{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:08:32Z","timestamp":1787069312762,"version":"build-2736575974"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We investigate the predictability of evolution in terms of the phylogenetic placement of new lineages. This leads us to develop a class of coalescent models that relax neutrality by allowing the rate of coalescence to vary as a continuous heritable trait. In this setting, each lineage has a relative propensity to coalesce, with coalescent odds ratios defined from the product of pairwise propensities. Estimated coalescent odds provide a statistic that captures variation in lineage growth and are informative about the strength of natural selection acting on individual lineages. A number of practical statistical methods are then developed: techniques to adjust for biased and nonuniform sampling; procedures to automatically calibrate hyperparameters governing the evolution of coalescent propensity; and methods for clustering phylogenies into sets that delineate clades according to coalescent propensity. Simulations show sensitivity of these methods to detecting small selective effects acting on rare variants and strong robustness to imbalanced sampling. We demonstrate these methods using two datasets reflecting microbial populations evolving under strong selection. First, we examine a large set of Neisseria gonorrhoeae genomes and show that lineages with high coalescent odds feature a unique antibiotic resistance pattern, which presaged its subsequent expansion. We then reanalyze SARS-CoV-2 data in combination with independent estimates of reproduction numbers corresponding to major variants of concern 2020\u20132023. This indicates that coalescent odds can function as an excellent tree-based proxy for relative fitness of major SARS-CoV-2 lineages.<\/jats:p>","DOI":"10.1093\/molbev\/msag195","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T11:51:13Z","timestamp":1786189873000},"source":"Crossref","is-referenced-by-count":0,"title":["Quantifying the predictability of evolution by analysis of coalescent rate variation"],"prefix":"10.1093","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-8937","authenticated-orcid":false,"given":"Erik","family":"Volz","sequence":"first","affiliation":[{"name":"MRC Centre for Global Infectious Disease Analysis and the Department of Infectious Disease Epidemiology, Imperial College London , London 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