{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:54:59Z","timestamp":1775076899924,"version":"3.50.1"},"reference-count":153,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01HG010774"],"award-info":[{"award-number":["R01HG010774"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R35GM138286"],"award-info":[{"award-number":["R35GM138286"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R35GM148244"],"award-info":[{"award-number":["R35GM148244"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The Aedes aegypti mosquito is a vector for human arboviruses and zoonotic diseases and therefore poses a serious threat to public health. Understanding how Ae. aegypti adapts to environmental pressures\u2014such as insecticides\u2014is critical for developing effective mitigation strategies. However, most traditional methods for detecting recent positive selection search for signatures of classic \u201chard\u201d selective sweeps, and to date no studies have examined soft sweeps in Ae. aegypti. This is a significant limitation as this is vital information for understanding the pace of adaptation\u2014populations that can immediately respond to new selective pressures are expected to adapt more often via standing variation or recurrent adaptive mutations (both of which may produce soft sweeps) than via de novo mutations (which produce hard sweeps). To this end, we used a machine learning method capable of detecting hard and soft sweeps to investigate positive selection in Ae. aegypti population samples from Africa and the Americas. Our results reveal that soft sweeps are significantly more common than hard sweeps, which may imply that this species can respond quickly to environmental stressors. This is a particularly concerning finding for vector control methods that aim to eradicate Ae. aegypti using insecticides. We highlight genes under selection that include both well-characterized and putatively novel insecticide resistance genes. These findings underscore the importance of using methods capable of detecting and distinguishing hard and soft sweeps, implicate soft sweeps as a major selective mode in Ae. aegypti, and highlight genes that may aid in the control of Ae. aegypti populations.<\/jats:p>","DOI":"10.1093\/molbev\/msag068","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T12:49:07Z","timestamp":1773233347000},"source":"Crossref","is-referenced-by-count":0,"title":["Soft Selective Sweeps Predominate in the Yellow Fever Mosquito\n                    <i>Aedes aegypti<\/i>"],"prefix":"10.1093","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0818-2908","authenticated-orcid":false,"given":"Remi N","family":"Ketchum","sequence":"first","affiliation":[{"name":"Department of Genetics, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7597-602X","authenticated-orcid":false,"given":"Daniel R","family":"Matute","sequence":"additional","affiliation":[{"name":"Department of Biology, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5249-4151","authenticated-orcid":false,"given":"Daniel R","family":"Schrider","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of North Carolina at Chapel Hill , Chapel Hill, NC 27599 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"2026040114140028400_msag068-B1","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1093\/molbev\/msaa038","article-title":"Predicting the landscape of recombination using deep learning","volume":"37","author":"Adrion","year":"2020","journal-title":"Mol Biol Evol."},{"key":"2026040114140028400_msag068-B2","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/s42003-018-0085-8","article-title":"RAiSD detects positive selection based on multiple signatures of a selective sweep and SNP vectors","volume":"1","author":"Alachiotis","year":"2018","journal-title":"Commun Biol."},{"key":"2026040114140028400_msag068-B3","doi-asserted-by":"publisher","first-page":"msad157","DOI":"10.1093\/molbev\/msad157","article-title":"Uncovering footprints of natural selection through spectral analysis of genomic summary statistics","volume":"40","author":"Arnab","year":"2023","journal-title":"Mol Biol Evol."},{"key":"2026040114140028400_msag068-B4","doi-asserted-by":"publisher","first-page":"9268","DOI":"10.1073\/pnas.1608295113","article-title":"Cytochrome P450 associated with insecticide resistance catalyzes cuticular hydrocarbon production in Anopheles gambiae","volume":"113","author":"Balabanidou","year":"2016","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026040114140028400_msag068-B5","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1126\/science.1159978","article-title":"Natural selection on a major armor gene in threespine stickleback","volume":"322","author":"Barrett","year":"2008","journal-title":"Science"},{"key":"2026040114140028400_msag068-B6","doi-asserted-by":"publisher","first-page":"4337","DOI":"10.1111\/mec.13762","article-title":"Historical environmental change in Africa drives divergence and admixture of Aedes aegypti mosquitoes: a precursor to successful worldwide colonization?","volume":"25","author":"Bennett","year":"2016","journal-title":"Mol Ecol."},{"key":"2026040114140028400_msag068-B7","doi-asserted-by":"publisher","first-page":"e1004412","DOI":"10.1371\/journal.pgen.1004412","article-title":"A population genetic signal of polygenic adaptation","volume":"10","author":"Berg","year":"2014","journal-title":"PLoS Genet."},{"key":"2026040114140028400_msag068-B8","doi-asserted-by":"publisher","first-page":"912","DOI":"10.3390\/biom13060912","article-title":"The janus-faced role of lipid droplets in aging: insights from the cellular perspective","volume":"13","author":"Bresgen","year":"2023","journal-title":"Biomolecules"},{"key":"2026040114140028400_msag068-B9","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1111\/evo.12281","article-title":"Human impacts have shaped historical and recent evolution in Aedes aegypti, the dengue and yellow fever mosquito","volume":"68","author":"Brown","year":"2014","journal-title":"Evolution"},{"key":"2026040114140028400_msag068-B10","doi-asserted-by":"publisher","author":"Caldas","year":"2022","DOI":"10.1101\/2022.07.19.500702"},{"key":"2026040114140028400_msag068-B11","doi-asserted-by":"publisher","first-page":"e0211497","DOI":"10.1371\/journal.pone.0211497","article-title":"Vgsc-interacting proteins are genetically associated with pyrethroid resistance in Aedes aegypti","volume":"14","author":"Campbell","year":"2019","journal-title":"PLoS One"},{"key":"2026040114140028400_msag068-B12","doi-asserted-by":"publisher","first-page":"13054","DOI":"10.1038\/s41598-018-31360-2","article-title":"Redox state affects fecundity and insecticide susceptibility in Anopheles gambiae","volume":"8","author":"Champion","year":"2018","journal-title":"Sci Rep."