{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:29:07Z","timestamp":1792794547185,"version":"4.5.0"},"reference-count":139,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FRN 173252"],"award-info":[{"award-number":["FRN 173252"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canada Foundation for Innovation and the Ontario Ministry of Research and Innovation","id":[{"id":"https:\/\/ror.org\/000az4664","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000038","name":"Natural Science and Engineering Research Council of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The onset of labour is a culmination of a series of highly coordinated and preparatory physiological events that take place throughout the gestational period. In order to produce the associated contractions needed for foetal delivery, smooth muscle cells in the muscular layer of the uterus (i.e. myometrium) undergo a transition from quiescent to contractile phenotypes. Here, we present the current understanding of the roles transcription factors play in critical labour-associated gene expression changes as part of the molecular mechanistic basis for this transition. Consideration is given to both transcription factors that have been well-studied in a myometrial context, i.e. activator protein 1, progesterone receptors, oestrogen receptors, and nuclear factor kappa B, as well as additional transcription factors whose gestational event-driving contributions have been demonstrated more recently. These transcription factors may form pregnancy- and labour-associated transcriptional regulatory networks in the myometrium to modulate the timing of labour onset. A more thorough understanding of the transcription factor-mediated, labour-promoting regulatory pathways holds promise for the development of new therapeutic treatments that can be used for the prevention of preterm labour in at-risk women.<\/jats:p>","DOI":"10.1093\/molehr\/gaab024","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T07:17:23Z","timestamp":1617693443000},"source":"Crossref","is-referenced-by-count":27,"title":["Transcriptional control of parturition: insights from gene regulation studies in the myometrium"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9475-6316","authenticated-orcid":false,"given":"Nawrah","family":"Khader","sequence":"first","affiliation":[{"name":"Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1083-4888","authenticated-orcid":false,"given":"Virlana M","family":"Shchuka","sequence":"additional","affiliation":[{"name":"Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6084-8156","authenticated-orcid":false,"given":"Oksana","family":"Shynlova","sequence":"additional","affiliation":[{"name":"Lunenfeld Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada"},{"name":"Department of Obstetrics & Gynaecology, University of Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7147-4604","authenticated-orcid":false,"given":"Jennifer A","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,6]]},"reference":[{"key":"2021070802585911900_gaab024-B1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1055\/s-0031-1284227","article-title":"Indomethacin in pregnancy: applications and safety","volume":"29","author":"Abou-Ghannam","year":"2012","journal-title":"Am J Perinatol"},{"key":"2021070802585911900_gaab024-B2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/molehr\/7.6.581","article-title":"Human labour is associated with nuclear factor-\u03baB activity which mediates cyclo-oxygenase-2 expression and is involved with the \u2018functional progesterone withdrawal\u2019","volume":"7","author":"Allport","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"2021070802585911900_gaab024-B3","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.ebiom.2018.11.038","article-title":"Estrogen receptor alpha isoform ERdelta7 in myometrium modulates uterine quiescence during pregnancy","volume":"39","author":"Anamthathmakula","year":"2019","journal-title":"EBioMedicine"},{"key":"2021070802585911900_gaab024-B4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1385\/CT:6:2:111","article-title":"The NF-\u03baB regulatory network","volume":"6","author":"Brasier","year":"2006","journal-title":"Cardiovasc Toxicol"},{"key":"2021070802585911900_gaab024-B5","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/ng1051","article-title":"Long-range chromatin regulatory interactions in vivo","volume":"32","author":"Carter","year":"2002","journal-title":"Nat Genet"},{"key":"2021070802585911900_gaab024-B6","first-page":"3387","article-title":"HOXA10 expression is repressed by progesterone in the myometrium: differential tissue-specific regulation of HOX gene expression in the reproductive tract","volume":"86","author":"Cermik","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2021070802585911900_gaab024-B7","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/molehr\/gas012","article-title":"Term myometrium is characterized by increased activating epigenetic modifications at the progesterone receptor-A promoter","volume":"18","author":"Chai","year":"2012","journal-title":"Mol