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However, the exact molecular mechanism that leads to polyploid formation, especially in vertebrates, is not fully understood. Our study aimed to elucidate this phenomenon using the zebrafish model. We successfully achieved an effective knockout of the cyclin N-terminal domain containing 1 (cntd1) using CRISPR\/Cas9 technology. This resulted in impaired formation of meiotic crossovers, leading to cell-cycle arrest during meiotic metaphase and triggering apoptosis of spermatocytes in the testes. Despite these defects, the mutant (cntd1\u2212\/\u2212) males were still able to produce a limited amount of sperm with normal ploidy and function. Interestingly, in the mutant females, it was the ploidy not the capacity of egg production that was altered. This resulted in the production of haploid, aneuploid, and unreduced gametes. This alteration enabled us to successfully obtain triploid and tetraploid zebrafish from cntd1\u2212\/\u2212 and cntd1\u2212\/\u2212\/\u2212 females, respectively. Furthermore, the tetraploid-heterozygous zebrafish produced reduced-diploid gametes and yielded all-triploid or all-tetraploid offspring when crossed with wild-type (WT) or tetraploid zebrafish, respectively. Collectively, our findings provide direct evidence supporting the crucial role of meiotic crossover defects in the process of polyploidization. This is particularly evident in the generation of unreduced eggs in fish and, potentially, other vertebrate species.<\/jats:p>","DOI":"10.1093\/molbev\/msae047","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T09:37:09Z","timestamp":1709113029000},"source":"Crossref","is-referenced-by-count":15,"title":["Formation of Different Polyploids Through Disrupting Meiotic Crossover Frequencies Based on\n                    <i>cntd1<\/i>\n                    Knockout in Zebrafish"],"prefix":"10.1093","volume":"41","author":[{"given":"Yuan","family":"Ou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Sciences, Hunan Normal University , Changsha 410081 , China"},{"name":"College of Life Sciences, Hunan Normal University , Changsha 410081 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Sciences, Hunan Normal University , Changsha 410081 , China"},{"name":"College of Life Sciences, Hunan Normal University , Changsha 410081 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Sciences, Hunan Normal University , Changsha 410081 , China"},{"name":"College of Life Sciences, Hunan Normal University , Changsha 410081 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyan","family":"Dai","sequence":"additional","affiliation":[{"name":"Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University , Chongqing 400715 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences, Central South University , Changsha 410078 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Sciences, Hunan Normal University , Changsha 410081 , China"},{"name":"College of Life Sciences, Hunan Normal University , Changsha 410081 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Sciences, Hunan Normal University , Changsha 410081 , China"},{"name":"College of Life Sciences, Hunan Normal University , Changsha 410081 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conghui","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Sciences, Hunan Normal University , Changsha 410081 , China"},{"name":"College of Life Sciences, Hunan Normal University , Changsha 410081 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Sciences, Hunan Normal University , Changsha 410081 , China"},{"name":"College of Life Sciences, Hunan Normal University , Changsha 410081 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rurong","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Sciences, Hunan Normal University , Changsha 410081 , China"},{"name":"College of Life Sciences, Hunan Normal University , Changsha 410081 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan, Hubei 430072 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1547-4319","authenticated-orcid":false,"given":"Yuqin","family":"Shu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of 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