{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:08:49Z","timestamp":1776082129835,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Coccidioidomycosis in dogs can range from mild respiratory disease or vague, chronic malaise to acute, severe life-threatening illness. The diagnosis of coccidioidomycosis in dogs is based on clinical presentation and serology. Spherule identification is not typical because of low numbers of organisms in specimens, and the invasive nature of sampling tissues and lungs. Conventional serological assays require samples to be submitted to a reference laboratory and results take several days to one week. The s\u014dna Coccidioides Antibody Lateral Flow Assay (LFA) (IMMY Diagnostics) is a rapid, bench-side test used for detection of Coccidioides antibodies that is available and FDA-cleared for use in humans but has not been evaluated in dogs. The goal of this study was to compare the LFA to conventional agar gel immunodiffusion (AGID). Paired serum samples were collected for screening by the LFA and submitted to a commercial reference laboratory for AGID screen and titer. Of 56 paired serum samples analyzed, 30 were positive and 26 were negative on the s\u014dna Coccidioides antibody LFA. The overall percentage agreement plus 95% confidence interval (CI) was 87.5% (76.20\u201393.99). Positive percent agreement was 89.7% (73.38\u201396.65) and negative percent agreement was 85.2% (67.25\u201394.36). The kappa coefficient to assess agreement was 0.749 (95% CI, 0.576\u20130.923), which is interpreted as good agreement between the tests (&amp;gt;70%). The s\u014dna Coccidioides antibody LFA provided rapid, point-of-care results with a high level of agreement to standard AGID serology in dogs clinically suspected to have coccidioidomycosis, and may aid in diagnosis of coccidioidomycosis in dogs.<\/jats:p>","DOI":"10.1093\/mmy\/myz067","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T19:13:18Z","timestamp":1559848398000},"page":"328-332","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of a commercially available, point-of-care Coccidioides antibody lateral flow assay to aid in rapid diagnosis of coccidioidomycosis in dogs"],"prefix":"10.1093","volume":"58","author":[{"given":"Sallianne","family":"Schlacks","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Veterinary Specialty Center of Tucson, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Polina","family":"Vishkautsan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Veterinary Specialty Center of Tucson, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Butkiewicz","sequence":"first","affiliation":[{"name":"Valley Fever Center for Excellence, University of Arizona, Tucson, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Shubitz","sequence":"first","affiliation":[{"name":"Valley Fever Center for Excellence, University of Arizona, Tucson, Arizona, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,6,18]]},"reference":[{"key":"2020033113351326100_bib1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.5326\/0440226","article-title":"Coccidioidomycosis in dogs and cats: a review","volume":"44","author":"Graupmann-Kuzma","year":"2008","journal-title":"J Am Anim Hosp Assoc"},{"key":"2020033113351326100_bib2","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/ciu681","article-title":"Valley fever: finding new places for an old disease: Coccidioides immitis found in Washington State soil associated with recent human infection","volume":"60","author":"Litvintseva","year":"2015","journal-title":"Clin Infect Dis"},{"key":"2020033113351326100_bib3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/cid\/cis1028","article-title":"Coccidioidomycosis acquired in Washington State","volume":"56","author":"Marsden-Haug","year":"2013","journal-title":"Clin Infect Dis"},{"key":"2020033113351326100_bib4","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1055\/s-0031-1295723","article-title":"3rd. 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