{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:35:33Z","timestamp":1790710533883,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1093\/molbev\/mst231","type":"journal-article","created":{"date-parts":[[2013,11,29]],"date-time":"2013-11-29T01:51:18Z","timestamp":1385689878000},"page":"594-604","source":"Crossref","is-referenced-by-count":22,"title":["Human-Specific Hypomethylation of CENPJ, a Key Brain Size Regulator"],"prefix":"10.1093","volume":"31","author":[{"given":"Lei","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,11,28]]},"reference":[{"key":"key\n\t\t\t\t20170413073520_mst231-B1"},{"key":"key\n\t\t\t\t20170413073520_mst231-B2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1136\/jmg.2009.076646","article-title":"Novel CENPJ mutation causes Seckel syndrome","volume":"47","author":"Al-Dosari","year":"2010","journal-title":"J Med Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B3","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.devcel.2010.05.017","article-title":"CDK5RAP2 regulates centriole engagement and cohesion in mice","volume":"18","author":"Barrera","year":"2010","journal-title":"Dev Cell."},{"key":"key\n\t\t\t\t20170413073520_mst231-B4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature09327","article-title":"Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations","volume":"467","author":"Bilguvar","year":"2010","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170413073520_mst231-B5","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1093\/bioinformatics\/bti652","article-title":"BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing","volume":"21","author":"Bock","year":"2005","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20170413073520_mst231-B6","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/ng995","article-title":"ASPM is a major determinant of cerebral cortical size","volume":"32","author":"Bond","year":"2002","journal-title":"Nat Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ng1539","article-title":"A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size","volume":"37","author":"Bond","year":"2005","journal-title":"Nat Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B8","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.neuron.2010.03.036","article-title":"Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex","volume":"66","author":"Buchman","year":"2010","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170413073520_mst231-B9","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1126\/science.1088821","article-title":"Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios","volume":"302","author":"Clark","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20170413073520_mst231-B10","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/hmg\/ddh126","article-title":"Reconstructing the evolutionary history of microcephalin, a gene controlling human brain size","volume":"13","author":"Evans","year":"2004","journal-title":"Hum Mol Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B11","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/hmg\/ddh055","article-title":"Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans","volume":"13","author":"Evans","year":"2004","journal-title":"Hum Mol Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.gene.2006.02.019","article-title":"Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ","volume":"375","author":"Evans","year":"2006","journal-title":"Gene"},{"key":"key\n\t\t\t\t20170413073520_mst231-B13","doi-asserted-by":"crossref","first-page":"11836","DOI":"10.1073\/pnas.1209647109","article-title":"Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal","volume":"109","author":"Fietz","year":"2012","journal-title":"Proc Natl Acad Sci U S A."},{"key":"key\n\t\t\t\t20170413073520_mst231-B14","doi-asserted-by":"crossref","first-page":"e216","DOI":"10.1371\/journal.pone.0000216","article-title":"Comparison of protein and mRNA expression evolution in humans and chimpanzees","volume":"2","author":"Fu","year":"2007","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170413073520_mst231-B15","doi-asserted-by":"crossref","first-page":"5306","DOI":"10.1093\/hmg\/dds386","article-title":"Kinetochore KMN network gene CASC5 mutated in primary microcephaly","volume":"21","author":"Genin","year":"2012","journal-title":"Hum Mol Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbr.2008.01.021","article-title":"Epigenetic codes in cognition and behaviour","volume":"192","author":"Graff","year":"2008","journal-title":"Behav Brain Res."},{"key":"key\n\t\t\t\t20170413073520_mst231-B17","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1038\/ncb2342","article-title":"MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway","volume":"13","author":"Gruber","year":"2011","journal-title":"Nat Cell Biol."