arab Emirates University , Al Ain, Abu Dhabi 15551 ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akela","family":"Ghazawi","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences Department of Pediatrics and Department of Medical Microbiology and Immunology, , Al Ain, Abu Dhabi 15551 ,","place":["United Arab Emirates"]},{"name":"Zayed Bin Sultan Centre for Health Sciences, United Arab Emirates University , Al Ain, Abu Dhabi 15551 ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari Pankaj","family":"Vanam","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences Department of Pediatrics and Department of Medical Microbiology and Immunology, , Al Ain, Abu Dhabi 15551 ,","place":["United Arab Emirates"]},{"name":"Zayed Bin Sultan Centre for Health Sciences, United Arab Emirates University , Al Ain, Abu Dhabi 15551 ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Aljneibi","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences Department of Pediatrics and Department of Medical Microbiology and Immunology, , Al Ain, Abu Dhabi 15551 ,","place":["United Arab Emirates"]},{"name":"Zayed Bin Sultan Centre for Health Sciences, United Arab Emirates University , Al Ain, Abu Dhabi 15551 ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2434-1411","authenticated-orcid":false,"given":"Mushtaq","family":"Khan","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences Department of Pediatrics and Department of Medical Microbiology and Immunology, , Al Ain, Abu Dhabi 15551 ,","place":["United Arab Emirates"]},{"name":"Zayed Bin Sultan Centre for Health Sciences, United Arab Emirates University , Al Ain, Abu Dhabi 15551 ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fouzia","family":"Jabeen","sequence":"additional","affiliation":[{"name":"Sheikh Khalifa Medical City, PureLab , Abu Dhabi 51900 ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed R","family":"Alsuwaidi","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences Department of Pediatrics and Department of Medical Microbiology and Immunology, , Al Ain, Abu Dhabi 15551 ,","place":["United Arab Emirates"]},{"name":"Zayed Bin Sultan Centre for Health Sciences, United Arab Emirates University , Al Ain, Abu Dhabi 15551 ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Medics Labor AG , Bern 3001 ,","place":["Switzerland"]},{"name":"Institute of Medical Microbiology, University of Z\u00fcrich 8028 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"AlBataineh","sequence":"additional","affiliation":[{"name":"Khalifa University , Abu Dhabi 127788 ,","place":["United Arab Emirates"]},{"name":"Yarmouk University , Irbid 21163 ,","place":["Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Weber","sequence":"additional","affiliation":[{"name":"Sheikh Khalifa Medical City, PureLab , Abu Dhabi 51900 ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Gibas","sequence":"additional","affiliation":[{"name":"Fungus Testing Laboratory & Molecular Diagnostics Laboratory, Department of Pathology and Laboratory Medicine, University of Texas Health Science Center , San Antonio 78229, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-5122","authenticated-orcid":false,"given":"Nathan P","family":"Wiederhold","sequence":"additional","affiliation":[{"name":"Fungus Testing Laboratory & Molecular Diagnostics Laboratory, Department of Pathology and Laboratory Medicine, University of Texas Health Science Center , San Antonio 78229, Texas ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5412-6157","authenticated-orcid":false,"given":"Fatima Al","family":"Dhaheri","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences Department of Pediatrics and Department of Medical Microbiology and Immunology, , Al Ain, Abu Dhabi 15551 ,","place":["United Arab Emirates"]},{"name":"Zayed Bin Sultan Centre for Health Sciences, United Arab Emirates University , Al Ain, Abu Dhabi 15551 ,","place":["United Arab 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