Hum Reprod"},{"key":"2021070802585911900_gaab024-B8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0092-8674(88)90157-2","article-title":"Differential gene activation by glucocorticoids and progestins through the hormone regulatory element of mouse mammary tumor virus","volume":"53","author":"Chalepakis","year":"1988","journal-title":"Cell"},{"key":"2021070802585911900_gaab024-B9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/229208a0","article-title":"Sharp increase in free circulating oestrogens immediately before parturition in sheep","volume":"229","author":"Challis","year":"1971","journal-title":"Nature"},{"key":"2021070802585911900_gaab024-B10","first-page":"514","article-title":"Endocrine and paracrine regulation of birth at term and preterm","volume":"21","author":"Challis","year":"2000","journal-title":"Endocr Rev"},{"key":"2021070802585911900_gaab024-B11","first-page":"985","article-title":"Parturition","volume":"2","author":"Challis","year":"1994","journal-title":"Physiol Reprod"},{"key":"2021070802585911900_gaab024-B12","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1113\/expphysiol.2013.072868","article-title":"Assessment of myometrial transcriptome changes associated with spontaneous human labour by high-throughput RNA-seq","volume":"99","author":"Chan","year":"2014","journal-title":"Exp Physiol"},{"key":"2021070802585911900_gaab024-B13","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.1210\/jc.2004-0873","article-title":"Expression and deoxyribonucleic acid-binding activity of the nuclear factor \u03baB family in the human myometrium during pregnancy and labor","volume":"89","author":"Chapman","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2021070802585911900_gaab024-B14","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/S2214-109X(18)30451-0","article-title":"Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis","volume":"7","author":"Chawanpaiboon","year":"2019","journal-title":"Lancet Glob Health"},{"key":"2021070802585911900_gaab024-B15","doi-asserted-by":"crossref","first-page":"43091","DOI":"10.1074\/jbc.M111.295865","article-title":"Progesterone receptor inhibits proliferation of human breast cancer cells via induction of MAPK phosphatase 1 (MKP-1\/DUSP1)","volume":"286","author":"Chen","year":"2011","journal-title":"J Biol Chem"},{"key":"2021070802585911900_gaab024-B16","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nrm1368","article-title":"Shaping the nuclear action of NF-\u03baB","volume":"5","author":"Chen","year":"2004","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2021070802585911900_gaab024-B17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nsb0198-67","article-title":"A novel DNA recognition mode by the NF-\u03baB p65 homodimer","volume":"5","author":"Chen","year":"1998","journal-title":"Nat Struct Biol"},{"key":"2021070802585911900_gaab024-B18","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1038\/sj.onc.1204385","article-title":"Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity","volume":"20","author":"Chinenov","year":"2001","journal-title":"Oncogene"},{"key":"2021070802585911900_gaab024-B19","doi-asserted-by":"crossref","first-page":"e35859","DOI":"10.1371\/journal.pone.0035859","article-title":"Non-overlapping progesterone receptor cistromes contribute to cell-specific transcriptional outcomes","volume":"7","author":"Clarke","year":"2012","journal-title":"PLoS One"},{"key":"2021070802585911900_gaab024-B20","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1210\/me.2005-0242","article-title":"Up-regulation of the progesterone receptor (PR)-C isoform in laboring myometrium by activation of nuclear factor-\u03baB may contribute to the onset of labor through inhibition of PR function","volume":"20","author":"Condon","year":"2006","journal-title":"Mol Endocrinol"},{"key":"2021070802585911900_gaab024-B21","doi-asserted-by":"crossref","first-page":"4978","DOI":"10.1073\/pnas.0401124101","article-title":"Surfactant protein secreted by the maturing mouse fetal lung acts as a hormone that signals the initiation of parturition","volume":"101","author":"Condon","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021070802585911900_gaab024-B22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cophys.2019.10.017","article-title":"Estrogen\/estrogen receptor action and the pregnant myometrium","volume":"13","author":"Condon","year":"2020","journal-title":"Curr Opin Physiol"},{"key":"2021070802585911900_gaab024-B23","author":"Csapo","year":"1956"},{"key":"2021070802585911900_gaab024-B24","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1073\/pnas.54.4.1069","article-title":"The effect of progesterone on the human uterus","volume":"54","author":"Csapo","year":"1965","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021070802585911900_gaab024-B25","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1210\/er.2002-0006","article-title":"The interplay between the glucocorticoid receptor and nuclear factor-\u03baB or activator protein-1: molecular mechanisms for gene repression","volume":"24","author":"De Bosscher","year":"2003","journal-title":"Endocr