},{"key":"key\n\t\t\t\t20170413073520_mst231-B18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ajhg.2010.06.003","article-title":"mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4","volume":"87","author":"Guernsey","year":"2010","journal-title":"Am J Hum Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B19","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1007\/s10038-006-0017-1","article-title":"A novel deletion mutation in CENPJ gene in a Pakistani family with autosomal recessive primary microcephaly","volume":"51","author":"Gul","year":"2006","journal-title":"J Hum Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B20","doi-asserted-by":"crossref","first-page":"e1002327","DOI":"10.1371\/journal.pgen.1002327","article-title":"MicroRNA expression and regulation in human, chimpanzee, and macaque brains","volume":"7","author":"Hu","year":"2011","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B21","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1086\/341283","article-title":"identification of microcephalin, a protein implicated in determining the size of the human brain","volume":"71","author":"Jackson","year":"2002","journal-title":"Am J Hum Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B22","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1126\/science.1108296","article-title":"Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees","volume":"309","author":"Khaitovich","year":"2005","journal-title":"Science"},{"key":"key\n\t\t\t\t20170413073520_mst231-B23","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1242\/jcs.089888","article-title":"Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL","volume":"124","author":"Kitagawa","year":"2011","journal-title":"J Cell Sci."},{"key":"key\n\t\t\t\t20170413073520_mst231-B24","doi-asserted-by":"crossref","first-page":"E126","DOI":"10.1371\/journal.pbio.0020126","article-title":"Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion","volume":"2","author":"Kouprina","year":"2004","journal-title":"PLoS Biol."},{"key":"key\n\t\t\t\t20170413073520_mst231-B25","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.ajhg.2009.01.017","article-title":"Mutations in STIL, encoding a pericentriolar and centrosomal protein, cause primary microcephaly","volume":"84","author":"Kumar","year":"2009","journal-title":"Am J Hum Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B26","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/0888-7543(92)90024-M","article-title":"CpG islands as gene markers in the human genome","volume":"13","author":"Larsen","year":"1992","journal-title":"Genomics"},{"key":"key\n\t\t\t\t20170413073520_mst231-B27","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrn1604","article-title":"Epigenetic mechanisms in memory formation","volume":"6","author":"Levenson","year":"2005","journal-title":"Nat Rev Neurosci."},{"key":"key\n\t\t\t\t20170413073520_mst231-B28","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0092-8674(03)00430-6","article-title":"Multiple tumor suppressor pathways negatively regulate telomerase","volume":"113","author":"Lin","year":"2003","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170413073520_mst231-B29","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1101\/gr.127324.111","article-title":"Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques","volume":"22","author":"Liu","year":"2012","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20170413073520_mst231-B30","doi-asserted-by":"crossref","first-page":"e1003022","DOI":"10.1371\/journal.pgen.1003022","article-title":"Disruption of mouse cenpj, a regulator of centriole biogenesis, phenocopies seckel syndrome","volume":"8","author":"McIntyre","year":"2012","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B31","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1126\/science.1224344","article-title":"A high-coverage genome sequence from an archaic Denisovan individual","volume":"338","author":"Meyer","year":"2012","journal-title":"Science"},{"key":"key\n\t\t\t\t20170413073520_mst231-B32","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/molbev\/msq237","article-title":"Adaptive evolution of four microcephaly genes and the evolution of brain size in anthropoid primates","volume":"28","author":"Montgomery","year":"2011","journal-title":"Mol Biol Evol."},{"key":"key\n\t\t\t\t20170413073520_mst231-B33","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/ng.682","article-title":"WDR62 is associated with the spindle pole and is mutated in human microcephaly","volume":"42","author":"Nicholas","year":"2010","journal-title":"Nat Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B34","doi-asserted-by":"crossref","first-page":"16595","DOI":"10.1073\/pnas.1010494107","article-title":"Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline","volume":"107","author":"Pulvers","year":"2010","journal-title":"Proc Natl Acad Sci U S A."},{"key":"key\n\t\t\t\t20170413073520_mst231-B35","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/nrn2719","article-title":"Evolution of the neocortex: a perspective from developmental biology","volume":"10","author":"Rakic","year":"2009","journal-title":"Nat Rev Neurosci."