{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:29:40Z","timestamp":1792794580783,"version":"4.5.0"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31925004"],"award-info":[{"award-number":["31925004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Strategic Priority Research Program of the Chinese Academy of Sciences","award":["XDB27010305"],"award-info":[{"award-number":["XDB27010305"]}],"id":[{"id":"https:\/\/ror.org\/034t30j35","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Second Tibetan Plateau Scientific Expedition and Research (STEP) program","award":["2019QZKK0502"],"award-info":[{"award-number":["2019QZKK0502"]}]},{"name":"State Key Laboratory of Systematic and Evolutionary Botany","id":[{"id":"https:\/\/ror.org\/05wq99a66","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Institute of Botany"},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>High mountains harbor a considerable proportion of biodiversity, but we know little about how diverse plants adapt to the harsh environment. Here we finished a high-quality genome assembly for Dasiphora fruticosa, an ecologically important plant distributed in the Qinghai-Tibetan Plateau and lowland of the Northern Hemisphere, and resequenced 592 natural individuals to address how this horticulture plant adapts to highland. Demographic analysis revealed D. fruticosa underwent a bottleneck after Naynayxungla Glaciation. Selective sweep analysis of two pairs of lowland and highland populations identified 63 shared genes related to cell wall organization or biogenesis, cellular component organization, and dwarfism, suggesting parallel adaptation to highland habitats. Most importantly, we found that stronger purging of estimated genetic load due to inbreeding in highland populations apparently contributed to their adaptation to the highest mountain. Our results revealed how plants could tolerate the extreme plateau, which could provide potential insights for species conservation and crop breeding.<\/jats:p>","DOI":"10.1093\/molbev\/msae099","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T13:45:40Z","timestamp":1716212740000},"source":"Crossref","is-referenced-by-count":21,"title":["Signatures of Adaptation and Purifying Selection in Highland Populations of\n                    <i>Dasiphora fruticosa<\/i>"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-9160","authenticated-orcid":false,"given":"Fu-Sheng","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences , Beijing 100093 , China"},{"name":"China National Botanical Garden , Beijing 100093 , China"},{"name":"College of Life Sciences, University of Chinese Academy of Sciences , Beijing 100049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8876-7534","authenticated-orcid":false,"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Genomics, Key Laboratory of Genomics, Ministry of Agriculture, BGI Research , Shenzhen 518083 , China"},{"name":"BGI Research , Wuhan 430074 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Genomics, Key Laboratory of Genomics, Ministry of Agriculture, BGI Research , Shenzhen 518083 , China"},{"name":"BGI Research , Wuhan 430074 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9678-4772","authenticated-orcid":false,"given":"Chao","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Systematic and Evolutionary 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Shenzhen 518083 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongming","family":"Fang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Genomics, Key Laboratory of Genomics, Ministry of Agriculture, BGI Research , Shenzhen 518083 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1378-4049","authenticated-orcid":false,"given":"Yong-Chao","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences , Beijing 100093 , China"},{"name":"China National Botanical Garden , Beijing 100093 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4766-8078","authenticated-orcid":false,"given":"Fu-Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences , Beijing 100093 , China"},{"name":"China National Botanical Garden , Beijing 100093 , China"},{"name":"College of Life Sciences, University of Chinese Academy of Sciences , Beijing 100049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6242-0041","authenticated-orcid":false,"given":"Ying-Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences , Beijing 100093 , China"},{"name":"China National Botanical Garden , Beijing 100093 , China"},{"name":"College of Life Sciences, University of Chinese Academy of Sciences , Beijing 100049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2872-4954","authenticated-orcid":false,"given":"Ting","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Genomics, Key Laboratory of Genomics, Ministry of Agriculture, BGI Research , Shenzhen 518083 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8422-9619","authenticated-orcid":false,"given":"Hongyun","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Genomics, Key Laboratory of Genomics, Ministry of Agriculture, BGI Research , Shenzhen 518083 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4742-9870","authenticated-orcid":false,"given":"Sunil Kumar","family":"Sahu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Genomics, Key Laboratory of Genomics, Ministry of Agriculture, BGI Research , Shenzhen 518083 , China"},{"name":"BGI Research , Wuhan 430074 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0254-2554","authenticated-orcid":false,"given":"Ruirui","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Sciences, University of Chinese Academy of Sciences , Beijing 100049 , China"},{"name":"State Key Laboratory of Agricultural Genomics, Key Laboratory of Genomics, Ministry of Agriculture, BGI Research , Shenzhen 518083 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4652-1715","authenticated-orcid":false,"given":"Guanlong","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Genomics, Key Laboratory of Genomics, Ministry of Agriculture, BGI Research , Shenzhen 518083 , 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4643-4889","authenticated-orcid":false,"given":"Ya-Long","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences , Beijing 100093 , China"},{"name":"China National Botanical Garden , Beijing 100093 , China"},{"name":"College of Life Sciences, University of Chinese Academy of Sciences , Beijing 100049 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"issue":"7914","key":"2024062904205584700_msae099-B1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41586-022-04740-y","article-title":"An oxygen-sensing mechanism for angiosperm adaptation to 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