},{"key":"2026040114140028400_msag068-B13","doi-asserted-by":"publisher","first-page":"8594","DOI":"10.48550\/arXiv.1802.06153","article-title":"A likelihood-free inference framework for population genetic data using exchangeable neural networks","volume":"31","author":"Chan","year":"2018","journal-title":"Adv Neural Inf Process Syst"},{"key":"2026040114140028400_msag068-B14","doi-asserted-by":"publisher","first-page":"iyac140","DOI":"10.1093\/genetics\/iyac140","article-title":"Marker-assisted mapping enables forward genetic analysis in Aedes aegypti, an arboviral vector with vast recombination deserts","volume":"222","author":"Chen","year":"2022","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B15","doi-asserted-by":"publisher","first-page":"101000","DOI":"10.1016\/j.cois.2022.101000","article-title":"Rapid evolution of insecticide resistance in the Colorado potato beetle, Leptinotarsa decemlineata","volume":"55","author":"Chen","year":"2023","journal-title":"Curr Opin Insect Sci."},{"key":"2026040114140028400_msag068-B16","doi-asserted-by":"publisher","author":"Chotai","year":"2024","DOI":"10.1101\/2024.07.26.605365"},{"key":"2026040114140028400_msag068-B17","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1101\/gr.262790.120","article-title":"Genome variation and population structure among 1142 mosquitoes of the African malaria vector species Anopheles gambiae and Anopheles coluzzii","volume":"30","author":"Clarkson","year":"2020","journal-title":"Genome Res."},{"key":"2026040114140028400_msag068-B18","doi-asserted-by":"publisher","first-page":"2938","DOI":"10.1093\/bioinformatics\/btx364","article-title":"Upsetr: an R package for the visualization of intersecting sets and their properties","volume":"33","author":"Conway","year":"2017","journal-title":"Bioinformatics"},{"key":"2026040114140028400_msag068-B19","doi-asserted-by":"publisher","first-page":"867231","DOI":"10.3389\/fgene.2022.867231","article-title":"Genome-wide association study reveals new loci associated with pyrethroid resistance in Aedes aegypti","volume":"13","author":"Cosme","year":"2022","journal-title":"Front Genet."},{"key":"2026040114140028400_msag068-B20","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-017-0351-0","article-title":"Population genomics reveals that an anthropophilic population of Aedes aegypti mosquitoes in West Africa recently gave rise to American and Asian populations of this major disease vector","volume":"15","author":"Crawford","year":"2017","journal-title":"BMC Bio"},{"key":"2026040114140028400_msag068-B21","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1126\/science.1074170","article-title":"A single P450 allele associated with insecticide resistance in Drosophila","volume":"297","author":"Daborn","year":"2002","journal-title":"Science"},{"key":"2026040114140028400_msag068-B22","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1093\/bioinformatics\/btw051","article-title":"SweepFinder2: increased sensitivity, robustness and flexibility","volume":"32","author":"DeGiorgio","year":"2016","journal-title":"Bioinformatics"},{"key":"2026040114140028400_msag068-B23","doi-asserted-by":"publisher","first-page":"4872","DOI":"10.1128\/MCB.01767-05","article-title":"Cytochrome c oxidase is required for the assembly\/stability of respiratory complex I in mouse fibroblasts","volume":"26","author":"Diaz","year":"2006","journal-title":"Mol Cell Biol."},{"key":"2026040114140028400_msag068-B24","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1365-2583.2004.00529.x","article-title":"Insect glutathione transferases and insecticide resistance","volume":"14","author":"Enayati","year":"2005","journal-title":"Insect Mol Biol."},{"key":"2026040114140028400_msag068-B25","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1093\/genetics\/155.3.1405","article-title":"Hitchhiking under positive Darwinian selection","volume":"155","author":"Fay","year":"2000","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B26","doi-asserted-by":"publisher","first-page":"e10670","DOI":"10.7554\/eLife.10670","article-title":"More effective drugs lead to harder selective sweeps in the evolution of drug resistance in HIV-1","volume":"5","author":"Feder","year":"2016","journal-title":"Elife"},{"key":"2026040114140028400_msag068-B27","doi-asserted-by":"publisher","first-page":"e1009050","DOI":"10.1371\/journal.pgen.1009050","article-title":"The clarifying role of time series data in the population genetics of HIV","volume":"17","author":"Feder","year":"2021","journal-title":"PLoS Genet."},{"key":"2026040114140028400_msag068-B28","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1093\/molbev\/msu077","article-title":"On detecting incomplete soft or hard selective sweeps using haplotype structure","volume":"31","author":"Ferrer-Admetlla","year":"2014","journal-title":"Mol Biol Evol."},{"key":"2026040114140028400_msag068-B29","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1093\/molbev\/msy224","article-title":"The unreasonable effectiveness of convolutional neural networks in population genetic inference","volume":"36","author":"Flagel","year":"2019","journal-title":"Mol Biol Evol."},{"key":"2026040114140028400_msag068-B30","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/0163-7258(80)90028-5","article-title":"Metabolism of several insecticides by glutathion S-transferase","volume":"10","author":"Fukami","year":"1980","journal-title":"Pharmacol Ther."},{"key":"2026040114140028400_msag068-B31","doi-asserted-by":"publisher","first-page":"102403","DOI":"10.1016\/j.aspen.2025.102403","article-title":"Characterization of the thioredoxin peroxidase gene and its role in lambda-cyhalothrin tolerance in Agrotis ipsilon (Lepidoptera: Noctuidae)","volume":"28","author":"Gao","year":"2025","journal-title":"J Asia Pac Entomol."},{"key":"2026040114140028400_msag068-B32","doi-asserted-by":"publisher","first-page":"e1005004","DOI":"10.1371\/journal.pgen.1005004","article-title":"Recent selective sweeps in North American Drosophila melanogaster show signatures of soft sweeps","volume":"11","author":"Garud","year":"2015","journal-title":"PLoS Genet."