{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:23:05Z","timestamp":1792437785106,"version":"4.5.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"7","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"DOI":"10.1093\/molbev\/msx097","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T20:54:42Z","timestamp":1487883282000},"page":"1587-1595","source":"Crossref","is-referenced-by-count":24,"title":["Probing the Evolutionary History of Human Bitter Taste Receptor Pseudogenes by Restoring Their Function"],"prefix":"10.1093","volume":"34","author":[{"given":"Davide","family":"Risso","sequence":"first","affiliation":[{"name":"National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD"},{"name":"Department of BiGeA, Laboratory of Molecular Anthropology and Centre for Genome Biology, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maik","family":"Behrens","sequence":"additional","affiliation":[{"name":"Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Sainz","sequence":"additional","affiliation":[{"name":"National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Meyerhof","sequence":"additional","affiliation":[{"name":"Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Drayna","sequence":"additional","affiliation":[{"name":"National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,3,13]]},"reference":[{"issue":"7571","key":"key\n\t\t\t\t20180315050555_msx097-B1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"1000 Genomes Project Consortium","year":"2015","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180315050555_msx097-B2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0092-8674(00)80705-9","article-title":"A novel family of mammalian taste receptors","volume":"100","author":"Adler","year":"2000","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180315050555_msx097-B3","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baw093","article-title":"The Ensembl gene annotation system","author":"Aken","year":"2016","journal-title":"Database (Oxford)"},{"key":"key\n\t\t\t\t20180315050555_msx097-B4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1076\/apab.110.1.137.908","article-title":"Presence of a plasma membrane targeting sequence in the amino-terminal region of the rat somatostatin receptor 3","volume":"110","author":"Ammon","year":"2001","journal-title":"Arch Physiol Biochem."},{"issue":"16","key":"key\n\t\t\t\t20180315050555_msx097-B5","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.2174\/13816128113199990566","article-title":"Genetics of taste receptors","volume":"20","author":"Bachmanov","year":"2014","journal-title":"Curr Pharm Des."},{"issue":"6","key":"key\n\t\t\t\t20180315050555_msx097-B6","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/chemse\/bjt016","article-title":"Genetic, functional, and phenotypic diversity in TAS2R38-mediated bitter taste perception","volume":"38","author":"Behrens","year":"2013","journal-title":"Chem Senses"},{"issue":"12","key":"key\n\t\t\t\t20180315050555_msx097-B7","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1093\/molbev\/msu254","article-title":"Tuning properties of avian and frog bitter taste receptors dynamically fit gene repertoire sizes","volume":"31","author":"Behrens","year":"2014","journal-title":"Mol Biol Evol."},{"issue":"8","key":"key\n\t\t\t\t20180315050555_msx097-B8","doi-asserted-by":"crossref","first-page":"e12394.","DOI":"10.1371\/journal.pone.0012394","article-title":"Insights into the binding of Phenyltiocarbamide (PTC) agonist to its target human TAS2R38 bitter receptor","volume":"5","author":"Biarn\u00e9s","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"key\n\t\t\t\t20180315050555_msx097-B9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1523\/JNEUROSCI.3248-12.2013","article-title":"The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands","volume":"33","author":"Born","year":"2013","journal-title":"J Neurosci."},{"issue":"24","key":"key\n\t\t\t\t20180315050555_msx097-B10","doi-asserted-by":"crossref","first-page":"11110","DOI":"10.1073\/pnas.0913862107","article-title":"Structural requirements of bitter taste receptor activation","volume":"107","author":"Brockhoff","year":"2010","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"3","key":"key\n\t\t\t\t20180315050555_msx097-B11","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/ng1014","article-title":"The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides","volume":"32","author":"Bufe","year":"2002","journal-title":"Nat Genet."