{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T03:37:50Z","timestamp":1791776270466,"version":"4.3.4"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002360","name":"Beijing Genomics Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002360","id-type":"DOI","asserted-by":"crossref"}]},{"name":"BGI"},{"DOI":"10.13039\/100011099","name":"Stanford Center for Computational, Evolutionary and Human Genomics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011099","name":"CEHG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011099","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Laboratorio Nacional de Visualizaci\u00f3n Cient\u00edfica Avanzada"},{"name":"Mexico\u2019s CONACYT Basic Research Program","award":["CB-2015-01-251380"],"award-info":[{"award-number":["CB-2015-01-251380"]}]},{"DOI":"10.13039\/100007675","name":"International Center for Genetic Engineering and Biotechnology","doi-asserted-by":"publisher","award":["ICGEB"],"award-info":[{"award-number":["ICGEB"]}],"id":[{"id":"10.13039\/100007675","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007675","name":"International Center for Genetic Engineering and Biotechnology","doi-asserted-by":"publisher","award":["CRP\/MEX15-04_EC"],"award-info":[{"award-number":["CRP\/MEX15-04_EC"]}],"id":[{"id":"10.13039\/100007675","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Care Research in Developing Countries"},{"name":"Programa de Apoyo a Proyectos de Investigaci\u00f3n e Innovaci\u00f3n Tecnol\u00f3gica"},{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["IA206817"],"award-info":[{"award-number":["IA206817"]}],"id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CONACYT Infrastructure","award":["26944"],"award-info":[{"award-number":["26944"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Native American genetic variation remains underrepresented in most catalogs of human genome sequencing data. Previous genotyping efforts have revealed that Mexico\u2019s Indigenous population is highly differentiated and substructured, thus potentially harboring higher proportions of private genetic variants of functional and biomedical relevance. Here we have targeted the coding fraction of the genome and characterized its full site frequency spectrum by sequencing 76 exomes from five Indigenous populations across Mexico. Using diffusion approximations, we modeled the demographic history of Indigenous populations from Mexico with northern and southern ethnic groups splitting 7.2 KYA and subsequently diverging locally 6.5 and 5.7 KYA, respectively. Selection scans for positive selection revealed BCL2L13 and KBTBD8 genes as potential candidates for adaptive evolution in Rar\u00e1muris and Triquis, respectively. BCL2L13 is highly expressed in skeletal muscle and could be related to physical endurance, a well-known phenotype of the northern Mexico Rar\u00e1muri. The KBTBD8 gene has been associated with idiopathic short stature and we found it to be highly differentiated in Triqui, a southern Indigenous group from Oaxaca whose height is extremely low compared to other Native populations.<\/jats:p>","DOI":"10.1093\/molbev\/msz282","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T15:13:05Z","timestamp":1575385985000},"page":"994-1006","source":"Crossref","is-referenced-by-count":48,"title":["Population History and Gene Divergence in Native Mexicans Inferred from 76 Human Exomes"],"prefix":"10.1093","volume":"37","author":[{"given":"Mar\u00eda C","family":"\u00c1vila-Arcos","sequence":"first","affiliation":[{"name":"International Laboratory for Human Genome Research (LIIGH), UNAM Juriquilla, Queretaro, Mexico"},{"name":"Department of Genetics, Stanford University School of Medicine, Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly F","family":"McManus","sequence":"first","affiliation":[{"name":"Department of Biology, Stanford University, Stanford, CA"},{"name":"Department of Biomedical Informatics, Stanford School of Medicine, Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Sandoval","sequence":"first","affiliation":[{"name":"National Laboratory of Genomics for Biodiversity (LANGEBIO), UGA, CINVESTAV, Irapuato, Guanajuato 36821, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Esteban","family":"Rodr\u00edguez-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"National Laboratory of Genomics for Biodiversity (LANGEBIO), UGA, CINVESTAV, Irapuato, Guanajuato 36821, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viridiana","family":"Villa-Islas","sequence":"first","affiliation":[{"name":"International Laboratory for Human Genome Research (LIIGH), UNAM Juriquilla, Queretaro, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia R","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Genetics, Stanford University School of Medicine, Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Luisi","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n y Desarrollo en Inmunolog\u00eda y Enfermedades Infecciosas, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, C\u00f3rdoba, Argentina"},{"name":"Facultad de Filosof\u00eda y Humanidades, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosenda I","family":"Pe\u00f1aloza-Espinosa","sequence":"first","affiliation":[{"name":"Division of Biological and Health Sciences, Department of Biological Systems, Universidad Aut\u00f3noma Metropolitana-Xochimilco, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste","family":"Eng","sequence":"first","affiliation":[{"name":"Department Bioengineering & Therapeutic Sciences and Medicine, University of California San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Huntsman","sequence":"first","affiliation":[{"name":"Department Bioengineering & Therapeutic Sciences and Medicine, University of California San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban G","family":"Burchard","sequence":"first","affiliation":[{"name":"Department Bioengineering & Therapeutic Sciences and Medicine, University of California San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R","family":"Gignoux","sequence":"first","affiliation":[{"name":"Division of Biomedical Informatics and Personalized Medicine, University of Colorado, Denver, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos D","family":"Bustamante","sequence":"first","affiliation":[{"name":"Department of Genetics, Stanford University School of Medicine, Stanford, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Moreno-Estrada","sequence":"first","affiliation":[{"name":"National Laboratory of Genomics for Biodiversity (LANGEBIO), UGA, CINVESTAV, Irapuato, Guanajuato 36821, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,12,17]]},"reference":[{"issue":"4","key":"2020032303575973700_msz282-B1","doi-asserted-by":"crossref","first-page":"360.","DOI":"10.3201\/eid0804.010175","article-title":"Megadrought and megadeath in 16th century Mexico","volume":"8","author":"Acuna-Soto","year":"2002","journal-title":"Emerg Infect 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