{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:51:45Z","timestamp":1791366705860,"version":"4.3.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Candidozyma auris (Candida auris) candidemia is a serious healthcare-associated infection with substantial mortality and limited treatment options. We retrospectively evaluated adult patients with C. auris candidemia at a tertiary care center between June 2022 and December 2025 to describe clinical management, microbiological outcomes, antifungal susceptibility, and factors associated with 28-day mortality. The descriptive cohort included 108 patients; mortality status was available for 107. Most patients (92.6%) were in intensive care at candidemia onset, and among evaluable patients, 76.1% had prior C. auris colonisation detected. Twenty-eight-day mortality was 41.1% (44\/107). Non-survivors were older and had higher Charlson Comorbidity Index, Pitt bacteremia, and Sequential Organ Failure Assessment (SOFA) scores. Central venous catheter removal was more frequent among survivors (72.7% vs. 45.0%; P = .012), although removal timing and time to initiation of effective antifungal therapy did not differ significantly between groups. In multivariable analysis, Charlson Comorbidity Index (adjusted odds ratio [aOR], 1.22; 95% confidence interval [CI], 1.02\u20131.44) and SOFA score (aOR, 1.16; 95% CI, 1.05\u20131.27) were independently associated with 28-day mortality. Resistance rates were 95.1% for fluconazole, 31.2% for amphotericin B, and 1.3% for both anidulafungin and micafungin; multidrug resistance rate was 28.6%, and no isolate met the definition of pandrug resistance. Mortality in C. auris candidemia was mainly associated with baseline comorbidity burden and acute organ dysfunction. Local susceptibility surveillance and early recognition of high-risk patients may support treatment and infection-control strategies.<\/jats:p>","DOI":"10.1093\/mmy\/myag105","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:14:31Z","timestamp":1790334871000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical management, antifungal susceptibility, and predictors of 28-day mortality in\n                    <i>Candidozyma auris<\/i>\n                    candidemia: A single-center cohort study"],"prefix":"10.1093","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4759-0066","authenticated-orcid":false,"given":"Ayse","family":"Kaya","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Faculty of Medicine , Ankara ,","place":["T\u00fcrkiye"]},{"name":"Department of Infectious Diseases and Clinical Microbiology, Ankara Bilkent City Hospital , Ankara ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice Rahmet","family":"Guner","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Faculty of Medicine , Ankara ,","place":["T\u00fcrkiye"]},{"name":"Department of Infectious Diseases and Clinical Microbiology, Ankara Bilkent City Hospital , Ankara ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Hasanoglu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Faculty of Medicine , Ankara ,","place":["T\u00fcrkiye"]},{"name":"Department of Infectious Diseases and Clinical Microbiology, Ankara Bilkent City Hospital , Ankara ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Eser","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Faculty of Medicine , Ankara ,","place":["T\u00fcrkiye"]},{"name":"Department of Infectious Diseases and Clinical Microbiology, Ankara Bilkent City Hospital , Ankara ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziz","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Ankara Bilkent City Hospital , Ankara ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesim Aybar","family":"Bilir","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Ankara Bilkent City Hospital , Ankara ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muge","family":"Ayhan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Faculty of Medicine , Ankara ,","place":["T\u00fcrkiye"]},{"name":"Department of Infectious Diseases and Clinical Microbiology, Ankara Bilkent City Hospital , Ankara ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bedia","family":"Dinc","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Health Sciences University, Ankara Bilkent City Hospital , Ankara ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bircan","family":"Kayaaslan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Faculty of Medicine , Ankara ,","place":["T\u00fcrkiye"]},{"name":"Department of Infectious Diseases and Clinical Microbiology, Ankara Bilkent City Hospital , Ankara ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"2026100705063823700_bib1","volume-title":"Clinical overview of Candida auris","author":"Centers for