{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:47:33Z","timestamp":1789512453226,"version":"build-2803163510"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T00:00:00Z","timestamp":1539907200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2011\/15304-0"],"award-info":[{"award-number":["2011\/15304-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2012\/02942-0"],"award-info":[{"award-number":["2012\/02942-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CEPOF RIDC FAPESP","award":["13\/07276-1"],"award-info":[{"award-number":["13\/07276-1"]}]},{"name":"Brazilian Research Council","award":["304133\/2016-7"],"award-info":[{"award-number":["304133\/2016-7"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study evaluated the efficacy of antimicrobial Photodynamic Therapy (aPDT) against fluconazole-resistant Candida albicans in a murine model of oral candidosis. Mice were inoculated with two clinical isolates (R10, R15) and one reference strain (ATCC) of resistant C. albicans to produce oral candidosis. After inoculation, aPDT mediated by Photodithazine\u00ae (PDZ) and LED light was performed. The use of PDZ or light only was also investigated. Additional animals were treated with Nystatin (NYS). Untreated or healthy mice were also evaluated. Microbiological evaluation was performed by recovering C. albicans from the tongue via colony-forming units. Animals were killed 24 hours after treatments, and the tongues were removed for histological analysis. Data were analyzed by one-way ANOVA and Tukey test (P &amp;lt; .05). The results demonstrated that all strains showed the same behavior after aPDT and NYS treatment. A significant reduction in C. albicans viability was achieved after both treatments for R15 and ATCC. No significant reduction was verified for C. albicans R10 submitted to aPDT or NYS. The histological analysis revealed that aPDT did not cause side effects on tissues. aPDT was effective for inactivation of two fluconazole-resistant C. albicans of the three strains evaluated.<\/jats:p>","DOI":"10.1093\/mmy\/myy083","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T23:53:34Z","timestamp":1535759614000},"page":"609-617","source":"Crossref","is-referenced-by-count":32,"title":["Photodithazine-mediated antimicrobial photodynamic therapy against fluconazole-resistant\n                    <i>Candida albicans in vivo<\/i>"],"prefix":"10.1093","volume":"57","author":[{"given":"Fernanda","family":"Alves","sequence":"first","affiliation":[{"name":"Department of Dental Materials and Prosthodontics, S\u00e3o Paulo State University (Unesp), School of Dentistry, Araraquara, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Cabrini","family":"Carmello","sequence":"additional","affiliation":[{"name":"Department of Dental Materials and Prosthodontics, S\u00e3o Paulo State University (Unesp), School of Dentistry, Araraquara, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewerton Garcia de Oliveira","family":"Mima","sequence":"additional","affiliation":[{"name":"Department of Dental Materials and Prosthodontics, S\u00e3o Paulo State University (Unesp), School of Dentistry, Araraquara, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alberto de Souza","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathology, S\u00e3o Paulo State University (Unesp), School of Dentistry, Araraquara, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanderlei Salvador","family":"Bagnato","sequence":"additional","affiliation":[{"name":"Biophotonics Lab, Group of Optics, Physics Institute of S\u00e3o Carlos, University of S\u00e3o Paulo - USP, Av. 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