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The nematode Caenorhabditis briggsae is distributed world-wide and is a comparative model to Caenorhabditis elegans in the biology of development, cellular mechanisms, neurobiology, complex trait mappings, and evolution. Following massive collection efforts by the nematode research community, we present the isolation of over 1,900 wild strains and analyses of genome sequences that catalog over six million single-nucleotide and insertion\u2013deletion variants. These resources provide a powerful means to interrogate the causal genetic bases of phenotypic variation. Additionally, we describe C. briggsae population structure and discover new, genetically distinct groups within this primarily self-fertilizing species, including groups of highly related strains sampled across entire continents. We leveraged expansive genetic variation to decipher the effects of linkage and selection on the distribution of genetic diversity across the genome and across geographic regions. Within the species, we find genomic regions with extremely high levels of genetic variation similar to hyper-divergent regions found in C. elegans and other species. These regions harbor new genes and variation enriched for environmental sensing and pathogen responses. Based on comparisons to the outbreeding sister species Caenorhabditis nigoni, we conclude that long-term balancing selection has maintained substantial functional variation, likely associated with ecological variation, within C. briggsae since its divergence from an outbreeding ancestor. Overall, this massive strain resource enables future comparative genetics studies, including genome-wide association study contrasts between Caenorhabditis species.<\/jats:p>","DOI":"10.1093\/molbev\/msag202","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:31:40Z","timestamp":1786563100000},"source":"Crossref","is-referenced-by-count":0,"title":["Population structure and punctuated genomic hyper-diversity in\n                    <i>Caenorhabditis briggsae<\/i>"],"prefix":"10.1093","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6817-1784","authenticated-orcid":false,"given":"Nicolas D","family":"Moya","sequence":"first","affiliation":[{"name":"Department of Biology, Johns Hopkins University , Baltimore, MD 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