Rev"},{"key":"2021070802585911900_gaab024-B26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1210\/jcem-40-1-93","article-title":"Plasma levels of unconjugated estrone, estradiol and estriol and of HCS throughout pregnancy in normal women","volume":"40","author":"De Hertogh","year":"1975","journal-title":"J Clin Endocrinol Metab"},{"key":"2021070802585911900_gaab024-B27","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1210\/me.2008-0357","article-title":"p54nrb is a transcriptional corepressor of the progesterone receptor that modulates transcription of the labor-associated gene, connexin 43 (Gja1)","volume":"23","author":"Dong","year":"2009","journal-title":"Mol Endocrinol"},{"key":"2021070802585911900_gaab024-B28","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1242\/jcs.02892","article-title":"Ablation of connexin43 in uterine smooth muscle cells of the mouse causes delayed parturition","volume":"119","author":"D\u00f6ring","year":"2006","journal-title":"J Cell Sci"},{"key":"2021070802585911900_gaab024-B29","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0140-6736(11)60993-8","article-title":"Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials","volume":"378","author":"Early Breast Cancer Trialists\u2019 Collaborative Group (EBCTCG)","year":"2011","journal-title":"Lancet Lond Engl"},{"key":"2021070802585911900_gaab024-B30","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/molehr\/5.8.757","article-title":"Localization of regulatory protein binding sites in the proximal region of human myometrial connexin 43 gene","volume":"5","author":"Echetebu","year":"1999","journal-title":"Mol Hum Reprod"},{"key":"2021070802585911900_gaab024-B31","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1097\/01.ogx.0000248747.52343.5f","article-title":"Preterm birth: a review of genetic factors and future directions for genetic study","volume":"61","author":"Esplin","year":"2006","journal-title":"Obstet Gynecol Surv"},{"key":"2021070802585911900_gaab024-B32","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1093\/emboj\/19.17.4688","article-title":"Identification of a new isoform of the human estrogen receptor-alpha (hER-\u03b1) that is encoded by distinct transcripts and that is able to repress hER-\u03b1 activation function 1","volume":"19","author":"Flouriot","year":"2000","journal-title":"EMBO J"},{"key":"2021070802585911900_gaab024-B33","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1139\/y82-047","article-title":"Changes of gap junctions in myometrium of guinea pig at parturition and abortion","volume":"60","author":"Garfield","year":"1982","journal-title":"Can J Physiol Pharmacol"},{"key":"2021070802585911900_gaab024-B34","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1095\/biolreprod21.4.999","article-title":"Hormonal control of gap junction formation in sheep myometrium during parturition","volume":"21","author":"Garfield","year":"1979","journal-title":"Biol Reprod"},{"key":"2021070802585911900_gaab024-B35","first-page":"1177","article-title":"Elevated connexin-43 expression in term human myometrium correlates with elevated c-Jun expression and is independent of myometrial estrogen receptors","volume":"83","author":"Geimonen","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"2021070802585911900_gaab024-B36","doi-asserted-by":"crossref","first-page":"23667","DOI":"10.1074\/jbc.271.39.23667","article-title":"Activation of protein kinase C in human uterine smooth muscle induces connexin-43 gene transcription through an AP-1 site in the promoter sequence","volume":"271","author":"Geimonen","year":"1996","journal-title":"J Biol Chem"},{"key":"2021070802585911900_gaab024-B37","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/molehr\/gaw037","article-title":"The study of progesterone action in human myometrial explants","volume":"22","author":"Georgiou","year":"2016","journal-title":"Mol Hum Reprod"},{"key":"2021070802585911900_gaab024-B38","first-page":"219\u2013313; discussion 313","article-title":"The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene","volume":"54","author":"Giangrande","year":"1999","journal-title":"Recent Prog Horm Res"},{"key":"2021070802585911900_gaab024-B39","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/373257a0","article-title":"Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA","volume":"373","author":"Glover","year":"1995","journal-title":"Nature"},{"key":"2021070802585911900_gaab024-B40","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"Goldenberg","year":"2008","journal-title":"Lancet Lond Engl"},{"key":"2021070802585911900_gaab024-B41","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/cmi.2014.46","article-title":"Immune cells in term and preterm labor","volume":"11","author":"Gomez-Lopez","year":"2014","journal-title":"Cell Mol Immunol"},{"key":"2021070802585911900_gaab024-B42","doi-asserted-by":"crossref","first-page":"e6226","DOI":"10.1136\/bmj.e6226","article-title":"Tocolytic therapy for preterm delivery: systematic review and network