},{"key":"2026040114140028400_msag068-B33","doi-asserted-by":"publisher","first-page":"e1009373","DOI":"10.1371\/journal.pgen.1009373","article-title":"Detection of hard and soft selective sweeps from Drosophila melanogaster population genomic data","volume":"17","author":"Garud","year":"2021","journal-title":"PLoS Genet."},{"key":"2026040114140028400_msag068-B34","doi-asserted-by":"publisher","first-page":"20023","DOI":"10.1038\/s41598-020-76891-9","article-title":"Spen modulates lipid droplet content in adult Drosophila glial cells and protects against paraquat toxicity","volume":"10","author":"Girard","year":"2020","journal-title":"Sci Rep."},{"key":"2026040114140028400_msag068-B35","doi-asserted-by":"publisher","first-page":"jkae082","DOI":"10.1093\/g3journal\/jkae082","article-title":"Robustness in population-structure and demographic-inference results derived from the Aedes aegypti genotyping chip and whole-genome sequencing data","volume":"14","author":"G\u00f3mez-Palacio","year":"2024","journal-title":"G3 (Bethesda)"},{"key":"2026040114140028400_msag068-B36","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1111\/j.1752-4571.2012.00244.x","article-title":"Gene flow networks among American Aedes aegypti populations","volume":"5","author":"Gon\u00e7alves da Silva","year":"2012","journal-title":"Evol Appl."},{"key":"2026040114140028400_msag068-B37","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1111\/1744-7917.13368","article-title":"Strong resistance to \u03b2-cyfluthrin in a strain of the beetle Alphitobius diaperinus: a de novo transcriptome analysis","volume":"32","author":"Gouesbet","year":"2025","journal-title":"Insect Sci."},{"key":"2026040114140028400_msag068-B38","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.pharmthera.2005.09.008","article-title":"The structural basis of arrestin-mediated regulation of G-protein-coupled receptors","volume":"110","author":"Gurevich","year":"2006","journal-title":"Pharmacol Ther."},{"key":"2026040114140028400_msag068-B39","doi-asserted-by":"publisher","first-page":"e68472","DOI":"10.1371\/journal.pone.0068472","article-title":"Integrating circadian activity and gene expression profiles to predict chronotoxicity of Drosophila suzukii response to insecticides","volume":"8","author":"Hamby","year":"2013","journal-title":"PLoS One"},{"key":"2026040114140028400_msag068-B40","doi-asserted-by":"publisher","first-page":"e1007859","DOI":"10.1371\/journal.pgen.1007859","article-title":"On the unfounded enthusiasm for soft selective sweeps II: examining recent evidence from humans, flies, and viruses","volume":"14","author":"Harris","year":"2018","journal-title":"PLoS Genet."},{"key":"2026040114140028400_msag068-B41","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1083\/jcb.147.3.659","article-title":"Cloning and characterization of a potassium-dependent sodium\/calcium exchanger in Drosophila","volume":"147","author":"Haug-Collet","year":"1999","journal-title":"J Cell Biol."},{"key":"2026040114140028400_msag068-B42","doi-asserted-by":"publisher","first-page":"e66697","DOI":"10.7554\/eLife.66697","article-title":"Polygenic adaptation after a sudden change in environment","volume":"11","author":"Hayward","year":"2022","journal-title":"Elife"},{"key":"2026040114140028400_msag068-B43","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/imb.12337","article-title":"Identification of glutathione S-transferases in Bemisia tabaci (Hemiptera: Aleyrodidae) and evidence that GSTd7 helps explain the difference in insecticide susceptibility between B. tabaci Middle East-Minor Asia 1 and Mediterranean","volume":"27","author":"He","year":"2018","journal-title":"Insect Mol Biol."},{"key":"2026040114140028400_msag068-B44","doi-asserted-by":"publisher","first-page":"msab332","DOI":"10.1093\/molbev\/msab332","article-title":"A deep-learning approach for inference of selective sweeps from the ancestral recombination graph","volume":"39","author":"Hejase","year":"2022","journal-title":"Mol Biol Evol."},{"key":"2026040114140028400_msag068-B45","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1534\/genetics.104.036947","article-title":"Soft sweeps: molecular population genetics of adaptation from standing genetic variation","volume":"169","author":"Hermisson","year":"2005","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B46","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1111\/eva.13546","article-title":"Insecticide resistance management strategies for public health control of mosquitoes exhibiting polygenic resistance: a comparison of sequences, rotations, and mixtures","volume":"16","author":"Hobbs","year":"2023","journal-title":"Evol Appl."},{"key":"2026040114140028400_msag068-B47","doi-asserted-by":"publisher","first-page":"e1008035","DOI":"10.1371\/journal.pgen.1008035","article-title":"Polygenic adaptation: from sweeps to subtle frequency shifts","volume":"15","author":"H\u00f6llinger","year":"2019","journal-title":"PLoS Genet."},{"key":"2026040114140028400_msag068-B48","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/nature13408","article-title":"Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA","volume":"512","author":"Huerta-S\u00e1nchez","year":"2014","journal-title":"Nature"},{"key":"2026040114140028400_msag068-B49","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1038\/s41467-020-16010-4","article-title":"Accelerating invasion potential of disease vector Aedes aegypti under climate change","volume":"11","author":"Iwamura","year":"2020","journal-title":"Nat Commun."},{"key":"2026040114140028400_msag068-B50","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1021\/jf052046n","article-title":"Gene expression profiles of Drosophila melanogaster exposed to an insecticidal extract of Piper nigrum","volume":"54","author":"Jensen","year":"2006","journal-title":"J Agric Food Chem."},{"key":"2026040114140028400_msag068-B51","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1534\/genetics.104.038224","article-title":"Distinguishing between selective sweeps and demography using DNA polymorphism data","volume":"170","author":"Jensen","year":"2005","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B52","doi-asserted-by":"publisher","first-page":"e1010022","DOI":"10.1371\/journal.pgen.1010022","article-title":"Soft selective sweeps: addressing new definitions, evaluating competing models, and interpreting empirical outliers","volume":"18","author":"Johri","year":"2022","journal-title":"PLoS Genet."