{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:28:01Z","timestamp":1772818081717,"version":"3.50.1"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Biol Evol"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1093\/molbev\/msw065","type":"journal-article","created":{"date-parts":[[2016,4,6]],"date-time":"2016-04-06T00:08:57Z","timestamp":1459901337000},"page":"1907-1920","source":"Crossref","is-referenced-by-count":22,"title":["Target-Driven Positive Selection at Hot Spots of Scorpion Toxins Uncovers Their Potential in Design of Insecticides"],"prefix":"10.1093","volume":"33","author":[{"given":"Limei","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Peigneur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangfei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Tytgat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunyi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,4,4]]},"reference":[{"key":"2016071808574826000_33.8.1907.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2009.09.022"},{"key":"2016071808574826000_33.8.1907.2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.4474"},{"key":"2016071808574826000_33.8.1907.3","doi-asserted-by":"publisher","DOI":"10.2174\/0929866053765635"},{"key":"2016071808574826000_33.8.1907.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2006.09.023"},{"key":"2016071808574826000_33.8.1907.5","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.4.4"},{"key":"2016071808574826000_33.8.1907.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(00)01174-3"},{"key":"2016071808574826000_33.8.1907.7","doi-asserted-by":"publisher","DOI":"10.1021\/bi300776g"},{"key":"2016071808574826000_33.8.1907.8","doi-asserted-by":"publisher","DOI":"10.1101\/gr.849004"},{"key":"2016071808574826000_33.8.1907.9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.12.6820"},{"key":"2016071808574826000_33.8.1907.10","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a026412"},{"key":"2016071808574826000_33.8.1907.11","doi-asserted-by":"publisher","DOI":"10.1021\/bi026252p"},{"key":"2016071808574826000_33.8.1907.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(02)00294-5"},{"key":"2016071808574826000_33.8.1907.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2006.11.016"},{"key":"2016071808574826000_33.8.1907.14","doi-asserted-by":"publisher","DOI":"10.1038\/326096a0"},{"key":"2016071808574826000_33.8.1907.15","doi-asserted-by":"publisher","DOI":"10.1038\/335167a0"},{"key":"2016071808574826000_33.8.1907.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(80)80082-9"},{"key":"2016071808574826000_33.8.1907.17","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msn179"},{"key":"2016071808574826000_33.8.1907.18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.021303"},{"key":"2016071808574826000_33.8.1907.19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402048200"},{"key":"2016071808574826000_33.8.1907.20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2007.05737.x"},{"key":"2016071808574826000_33.8.1907.21","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1432-1033.1989.tb14735.x","article-title":"Structure\/activity relationships of scorpion \u03b1-toxins. Multiple residues contribute to the interaction with receptors","volume":"181","author":"Kharrat","year":"1989","journal-title":"Eur J Biochem"},{"key":"2016071808574826000_33.8.1907.22","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-187179"},{"key":"2016071808574826000_33.8.1907.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.05.077"},{"key":"2016071808574826000_33.8.1907.24","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2768"},{"key":"2016071808574826000_33.8.1907.25","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2485fje"},{"key":"2016071808574826000_33.8.1907.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2011.06.009"},{"key":"2016071808574826000_33.8.1907.27","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21502"},{"key":"2016071808574826000_33.8.1907.28","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-12-114"},{"key":"2016071808574826000_33.8.1907.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2015.12.019"},{"key":"2016071808574826000_33.8.1907.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2013.04.015"},{"key":"2016071808574826000_33.8.1907.31","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu097"},{"key":"2016071808574826000_33.8.1907.32","unstructured":"Polis GA. 1990. The Biology of scorpions. Stanford (CA): Stanford University Press."},{"key":"2016071808574826000_33.8.1907.33","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1999.00625.x"},{"key":"2016071808574826000_33.8.1907.34","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-010-9321-7"},{"key":"2016071808574826000_33.8.1907.35","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.72"},{"key":"2016071808574826000_33.8.1907.36","doi-asserted-by":"publisher","DOI":"10.1021\/bi701323k"},{"key":"2016071808574826000_33.8.1907.37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103501108"},{"key":"2016071808574826000_33.8.1907.38","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211931200"},{"key":"2016071808574826000_33.8.1907.39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102199200"},{"key":"2016071808574826000_33.8.1907.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2007.11.010"},{"key":"2016071808574826000_33.8.1907.41","doi-asserted-by":"publisher","DOI":"10.1038\/nature07175"},{"key":"2016071808574826000_33.8.1907.42","doi-asserted-by":"publisher","DOI":"10.1006\/prep.1997.0724"},{"key":"2016071808574826000_33.8.1907.43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1314702110"},{"key":"2016071808574826000_33.8.1907.44","doi-asserted-by":"publisher","DOI":"10.1021\/bi0270438"},{"key":"2016071808574826000_33.8.1907.45","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1357"},{"key":"2016071808574826000_33.8.1907.46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112320108"},{"key":"2016071808574826000_33.8.1907.47","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.10.065"},{"key":"2016071808574826000_33.8.1907.48","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1046\/j.1432-1327.1999.00646.x","article-title":"Structure-function studies of \u03c9-atracotoxin, a potent antagonist of insect voltage-gated calcium channels","volume":"264","author":"Wang","year":"1999","journal-title":"Eur J Biochem"},{"key":"2016071808574826000_33.8.1907.49","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msp310"},{"key":"2016071808574826000_33.8.1907.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.01.009"},{"key":"2016071808574826000_33.8.1907.51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.08.068"},{"key":"2016071808574826000_33.8.1907.52","doi-asserted-by":"publisher","DOI":"10.1038\/srep14973"},{"key":"2016071808574826000_33.8.1907.53","doi-asserted-by":"crossref","unstructured":"Zhang S Gao B Zhu S. 2016. Independent origins of scorpion toxins affecting potassium and sodium channels. Evolution of venomous animals and their toxins. Doi: 10.1007\/978-94-007-6727-0_12-1. Springer Science + Business Media Dordrecht, Berlin, Heidelberg, Germany.","DOI":"10.1007\/978-94-007-6727-0_12-1"},{"key":"2016071808574826000_33.8.1907.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2013.05.009"},{"key":"2016071808574826000_33.8.1907.55","doi-asserted-by":"publisher","DOI":"10.1007\/s00239-003-2534-2"},{"key":"2016071808574826000_33.8.1907.56","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5200-6"},{"key":"2016071808574826000_33.8.1907.57","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M111.012054"},{"key":"2016071808574826000_33.8.1907.58","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msu038"},{"key":"2016071808574826000_33.8.1907.59","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.23.14810"}],"container-title":["Molecular Biology and Evolution"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mbe\/article-pdf\/33\/8\/1907\/17472823\/msw065.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,25]],"date-time":"2017-08-25T02:13:52Z","timestamp":1503627232000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mbe\/article-lookup\/doi\/10.1093\/molbev\/msw065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,4]]},"references-count":59,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,7,18]]},"published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1093\/molbev\/msw065"],"URL":"https:\/\/doi.org\/10.1093\/molbev\/msw065","relation":{},"ISSN":["0737-4038","1537-1719"],"issn-type":[{"value":"0737-4038","type":"print"},{"value":"1537-1719","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,4]]}}}