{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T02:26:19Z","timestamp":1783736779227,"version":"3.55.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T00:00:00Z","timestamp":1601683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Postgraduate Scholarship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We previously showed that annexin A2 (Axna2) was transiently expressed at the embryo-uterine luminal epithelium interface during the window of implantation and was involved in mouse embryo implantation. At the same time, Axna2 was reported to be upregulated in human receptive endometrium, which was critical for embryo attachment as an intracellular molecule. Here, we identified Axna2 as a membrane-bound molecule on human endometrial epithelial cells and trophoblast cells, and the outer surface membrane-bound Axna2 was involved in human embryo attachment. In addition, physiological levels of estrogen and progesterone increased the expression of overall Axna2 as well as that in the extracellular surface membrane protein fraction in human endometrial cells. Furthermore, p11 (or S100A10, a member of the S100 EF-hand family protein, molecular weight 11\u2009kDa) was involved in the translocation of Axna2 to the outer surface membrane of endometrial epithelial cells without affecting its overall expression. Finally, the surface relocation of Axna2 was also dependent on cell\u2013cell contact and calcium binding. A better understanding of the function and regulation of Axna2 in human endometrium may help us to identify a potential therapeutic target for subfertile and infertile patients.<\/jats:p>","DOI":"10.1093\/molehr\/gaaa065","type":"journal-article","created":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T11:13:25Z","timestamp":1600514005000},"page":"825-836","source":"Crossref","is-referenced-by-count":18,"title":["Annexin A2 acts as an adherent molecule under the regulation of steroids during embryo implantation"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4742-8456","authenticated-orcid":false,"given":"Bing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China"},{"name":"R & D Department, Shenzhen Wingor Biotechnology Co., Ltd, Room 304, Shenzhen IC Design & Application Industrial Park, Shenzhen City, Guangdong Province, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Shatin, NT, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,3]]},"reference":[{"key":"2020110806522777100_gaaa065-B1","doi-asserted-by":"crossref","first-page":"11408","DOI":"10.1073\/pnas.88.24.11408","article-title":"Uterine expression of leukemia inhibitory factor coincides with the onset of blastocyst implantation","volume":"88","author":"Bhatt","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020110806522777100_gaaa065-B2","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1080\/19336918.2015.1128623","article-title":"Human S100A10 plays a crucial role in 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