},{"issue":"2","key":"key\n\t\t\t\t20180315050555_msx097-B12","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/molbev\/mst211","article-title":"Origin and differential selection of allelic variation at TAS2R16 associated with salicin bitter taste sensitivity in Africa","volume":"31","author":"Campbell","year":"2014","journal-title":"Mol Biol Evol."},{"key":"key\n\t\t\t\t20180315050555_msx097-B13","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)80706-0","article-title":"T2Rs function as bitter taste receptors","volume":"100","author":"Chandrashekar","year":"2000","journal-title":"Cell"},{"issue":"20","key":"key\n\t\t\t\t20180315050555_msx097-B14","doi-asserted-by":"crossref","first-page":"11751","DOI":"10.1073\/pnas.95.20.11751","article-title":"A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence","volume":"95","author":"Chou","year":"1998","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"1","key":"key\n\t\t\t\t20180315050555_msx097-B15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000068546","article-title":"Identification and characterization of human taste receptor genes belonging to the TAS2R family","volume":"98","author":"Conte","year":"2002","journal-title":"Cytogenet Genome Res."},{"issue":"15","key":"key\n\t\t\t\t20180315050555_msx097-B16","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1093\/bioinformatics\/btr330","article-title":"The variant call format and VCFtools","volume":"27","author":"Danecek","year":"2011","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20180315050555_msx097-B17","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/gbe\/evp026","article-title":"Evolution of olfactory receptor genes in primates dominated by birth-and-death process","volume":"1","author":"Dong","year":"2009","journal-title":"Genome Biol Evol."},{"key":"key\n\t\t\t\t20180315050555_msx097-B18","doi-asserted-by":"crossref","first-page":"12.","DOI":"10.1186\/1471-2148-9-12","article-title":"Dynamic evolution of bitter taste receptor genes in vertebrates","volume":"9","author":"Dong","year":"2009","journal-title":"BMC Evol Biol."},{"issue":"6","key":"key\n\t\t\t\t20180315050555_msx097-B19","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1753-4887.2001.tb07007.x","article-title":"The science and complexity of bitter taste","volume":"59","author":"Drewnowski","year":"2001","journal-title":"Nutr Rev."},{"issue":"3","key":"key\n\t\t\t\t20180315050555_msx097-B20","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1755-0998.2010.02847.x","article-title":"Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows","volume":"10","author":"Excoffier","year":"2010","journal-title":"Mol Ecol Resour."},{"key":"key\n\t\t\t\t20180315050555_msx097-B21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/B978-0-12-209750-8.50014-7","volume-title":"Olfaction and Taste V, Proceedings of the 5th International Symposium in Melbourne, Australia","author":"Garcia","year":"1975"},{"issue":"1","key":"key\n\t\t\t\t20180315050555_msx097-B22","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1534\/genetics.104.037523","article-title":"Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates","volume":"170","author":"Go","year":"2005","journal-title":"Genetics"},{"issue":"8","key":"key\n\t\t\t\t20180315050555_msx097-B23","doi-asserted-by":"crossref","first-page":"e43277.","DOI":"10.1371\/journal.pone.0043277","article-title":"Eco-geographical diversification of bitter taste receptor genes (TAS2Rs) among subspecies of chimpanzees (Pan troglodytes)","volume":"7","author":"Hayakawa","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"key\n\t\t\t\t20180315050555_msx097-B24","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1093\/molbev\/msu144","article-title":"Frequent expansions of the bitter taste receptor gene repertoire during evolution of mammals in the Euarchontoglires clade","volume":"31","author":"Hayakawa","year":"2014","journal-title":"Mol Biol Evol."},{"issue":"9","key":"key\n\t\t\t\t20180315050555_msx097-B25","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1093\/bioinformatics\/btr119","article-title":"Rapid membrane protein topology prediction","volume":"27","author":"Hennerdal","year":"2011","journal-title":"Bioinformatics"},{"issue":"1","key":"key\n\t\t\t\t20180315050555_msx097-B26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/genetics\/116.1.153","article-title":"A test of neutral molecular evolution based on nucleotide data","volume":"116","author":"Hudson","year":"1987","journal-title":"Genetics"},{"issue":"4","key":"key\n\t\t\t\t20180315050555_msx097-B27","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1098\/rsbl.2011.1251","article-title":"Functional diversity of bitter taste receptor TAS2R16 in primates","volume":"8","author":"Imai","year":"2012","journal-title":"Biol Lett."