},{"key":"2026040114140028400_msag068-B53","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1534\/genetics.108.092270","article-title":"The influence of gene conversion on linkage disequilibrium around a selective sweep","volume":"180","author":"Jones","year":"2008","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B54","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1093\/gbe\/evy185","article-title":"The demographic history of African Drosophila melanogaster","volume":"10","author":"Kapopoulou","year":"2018","journal-title":"Genome Biol Evol."},{"key":"2026040114140028400_msag068-B55","doi-asserted-by":"publisher","first-page":"e1000924","DOI":"10.1371\/journal.pgen.1000924","article-title":"Evidence that adaptation in Drosophila is not limited by mutation at single sites","volume":"6","author":"Karasov","year":"2010","journal-title":"PLoS Genet."},{"key":"2026040114140028400_msag068-B56","doi-asserted-by":"publisher","first-page":"703873","DOI":"10.3389\/fitd.2021.703873","article-title":"Evidence of local extinction and reintroduction of Aedes aegypti in Exeter, California","volume":"2","author":"Kelly","year":"2021","journal-title":"Front Trop Dis."},{"key":"2026040114140028400_msag068-B57","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1093\/genetics\/146.3.1197","article-title":"A test of neutrality based on interlocus associations","volume":"146","author":"Kelly","year":"1997","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B58","doi-asserted-by":"publisher","first-page":"evaf066","DOI":"10.1093\/gbe\/evaf066","article-title":"Demographic history, genetic load, and the efficacy of selection in the globally invasive mosquito Aedes aegypti","volume":"17","author":"Kent","year":"2025","journal-title":"Genome Biol Evol."},{"key":"2026040114140028400_msag068-B59","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1101\/gr.229102","article-title":"The human genome browser at UCSC","volume":"12","author":"Kent","year":"2002","journal-title":"Genome Res."},{"key":"2026040114140028400_msag068-B60","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.1093\/bioinformatics\/btw556","article-title":"Discoal: flexible coalescent simulations with selection","volume":"32","author":"Kern","year":"2016","journal-title":"Bioinformatics"},{"key":"2026040114140028400_msag068-B61","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1534\/g3.118.200262","article-title":"Diplos\/HIC: an updated approach to classifying selective sweeps","volume":"8","author":"Kern","year":"2018","journal-title":"G3 (Bethesda)"},{"key":"2026040114140028400_msag068-B62","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1534\/genetics.103.025387","article-title":"Linkage disequilibrium as a signature of selective sweeps","volume":"167","author":"Kim","year":"2004","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B63","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1002\/ps.3395","article-title":"Fitness costs associated with insecticide resistance","volume":"68","author":"Kliot","year":"2012","journal-title":"Pest Manag Sci."},{"key":"2026040114140028400_msag068-B64","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s13073-020-00791-w","article-title":"Best practices for variant calling in clinical sequencing","volume":"12","author":"Koboldt","year":"2020","journal-title":"Genome Med."},{"key":"2026040114140028400_msag068-B65","doi-asserted-by":"publisher","first-page":"e0009631","DOI":"10.1371\/journal.pntd.0009631","article-title":"The role of urbanisation in the spread of Aedes mosquitoes and the diseases they transmit\u2014A systematic review","volume":"15","author":"Kolimenakis","year":"2021","journal-title":"PLoS Negl Trop Dis."},{"key":"2026040114140028400_msag068-B66","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.gene.2013.01.036","article-title":"Dissecting the mechanisms responsible for the multiple insecticide resistance phenotype in Anopheles gambiae ss, M form, from Vallee du Kou, Burkina Faso","volume":"519","author":"Kwiatkowska","year":"2013","journal-title":"Gene"},{"key":"2026040114140028400_msag068-B67","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3390\/insects14010049","article-title":"Global distribution of Aedes aegypti and Aedes albopictus in a climate change scenario of regional rivalry","volume":"14","author":"Laporta","year":"2023","journal-title":"Insects"},{"key":"2026040114140028400_msag068-B68","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1534\/genetics.110.122614","article-title":"Distinguishing positive selection from neutral evolution: boosting the performance of summary statistics","volume":"187","author":"Lin","year":"2011","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B69","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/ng.3254","article-title":"Exploring population size changes using SNP frequency spectra","volume":"47","author":"Liu","year":"2015","journal-title":"Nat Genet."},{"key":"2026040114140028400_msag068-B70","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1186\/s13059-020-02196-9","article-title":"Stairway plot 2: demographic history inference with folded SNP frequency spectra","volume":"21","author":"Liu","year":"2020","journal-title":"Genome Biol."},{"key":"2026040114140028400_msag068-B71","doi-asserted-by":"publisher","first-page":"msad072","DOI":"10.1093\/molbev\/msad072","article-title":"Strong positive selection in Aedes aegypti and the rapid evolution of insecticide resistance","volume":"40","author":"Love","year":"2023","journal-title":"Mol Biol Evol."},{"key":"2026040114140028400_msag068-B72","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/s41559-025-02643-5","article-title":"Adaptive genomic signatures of globally invasive populations of the yellow fever mosquito Aedes aegypti","volume":"9","author":"Lozada-Ch\u00e1vez","year":"2025","journal-title":"Nat Ecol Evol."