{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:12:06Z","timestamp":1789621926166,"version":"build-2803163510"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Program from SECTyP, National University of Cuyo"},{"name":"CIUDA, University of Aconcagua"},{"name":"Agencia Nacional para la Promoci\u00f3n de la Ciencia y la Tecnolog\u00eda\u2014FONCyT, Argentina","award":["PICT-2017-1236"],"award-info":[{"award-number":["PICT-2017-1236"]}]},{"DOI":"10.13039\/501100002923","name":"CONICET","doi-asserted-by":"publisher","award":["PIP 0380 2017-2019"],"award-info":[{"award-number":["PIP 0380 2017-2019"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Male fertility has been shown to be dependent on cholesterol homeostasis. This lipid is essential for testosterone synthesis and spermatogenesis, but its levels must be maintained in an optimal range for proper testicular function. In particular, sperm cells\u2019 development is very sensitive to high cholesterol levels, noticeably during acrosomal formation. The aim of this work was to study whether the molecular pathway that regulates intracellular cholesterol, the sterol regulatory element-binding protein (SREBP) pathway, is affected in the testicles of animals under a fat diet. To investigate this, we took advantage of the non-obese hypercholesterolemia (HC) model in New Zealand rabbits that displays poor sperm and seminal quality. The testicular expression of SREBP isoform 2 (SREBP2) and its target molecules 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) and low-density lipoprotein receptor (LDLR) were studied under acute (6\u2009months) and chronic (more than 12\u2009months) fat intake by RT\u2013PCR, western blot and immunofluorescence. Our findings showed that fat consumption promoted down-regulation of the SREBP2 pathway in the testicle at 6\u2009months, but upregulation after a chronic period. This was consistent with load of testicular cholesterol, assessed by filipin staining. In conclusion, the intracellular pathway that regulates cholesterol levels in the testicle is sensitive to dietary fats, and behaves differently depending on the duration of consumption: it has a short-term protective effect, but became deregulated in the long term, ultimately leading to a detrimental situation. These results will contribute to the understanding of the basic mechanisms of the effect of fat consumption in humans with idiopathic infertility.<\/jats:p>","DOI":"10.1093\/molehr\/gaab023","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T19:11:44Z","timestamp":1617131504000},"source":"Crossref","is-referenced-by-count":9,"title":["Impact of high fat diet on the sterol regulatory element-binding protein 2 cholesterol pathway in the testicle"],"prefix":"10.1093","volume":"27","author":[{"given":"Abi K","family":"Funes","sequence":"first","affiliation":[{"name":"Laboratorio de Investigaciones Androl\u00f3gicas de Mendoza (LIAM) \u2020. Instituto de Histolog\u00eda y Embriolog\u00eda (IHEM), Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Centro Cient\u00edfico y Tecnol\u00f3gico (CCT), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mendoza, Argentina"},{"name":"Laboratorio de Biolog\u00eda Molecular del Metabolismo & Nutrici\u00f3n (bMeNu)\u2020, Instituto de Histolog\u00eda y Embriolog\u00eda (IHEM), Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Centro Cient\u00edfico y Tecnol\u00f3gico (CCT), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layla","family":"Sim\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaciones Androl\u00f3gicas de Mendoza (LIAM) \u2020. Instituto de Histolog\u00eda y Embriolog\u00eda (IHEM), Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Centro Cient\u00edfico y Tecnol\u00f3gico (CCT), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Colombo","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaciones Androl\u00f3gicas de Mendoza (LIAM) \u2020. Instituto de Histolog\u00eda y Embriolog\u00eda (IHEM), Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Centro Cient\u00edfico y Tecnol\u00f3gico (CCT), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mendoza, Argentina"},{"name":"Laboratorio de Biolog\u00eda Molecular del Metabolismo & Nutrici\u00f3n (bMeNu)\u2020, Instituto de Histolog\u00eda y Embriolog\u00eda (IHEM), Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Centro Cient\u00edfico y Tecnol\u00f3gico (CCT), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Virginia","family":"Avena","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaciones Androl\u00f3gicas de Mendoza (LIAM) \u2020. Instituto de Histolog\u00eda y Embriolog\u00eda (IHEM), Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Centro Cient\u00edfico y Tecnol\u00f3gico (CCT), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mendoza, Argentina"},{"name":"Laboratorio de Biolog\u00eda Molecular del Metabolismo & Nutrici\u00f3n (bMeNu)\u2020, Instituto de Histolog\u00eda y Embriolog\u00eda (IHEM), Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Centro Cient\u00edfico y Tecnol\u00f3gico (CCT), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Moncl\u00fas","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaciones Androl\u00f3gicas de Mendoza (LIAM) \u2020. Instituto de Histolog\u00eda y Embriolog\u00eda (IHEM), Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Centro Cient\u00edfico y Tecnol\u00f3gico (CCT), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mendoza, Argentina"},{"name":"Instituto de Investigaciones. Facultad de Ciencias M\u00e9dicas. Universidad del Aconcagua. Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julieta","family":"Crescitelli","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular del Metabolismo & Nutrici\u00f3n (bMeNu)\u2020, Instituto de Histolog\u00eda y Embriolog\u00eda (IHEM), Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Centro Cient\u00edfico y Tecnol\u00f3gico (CCT), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mendoza, Argentina"},{"name":"Instituto de Investigaciones. Facultad de Ciencias M\u00e9dicas. Universidad del Aconcagua. Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6794-8603","authenticated-orcid":false,"given":"Mar\u00eda E","family":"Cabrillana","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaciones Androl\u00f3gicas de Mendoza (LIAM) \u2020. Instituto de Histolog\u00eda y Embriolog\u00eda (IHEM), Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Centro Cient\u00edfico y Tecnol\u00f3gico (CCT), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda In\u00e9s","family":"Conte","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaciones Androl\u00f3gicas de Mendoza (LIAM) \u2020. Instituto de Histolog\u00eda y Embriolog\u00eda (IHEM), Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Centro Cient\u00edfico y Tecnol\u00f3gico (CCT), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niubys","family":"Cayado","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones. Facultad de Ciencias M\u00e9dicas. Universidad del Aconcagua. Mendoza, Argentina"},{"name":"Laboratorio de Oncolog\u00eda, Instituto de Medicina y Biolog\u00eda Experimental de Cuyo (IMBECU), Centro Cient\u00edfico y Tecnol\u00f3gico (CCT), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Boarelli","sequence":"additional","affiliation":[{"name":"Laboratorio de Enfermedades Metab\u00f3licas (LEM), Universidad Juan Agust\u00edn Maza, Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel W","family":"Forn\u00e9s","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaciones Androl\u00f3gicas de Mendoza (LIAM) \u2020. Instituto de Histolog\u00eda y Embriolog\u00eda (IHEM), Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Centro Cient\u00edfico y Tecnol\u00f3gico (CCT), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8830-6482","authenticated-orcid":false,"given":"Tania E","family":"Saez Lancellotti","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaciones Androl\u00f3gicas de Mendoza (LIAM) \u2020. Instituto de Histolog\u00eda y Embriolog\u00eda (IHEM), Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Centro Cient\u00edfico y Tecnol\u00f3gico (CCT), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mendoza, Argentina"},{"name":"Laboratorio de Biolog\u00eda Molecular del Metabolismo & Nutrici\u00f3n (bMeNu)\u2020, Instituto de Histolog\u00eda y Embriolog\u00eda (IHEM), Facultad de Ciencias M\u00e9dicas, Universidad Nacional de Cuyo, Centro Cient\u00edfico y Tecnol\u00f3gico (CCT), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mendoza, Argentina"},{"name":"Instituto de Investigaciones. Facultad de Ciencias M\u00e9dicas. Universidad del Aconcagua. Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"key":"2021070802585813500_gaab023-B1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.fertnstert.2013.10.022","article-title":"Semen quality and time to pregnancy: the Longitudinal Investigation of Fertility and the Environment Study","volume":"101","author":"Buck Louis","year":"2014","journal-title":"Fertil Steril"},{"key":"2021070802585813500_gaab023-B2","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.jhep.2008.12.016","article-title":"Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH","volume":"50","author":"Caballero","year":"2009","journal-title":"J Hepatol"},{"key":"2021070802585813500_gaab023-B3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1590\/S1677-5538.IBJU.2014.0244","article-title":"Metabolic and testicular effects of the long-term administration of different high-fat diets in adult rats","volume":"41","author":"Campos-Silva","year":"2015","journal-title":"Int Braz J Urol"},{"key":"2021070802585813500_gaab023-B4","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1136\/bmj.305.6854.609","article-title":"Evidence