Disease Control and Prevention (CDC)","year":"2026"},{"issue":"20","key":"2026100705063823700_bib2","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1056\/NEJMra2402635","article-title":"Candida auris Infections","volume":"391","author":"Lionakis","year":"2024","journal-title":"N Engl J Med"},{"key":"2026100705063823700_bib3","doi-asserted-by":"publisher","first-page":"e00187","DOI":"10.1128\/mmbr.00187-22","article-title":"Candida auris: Host interactions, antifungal drug resistance, and diagnostics","volume":"90","author":"Chowdhary","year":"2026","journal-title":"Microbiol Mol Biol Rev"},{"issue":"5","key":"2026100705063823700_bib4","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1093\/cid\/ciae411","article-title":"Factors associated with poor clinical and microbiologic outcomes in Candida auris bloodstream infection: A multicenter retrospective cohort study","volume":"79","author":"Jimenez","year":"2024","journal-title":"Clin Infect Dis"},{"issue":"8","key":"2026100705063823700_bib5","first-page":"e89455","article-title":"A comprehensive review of epidemiology, risk factors, clinical manifestations, antifungal susceptibility, and mortality of Candida auris in Saudi Arabia","volume":"17","author":"Almajid","year":"2025","journal-title":"Cureus"},{"issue":"3","key":"2026100705063823700_bib6","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.cmi.2025.12.022","article-title":"Candidozyma auris (formerly Candida auris): Resistant, long lasting, and everywhere","volume":"32","author":"Salmanton-Garc\u00eda","year":"2026","journal-title":"Clin Microbiol Infect"},{"issue":"8","key":"2026100705063823700_bib7","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3390\/jof11080552","article-title":"Candida auris vs. non-candida auris candidemia in critically ill patients: Clinical outcomes, risk factors, and mortality","volume":"11","author":"G\u00fclten","year":"2025","journal-title":"J Fungi (Basel)"},{"issue":"12","key":"2026100705063823700_bib8","doi-asserted-by":"publisher","first-page":"myaf107","DOI":"10.1093\/mmy\/myaf107","article-title":"Global prevalence of multidrug-resistant Candida auris in humans between 2015 and 2024: A systematic review and meta-analysis","volume":"63","author":"Achilonu","year":"2025","journal-title":"Med Mycol"},{"issue":"6","key":"2026100705063823700_bib9","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1097\/00000658-199412000-00010","article-title":"Candida colonization and subsequent infections in critically ill surgical patients","volume":"220","author":"Pittet","year":"1994","journal-title":"Ann Surg"},{"issue":"3","key":"2026100705063823700_bib10","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1097\/01.CCM.0000202208.11358.7E","article-title":"A bedside scoring system (\u201cCandida score\u201d) for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization","volume":"34","author":"Le\u00f3n","year":"2006","journal-title":"Crit Care Med"},{"key":"2026100705063823700_bib11","volume-title":"Antifungal susceptibility testing for Candida auris","author":"Centers for Disease Control and Prevention (CDC)","year":"2024"},{"issue":"3","key":"2026100705063823700_bib12","doi-asserted-by":"publisher","first-page":"e1436","DOI":"10.1093\/cid\/ciac735","article-title":"Comparative outcomes of Candida auris bloodstream infections: A multicenter retrospective case-control study","volume":"76","author":"Simon","year":"2023","journal-title":"Clin Infect Dis"},{"issue":"2","key":"2026100705063823700_bib13","doi-asserted-by":"publisher","first-page":"101622","DOI":"10.1016\/j.mycmed.2026.101622","article-title":"Candidozyma auris: A retrospective analysis of diagnostic challenges, antifungal susceptibility, and infection control measures","volume":"36","author":"U\u011fur","year":"2026","journal-title":"J Mycol Med"},{"key":"2026100705063823700_bib14","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.3201\/eid2410.180649","article-title":"Candida auris in healthcare facilities, New York, USA, 2013\u20132017","volume":"24","author":"Adams","year":"2018","journal-title":"Emerg Infect Dis"},{"issue":"7","key":"2026100705063823700_bib15","doi-asserted-by":"publisher","first-page":"715","DOI":"10.3390\/jof9070715","article-title":"Mortality caused by Candida auris bloodstream infections in comparison with other candida species, a multicentre retrospective cohort","volume":"9","author":"Ortiz-Roa","year":"2023","journal-title":"J Fungi (Basel)"},{"issue":"1","key":"2026100705063823700_bib16","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.jiph.2023.11.021","article-title":"Risk factors, antifungal susceptibility, complications, and outcome of Candida auris bloodstream infection in a tertiary care center in the western region of Saudi