{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:24:13Z","timestamp":1771068253164,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["KLI 561-B31"],"award-info":[{"award-number":["KLI 561-B31"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>T2Candida enables detection of five Candida species in whole blood within approximately 5 hours. Routinely drawn EDTA blood samples were prospectively stored and tested with T2Candida in patients with invasive candidiasis identified by routine index blood or sterile site cultures. T2Candida was compared to diagnostic blood and sterile site cultures and also performed with samples obtained prior and after collection of index cultures. T2Candida was evaluated with 133 samples of 32 patients with candidemia and 22 patients with deep-seated invasive candidiasis. In the candidemic group 28\/32 (87.5%) patients had at least one positive T2Candida result at any time point. A total of 17\/25 (68%) candidemic patients had a positive T2Candida sample that was drawn concurrently to the index blood culture. In the per patient analysis 17\/18 (94.4%) candidemic patients with matched T2Candida samples and peripheral blood cultures at any timepoint had a positive T2Candida test. T2Candida revealed discordant Candida species identification in two candidemic patients. Six of 22 (27.3%) deep-seated IC patients had a positive T2Candida result. Despite advanced time-to-results the clinical value of T2Candida in diagnosing candidemia seems to be limited by missing blood culture positive cases. Positivity rates of T2Candida increased when serial T2Candida samples were tested. In patients with suspected deep-seated invasive candidiasis T2Candida might act as a blood based adjunct to sterile site cultures.<\/jats:p>","DOI":"10.1093\/mmy\/myz101","type":"journal-article","created":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T11:15:13Z","timestamp":1570014913000},"page":"632-638","source":"Crossref","is-referenced-by-count":19,"title":["T2Candida magnetic resonance in patients with invasive candidiasis: Strengths and limitations"],"prefix":"10.1093","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0623-0360","authenticated-orcid":false,"given":"Christoph","family":"Zurl","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria"},{"name":"Division of General Paediatrics, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria"},{"name":"BioTechMed-Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juergen","family":"Prattes","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria"},{"name":"BioTechMed-Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"Zollner-Schwetz","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Valentin","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmin","family":"Rabensteiner","sequence":"first","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Wunsch","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria"},{"name":"BioTechMed-Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Hoenigl","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria"},{"name":"Division of Infectious Diseases, Department of Medicine, University of California San Diego, San Diego, California, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Krause","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria"},{"name":"BioTechMed-Graz, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,10,15]]},"reference":[{"key":"2020063020041128000_bib1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S1473-3099(03)00801-6","article-title":"Epidemiology of Candida species infections in critically ill non-immunosuppressed patients","volume":"3","author":"Eggimann","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"2020063020041128000_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/1469-0691.12039","article-title":"ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients","volume":"18","author":"Cornely","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"2020063020041128000_bib3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/1469-0691.12041","article-title":"ESCMID* guideline for the diagnosis and management of Candida diseases 2012: adults with haematological malignancies and after haematopoietic stem cell transplantation (HCT)","volume":"18","author":"Ullmann","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"2020063020041128000_bib4","first-page":"1","article-title":"Nosocomial candidiasis: antifungal stewardship and the importance of rapid diagnosis","volume":"54","author":"Pfaller","year":"2016","journal-title":"Med Mycol"},{"key":"2020063020041128000_bib5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s13054-019-2497-3","article-title":"Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project","volume":"23","author":"Bassetti","year":"2019","journal-title":"Crit