{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:07:04Z","timestamp":1792786024922,"version":"4.5.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004562","name":"French Ministry of Higher Education and Research","doi-asserted-by":"publisher","award":["CNRS\/IIS LIMMS IRL 2820"],"award-info":[{"award-number":["CNRS\/IIS LIMMS IRL 2820"]}],"id":[{"id":"10.13039\/501100004562","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universit\u00e9 de technologie de Compiegne","id":[{"id":"https:\/\/ror.org\/04y5kwa70","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Research Department of the Universit\u00e9 de technologie de Compi\u00e8gne","id":[{"id":"https:\/\/ror.org\/04y5kwa70","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Systemic interactions between the liver and pancreas are critical for regulating lipid and carbohydrate homeostasis. These organs are also deeply interdependent in pathological conditions such as insulin resistance, where the liver fails to respond appropriately to insulin stimulation, leading to dysfunction in both organs. To investigate the crosstalk between these tissues using human models, we developed an advanced organ-on-chip (OoC) device hosting human induced pluripotent stem cell-derived liver and pancreatic tissues. The proteomic response of pancreatic-like cell spheroids cocultured with hepatocyte-like cells was characterized. We observed that the presence of liver tissue enhanced the synthesis of proteins associated with extracellular matrix remodelling, inflammatory responses, and pro-apoptotic signalling in pancreatic cells. Conversely, monocultures of pancreatic cells exhibited a higher abundance of proteins involved in fatty acid metabolism, glycolysis, and the citrate cycle. Key pancreatic markers (GCG, TPH1, SCGN3, SCGN, CHGA, CHGB) were upregulated in monocultures, while no reduction was observed in the secretion of pancreatic hormones (IGF2, GHRL, and C-peptide). Overall, our results suggest a metabolic switch in cocultures, accompanied by cellular stress and moderate alterations in pancreatic secretion. These findings provide insights into liver-pancreas crosstalk and may guide the design of future multicellular OoC models.<\/jats:p>","DOI":"10.1093\/molecular-omics\/aaiag021","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:40:37Z","timestamp":1787744437000},"source":"Crossref","is-referenced-by-count":0,"title":["Proteomic analysis reveals a metabolic switch and cellular remodelling in pancreatic-like cell spheroids cocultured with hepatocyte-like cells using an interconnected liver-pancreas-on-chip system"],"prefix":"10.1093","volume":"22","author":[{"given":"Amal","family":"Essaouiba","sequence":"first","affiliation":[{"name":"Universit\u00e9 de technologie de Compi\u00e8gne, CNRS, Biomechanics and Bioengineering, Centre de recherche Royallieu CS 60319 , 60203 Compiegne ,","place":["France"]},{"name":"CNRS\/IIS IRL 2820, Laboratory for Integrated Micro Mechatronic Systems, Institute of Industrial Science, University of Tokyo , Tokyo 153-8505 ,","place":["Japan"]},{"name":"Department of Chemical System Engineering, Graduate School of Engineering, The University of Tokyo , Tokyo 113-8656 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8360-7497","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Vicogne","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity of Lille, Univ. 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