{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T23:51:15Z","timestamp":1792367475057,"version":"4.4.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9,1]]},"DOI":"10.1093\/molbev\/msi181","type":"journal-article","created":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:33:32Z","timestamp":1117672412000},"page":"1853-1864","source":"Crossref","is-referenced-by-count":62,"title":["Comparative Analysis of Prothrombin Activators from the Venom of Australian Elapids"],"prefix":"10.1093","volume":"22","author":[{"given":"Liam","family":"St. Pierre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul P.","family":"Masci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Filippovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Sorokina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neville","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin F.","family":"Lavin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,6,1]]},"reference":[{"key":"key\n\t\t\t\t20171012024702_BIB1","unstructured":"Adachi, J., and M. Hasegawa. 1996. MOLPHY version 2.3: program for molecular phylogenetics based on maximum likelihood. Comput. Sci. Monogr.28:1\u2013150."},{"key":"key\n\t\t\t\t20171012024702_BIB2","doi-asserted-by":"crossref","unstructured":"Baugh, R. J., and S. Krishnaswamy. 1996. Role of the activation peptide domain in human factor X activation by the extrinsic Xase complex. J. Biol. Chem.271:16126\u201316134.","DOI":"10.1074\/jbc.271.27.16126"},{"key":"key\n\t\t\t\t20171012024702_BIB3","doi-asserted-by":"crossref","unstructured":"Braud, S., C. Bon, and A. Wisner. 2000. Snake venom proteins acting on hemostasis. Biochimie82:851\u2013859.","DOI":"10.1016\/S0300-9084(00)01178-0"},{"key":"key\n\t\t\t\t20171012024702_BIB4","doi-asserted-by":"crossref","unstructured":"Broad, A. J., S. K. Sutherland, and A. R. Coulter. 1979. The lethality in mice of dangerous Australian and other snake venom. Toxicon17:661\u2013664.","DOI":"10.1016\/0041-0101(79)90245-9"},{"key":"key\n\t\t\t\t20171012024702_BIB5","doi-asserted-by":"crossref","unstructured":"Chattopadhyay, A., H. L. James, and D. S. Fair. 1992. Molecular recognition sites on factor Xa which participate in the prothrombinase complex. J. Biol. Chem.267:12323\u201312329.","DOI":"10.1016\/S0021-9258(19)49842-6"},{"key":"key\n\t\t\t\t20171012024702_BIB6","doi-asserted-by":"crossref","unstructured":"Chester, A., and G. P. Crawford. 1982. In vitro coagulant properties of venoms from Australian snakes. Toxicon20:501\u2013504.","DOI":"10.1016\/0041-0101(82)90014-9"},{"key":"key\n\t\t\t\t20171012024702_BIB7","doi-asserted-by":"crossref","unstructured":"Dambisya, Y. M., T. L. Lee, and P. Gopalakrishnakone. 1995. Anticoagulant effects of Pseudechis australis (Australian king brown snake) venom on human blood: a computerized thromboelastography study. Toxicon33:1378\u20131382.","DOI":"10.1016\/0041-0101(95)00067-V"},{"key":"key\n\t\t\t\t20171012024702_BIB8","doi-asserted-by":"crossref","unstructured":"Davie, E. W., K. Fujikawa, and W. Kisiel. 1991. The coagulation cascade: initiation, maintenance, and regulation. Biochemistry30:10363\u201310370.","DOI":"10.1021\/bi00107a001"},{"key":"key\n\t\t\t\t20171012024702_BIB9","doi-asserted-by":"crossref","unstructured":"Di Scipio, R. G., M. A. Hermodson, S. G. Yates, and E. W. Davie. 1977. A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein S. Biochemistry16:698\u2013706.","DOI":"10.1021\/bi00623a022"},{"key":"key\n\t\t\t\t20171012024702_BIB10","doi-asserted-by":"crossref","unstructured":"Fry, B. G. 1999. Structure-function properties of venom components from Australian elapids. Toxicon37:11\u201332.","DOI":"10.1016\/S0041-0101(98)00125-1"},{"key":"key\n\t\t\t\t20171012024702_BIB11","unstructured":"Jackson, C. M. 1984. Factor X. Prog. Hemost. Thromb.7:55\u2013109."},{"key":"key\n\t\t\t\t20171012024702_BIB12","doi-asserted-by":"crossref","unstructured":"Jackson, C. M., and Y. Nemerson. 