for decreasing quality of semen during past 50 years","volume":"305","author":"Carlsen","year":"1992","journal-title":"BMJ"},{"key":"2021070802585813500_gaab023-B5","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1194\/jlr.RA119000201","article-title":"Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing","volume":"60","author":"Chen","year":"2019","journal-title":"J Lipid Res"},{"key":"2021070802585813500_gaab023-B6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1095\/biolreprod59.1.7","article-title":"Role of cholesterol in sperm capacitation","volume":"59","author":"Cross","year":"1998","journal-title":"Biol Reprod"},{"key":"2021070802585813500_gaab023-B7","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1152\/physrev.00025.2005","article-title":"Transcriptional regulation of metabolism","volume":"86","author":"Desvergne","year":"2006","journal-title":"Physiol Rev"},{"key":"2021070802585813500_gaab023-B8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrurol.2010.6","article-title":"The effect of obesity on sperm disorders and male infertility","volume":"7","author":"Du Plessis","year":"2010","journal-title":"Nat Rev Urol"},{"key":"2021070802585813500_gaab023-B9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev.genet.41.110306.130315","article-title":"Regulation of sterol synthesis in eukaryotes","volume":"41","author":"Espenshade","year":"2007","journal-title":"Annu Rev Genet"},{"key":"2021070802585813500_gaab023-B10","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/j.1464-410X.2011.10813.x","article-title":"Association between obesity and alteration of sperm DNA integrity and mitochondrial activity","volume":"110","author":"Fariello","year":"2012","journal-title":"BJU Int"},{"key":"2021070802585813500_gaab023-B11","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1159\/000446514","article-title":"Short exposure to a high-sucrose diet and the first \u2018hit\u2019 of nonalcoholic fatty liver disease in mice","volume":"201","author":"Fernandes-Lima","year":"2016","journal-title":"Cells Tissues Organs"},{"key":"2021070802585813500_gaab023-B12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1001\/jama.2012.113905","article-title":"Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis","volume":"309","author":"Flegal","year":"2013","journal-title":"JAMA"},{"key":"2021070802585813500_gaab023-B13","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0960-0760(03)00191-2","article-title":"Lanosterol metabolism and sterol regulatory element binding protein (SREBP) expression in male germ cell maturation","volume":"85","author":"Fon Tacer","year":"2003","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2021070802585813500_gaab023-B14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1471-2458-9-88","article-title":"The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis","volume":"9","author":"Guh","year":"2009","journal-title":"BMC Public Health"},{"key":"2021070802585813500_gaab023-B15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1210\/edrv-3-3-299","article-title":"The role of lipoproteins in steroidogenesis and cholesterol metabolism in steroidogenic glands","volume":"3","author":"Gwynne","year":"1982","journal-title":"Endocr Rev"},{"key":"2021070802585813500_gaab023-B16","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.fertnstert.2008.08.026","article-title":"Impact of male obesity on infertility: a critical review of the current literature","volume":"90","author":"Hammoud","year":"2008","journal-title":"Fertil Steril"},{"key":"2021070802585813500_gaab023-B17","doi-asserted-by":"crossref","first-page":"G782","DOI":"10.1152\/ajpgi.90324.2008","article-title":"Short-term adaptation of postprandial lipoprotein secretion and intestinal gene expression to a high-fat diet","volume":"296","author":"Hernandez Vallejo","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2021070802585813500_gaab023-B18","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI0215593","article-title":"SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver","volume":"109","author":"Horton","year":"2002","journal-title":"J Clin Invest"},{"key":"2021070802585813500_gaab023-B19","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.chemphyslip.2016.02.011","article-title":"Cholesterol homeostasis: how do cells sense sterol excess?","volume":"199","author":"Howe","year":"2016","journal-title":"Chem Phys Lipids"},{"key":"2021070802585813500_gaab023-B20","first-page":"12","article-title":"Hyper-lipidemia and male fertility: a critical review of literature","volume":"4","author":"Jain","year":"2015","journal-title":"Andrology-Open Access"},{"key":"2021070802585813500_gaab023-B21","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1038\/s41366-020-0595-6","article-title":"High fat diet causes distinct aberrations in the testicular