{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:13:20Z","timestamp":1793366000660,"version":"4.5.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T00:00:00Z","timestamp":1576108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"European Union's Horizon 2020 research and innovation program","award":["642095"],"award-info":[{"award-number":["642095"]}]},{"name":"National Health Department of China","award":["2018ZX10101003"],"award-info":[{"award-number":["2018ZX10101003"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31770161"],"award-info":[{"award-number":["31770161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007054","name":"Second Military Medical University","doi-asserted-by":"publisher","award":["2017JZ47"],"award-info":[{"award-number":["2017JZ47"]}],"id":[{"id":"10.13039\/501100007054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Science and Technology Committee","doi-asserted-by":"publisher","award":["14DZ2272900"],"award-info":[{"award-number":["14DZ2272900"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Science and Technology Committee","doi-asserted-by":"publisher","award":["14495800500"],"award-info":[{"award-number":["14495800500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["98-01-43-21203"],"award-info":[{"award-number":["98-01-43-21203"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Candida tropicalis is one of the major candidaemia agents, associated with the highest mortality rates among Candida species, and developing resistance to azoles. Little is known about the molecular mechanisms of azole resistance, genotypic diversity, and the clinical background of C. tropicalis infections. Consequently, this study was designed to address those questions. Sixty-four C. tropicalis bloodstream isolates from 62 patients from three cities in Iran (2014\u20132019) were analyzed. Strain identification, antifungal susceptibility testing, and genotypic diversity analysis were performed by MALDI-TOF MS, CLSI-M27 A3\/S4 protocol, and amplified fragment length polymorphism (AFLP) fingerprinting, respectively. Genes related to drug resistance (ERG11, MRR1, TAC1, UPC2, and FKS1 hotspot9s) were sequenced. The overall mortality rate was 59.6% (37\/62). Strains were resistant to micafungin [minimum inhibitory concentration (MIC) \u22651 \u03bcg\/ml, 2\/64], itraconazole (MIC\u00a0&amp;gt;\u00a00.5 \u03bcg\/ml, 2\/64), fluconazole (FLZ; MIC\u00a0\u2265\u00a08 \u03bcg\/ml, 4\/64), and voriconazole (MIC\u00a0\u2265\u00a01 \u03bcg\/ml, 7\/64). Pan-azole and FLZ\u00a0+\u00a0VRZ resistance were observed in one and two isolates, respectively, while none of the patients were exposed to azoles. MRR1 (T255P, 647S), TAC1 (N164I, R47Q), and UPC2 (T241A, Q340H, T381S) mutations were exclusively identified in FLZ-resistant isolates. AFLP fingerprinting revealed five major and seven minor genotypes; genotype G4 was predominant in all centers. The increasing number of FLZ-R C. tropicalis blood isolates and acquiring FLZ-R in FLZ-naive patients limit the efficiency of FLZ, especially in developing countries. The high mortality rate warrants reaching a consensus regarding the nosocomial mode of C. tropicalis transmission.<\/jats:p>","DOI":"10.1093\/mmy\/myz124","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T20:11:09Z","timestamp":1575663069000},"page":"766-773","source":"Crossref","is-referenced-by-count":84,"title":["Antifungal susceptibility, genotyping, resistance mechanism, and clinical profile of Candida tropicalis blood isolates"],"prefix":"10.1093","volume":"58","author":[{"given":"Amir","family":"Arastehfar","sequence":"first","affiliation":[{"name":"Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Daneshnia","sequence":"additional","affiliation":[{"name":"Westerdijk Fungal Biodiversity Institute, Utrecht, The 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Medical Sciences, Tarbiat Modares University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamiar","family":"Zomorodian","sequence":"additional","affiliation":[{"name":"Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Pan","sequence":"additional","affiliation":[{"name":"Medical Mycology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-1916","authenticated-orcid":false,"given":"Ferry","family":"Hagen","sequence":"additional","affiliation":[{"name":"Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands"},{"name":"Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands"},{"name":"Laboratory of Medical Mycology, Jining No. 1 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