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Here, we analyzed the relative rates of nucleotide substitution in the mitochondrial, apicoplast, and nuclear genomes in four different lineages of Plasmodium species (malaria parasites) infecting mammals. The rates of substitution in the three genomes exhibit substantial variation among lineages, with the relative rates of nuclear and mitochondrial DNA being particularly divergent between the Laverania (including Plasmodium falciparum) and Vivax lineages (including Plasmodium vivax). Consideration of synonymous and nonsynonymous substitution rates suggests that their variation is largely due to changes in mutation rates, with constraints on amino acid replacements remaining more similar among lineages. Mitochondrial DNA mutation rate variations among lineages may reflect differences in the long-term average lengths of the sexual and asexual stages of the life cycle. These rate variations have far-reaching implications for the use of molecular clocks to date Plasmodium evolution.<\/jats:p>","DOI":"10.1093\/molbev\/msae243","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T17:28:21Z","timestamp":1732210101000},"source":"Crossref","is-referenced-by-count":8,"title":["Remarkable Evolutionary Rate Variations Among Lineages and Among Genome Compartments in Malaria Parasites of Mammals"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7911-2376","authenticated-orcid":false,"given":"Hend","family":"Abu-Elmakarem","sequence":"first","affiliation":[{"name":"Institute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh , Edinburgh ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4919-4697","authenticated-orcid":false,"given":"Oscar 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