Care"},{"key":"2020063020041128000_bib6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1086\/504810","article-title":"Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: a multi-institutional study","volume":"43","author":"Garey","year":"2006","journal-title":"Clin Infect Dis"},{"key":"2020063020041128000_bib7","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1097\/CCM.0b013e31817045e5","article-title":"Enhanced and earlier detection of bacteremia and fungemia by multiplex polymerase chain reaction: how much enhanced, how much earlier, and at what cost","volume":"36","author":"Falagas","year":"2008","journal-title":"Crit Care Med"},{"key":"2020063020041128000_bib8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/mmy.38.s1.147.159","article-title":"Non-culture based diagnostic tests for mycotic infections","volume":"38","author":"Reiss","year":"2000","journal-title":"Med Mycol"},{"key":"2020063020041128000_bib9","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1093\/cid\/cit006","article-title":"Finding the \u201cmissing 50%\u201d of invasive candidiasis: how nonculture diagnostics will improve understanding of disease spectrum and transform patient care","volume":"56","author":"Clancy","year":"2013","journal-title":"Clin Infect Dis"},{"key":"2020063020041128000_bib10","article-title":"Non-culture diagnostics for invasive candidiasis: promise and unintended consequences","volume":"4: E27","author":"Clancy","year":"2018","journal-title":"J Fungi."},{"key":"2020063020041128000_bib11","doi-asserted-by":"crossref","first-page":"182ra54","DOI":"10.1126\/scitranslmed.3005377","article-title":"T2 magnetic resonance enables nanoparticle-mediated rapid detection of candidemia in whole blood","volume":"5","author":"Neely","year":"2013","journal-title":"Sci Transl Med"},{"key":"2020063020041128000_bib12","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1093\/cid\/ciu959","article-title":"T2 magnetic resonance assay for the rapid diagnosis of candidemia in whole blood: a clinical trial","volume":"60","author":"Mylonakis","year":"2015","journal-title":"Clin Infect Dis"},{"key":"2020063020041128000_bib13","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1093\/cid\/cix1095","article-title":"Detecting infections rapidly and easily for candidemia trial, part 2 (DIRECT2): a prospective, multicenter study of the T2Candida panel","volume":"66","author":"Clancy","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2020063020041128000_bib14","doi-asserted-by":"crossref","first-page":"iv6","DOI":"10.1093\/jac\/dky047","article-title":"T2Candida MR as a predictor of outcome in patients with suspected invasive candidiasis starting empirical antifungal treatment: a prospective pilot study","volume":"73","author":"Munoz","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"2020063020041128000_bib15","doi-asserted-by":"crossref","first-page":"e01756","DOI":"10.1128\/JCM.01756-17","article-title":"Efficacy of T2 magnetic resonance assay in monitoring candidemia after initiation of antifungal therapy: the serial therapeutic and antifungal monitoring protocol (STAMP) trial","volume":"56","author":"Mylonakis","year":"2018","journal-title":"J Clin Microbiol"},{"key":"2020063020041128000_bib16","doi-asserted-by":"crossref","first-page":"iv13","DOI":"10.1093\/jac\/dky048","article-title":"T2MR contributes to the very early diagnosis of complicated candidaemia: a prospective study","volume":"73","author":"Munoz","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"2020063020041128000_bib17","volume-title":"Proposed EORTC\/MSG definitions of fungal infections in ICU","author":"Bassetti"},{"key":"2020063020041128000_bib18","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1086\/588660","article-title":"Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer\/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC\/MSG) Consensus Group","volume":"46","author":"De Pauw","year":"2008","journal-title":"Clin Infect Dis"},{"key":"2020063020041128000_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/599376","article-title":"Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America","volume":"49","author":"Mermel","year":"2009","journal-title":"Clin Infect Dis"},{"key":"2020063020041128000_bib20","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/myc.12869","article-title":"Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units.Protocol of the FUNgal infections Definitions in ICU patients (FUNDICU) project","volume":"62","author":"Bassetti","year":"2019","journal-title":"Mycoses"},{"key":"2020063020041128000_bib21","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/mmy\/myu023","article-title":"Automation