{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:06:54Z","timestamp":1792786014698,"version":"4.5.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Clinical Trials Career Development Award","id":[{"id":"https:\/\/ror.org\/02xjhr934","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Candida (C-BSI) is a rare infection in patients with left ventricular assist devices (LVADs). We aim to describe the characteristics and outcomes of C-BSI. We performed a retrospective search for C-BSI in patients with LVADs at our institution from January 2012 to May 2024. We performed a literature review using the keywords \u2018fungemia ventricular assist device\u2019, \u2018candidemia ventricular assist device\u2019, \u2018Candida ventricular assist device,\u2019 or \u2018Candida endocarditis ventricular assist device\u2019 from 1990 to 2024. Clinical characteristics and outcomes were extracted. We identified three institutional cases along with 21 additional cases from the literature. The incidence of candidemia was 3.1% (3\/97) and 1.8% (16\/867), respectively, in the case series and literature review. The mean age was 45.6 years (range 19\u201373 years), and the average body mass index (BMI) was 31.8 kg\/m\u00b2. There was a 100% mortality rate in our cohort and 62.5% mortality rate in the literature review cohort. Among the surviving patients in the literature review, 66.7% underwent heart transplantation, and 33.3% were discharged on antifungal therapy. About 41.2% of patients experienced right heart failure, with four requiring temporary mechanical circulatory support post-operatively. Obesity was present in 75.0% of patients, and 42.1% had an LVAD-related infection. C-BSI developed after an average of 426 days of LVAD support, with 33.3% occurring within 30 days postoperatively. The average duration of C-BSI was 29 days.\u00a0Candida auris was the most common species. C-BSI is a rare fatal complication in LVAD patients. Obesity, delayed sternal wound closure, and right heart failure may contribute to these poor outcomes.<\/jats:p>","DOI":"10.1093\/mmy\/myag095","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:38:34Z","timestamp":1788867514000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>Candida<\/i>\n                    bloodstream infection in left ventricular assist device recipients: Case series and review of the literature"],"prefix":"10.1093","volume":"64","author":[{"given":"Jacob","family":"Sama","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Krannert Cardiovascular Research Center, Indiana University School of Medicine , Indianapolis, IN , 46202","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3273-8379","authenticated-orcid":false,"given":"Saira","family":"Butt","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Indiana University School of Medicine , Indianapolis, IN , 46202","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6362-4553","authenticated-orcid":false,"given":"Abdalla Eltayeb A","family":"A","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Krannert Cardiovascular Research Center, Indiana University School of Medicine , Indianapolis, IN , 46202","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roopa","family":"Rao","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Krannert Cardiovascular Research Center, Indiana University School of Medicine , Indianapolis, IN , 46202","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Shariff","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Krannert Cardiovascular Research Center, Indiana University School of Medicine , Indianapolis, IN , 46202","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi K","family":"Misra","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Indiana University School of Medicine , Indianapolis, IN , 46202","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashif","family":"Saleem","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, Indiana University School of Medicine , Indianapolis, IN , 46202","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujal","family":"Modi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Krannert Cardiovascular Research Center, Indiana University School of Medicine , Indianapolis, IN , 46202","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Guglin","sequence":"additional","affiliation":[{"name":"Rutgers Health Robert Wood Johnson School of Medicine , New Brunswick, NJ , 08901","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2038-7786","authenticated-orcid":false,"given":"Onyedika J","family":"Ilonze","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Krannert Cardiovascular Research Center, Indiana University School of Medicine , Indianapolis, IN , 46202","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"issue":"1","key":"2026091702415180600_bib1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.athoracsur.2023.11.004","article-title":"The Society of Thoracic Surgeons Intermacs 2023 Annual Report: Focus on 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