proteome","volume":"44","author":"Jarvis","year":"2020","journal-title":"Int J Obes"},{"key":"2021070802585813500_gaab023-B22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tem.2011.10.004","article-title":"SREBPs: metabolic integrators in physiology and metabolism","volume":"23","author":"Jeon","year":"2012","journal-title":"Trends Endocrinol Metab"},{"key":"2021070802585813500_gaab023-B23","doi-asserted-by":"crossref","first-page":"e6884","DOI":"10.1371\/journal.pone.0006884","article-title":"Leptin contributes to the adaptive responses of mice to high-fat diet intake through suppressing the lipogenic pathway","volume":"4","author":"Jiang","year":"2009","journal-title":"PLoS One"},{"key":"2021070802585813500_gaab023-B24","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"2021070802585813500_gaab023-B25","doi-asserted-by":"crossref","first-page":"e1900773","DOI":"10.1002\/mnfr.201900773","article-title":"Omics insights into metabolic stress and resilience of rats in response to short-term fructose overfeeding","volume":"63","author":"Li","year":"2019","journal-title":"Mol Nutr Food Res"},{"key":"2021070802585813500_gaab023-B26","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12882-018-0986-2","article-title":"Lipoprotein(a) accelerated the progression of atherosclerosis in patients with end-stage renal disease","volume":"19","author":"Ma","year":"2018","journal-title":"BMC Nephrol"},{"key":"2021070802585813500_gaab023-B27","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/humupd\/dmp047","article-title":"The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis","volume":"16","author":"Macdonald","year":"2010","journal-title":"Hum Reprod Update"},{"key":"2021070802585813500_gaab023-B28","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1194\/jlr.C066712","article-title":"Srebp2: a master regulator of sterol and fatty acid synthesis","volume":"57","author":"Madison","year":"2016","journal-title":"J Lipid Res"},{"key":"2021070802585813500_gaab023-B29","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/humrep\/deh569","article-title":"Persistent organochlorines, sedentary occupation, obesity and human male subfertility","volume":"20","author":"Magnusdottir","year":"2005","journal-title":"Hum Reprod"},{"key":"2021070802585813500_gaab023-B30","doi-asserted-by":"crossref","first-page":"E1125","DOI":"10.1152\/ajpendo.00416.2014","article-title":"Cholesterol-enriched diet disrupts the blood-testis barrier in rabbits","volume":"307","author":"Morgan","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2021070802585813500_gaab023-B31","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1177\/002215540205000315","article-title":"Simple method for reduction of autofluorescence in fluorescence microscopy","volume":"50","author":"Neumann","year":"2002","journal-title":"J Histochem Cytochem"},{"key":"2021070802585813500_gaab023-B32","author":"World Health Organization","year":"2016"},{"key":"2021070802585813500_gaab023-B33","author":"World Health Organization","year":"2020"},{"key":"2021070802585813500_gaab023-B34","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1210\/endo.137.2.8593813","article-title":"Transcription factor Sp1 is expressed by three different developmentally regulated messenger ribonucleic acids in mouse spermatogenic cells","volume":"137","author":"Persengiev","year":"1996","journal-title":"Endocrinology"},{"key":"2021070802585813500_gaab023-B35","first-page":"1951","article-title":"Cyclic adenosine 3\u2019,5\u2019-monophosphate(cAMP)\/cAMP-responsive element modulator (CREM)-dependent regulation of cholesterogenic lanosterol 14alpha-demethylase (CYP51) in spermatids","volume":"13","author":"Rozman","year":"1999","journal-title":"Mol Endocrinol"},{"key":"2021070802585813500_gaab023-B36","doi-asserted-by":"crossref","first-page":"e13457","DOI":"10.1371\/journal.pone.0013457","article-title":"Hypercholesterolemia impaired sperm functionality in rabbits","volume":"5","author":"Saez Lancellotti","year":"2010","journal-title":"PLoS One"},{"key":"2021070802585813500_gaab023-B37","doi-asserted-by":"crossref","first-page":"e52386","DOI":"10.1371\/journal.pone.0052386","article-title":"Semen quality and sperm function loss by hypercholesterolemic diet was recovered by addition of olive oil to diet in rabbit","volume":"8","author":"Saez Lancellotti","year":"2013","journal-title":"PLoS One"},{"key":"2021070802585813500_gaab023-B38","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1073\/pnas.92.4.935","article-title":"Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver","volume":"92","author":"Sheng","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021070802585813500_gaab023-B39","doi-asserted-by":"crossref","first-page":"E5685","DOI":"10.1073\/pnas.1611424113","article-title":"SCAP\/SREBP pathway is required for the full steroidogenic response to