},{"issue":"13","key":"key\n\t\t\t\t20180315050555_msx097-B28","doi-asserted-by":"crossref","first-page":"4956","DOI":"10.1073\/pnas.1118360109","article-title":"Major taste loss in carnivorous mammals","volume":"109","author":"Jiang","year":"2012","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"14","key":"key\n\t\t\t\t20180315050555_msx097-B29","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1093\/nar\/gkf436","article-title":"MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform","volume":"30","author":"Katoh","year":"2002","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"key\n\t\t\t\t20180315050555_msx097-B30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0379-0738(99)00191-7","article-title":"Colchicine poisoning by accidental ingestion of meadow saffron (Colchicum autumnale): pathological and medicolegal aspects","volume":"106","author":"Klintschar","year":"1999","journal-title":"Forensic Sci Int."},{"issue":"20","key":"key\n\t\t\t\t20180315050555_msx097-B31","doi-asserted-by":"crossref","first-page":"8125","DOI":"10.1093\/nar\/15.20.8125","article-title":"An analysis of 5\u2032-noncoding sequences from 699 vertebrate messenger RNAs","volume":"15","author":"Kozak","year":"1987","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"key\n\t\t\t\t20180315050555_msx097-B32","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/molbev\/mst219","article-title":"Diet shapes the evolution of the vertebrate bitter taste receptor gene repertoire","volume":"31","author":"Li","year":"2014","journal-title":"Mol Biol Evol."},{"issue":"1","key":"key\n\t\t\t\t20180315050555_msx097-B33","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/molbev\/msq211","article-title":"A new test for detecting recent positive selection that is free from the confounding impacts of demography","volume":"28","author":"Li","year":"2011","journal-title":"Mol Biol Evol."},{"issue":"1","key":"key\n\t\t\t\t20180315050555_msx097-B34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1371\/journal.pgen.0010003","article-title":"Pseudogenization of a sweet-receptor gene accounts for cats\u2019 indifference toward sugar","volume":"1","author":"Li","year":"2005","journal-title":"PLoS Genet"},{"issue":"11","key":"key\n\t\t\t\t20180315050555_msx097-B35","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1093\/bioinformatics\/btp187","article-title":"DnaSP v5: a software for comprehensive analysis of DNA polymorphism data","volume":"25","author":"Librado","year":"2009","journal-title":"Bioinformatics"},{"issue":"1","key":"key\n\t\t\t\t20180315050555_msx097-B36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/ecam\/nek009","article-title":"A review of the biochemistry, metabolism and clinical benefits of thiamin(e) and its derivatives","volume":"3","author":"Lonsdale","year":"2006","journal-title":"Evid Based Complement Alternat Med."},{"issue":"29","key":"key\n\t\t\t\t20180315050555_msx097-B37","doi-asserted-by":"crossref","first-page":"15358","DOI":"10.1074\/jbc.M116.718544","article-title":"Comprehensive analysis of mouse bitter taste receptors reveals different molecular receptive ranges for orthologous receptors in mice and humans","volume":"291","author":"Lossow","year":"2016","journal-title":"J Biol Chem."},{"issue":"5","key":"key\n\t\t\t\t20180315050555_msx097-B38","doi-asserted-by":"crossref","first-page":"e64675.","DOI":"10.1371\/journal.pone.0064675","article-title":"Coarse-grained\/molecular mechanics of the TAS2R38 bitter taste receptor: experimentally-validated detailed structural prediction of agonist binding","volume":"8","author":"Marchiori","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"key\n\t\t\t\t20180315050555_msx097-B39","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/oxfordjournals.molbev.a025562","article-title":"Detecting non-neutral heterogeneity across a region of DNA sequence in the ratio of polymorphism to divergence","volume":"13","author":"McDonald","year":"1996","journal-title":"Mol Biol Evol."