},{"key":"key\n\t\t\t\t20170413073520_mst231-B36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/(SICI)1096-8628(19970516)70:2<155::AID-AJMG10>3.0.CO;2-I","article-title":"Central nervous system anomalies in Seckel syndrome: report of a new family and review of the literature","volume":"70","author":"Shanske","year":"1997","journal-title":"Am J Med Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev.biochem.75.103004.142422","article-title":"Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression","volume":"75","author":"Shilatifard","year":"2006","journal-title":"Annu Rev Biochem."},{"key":"key\n\t\t\t\t20170413073520_mst231-B38","doi-asserted-by":"crossref","first-page":"e1001427","DOI":"10.1371\/journal.pbio.1001427","article-title":"Human-specific histone methylation signatures at transcription start sites in prefrontal neurons","volume":"10","author":"Shulha","year":"2012","journal-title":"PLoS Biol."},{"key":"key\n\t\t\t\t20170413073520_mst231-B39","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrg2046","article-title":"Epigenetic signatures of stem-cell identity","volume":"8","author":"Spivakov","year":"2007","journal-title":"Nat Rev Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B40","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/ncb1889","article-title":"CPAP is a cell-cycle regulated protein that controls centriole length","volume":"11","author":"Tang","year":"2009","journal-title":"Nat Cell Biol."},{"key":"key\n\t\t\t\t20170413073520_mst231-B41","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1038\/emboj.2011.378","article-title":"The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation","volume":"30","author":"Tang","year":"2011","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170413073520_mst231-B42","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nrn2132","article-title":"Epigenetic regulation in psychiatric disorders","volume":"8","author":"Tsankova","year":"2007","journal-title":"Nat Rev Neurosci."},{"key":"key\n\t\t\t\t20170413073520_mst231-B43","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1093\/hmg\/ddh127","article-title":"Molecular evolution of microcephalin, a gene determining human brain size","volume":"13","author":"Wang","year":"2004","journal-title":"Hum Mol Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B44","doi-asserted-by":"crossref","first-page":"e1002942","DOI":"10.1371\/journal.pgen.1002942","article-title":"Hominoid-specific de novo protein-coding genes originating from long non-coding RNAs","volume":"8","author":"Xie","year":"2012","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B45","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/ng.683","article-title":"Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture","volume":"42","author":"Yu","year":"2010","journal-title":"Nat Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B46","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ajhg.2012.07.024","article-title":"Divergent whole-genome methylation maps of human and chimpanzee brains reveal epigenetic basis of human regulatory evolution","volume":"91","author":"Zeng","year":"2012","journal-title":"Am J Hum Genet."},{"key":"key\n\t\t\t\t20170413073520_mst231-B47","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1093\/genetics\/165.4.2063","article-title":"Evolution of the human ASPM gene, a major determinant of brain size","volume":"165","author":"Zhang","year":"2003","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20170413073520_mst231-B48","doi-asserted-by":"crossref","first-page":"e1001179","DOI":"10.1371\/journal.pbio.1001179","article-title":"Accelerated recruitment of new brain development genes into the human genome","volume":"9","author":"Zhang","year":"2011","journal-title":"PLoS Biol."},{"key":"key\n\t\t\t\t20170413073520_mst231-B49","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrg2905","article-title":"Charting histone modifications and the functional organization of mammalian genomes","volume":"12","author":"Zhou","year":"2011","journal-title":"Nat Rev Genet."}],"container-title":["Molecular Biology and Evolution"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mbe\/article-pdf\/31\/3\/594\/13169606\/mst231.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:22:02Z","timestamp":1647562922000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mbe\/article-lookup\/doi\/10.1093\/molbev\/mst231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,28]]},"references-count":49,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,11,28]]},"published-print":{"date-parts":[[2014,3]]}},"URL":"https:\/\/doi.org\/10.1093\/molbev\/mst231","relation":{},"ISSN":["1537-1719","0737-4038"],"issn-type":[{"value":"1537-1719","type":"electronic"},{"value":"0737-4038","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11,28]]}}}