cyclic AMP","volume":"113","author":"Shimizu-Albergine","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021070802585813500_gaab023-B40","doi-asserted-by":"crossref","first-page":"e0202748","DOI":"10.1371\/journal.pone.0202748","article-title":"Manchette-acrosome disorders and testicular efficiency decline observed in hypercholesterolemic rabbits are recovered with olive oil enriched diet","volume":"13","author":"Simon","year":"2018","journal-title":"PLoS One"},{"key":"2021070802585813500_gaab023-B41","doi-asserted-by":"crossref","first-page":"e0172994","DOI":"10.1371\/journal.pone.0172994","article-title":"Manchette-acrosome disorders during spermiogenesis and low efficiency of seminiferous tubules in hypercholesterolemic rabbit model","volume":"12","author":"Simon","year":"2017","journal-title":"PLoS One"},{"key":"2021070802585813500_gaab023-B42","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/aja.1001160206","article-title":"Duration of spermatogenesis and spermatozoan transport in the rabbit based on cytological changes, dna synthesis and labeling with tritiated thymidine","volume":"116","author":"Swierstra","year":"1965","journal-title":"Am J Anat"},{"key":"2021070802585813500_gaab023-B43","doi-asserted-by":"crossref","first-page":"492","DOI":"10.2337\/diabetes.54.2.492","article-title":"Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells","volume":"54","author":"Takahashi","year":"2005","journal-title":"Diabetes"},{"key":"2021070802585813500_gaab023-B44","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/humupd\/dmr017","article-title":"Functional relationship between obesity and male reproduction: from humans to animal models","volume":"17","author":"Teerds","year":"2011","journal-title":"Hum Reprod Update"},{"key":"2021070802585813500_gaab023-B45","doi-asserted-by":"crossref","first-page":"8478","DOI":"10.1128\/MCB.22.24.8478-8490.2002","article-title":"Expression of a novel, sterol-insensitive form of sterol regulatory element binding protein 2 (SREBP2) in male germ cells suggests important cell- and stage-specific functions for SREBP targets during spermatogenesis","volume":"22","author":"Wang","year":"2002","journal-title":"Mol Cell Biol"},{"key":"2021070802585813500_gaab023-B46","doi-asserted-by":"crossref","first-page":"10681","DOI":"10.1128\/MCB.24.24.10681-10688.2004","article-title":"Novel role for a sterol response element binding protein in directing spermatogenic cell-specific gene expression","volume":"24","author":"Wang","year":"2004","journal-title":"Mol Cell Biol"},{"key":"2021070802585813500_gaab023-B47","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/j.bbadis.2013.04.024","article-title":"Activation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase during high fat diet feeding","volume":"1832","author":"Wu","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"2021070802585813500_gaab023-B48","doi-asserted-by":"crossref","first-page":"19353","DOI":"10.1074\/jbc.M201584200","article-title":"Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)\/Lep(ob) mice","volume":"277","author":"Yahagi","year":"2002","journal-title":"J Biol Chem"},{"key":"2021070802585813500_gaab023-B49","author":"Yanagimachi","year":"1994"},{"key":"2021070802585813500_gaab023-B50","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1111\/jcmm.14143","article-title":"HC diet inhibited testosterone synthesis by activating endoplasmic reticulum stress in testicular Leydig cells","volume":"23","author":"Yu","year":"2019","journal-title":"J Cell Mol Med"},{"key":"2021070802585813500_gaab023-B51","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cbi.2018.05.014","article-title":"Ganoderic Acid A improves high fat diet-induced obesity, lipid accumulation and insulin sensitivity through regulating SREBP pathway","volume":"290","author":"Zhu","year":"2018","journal-title":"Chem Biol Interact"}],"container-title":["Molecular Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/molehr\/advance-article-pdf\/doi\/10.1093\/molehr\/gaab023\/36838692\/gaab023.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/molehr\/article-pdf\/27\/5\/gaab023\/37894908\/gaab023.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/molehr\/article-pdf\/27\/5\/gaab023\/37894908\/gaab023.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T07:15:57Z","timestamp":1625728557000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molehr\/article\/doi\/10.1093\/molehr\/gaab023\/6206393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,31]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5,8]]}},"URL":"https:\/\/doi.org\/10.1093\/molehr\/gaab023","relation":{},"ISSN":["1360-9947","1460-2407"],"issn-type":[{"value":"1360-9947","type":"print"},{"value":"1460-2407","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,5,1]]},"published":{"date-parts":[[2021,3,31]]},"article-number":"gaab023"}}