},{"key":"2026040114140028400_msag068-B73","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0378-1119(96)00446-5","article-title":"Three second chromosome-linked clustered Cyp6 genes show differential constitutive and barbital-induced expression in DDT-resistant and susceptible strains of Drosophila melanogaster","volume":"180","author":"Maitra","year":"1996","journal-title":"Gene"},{"key":"2026040114140028400_msag068-B74","doi-asserted-by":"publisher","first-page":"e31889","DOI":"10.1371\/journal.pone.0031889","article-title":"Effect of insecticide resistance on development, longevity and reproduction of field or laboratory selected Aedes aegypti populations","volume":"7","author":"Martins","year":"2012","journal-title":"PLoS One"},{"key":"2026040114140028400_msag068-B75","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/s41586-018-0692-z","article-title":"Improved reference genome of Aedes aegypti informs arbovirus vector control","volume":"563","author":"Matthews","year":"2018","journal-title":"Nature"},{"key":"2026040114140028400_msag068-B76","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.tree.2013.08.003","article-title":"Population genomics of rapid adaptation by soft selective sweeps","volume":"28","author":"Messer","year":"2013","journal-title":"Trends Ecol Evol."},{"key":"2026040114140028400_msag068-B77","doi-asserted-by":"publisher","first-page":"e1011032","DOI":"10.1371\/journal.pgen.1011032","article-title":"Domain-adaptive neural networks improve supervised machine learning based on simulated population genetic data","volume":"19","author":"Mo","year":"2023","journal-title":"PLoS Genet."},{"key":"2026040114140028400_msag068-B78","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1093\/molbev\/msy205","article-title":"Localizing and classifying adaptive targets with trend filtered regression","volume":"36","author":"Mughal","year":"2019","journal-title":"Mol Biol Evol."},{"key":"2026040114140028400_msag068-B79","doi-asserted-by":"publisher","first-page":"e1008896","DOI":"10.1371\/journal.pgen.1008896","article-title":"Learning the properties of adaptive regions with functional data analysis","volume":"16","author":"Mughal","year":"2020","journal-title":"PLoS Genet."},{"key":"2026040114140028400_msag068-B80","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1111\/evo.14459","article-title":"Dominance shifts increase the likelihood of soft selective sweeps","volume":"76","author":"Muralidhar","year":"2022","journal-title":"Evolution"},{"key":"2026040114140028400_msag068-B81","doi-asserted-by":"publisher","first-page":"5922","DOI":"10.1073\/pnas.91.13.5922","article-title":"Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase","volume":"91","author":"Mutero","year":"1994","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026040114140028400_msag068-B82","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1101\/gr.4252305","article-title":"Genomic scans for selective sweeps using SNP data","volume":"15","author":"Nielsen","year":"2005","journal-title":"Genome Res."},{"key":"2026040114140028400_msag068-B83","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1146\/annurev.genet.39.073003.112420","article-title":"Molecular signatures of natural selection","volume":"39","author":"Nielsen","year":"2005","journal-title":"Annu Rev Genet."},{"key":"2026040114140028400_msag068-B84","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1093\/genetics\/157.2.875","article-title":"Haldane's sieve and adaptation from the standing genetic variation","volume":"157","author":"Orr","year":"2001","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B85","doi-asserted-by":"publisher","first-page":"2906","DOI":"10.1093\/molbev\/msz191","article-title":"Contemporary demographic reconstruction methods are robust to genome assembly quality: a case study in Tasmanian devils","volume":"36","author":"Patton","year":"2019","journal-title":"Mol Biol Evol."},{"key":"2026040114140028400_msag068-B86","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1534\/genetics.110.116459","article-title":"Searching for footprints of positive selection in whole-genome SNP data from nonequilibrium populations","volume":"185","author":"Pavlidis","year":"2010","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B87","doi-asserted-by":"publisher","first-page":"e186","DOI":"10.1371\/journal.pgen.0020186","article-title":"Soft sweeps III: the signature of positive selection from recurrent mutation","volume":"2","author":"Pennings","year":"2006","journal-title":"PLoS Genet."},{"key":"2026040114140028400_msag068-B88","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1093\/molbev\/msj117","article-title":"Soft sweeps II\u2014molecular population genetics of adaptation from recurrent mutation or migration","volume":"23","author":"Pennings","year":"2006","journal-title":"Mol Biol Evol."},{"key":"2026040114140028400_msag068-B89","doi-asserted-by":"publisher","first-page":"D1243","DOI":"10.1093\/nar\/gkae974","article-title":"The UCSC genome browser database: 2025 update","volume":"53","author":"Perez","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"2026040114140028400_msag068-B90","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1093\/biosci\/biy119","article-title":"Recent history of Aedes aegypti: vector genomics and epidemiology records","volume":"68","author":"Powell","year":"2018","journal-title":"Bioscience"},{"key":"2026040114140028400_msag068-B91","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1111\/j.0014-3820.2005.tb00941.x","article-title":"The signature of positive selection on standing genetic variation","volume":"59","author":"Prezeworski","year":"2005","journal-title":"Evolution"},{"key":"2026040114140028400_msag068-B92","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1603\/033.046.0411","article-title":"Permethrin induces overexpression of cytochrome c oxidase subunit 3 in Aedes aegypti","volume":"46","author":"Pridgeon","year":"2009","journal-title":"J Med Entomol."},{"key":"2026040114140028400_msag068-B93","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/S0965-1748(03)00120-6","article-title":"Overexpression of the cytochrome c oxidase subunit I gene associated with a pyrethroid resistant strain of German cockroaches, Blattella germanica (L.)","volume":"33","author":"Pridgeon","year":"2003","journal-title":"Insect Biochem Mol Biol."