},{"issue":"2","key":"key\n\t\t\t\t20180315050555_msx097-B40","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/chemse\/bjp092","article-title":"The molecular receptive ranges of human TAS2R bitter taste receptors","volume":"35","author":"Meyerhof","year":"2010","journal-title":"Chem Senses"},{"issue":"1","key":"key\n\t\t\t\t20180315050555_msx097-B41","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1086\/302219","article-title":"When less is more: gene loss as an engine of evolutionary change","volume":"64","author":"Olson","year":"1999","journal-title":"Am J Hum Genet"},{"issue":"7481","key":"key\n\t\t\t\t20180315050555_msx097-B42","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nature12886","article-title":"The complete genome sequence of a Neanderthal from the Altai Mountains","volume":"505","author":"Pr\u00fcfer","year":"2014","journal-title":"Nature"},{"issue":"3","key":"key\n\t\t\t\t20180315050555_msx097-B43","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet."},{"issue":"1","key":"key\n\t\t\t\t20180315050555_msx097-B44","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1021\/np960018g","article-title":"Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani","volume":"59","author":"Ray","year":"1996","journal-title":"J Nat Prod."},{"issue":"7327","key":"key\n\t\t\t\t20180315050555_msx097-B45","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/nature09710","article-title":"Genetic history of an archaic hominin group from Denisova Cave in Siberia","volume":"468","author":"Reich","year":"2010","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180315050555_msx097-B46","doi-asserted-by":"crossref","first-page":"198.","DOI":"10.1186\/s12862-014-0198-8","article-title":"Genetic variation in taste receptor pseudogenes provides evidence for a dynamic role in human evolution","volume":"14","author":"Risso","year":"2014","journal-title":"BMC Evol Biol."},{"issue":"12","key":"key\n\t\t\t\t20180315050555_msx097-B47","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.nutres.2015.09.011","article-title":"A potential trigger for pine mouth: a case of a homozygous phenylthiocarbamide taster","volume":"35","author":"Risso","year":"2015","journal-title":"Nutr Res."},{"key":"key\n\t\t\t\t20180315050555_msx097-B48","doi-asserted-by":"crossref","first-page":"25506.","DOI":"10.1038\/srep25506","article-title":"Global diversity in the TAS2R38 bitter taste receptor: revisiting a classic evolutionary PROPosal","volume":"6","author":"Risso","year":"2016","journal-title":"Sci Rep."},{"key":"key\n\t\t\t\t20180315050555_msx097-B49","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1046\/j.1365-2826.1997.00632.x","article-title":"Distinct agonist-mediated endocytosis of cloned rat somatostatin receptor subtypes expressed in insulinoma cells","volume":"9","author":"Roosterman","year":"1997","journal-title":"J Neuroendocrinol."},{"issue":"8","key":"key\n\t\t\t\t20180315050555_msx097-B50","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/chemse\/bjw067","article-title":"Copy number variation in TAS2R bitter taste receptor genes: structure, origin, and population genetics","volume":"41","author":"Roudnitzky","year":"2016","journal-title":"Chem Senses"},{"issue":"36","key":"key\n\t\t\t\t20180315050555_msx097-B51","doi-asserted-by":"crossref","first-page":"28373","DOI":"10.1074\/jbc.M110.144444","article-title":"Characterization of the beta-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16","volume":"285","author":"Sakurai","year":"2010","journal-title":"J Biol Chem."},{"issue":"12","key":"key\n\t\t\t\t20180315050555_msx097-B52","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.1073\/pnas.74.12.5463","article-title":"DNA sequencing with chain-terminating inhibitors","volume":"74","author":"Sanger","year":"1977","journal-title":"Proc Natl Acad Sci U S A."},{"key":"key\n\t\t\t\t20180315050555_msx097-B53","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"issue":"5","key":"key\n\t\t\t\t20180315050555_msx097-B54","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/molbev\/msg083","article-title":"Adaptive diversification of bitter taste receptor genes in Mammalian evolution","volume":"20","author":"Shi","year":"2003","journal-title":"Mol Biol Evol"},{"issue":"2","key":"key\n\t\t\t\t20180315050555_msx097-B55","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/molbev\/msj028","article-title":"Contrasting modes of evolution between vertebrate sweet\/umami receptor genes and bitter receptor genes","volume":"23","author":"Shi","year":"2006","journal-title":"Mol Biol Evol."},{"issue":"14","key":"key\n\t\t\t\t20180315050555_msx097-B56","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.cub.2005.06.042","article-title":"Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16","volume":"15","author":"Soranzo","year":"2005","journal-title":"Curr Biol."