1980. Blood coagulation. Annu. Rev. Biochem.49:765\u2013811.","DOI":"10.1146\/annurev.bi.49.070180.004001"},{"key":"key\n\t\t\t\t20171012024702_BIB13","doi-asserted-by":"crossref","unstructured":"Joseph, J. S., M. C. Chung, K. Jeyaseelan, and R. M. Kini. 1999. Amino acid sequence of trocarin, a prothrombin activator from Tropidechis carinatus venom: its structural similarity to coagulation factor Xa. Blood94:621\u2013631.","DOI":"10.1182\/blood.V94.2.621"},{"key":"key\n\t\t\t\t20171012024702_BIB14","doi-asserted-by":"crossref","unstructured":"Joseph, J. S., M. Valiyaveettil, D. C. Gowda, and R. M. Kini. 2003. Occurrence of O-linked Xyl-GlcNAc and Xyl-Glc disaccharides in trocarin, a factor Xa homolog from snake venom. J. Thromb. Haemost.1:545\u2013550.","DOI":"10.1046\/j.1538-7836.2003.00090.x"},{"key":"key\n\t\t\t\t20171012024702_BIB15","unstructured":"Kalafatis, M., and D. O. Beck. 2002. Identification of a binding site for blood coagulation factor Xa on the heavy chain of factor Va. Amino acid residues 323\u2013331 of factor V represent an interactive site for activated factor X. Biochemistry41:12715\u201312728."},{"key":"key\n\t\t\t\t20171012024702_BIB16","doi-asserted-by":"crossref","unstructured":"Kalafatis, M., M. D. Rand, and K. G. Mann. 1994. The mechanism of inactivation of human factor V and human factor Va by activated protein C. J. Biol. Chem.269:31869\u201331880.","DOI":"10.1016\/S0021-9258(18)31776-9"},{"key":"key\n\t\t\t\t20171012024702_BIB17","doi-asserted-by":"crossref","unstructured":"Keogh, J. S., R. Shine, and S. Donnellan. 1998. Phylogenetic relationships of terrestrial Australo-Papuan elapid snakes (subfamily Hydrophiinae) based on cytochrome b and 16S rRNA sequences. Mol. Phylogenet. Evol.10:67\u201381.","DOI":"10.1006\/mpev.1997.0471"},{"key":"key\n\t\t\t\t20171012024702_BIB18","doi-asserted-by":"crossref","unstructured":"Kini, R. M., T. Morita, and J. Rosing. 2001. Classification and nomenclature of prothrombin activators isolated from snake venoms. Thromb. Haemost.86:710\u2013711.","DOI":"10.1055\/s-0037-1616108"},{"key":"key\n\t\t\t\t20171012024702_BIB19","unstructured":"Kini, R. M., V. S. Rao, and J. S. Joseph. 2001. Procoagulant proteins from snake venoms. Haemostasis31:218\u2013224."},{"key":"key\n\t\t\t\t20171012024702_BIB20","doi-asserted-by":"crossref","unstructured":"MacGillivray, R. T., and M. R. Fung. 1989. Molecular biology of factor X. Baillieres Clin. Haematol.2:897\u2013917.","DOI":"10.1016\/S0950-3536(89)80051-4"},{"key":"key\n\t\t\t\t20171012024702_BIB21","doi-asserted-by":"crossref","unstructured":"Marsh, N. A., T. L. Fyffe, and E. A. Bennett. 1997. Isolation and partial characterization of a prothrombin-activating enzyme from the venom of the Australian rough-scaled snake (Tropidechis carinatus). Toxicon35:563\u2013571.","DOI":"10.1016\/S0041-0101(96)00141-9"},{"key":"key\n\t\t\t\t20171012024702_BIB22","unstructured":"Masci, P. P., A. N. Whitaker, and J. de Jersey. 1988. Purification and characterization of a prothrombin activator from the venom of the Australian brown snake, Pseudonaja textilis textilis. Biochem. Int.17:825\u2013835."},{"key":"key\n\t\t\t\t20171012024702_BIB23","doi-asserted-by":"crossref","unstructured":"Matsui, T., Y. Fujimura, and K. Titani. 2000. Snake venom proteases affecting hemostasis and thrombosis. Biochim. Biophys. Acta1477:146\u2013156.","DOI":"10.1016\/S0167-4838(99)00268-X"},{"key":"key\n\t\t\t\t20171012024702_BIB24","doi-asserted-by":"crossref","unstructured":"Morita, T., and S. Iwanaga. 1978. Purification and properties of prothrombin activator from the venom of Echis carinatus. J. Biochem. (Tokyo)83:559\u2013570.","DOI":"10.1093\/oxfordjournals.jbchem.a131944"},{"key":"key\n\t\t\t\t20171012024702_BIB25","doi-asserted-by":"crossref","unstructured":"Nicolaes, G. A., B. O. Villoutreix, and B. Dahlback. 2000. Mutations in a potential phospholipid binding loop in the C2 domain of factor V affecting the assembly of the prothrombinase complex. Blood Coagul. Fibrinolysis11:89\u2013100.","DOI":"10.1097\/00001721-200001000-00010"},{"key":"key\n\t\t\t\t20171012024702_BIB26","unstructured":"Persson, E., P. J. Hogg, and J. Stenflo. 1993. Effects of Ca2+ binding on the protease module of factor Xa and its interaction with factor Va. Evidence for two Gla-independent Ca(2+)-binding sites in factor Xa. J. Biol. Chem.268:22531\u201322539."