},{"key":"2026040114140028400_msag068-B94","doi-asserted-by":"publisher","first-page":"3946","DOI":"10.1093\/bioinformatics\/btv493","article-title":"Hierarchical boosting: a machine-learning framework to detect and classify hard selective sweeps in human populations","volume":"31","author":"Pybus","year":"2015","journal-title":"Bioinformatics"},{"key":"2026040114140028400_msag068-B95","doi-asserted-by":"publisher","first-page":"4555","DOI":"10.1038\/s41598-021-83465-w","article-title":"Insecticide resistance and underlying targets-site and metabolic mechanisms in Aedes aegypti and Aedes albopictus from Lahore, Pakistan","volume":"11","author":"Rahman","year":"2021","journal-title":"Sci Rep."},{"key":"2026040114140028400_msag068-B96","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1534\/genetics.108.093153","article-title":"Linkage disequilibrium between loci with unknown phase","volume":"182","author":"Rogers","year":"2009","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B97","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1534\/genetics.113.152587","article-title":"Learning natural selection from the site frequency spectrum","volume":"195","author":"Ronen","year":"2013","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B98","doi-asserted-by":"publisher","first-page":"3570","DOI":"10.1016\/j.cub.2020.06.092","article-title":"Climate and urbanization drive mosquito preference for humans","volume":"30","author":"Rose","year":"2020","journal-title":"Curr Biol."},{"key":"2026040114140028400_msag068-B99","doi-asserted-by":"publisher","first-page":"e83524","DOI":"10.7554\/eLife.83524","article-title":"Dating the origin and spread of specialization on human hosts in Aedes aegypti mosquitoes","volume":"12","author":"Rose","year":"2023","journal-title":"Elife"},{"key":"2026040114140028400_msag068-B100","doi-asserted-by":"publisher","first-page":"e0007213","DOI":"10.1371\/journal.pntd.0007213","article-title":"Global expansion and redistribution of Aedes-borne virus transmission risk with climate change","volume":"13","author":"Ryan","year":"2019","journal-title":"PLoS Negl Trop Dis."},{"key":"2026040114140028400_msag068-B101","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/imb.12575","article-title":"Exome-wide association of deltamethrin resistance in Aedes aegypti from Mexico","volume":"28","author":"Saavedra-Rodriguez","year":"2019","journal-title":"Insect Mol Biol."},{"key":"2026040114140028400_msag068-B102","doi-asserted-by":"publisher","first-page":"229","DOI":"10.2307\/1538533","article-title":"Some aspects of respiratory metabolism during metamorphosis of normal and DDT-resistant house flies, Musca domestica L","volume":"100","author":"Sacktor","year":"1951","journal-title":"Biol Bull."},{"key":"2026040114140028400_msag068-B103","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13071-016-1735-7","article-title":"Investigating molecular basis of lambda-cyhalothrin resistance in an Anopheles funestus population from Senegal","volume":"9","author":"Samb","year":"2016","journal-title":"Parasit Vectors."},{"key":"2026040114140028400_msag068-B104","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1111\/1755-0998.13224","article-title":"Deep learning for population size history inference: design, comparison and combination with approximate Bayesian computation","volume":"21","author":"Sanchez","year":"2021","journal-title":"Mol Ecol Resour."},{"key":"2026040114140028400_msag068-B105","doi-asserted-by":"publisher","first-page":"6251","DOI":"10.1038\/s41467-024-49792-y","article-title":"Global, asynchronous partial sweeps at multiple insecticide resistance genes in Aedes mosquitoes","volume":"15","author":"Schmidt","year":"2024","journal-title":"Nat Commun."},{"key":"2026040114140028400_msag068-B106","doi-asserted-by":"publisher","first-page":"e0008463","DOI":"10.1371\/journal.pntd.0008463","article-title":"Population genomics of two invasive mosquitoes (Aedes aegypti and Aedes albopictus) from the Indo-Pacific","volume":"14","author":"Schmidt","year":"2020","journal-title":"PLoS Negl Trop Dis."},{"key":"2026040114140028400_msag068-B107","doi-asserted-by":"publisher","author":"Schrider","year":"2023","DOI":"10.1101\/2023.12.05.570141"},{"key":"2026040114140028400_msag068-B108","unstructured":"Schrider DR, Kern AD. On the well-founded enthusiasm for soft sweeps in humans: a reply to Harris, Sackman, and Jensen. Version 2. Zenodo. 10.5281\/zenodo.1473856. 29 October 2018."},{"key":"2026040114140028400_msag068-B109","doi-asserted-by":"publisher","first-page":"e1005928","DOI":"10.1371\/journal.pgen.1005928","article-title":"S\/HIC: robust identification of soft and hard sweeps using machine learning","volume":"12","author":"Schrider","year":"2016","journal-title":"PLoS Genet."},{"key":"2026040114140028400_msag068-B110","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1093\/molbev\/msx154","article-title":"Soft sweeps are the dominant mode of adaptation in the human genome","volume":"34","author":"Schrider","year":"2017","journal-title":"Mol Biol Evol."},{"key":"2026040114140028400_msag068-B111","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1534\/genetics.115.174912","article-title":"Soft shoulders ahead: spurious signatures of soft and partial selective sweeps result from linked hard sweeps","volume":"200","author":"Schrider","year":"2015","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B112","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1093\/genetics\/141.1.413","article-title":"Properties of statistical tests of neutrality for DNA polymorphism data","volume":"141","author":"Simonsen","year":"1995","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B113","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1017\/S0016672300014634","article-title":"The hitch-hiking effect of a favourable gene","volume":"23","author":"Smith","year":"1974","journal-title":"Genet Res."},{"key":"2026040114140028400_msag068-B114","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1002\/ps.1747","article-title":"Mitochondrial impacts of insecticidal formate esters in insecticide-resistant and insecticide-susceptible Drosophila melanogaster","volume":"65","author":"Song","year":"2009","journal-title":"Pest Manag Sci."},{"key":"2026040114140028400_msag068-B115","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1073\/pnas.96.3.1100","article-title":"Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses","volume":"96","author":"Song","year":"1999","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026040114140028400_msag068-B116","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jisesa\/iey101","article-title":"Variation in mitochondria-derived transcript levels associated with DDT resistance in the 91-R strain of Drosophila melanogaster (Diptera: Drosophilidae)","volume":"18","author":"Steele","year":"2018","journal-title":"J Insect Sci."