{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:12:16Z","timestamp":1790467936347,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,11,10]],"date-time":"2018-11-10T00:00:00Z","timestamp":1541808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Plan Nacional de I+D+i and Instituto de Salud Carlos III"},{"name":"Subdirecci\u00f3n General de Redes y Centros de Investigaci\u00f3n Cooperativa"},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Network for Research in Infectious Diseases","award":["REIPI RD12\/0015"],"award-info":[{"award-number":["REIPI RD12\/0015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to analyze whether the lack of inclusion of specific recommendations for the management of candidemia is an independent risk factor for early and overall mortality. Multicenter study of adult patients with candidemia in 13 hospitals. We assessed the proportion of patients on whom nine specific ESCMID and IDSA guidelines recommendations had been applied, and analyzed its impact on mortality. 455 episodes of candidemia were documented. Patients who died within the first 48 hours were excluded. Sixty-two percent of patients received an appropriate antifungal treatment. Either echinocandin or amphotericin B therapy were administered in 43% of patients presenting septic shock and in 71% of those with neutropenia. Sixty-one percent of patients with breakthrough candidemia underwent a change in antifungal drug class. Venous catheters were removed in 79% of cases. Follow-up blood cultures were performed in 72% of cases. Ophthalmoscopy and echocardiogram were performed in 48% and 50% of patients, respectively. Length of treatment was appropriate in 78% of cases. Early (2\u20137 days) and overall (2\u201330 days) mortality were 8% and 27.7%, respectively. Inclusion of less than 50% of the specific recommendations was independently associated with a higher early (HR = 7.02, 95% CI: 2.97\u201316.57; P &lt; .001) and overall mortality (HR = 3.55, 95% CI: 2.24\u20135.64; P &lt; .001). In conclusion, ESCMID and IDSA guideline recommendations were not performed on a significant number of patients. Lack of inclusion of these recommendations proved to be an independent risk factor for early and overall mortality.<\/jats:p>","DOI":"10.1093\/mmy\/myy118","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T19:24:26Z","timestamp":1540581866000},"page":"659-667","source":"Crossref","is-referenced-by-count":34,"title":["Usefulness of guideline recommendations for prognosis in patients with candidemia"],"prefix":"10.1093","volume":"57","author":[{"given":"Guillermo","family":"Cuervo","sequence":"first","affiliation":[{"name":"Hospital Universitari de Bellvitge, IDIBELL (Institut D\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge), Universitat de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Garcia-Vidal","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic, Universitat de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Puig-Asensio","sequence":"additional","affiliation":[{"name":"Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Merino","sequence":"additional","affiliation":[{"name":"Hospital Universitario Cl\u00ednico \u201cSan Carlos\u201d, Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Vena","sequence":"additional","affiliation":[{"name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n e Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Universidad Complutense de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena","family":"Mart\u00edn-Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Hospital Universitario \u201cVirgen del Roc\u00edo\u201d, 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