of serum (1\u21923)-beta-D-glucan testing allows reliable and rapid discrimination of patients with and without candidemia","volume":"52","author":"Pruller","year":"2014","journal-title":"Med Mycol"},{"key":"2020063020041128000_bib22","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/ajcp\/aqw063","article-title":"T2candida provides rapid and accurate species identification in pediatric cases of candidemia","volume":"145","author":"Hamula","year":"2016","journal-title":"Am J Clin Pathol"},{"key":"2020063020041128000_bib23","doi-asserted-by":"crossref","first-page":"18","DOI":"10.7326\/0003-4819-140-1-200401060-00007","article-title":"Differential time to positivity: a useful method for diagnosing catheter-related bloodstream infections","volume":"140","author":"Raad","year":"2004","journal-title":"Ann Intern Med"},{"key":"2020063020041128000_bib24","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S1473-3099(07)70235-9","article-title":"Intravascular catheter-related infections: advances in diagnosis, prevention, and management","volume":"7","author":"Raad","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"2020063020041128000_bib25","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S0140-6736(98)11134-0","article-title":"Diagnosis of catheter-related bacteraemia: a prospective comparison of the time to positivity of hub-blood versus peripheral-blood cultures","volume":"354","author":"Blot","year":"1999","journal-title":"Lancet."},{"key":"2020063020041128000_bib26","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1128\/JCM.36.1.105-109.1998","article-title":"Earlier positivity of central-venous- versus peripheral-blood cultures is highly predictive of catheter-related sepsis","volume":"36","author":"Blot","year":"1998","journal-title":"J Clin Microbiol"},{"key":"2020063020041128000_bib27","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1128\/JCM.00085-07","article-title":"Delayed processing of blood samples influences time to positivity of blood cultures and results of Gram stain-acridine orange leukocyte Cytospin test","volume":"45","author":"Schwetz","year":"2007","journal-title":"J Clin Microbiol"},{"key":"2020063020041128000_bib28","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.mmcr.2018.05.006","article-title":"T2Candida((R)) to guide antifungal and lengh of treatment of candidemia in a pediatric multivisceral transplant recipient","volume":"21","author":"Falces-Romero","year":"2018","journal-title":"Med Mycol Case Rep."},{"key":"2020063020041128000_bib29","first-page":"1671","article-title":"A randomized, placebo-controlled trial of preemptive antifungal therapy for the prevention of invasive candidiasis following gastrointestinal surgery for intra-abdominal infections","volume":"61","author":"Knitsch","year":"2015","journal-title":"Clin Infect Dis"},{"key":"2020063020041128000_bib30","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/1471-2334-14-385","article-title":"Empirical antifungal therapy with an echinocandin in critically-ill patients: prospective evaluation of a pragmatic Candida score-based strategy in one medical ICU","volume":"14","author":"Bruyere","year":"2014","journal-title":"BMC Infect Dis"},{"key":"2020063020041128000_bib31","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/myc.12817","article-title":"Evaluation of a new T2 Magnetic Resonance assay for rapid detection of emergent fungal pathogen Candida auris on clinical skin swab samples","volume":"61","author":"Sexton","year":"2018","journal-title":"Mycoses"},{"key":"2020063020041128000_bib32","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.3201\/eid2408.180495","article-title":"Isolation of Candida auris from ear of otherwise healthy patient, Austria, 2018","volume":"24","author":"Pekard-Amenitsch","year":"2018","journal-title":"Emerg Infect Dis"}],"container-title":["Medical Mycology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mmy\/article-pdf\/58\/5\/632\/33431534\/myz101.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/mmy\/article-pdf\/58\/5\/632\/33431534\/myz101.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:15:46Z","timestamp":1593562546000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mmy\/article\/58\/5\/632\/5587746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,15]]},"references-count":32,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,10,15]]},"published-print":{"date-parts":[[2020,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/mmy\/myz101","relation":{},"ISSN":["1369-3786","1460-2709"],"issn-type":[{"value":"1369-3786","type":"print"},{"value":"1460-2709","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,7]]},"published":{"date-parts":[[2019,10,15]]}}}