{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:40:58Z","timestamp":1793947258700,"version":"4.8.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Candida auris has emerged as a nosocomial multi-drug resistant pathogen. This study aimed to compare the risk factors and outcomes of C. auris candidemia patients with non-C. auris candidemia, at a single center in Pakistan. A retrospective study compared 38 C. auris with 101 non-C. auris (36 C. albicans, 38 C. tropicalis, and 27 C. parapsilosis) candidemia patients between September 2014 and March 2017 at the Aga Khan University Hospital, Pakistan. Demographics, clinical history, management and outcomes were studied. Prior history of surgery (adjusted odds ratio [aOR] 4.9, 95% confidence interval [CI]: 1.4\u201317.5), antifungals exposure (aOR 38.3, 95% CI: 4.1\u2013356) and prior MDR bacteria isolation (aOR 5.09, 95% CI: 1.6\u201315.9) were associated with C. auris candidemia. On survival analysis both groups of patients had similar outcome in terms of mortality (62.6%\u00a0vs. 52.54%, hazard ratio [HR] 1.45, 95% CI: 0.84\u20132.4, P-value\u00a0=\u00a0.17) and microbiological failure rates (42.3%\u00a0vs. 32.2%, HR 0.65, 95% CI: 0.35\u20131.2, P-value\u00a0=\u00a0.17) however, C. auris patients had a higher mean hospital stay (36.32 days vs. 14.8 days, P-value = &amp;lt;.001) and higher\u00a0&amp;gt;15-day in-hospital stay from positive culture (HR 2.68, 95% CI: 1.1\u20136.3, P-value\u00a0=\u00a0.025). Antifungal susceptibility was different, with C. auris more often resistant to voriconazole (29.6%\u00a0vs. 0%) and amphotericin (3.7\u00a0vs. 0%); though no echinocandin resistance was detected in either group. As opposed to other Candida species, C. auris candidemia occurred after nosocomial exposure, and its source was most commonly an indwelling line. Although these patients had a higher in-hospital stay, but there was no excess mortality when compared to other Candida species.<\/jats:p>","DOI":"10.1093\/mmy\/myz112","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T07:10:33Z","timestamp":1574320233000},"page":"721-729","source":"Crossref","is-referenced-by-count":63,"title":["Comparison of risk factors and outcomes of Candida auris candidemia with non-Candida auris candidemia: A retrospective study from Pakistan"],"prefix":"10.1093","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4971-295X","authenticated-orcid":false,"given":"Muneeba Ahsan","family":"Sayeed","sequence":"first","affiliation":[{"name":"Department of Medicine, Aga Khan University, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joveria","family":"Farooqi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi 74800, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2497-7847","authenticated-orcid":false,"given":"Kauser","family":"Jabeen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi 74800, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Faisal","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Department of Medicine, Aga Khan University, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"2020080320004358800_bib1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s10096-013-2027-1","article-title":"Multidrug-resistant endemic clonal strain of Candida auris in India","volume":"33","author":"Chowdhary","year":"2014","journal-title":"Eur J ClinMicrobiol Infect Dis"},{"key":"2020080320004358800_bib2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.4103\/0255-0857.108746","article-title":"Candidemia caused by amphotericin B and fluconazole resistant Candida auris","volume":"31","author":"Sarma","year":"2013","journal-title":"Indian J Med Microbiol"},{"key":"2020080320004358800_bib3","first-page":"1250","article-title":"Candida auris-associated candidemia","volume":"20","author":"Magobo","year":"2014","journal-title":"South Africa. 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