Arabia","volume":"17","author":"Munshi","year":"2024","journal-title":"J Infect Public Health"},{"issue":"8","key":"2026100705063823700_bib17","doi-asserted-by":"publisher","first-page":"e0035825","DOI":"10.1128\/aac.00358-25","article-title":"Managing Candida auris fungemias: The results of a prospective and international study","volume":"69","author":"Erdem","year":"2025","journal-title":"Antimicrob Agents Chemother"},{"issue":"9","key":"2026100705063823700_bib18","doi-asserted-by":"publisher","first-page":"e69699","DOI":"10.7759\/cureus.69699","article-title":"Mortality and associated risk factors in patients with Candida auris: Insights from a Tertiary Care Hospital in Bahrain","volume":"16","author":"Alagha","year":"2024","journal-title":"Cureus"},{"key":"2026100705063823700_bib19","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1111\/myc.13380","article-title":"Modified Pitt bacteremia score for predicting mortality in patients with candidaemia: A multicentre seven-year retrospective study conducted in Japan","volume":"64","author":"Nakada-Motokawa","year":"2021","journal-title":"Mycoses"},{"issue":"1","key":"2026100705063823700_bib20","doi-asserted-by":"publisher","first-page":"44769","DOI":"10.1038\/s41598-025-29061-8","article-title":"Analysis of Candida auris resistance and associated risk factors in hospitalized patients at a tertiary care hospital in China","volume":"15","author":"Fan","year":"2025","journal-title":"Sci Rep"},{"key":"2026100705063823700_bib21","doi-asserted-by":"publisher","first-page":"S594","DOI":"10.1093\/ofid\/ofy210.1695","article-title":"New York State 2016\u20132018: Progression from Candida auris colonization to bloodstream infection","volume":"5","author":"Southwick","year":"2018","journal-title":"Open Forum Infect Dis"},{"key":"2026100705063823700_bib22","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1093\/cid\/ciab327","article-title":"Positive correlation between Candida auris skin-colonization burden and environmental contamination at a ventilator-capable skilled nursing facility in Chicago","volume":"73","author":"Sexton","year":"2021","journal-title":"Clin Infect Dis"},{"key":"2026100705063823700_bib23","doi-asserted-by":"publisher","first-page":"e131","DOI":"10.1017\/S0950268825100721","article-title":"Risk factors associated with Candida auris Candidemia: A single-centre retrospective case-control study","volume":"153","author":"Kaya","year":"2025","journal-title":"Epidemiol Infect"},{"issue":"11","key":"2026100705063823700_bib24","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1016\/j.cmi.2020.02.001","article-title":"A clinical predictive model of candidaemia by Candida auris in previously colonized critically ill patients","volume":"26","author":"Garcia-Bustos","year":"2020","journal-title":"Clin Microbiol Infect"},{"issue":"8","key":"2026100705063823700_bib25","doi-asserted-by":"publisher","first-page":"e66364","DOI":"10.7759\/cureus.66364","article-title":"Time-to-positivity for candida in bloodstream infections: Prognostic implications for mortality","volume":"16","author":"Balaji","year":"2024","journal-title":"Cureus"},{"key":"2026100705063823700_bib26","doi-asserted-by":"publisher","first-page":"100618","DOI":"10.1016\/j.ijmmb.2024.100618","article-title":"Candida auris - Comparison of sensititre YeastOne and Vitek 2 AST systems for antifungal susceptibility testing - A single centre experience","volume":"50","author":"Patwardhan","year":"2024","journal-title":"Indian J Med Microbiol"},{"issue":"2","key":"2026100705063823700_bib27","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1556\/030.2025.02615","article-title":"Candida auris infections in an intensive care unit: Antifungal resistance, mortality rates and infection control interventions","volume":"72","author":"Solak\u00a0Grassie","year":"2025","journal-title":"Acta Microbiol Immunol Hung"}],"container-title":["Medical Mycology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mmy\/advance-article-pdf\/doi\/10.1093\/mmy\/myag105\/71396094\/myag105.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mmy\/article-pdf\/64\/10\/myag105\/71396094\/myag105.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mmy\/article-pdf\/64\/10\/myag105\/71396094\/myag105.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:06:50Z","timestamp":1791364010000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mmy\/article\/doi\/10.1093\/mmy\/myag105\/8835795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,2]]}},"URL":"https:\/\/doi.org\/10.1093\/mmy\/myag105","relation":{},"ISSN":["1369-3786","1460-2709"],"issn-type":[{"value":"1369-3786","type":"print"},{"value":"1460-2709","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,9,25]]},"article-number":"myag105"}}