},{"key":"2026040114140028400_msag068-B117","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/mec.13288","article-title":"Signatures of positive selection: from selective sweeps at individual loci to subtle allele frequency changes in polygenic adaptation","volume":"25","author":"Stephan","year":"2016","journal-title":"Mol Ecol."},{"key":"2026040114140028400_msag068-B118","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1111\/1467-9868.00346","article-title":"A direct approach to false discovery rates","volume":"64","author":"Storey","year":"2002","journal-title":"J R Stat Soc Series B Stat Methodol."},{"key":"2026040114140028400_msag068-B119","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1756-3305-5-134","article-title":"Functional characterization of an arrestin gene on insecticide resistance of Culex pipiens pallens","volume":"5","author":"Sun","year":"2012","journal-title":"Parasit Vectors."},{"key":"2026040114140028400_msag068-B120","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.2007.0018-0661.01990.x","article-title":"Thioredoxin-2 affects lifespan and oxidative stress in Drosophila","volume":"144","author":"Svensson","year":"2007","journal-title":"Hereditas"},{"key":"2026040114140028400_msag068-B121","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1093\/ae\/37.1.14","article-title":"Evolutionary genetics and arthropod-borne disease: the yellow fever mosquito","volume":"37","author":"Tabachnick","year":"1991","journal-title":"Am Entomol"},{"key":"2026040114140028400_msag068-B122","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1093\/genetics\/105.2.437","article-title":"Evolutionary relationship of DNA sequences in finite populations","volume":"105","author":"Tajima","year":"1983","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B123","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1093\/genetics\/123.3.585","article-title":"Statistical method for testing the neutral mutation hypothesis by DNA polymorphism","volume":"123","author":"Tajima","year":"1989","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B124","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3390\/proteomes6040047","article-title":"Paraquat-mediated oxidative stress in Anopheles gambiae mosquitoes is regulated by an endoplasmic Reticulum (ER) stress response","volume":"6","author":"Tarimo","year":"2018","journal-title":"Proteomes"},{"key":"2026040114140028400_msag068-B125","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1038\/ng.3748","article-title":"Robust and scalable inference of population history from hundreds of unphased whole genomes","volume":"49","author":"Terhorst","year":"2017","journal-title":"Nat Genet."},{"key":"2026040114140028400_msag068-B126","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1101\/gr.5105206","article-title":"How reliable are empirical genomic scans for selective sweeps?","volume":"16","author":"Teshima","year":"2006","journal-title":"Genome Res."},{"key":"2026040114140028400_msag068-B127","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s12864-025-11214-8","article-title":"Genomic patterns of strain-specific genetic structure, linkage, and selection across fall armyworm populations","volume":"26","author":"Tessnow","year":"2025","journal-title":"BMC Genomics"},{"key":"2026040114140028400_msag068-B128","doi-asserted-by":"publisher","first-page":"183","DOI":"10.12688\/wellcomeopenres.15974.1","article-title":"Insecticide resistance selection and reversal in two strains of Aedes aegypti","volume":"5","author":"Thornton","year":"2020","journal-title":"Wellcome Open Res."},{"key":"2026040114140028400_msag068-B129","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1534\/genetics.119.302662","article-title":"Polygenic adaptation to an environmental shift: temporal dynamics of variation under Gaussian stabilizing selection and additive effects on a single trait","volume":"213","author":"Thornton","year":"2019","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B130","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1186\/s12859-019-2927-x","article-title":"ImaGene: a convolutional neural network to quantify natural selection from genomic data","volume":"20","author":"Torada","year":"2019","journal-title":"BMC Bioinformatics"},{"key":"2026040114140028400_msag068-B131","doi-asserted-by":"publisher","first-page":"1573634","DOI":"10.3389\/fpls.2025.1573634","article-title":"Nanocarrier-mediated RNAi of CYP9E2 and CYB5R enhance susceptibility of invasive tomato pest, Tuta absoluta to cyantraniliprole","volume":"16","author":"Ullah","year":"2025","journal-title":"Front Plant Sci."},{"key":"2026040114140028400_msag068-B132","first-page":"314","volume-title":"2019 IEEE International Parallel and Distributed Processing Symposium (IPDPS)","author":"Vasimuddin","year":"2019"},{"key":"2026040114140028400_msag068-B133","doi-asserted-by":"publisher","author":"Venkataraman","year":"2022","DOI":"10.1101\/2022.03.01.482582"},{"key":"2026040114140028400_msag068-B134","doi-asserted-by":"publisher","first-page":"e72","DOI":"10.1371\/journal.pbio.0040072","article-title":"A map of recent positive selection in the human genome","volume":"4","author":"Voight","year":"2006","journal-title":"PLoS Biol."},{"key":"2026040114140028400_msag068-B135","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/j.1365-2583.2005.00582.x","article-title":"Gene expression in insecticide resistant and susceptible Anopheles gambiae strains constitutively or after insecticide exposure","volume":"14","author":"Vontas","year":"2005","journal-title":"Insect Mol Biol."},{"key":"2026040114140028400_msag068-B136","doi-asserted-by":"publisher","first-page":"20220011","DOI":"10.1098\/rstb.2022.0011","article-title":"Assessing the role of family level variation and heat shock gene expression in the thermal stress response of the mosquito Aedes aegypti","volume":"378","author":"Ware-Gilmore","year":"2023","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"2026040114140028400_msag068-B137","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/0040-5809(75)90020-9","article-title":"On the number of segregating sites in genetical models without recombination","volume":"7","author":"Watterson","year":"1975","journal-title":"Theor Popul Biol."