},{"issue":"6981","key":"key\n\t\t\t\t20180315050555_msx097-B57","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature02358","article-title":"Myosin gene mutation correlates with anatomical changes in the human lineage","volume":"428","author":"Stedman","year":"2004","journal-title":"Nature"},{"issue":"3","key":"key\n\t\t\t\t20180315050555_msx097-B58","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/genetics\/123.3.585","article-title":"Statistical method for testing the neutral mutation hypothesis by DNA polymorphism","volume":"123","author":"Tajima","year":"1989","journal-title":"Genetics"},{"issue":"2","key":"key\n\t\t\t\t20180315050555_msx097-B59","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bbrc.2013.04.066","article-title":"Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol","volume":"435","author":"Thalmann","year":"2013","journal-title":"Biochem Biophys Res Commun."},{"issue":"19","key":"key\n\t\t\t\t20180315050555_msx097-B100","doi-asserted-by":"crossref","first-page":"7376","DOI":"10.1523\/JNEUROSCI.23-19-07376.2003","article-title":"Functional interaction between T2R taste receptors and G-protein alpha subunits expressed in taste receptor cells","volume":"23","author":"Ueda","year":"2003","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180315050555_msx097-B60","doi-asserted-by":"crossref","first-page":"963248.","DOI":"10.1155\/2013\/963248","article-title":"Review on natural coumarin lead compounds for their pharmacological activity","volume":"2013","author":"Venugopala","year":"2013","journal-title":"Biomed Res Int."},{"issue":"3","key":"key\n\t\t\t\t20180315050555_msx097-B61","doi-asserted-by":"crossref","first-page":"e52.","DOI":"10.1371\/journal.pbio.0040052","article-title":"Gene losses during human origins","volume":"4","author":"Wang","year":"2006","journal-title":"PLoS Biol."},{"issue":"21","key":"key\n\t\t\t\t20180315050555_msx097-B62","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1093\/hmg\/ddh289","article-title":"Relaxation of selective constraint and loss of function in the evolution of human bitter taste receptor genes","volume":"13","author":"Wang","year":"2004","journal-title":"Hum Mol Genet."},{"issue":"7086","key":"key\n\t\t\t\t20180315050555_msx097-B63","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nature04655","article-title":"Independent evolution of bitter-taste sensitivity in humans and chimpanzees","volume":"440","author":"Wooding","year":"2006","journal-title":"Nature"},{"issue":"4","key":"key\n\t\t\t\t20180315050555_msx097-B64","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1086\/383092","article-title":"Natural selection and molecular evolution in PTC, a bitter-taste receptor gene","volume":"74","author":"Wooding","year":"2004","journal-title":"Am J Hum Genet."},{"key":"key\n\t\t\t\t20180315050555_msx097-B65","doi-asserted-by":"crossref","first-page":"96.","DOI":"10.1186\/1471-2350-13-96","article-title":"Association of a bitter taste receptor mutation with Balkan Endemic Nephropathy (BEN)","volume":"13","author":"Wooding","year":"2012","journal-title":"BMC Med Genet."},{"key":"key\n\t\t\t\t20180315050555_msx097-B66","first-page":"323","article-title":"The genetical structure of populations","volume":"15","author":"Wright","year":"1949","journal-title":"Ann Hum Genet."},{"key":"key\n\t\t\t\t20180315050555_msx097-B67","doi-asserted-by":"crossref","first-page":"40.","DOI":"10.1186\/1471-2105-9-40","article-title":"I-TASSER server for protein 3D structure prediction","volume":"9","author":"Zhang","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t20180315050555_msx097-B68","first-page":"2669","article-title":"Pseudogenization of the umami taste receptor gene Tas1r1 in the giant panda coincided with its dietary switch to bamboo","volume-title":"Mol Biol Evol","author":"Zhao","year":"2010"}],"container-title":["Molecular Biology and Evolution"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mbe\/article-pdf\/34\/7\/1587\/24366821\/msx097.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T17:41:57Z","timestamp":1658684517000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mbe\/article\/34\/7\/1587\/3067078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,13]]},"references-count":69,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,3,13]]},"published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/molbev\/msx097","relation":{},"ISSN":["0737-4038","1537-1719"],"issn-type":[{"value":"0737-4038","type":"print"},{"value":"1537-1719","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,7]]},"published":{"date-parts":[[2017,3,13]]}}}