meta-analysis","volume":"345","author":"Haas","year":"2012","journal-title":"BMJ"},{"key":"2021070802585911900_gaab024-B43","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/0092-8674(88)90147-X","article-title":"c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities","volume":"55","author":"Halazonetis","year":"1988","journal-title":"Cell"},{"key":"2021070802585911900_gaab024-B44","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1095\/biolreprod.111.095505","article-title":"Macrophages infiltrate the human and rat decidua during term and preterm labor: evidence that decidual inflammation precedes labor","volume":"86","author":"Hamilton","year":"2012","journal-title":"Biol Reprod"},{"key":"2021070802585911900_gaab024-B45","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1210\/me.2006-0112","article-title":"Progesterone receptor plays a major antiinflammatory role in human myometrial cells by antagonism of nuclear factor-\u03baB activation of cyclooxygenase 2 expression","volume":"20","author":"Hardy","year":"2006","journal-title":"Mol Endocrinol"},{"key":"2021070802585911900_gaab024-B46","doi-asserted-by":"crossref","first-page":"130","DOI":"10.2471\/BLT.08.050963","article-title":"Neonatal mortality, risk factors and causes: a prospective population-based cohort study in urban Pakistan","volume":"87","author":"Jehan","year":"2009","journal-title":"Bull World Health Organ"},{"key":"2021070802585911900_gaab024-B47","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1471-2431-14-93","article-title":"The economic burden of prematurity in Canada","volume":"14","author":"Johnston","year":"2014","journal-title":"BMC Pediatr"},{"key":"2021070802585911900_gaab024-B48","doi-asserted-by":"crossref","first-page":"6217","DOI":"10.1074\/jbc.271.11.6217","article-title":"Negative interaction between the RelA(p65) subunit of NF-B and the progesterone receptor","volume":"271","author":"Kalkhoven","year":"1996","journal-title":"J Biol Chem"},{"key":"2021070802585911900_gaab024-B49","doi-asserted-by":"crossref","first-page":"16483","DOI":"10.1074\/jbc.270.28.16483","article-title":"The regulation of AP-1 activity by mitogen-activated protein kinases","volume":"270","author":"Karin","year":"1995","journal-title":"J Biol Chem"},{"key":"2021070802585911900_gaab024-B50","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0955-0674(97)80068-3","article-title":"AP-1 function and regulation","volume":"9","author":"Karin","year":"1997","journal-title":"Curr Opin Cell Biol"},{"key":"2021070802585911900_gaab024-B51","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1002\/j.1460-2075.1990.tb08280.x","article-title":"Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B","volume":"9","author":"Kastner","year":"1990","journal-title":"EMBO J"},{"key":"2021070802585911900_gaab024-B52","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1111\/j.1582-4934.2010.01069.x","article-title":"NF-\u03baB regulates a cassette of immune\/inflammatory genes in human pregnant myometrium at term","volume":"15","author":"Khanjani","year":"2011","journal-title":"J Cell Mol Med"},{"key":"2021070802585911900_gaab024-B53","doi-asserted-by":"crossref","first-page":"e504952","DOI":"10.1155\/2012\/504952","article-title":"NF\u03baB and AP-1 drive human myometrial IL8 expression","volume":"2012","author":"Khanjani","year":"2012","journal-title":"Mediators Inflamm"},{"key":"2021070802585911900_gaab024-B54","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1046\/j.1365-201X.1996.500247000.x","article-title":"Progesterone, oestradiol and oxytocin and their in vitro effect on maintaining the number of gap junction plaques in human myometrium at term","volume":"157","author":"Kilarski","year":"1996","journal-title":"Acta Physiol Scand"},{"key":"2021070802585911900_gaab024-B55","first-page":"3","article-title":"Effect of progesterone and oestradiol on expression of connexin43 in cultured human myometrium cells","volume":"38","author":"Kilarski","year":"2000","journal-title":"Folia Histochem Cytobiol"},{"key":"2021070802585911900_gaab024-B56","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1046\/j.0004-8666.2003.00074.x","article-title":"Calcium channel blockers for inhibiting preterm labour; a systematic review of the evidence and a protocol for administration of nifedipine","volume":"43","author":"King","year":"2003","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"2021070802585911900_gaab024-B57","doi-asserted-by":"crossref","first-page":"18868","DOI":"10.1074\/jbc.M212777200","article-title":"CCAAT\/enhancer-binding protein and activator protein-1 transcription factors regulate the expression of interleukin-8 through the mitogen-activated protein kinase pathways in response to mechanical stretch of human airway smooth muscle cells","volume":"278","author":"Kumar","year":"2003","journal-title":"J Biol Chem"},{"key":"2021070802585911900_gaab024-B58","article-title":"Targeting transcription factors for cancer treatment","volume":"23","author":"Lambert","year":"2018","journal-title":"Mol J Synth Chem Nat Prod Chem"},{"key":"2021070802585911900_gaab024-B59","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jri.2013.04.005","article-title":"Forkhead