},{"key":"2026040114140028400_msag068-B138","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/j.1749-6632.2002.tb04753.x","article-title":"Potassium-dependent sodium-calcium exchange through the eye of the fly","volume":"976","author":"Webel","year":"2002","journal-title":"Ann N Y Acad Sci."},{"key":"2026040114140028400_msag068-B139","doi-asserted-by":"publisher","first-page":"e1008822","DOI":"10.1371\/journal.pgen.1008822","article-title":"An Africa-wide genomic evolution of insecticide resistance in the malaria vector Anopheles funestus involves selective sweeps, copy number variations, gene conversion and transposons","volume":"16","author":"Weedall","year":"2020","journal-title":"PLoS Genet."},{"key":"2026040114140028400_msag068-B140","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3390\/ijerph15020220","article-title":"Aedes mosquitoes and Aedes-borne arboviruses in Africa: current and future threats","volume":"15","author":"Weetman","year":"2018","journal-title":"Int J Environ Res Public Health."},{"key":"2026040114140028400_msag068-B141","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1093\/zoolinnean\/zly007","article-title":"Detecting signatures of positive selection in non-model species using genomic data","volume":"184","author":"Weigand","year":"2018","journal-title":"Zool J Linn Soc."},{"key":"2026040114140028400_msag068-B142","doi-asserted-by":"publisher","first-page":"iyad084","DOI":"10.1093\/genetics\/iyad084","article-title":"Timesweeper: accurately identifying selective sweeps using population genomic time series","volume":"224","author":"Whitehouse","year":"2023","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B143","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/BF02173204","article-title":"Identification of mutations in the housefly para-type sodium channel gene associated with knockdown resistance (kdr) to pyrethroid insecticides","volume":"252","author":"Williamson","year":"1996","journal-title":"Mol Gen Genet."},{"key":"2026040114140028400_msag068-B144","doi-asserted-by":"publisher","first-page":"e0007831","DOI":"10.1371\/journal.pntd.0007831","article-title":"The importance of vector control for the control and elimination of vector-borne diseases","volume":"14","author":"Wilson","year":"2020","journal-title":"PLoS Negl Trop Dis."},{"key":"2026040114140028400_msag068-B145","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1534\/genetics.114.165571","article-title":"Soft selective sweeps in complex demographic scenarios","volume":"198","author":"Wilson","year":"2014","journal-title":"Genetics"},{"key":"2026040114140028400_msag068-B146","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1093\/molbev\/msaa259","article-title":"Discovery of ongoing selective sweeps within Anopheles mosquito populations using deep learning","volume":"38","author":"Xue","year":"2021","journal-title":"Mol Biol Evol."},{"key":"2026040114140028400_msag068-B147","doi-asserted-by":"publisher","first-page":"11091","DOI":"10.1038\/s41598-017-11357-z","article-title":"Contributions of cuticle permeability and enzyme detoxification to pyrethroid resistance in the major malaria vector Anopheles gambiae","volume":"7","author":"Yahou\u00e9do","year":"2017","journal-title":"Sci Rep."},{"key":"2026040114140028400_msag068-B148","doi-asserted-by":"publisher","first-page":"e0012138","DOI":"10.1371\/journal.pntd.0012138","article-title":"Three years of insecticide resistance evolution and associated mechanisms in Aedes aegypti populations of Ouagadougou, Burkina Faso","volume":"18","author":"Yam\u00e9ogo","year":"2024","journal-title":"PLoS Negl Trop Dis."},{"key":"2026040114140028400_msag068-B149","doi-asserted-by":"publisher","first-page":"9041","DOI":"10.1038\/s41598-021-88121-x","article-title":"Multiple cytochrome P450 genes: conferring high levels of permethrin resistance in mosquitoes, Culex quinquefasciatus","volume":"11","author":"Yang","year":"2021","journal-title":"Sci Rep."},{"key":"2026040114140028400_msag068-B150","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.freeradbiomed.2013.12.020","article-title":"Glutaredoxin 1, glutaredoxin 2, thioredoxin 1, and thioredoxin peroxidase 3 play important roles in antioxidant defense in Apis cerana cerana","volume":"68","author":"Yao","year":"2014","journal-title":"Free Radic Biol Med."},{"key":"2026040114140028400_msag068-B151","doi-asserted-by":"publisher","first-page":"15531","DOI":"10.1038\/srep15531","article-title":"Sequence analysis, expression profiles and function of thioredoxin 2 and thioredoxin reductase 1 in resistance to nucleopolyhedrovirus in Helicoverpa armigera","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci Rep."},{"key":"2026040114140028400_msag068-B152","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.gene.2012.09.007","article-title":"Identification and expression analysis of NADH-cytochrome b5 reductase gene in the cotton bollworm, Helicoverpa armigera","volume":"511","author":"Zhao","year":"2012","journal-title":"Gene"},{"key":"2026040114140028400_msag068-B153","doi-asserted-by":"publisher","first-page":"e21964","DOI":"10.1002\/arch.21964","article-title":"A thioredoxin peroxidase protects Pieris rapae from oxidative stress induced by chlorantraniliprole exposure","volume":"111","author":"Zhao","year":"2022","journal-title":"Arch Insect Biochem Physiol."}],"container-title":["Molecular Biology and Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mbe\/advance-article-pdf\/doi\/10.1093\/molbev\/msag068\/67317237\/msag068.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mbe\/article-pdf\/43\/4\/msag068\/67317237\/msag068.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mbe\/article-pdf\/43\/4\/msag068\/67317237\/msag068.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T18:15:56Z","timestamp":1775067356000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mbe\/article\/doi\/10.1093\/molbev\/msag068\/8516432"}},"subtitle":[],"editor":[{"given":"Haipeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,3,12]]},"references-count":153,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/molbev\/msag068","relation":{},"ISSN":["0737-4038","1537-1719"],"issn-type":[{"value":"0737-4038","type":"print"},{"value":"1537-1719","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,3,12]]},"article-number":"msag068"}}