},{"key":"key\n\t\t\t\t20171012024702_BIB27","doi-asserted-by":"crossref","unstructured":"Rao, V. S., J. S. Joseph, and R. M. Kini. 2003. Group D prothrombin activators from snake venom are structural homologues of mammalian blood coagulation factor Xa. Biochem. J.369:635\u2013642.","DOI":"10.1042\/bj20020889"},{"key":"key\n\t\t\t\t20171012024702_BIB28","doi-asserted-by":"crossref","unstructured":"Rao, V. S., and R. M. Kini. 2002. Pseutarin C, a prothrombin activator from Pseudonaja textilis venom: its structural and functional similarity to mammalian coagulation factor Xa-Va complex. Thromb. Haemost.88:611\u2013619.","DOI":"10.1055\/s-0037-1613264"},{"key":"key\n\t\t\t\t20171012024702_BIB29","doi-asserted-by":"crossref","unstructured":"Rao, V. S., S. Swarup, and R. M. Kini. 2004. The catalytic subunit of pseutarin C, a group C prothrombin activator from the venom of Pseudonaja textilis, is structurally similar to mammalian blood coagulation factor Xa. Thromb. Haemost.92:509\u2013521.","DOI":"10.1160\/TH04-03-0144"},{"key":"key\n\t\t\t\t20171012024702_BIB30","doi-asserted-by":"crossref","unstructured":"Rao, V. S., S. Swarup, and R. M. Kini. 2003. The nonenzymatic subunit of pseutarin C, a prothrombin activator from eastern brown snake (Pseudonaja textilis) venom, shows structural similarity to mammalian coagulation factor V. Blood102:1347\u20131354.","DOI":"10.1182\/blood-2002-12-3839"},{"key":"key\n\t\t\t\t20171012024702_BIB31","doi-asserted-by":"crossref","unstructured":"Shea, G. M. 1999. The distribution and identification of dangerously venomous Australian terrestrial snakes. Aust. Vet. J.77:791\u2013798.","DOI":"10.1111\/j.1751-0813.1999.tb12947.x"},{"key":"key\n\t\t\t\t20171012024702_BIB32","doi-asserted-by":"crossref","unstructured":"Steen, M. 2002. Factor Va-factor Xa interactions: molecular sites involved in enzyme:cofactor assembly. Scand. J. Clin. Lab. Invest. Suppl.237:5\u201311.","DOI":"10.1080\/003655102762377439"},{"key":"key\n\t\t\t\t20171012024702_BIB33","doi-asserted-by":"crossref","unstructured":"Tan, N. H., and G. Ponnudurai. 1990. A comparative study of the biological properties of Australian elapid venoms. Comp. Biochem. Physiol. C97:99\u2013106.","DOI":"10.1016\/0742-8413(90)90178-C"},{"key":"key\n\t\t\t\t20171012024702_BIB34","doi-asserted-by":"crossref","unstructured":"Tans, G., J. W. Govers-Riemslag, J. L. van Rijn, and J. Rosing. 1985. Purification and properties of a prothrombin activator from the venom of Notechis scutatus scutatus. J. Biol. Chem.260:9366\u20139372.","DOI":"10.1016\/S0021-9258(17)39373-0"},{"key":"key\n\t\t\t\t20171012024702_BIB35","doi-asserted-by":"crossref","unstructured":"Tracy, P. B., L. L. Eide, and K. G. Mann. 1985. Human prothrombinase complex assembly and function on isolated peripheral blood cell populations. J. Biol. Chem.260:2119\u20132124.","DOI":"10.1016\/S0021-9258(18)89525-4"},{"key":"key\n\t\t\t\t20171012024702_BIB36","doi-asserted-by":"crossref","unstructured":"Walker, F. J., W. G. Owen, and C. T. Esmon. 1980. Characterization of the prothrombin activator from the venom of Oxyuranus scutellatus scutellatus (taipan venom). Biochemistry19:1020\u20131023.","DOI":"10.1021\/bi00546a029"},{"key":"key\n\t\t\t\t20171012024702_BIB37","doi-asserted-by":"crossref","unstructured":"Weinstein, S. A., V. Williams, and J. White. 2001. Preliminary characteristics of the prothrombin converting enzyme from venom of Stephen's banded snake (Hoplocephalus stephensii). Toxicon39:1937\u20131939.","DOI":"10.1016\/S0041-0101(01)00168-4"}],"container-title":["Molecular Biology and Evolution"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mbe\/article-pdf\/22\/9\/1853\/3047182\/msi181.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T12:14:25Z","timestamp":1626005665000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/mbe\/article\/22\/9\/1853\/982126\/Comparative-Analysis-of-Prothrombin-Activators"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,1]]},"references-count":37,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2005,6,1]]},"published-print":{"date-parts":[[2005,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/molbev\/msi181","relation":{},"ISSN":["1537-1719","0737-4038"],"issn-type":[{"value":"1537-1719","type":"electronic"},{"value":"0737-4038","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,9]]},"published":{"date-parts":[[2005,6,1]]}}}