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Intraspecific variation in snake venoms is widely reported, and one of the most dramatic patterns described is the parallel evolution of streamlined neurotoxic rattlesnake venoms from hemorrhagic ancestors by means of deletion of snake venom metalloproteinase (SVMP) toxins and recruitment of neurotoxic dimeric phospholipase A2 (PLA2) toxins. While generating a haplotype-resolved, chromosome-level genome assembly for the eastern diamondback rattlesnake (Crotalus adamanteus), we discovered that our genome animal was heterozygous for a \u223c225 Kb deletion containing six SVMP genes, paralleling one of the two steps involved in the origin of neurotoxic rattlesnake venoms. Range-wide population-genomic analysis revealed that, although this deletion is rare overall, it is the dominant homozygous genotype near the northwestern periphery of the species\u2019 range, where this species is vulnerable to extirpation. Although major SVMP deletions have been described in at least five other rattlesnake species, C. adamanteus is unique in not additionally gaining neurotoxic PLA2s. Previous work established a superficially complementary north\u2013south gradient in myotoxin (MYO) expression based on copy number variation with high expression in the north and low in the south, yet we found that the SVMP and MYO genotypes vary independently, giving rise to an array of diverse, novel venom phenotypes across the range. Structural variation, therefore, forms the basis for the major axes of geographic venom variation for C. adamanteus.<\/jats:p>","DOI":"10.1093\/molbev\/msaf058","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T18:22:51Z","timestamp":1742322171000},"source":"Crossref","is-referenced-by-count":13,"title":["A Segregating Structural Variant Defines Novel Venom Phenotypes in the Eastern Diamondback Rattlesnake"],"prefix":"10.1093","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3196-0173","authenticated-orcid":false,"given":"Pedro G","family":"Nachtigall","sequence":"first","affiliation":[{"name":"Department of Biological Science, Florida State University , Tallahassee, FL ,","place":["USA"]},{"name":"Laborat\u00f3rio de Toxinologia Aplicada, CeTICS, Instituto Butantan , S\u00e3o Paulo, SP 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