box O1 (FOXO1) in pregnant human myometrial cells: A role as a pro-inflammatory mediator in human parturition","volume":"99","author":"Lappas","year":"2013","journal-title":"J Reprod Immunol"},{"key":"2021070802585911900_gaab024-B60","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1530\/REP-14-0597","article-title":"KLF5 regulates infection- and inflammation-induced pro-labour mediators in human myometrium","volume":"149","author":"Lappas","year":"2015","journal-title":"Reproduction"},{"key":"2021070802585911900_gaab024-B61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/3140420","article-title":"Identification of SMAD3 as a novel mediator of inflammation in human myometrium in vitro","volume":"2018","author":"Lappas","year":"2018","journal-title":"Mediators Inflamm"},{"key":"2021070802585911900_gaab024-B62","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5625\/lar.2012.28.2.71","article-title":"Functions and physiological roles of two types of estrogen receptors, ER\u03b1 and ER\u03b2, identified by estrogen receptor knockout mouse","volume":"28","author":"Lee","year":"2012","journal-title":"Lab Anim Res"},{"key":"2021070802585911900_gaab024-B63","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1093\/hmg\/ddg180","article-title":"A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly","volume":"12","author":"Lettice","year":"2003","journal-title":"Hum Mol Genet"},{"key":"2021070802585911900_gaab024-B64","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1210\/en.2015-2005","article-title":"HoxA13 stimulates myometrial cells to secrete IL-1\u03b2 and enhance the expression of contraction-associated proteins","volume":"157","author":"Li","year":"2016","journal-title":"Endocrinology"},{"key":"2021070802585911900_gaab024-B65","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1177\/1933719117699706","article-title":"HoxA10 and HoxA11 regulate the expression of contraction-associated proteins and contribute to regionalized myometrium phenotypes in women","volume":"25","author":"Li","year":"2018","journal-title":"Reprod Sci"},{"key":"2021070802585911900_gaab024-B66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.113.108126","article-title":"A novel role for FOXO3 in human labor: increased expression in laboring myometrium, and regulation of proinflammatory and prolabor mediators in pregnant human myometrial cells","volume":"88","author":"Lim","year":"2013","journal-title":"Biol Reprod"},{"key":"2021070802585911900_gaab024-B67","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1093\/biolre\/iox080","article-title":"SMAD7 regulates proinflammatory and prolabor mediators in amnion and myometrium","volume":"97","author":"Lim","year":"2017","journal-title":"Biol Reprod"},{"key":"2021070802585911900_gaab024-B68","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1530\/REP-18-0140","article-title":"IRF5 is increased in labouring myometrium and regulates pro-labour mediators","volume":"156","author":"Lim","year":"2018","journal-title":"Reproduction"},{"key":"2021070802585911900_gaab024-B69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.115.134726","article-title":"The transcription factor interferon regulatory factor-1 (IRF1) plays a key role in the terminal effector pathways of human preterm labor1","volume":"94","author":"Lim","year":"2016","journal-title":"Biol Reprod"},{"key":"2021070802585911900_gaab024-B70","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1530\/rep.1.00197","article-title":"The role of nuclear factor kappa B in human labour","volume":"130","author":"Lindstr\u00f6m","year":"2005","journal-title":"Reproduction"},{"key":"2021070802585911900_gaab024-B71","doi-asserted-by":"crossref","first-page":"E1512","DOI":"10.1210\/jc.2015-2815","article-title":"HoxA13 regulates phenotype regionalization of human pregnant myometrium","volume":"100","author":"Liu","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"2021070802585911900_gaab024-B72","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1210\/endo.132.6.8389279","article-title":"Increased expression of connexin-43 in the rat myometrium during labor is associated with an increase in the plasma estrogen:progesterone ratio","volume":"132","author":"Lye","year":"1993","journal-title":"Endocrinology"},{"key":"2021070802585911900_gaab024-B73","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1096\/fj.13-247783","article-title":"Activator protein 1 is a key terminal mediator of inflammation-induced preterm labor in mice","volume":"28","author":"MacIntyre","year":"2014","journal-title":"FASEB J"},{"key":"2021070802585911900_gaab024-B74","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/1933719107302380","article-title":"Progesterone receptor or cytoskeletal protein?","volume":"14","author":"Madsen","year":"2007","journal-title":"Reprod Sci"},{"key":"2021070802585911900_gaab024-B75","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1182\/blood-2015-03-632984","article-title":"Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies","volume":"126","author":"Matthews","year":"2015","journal-title":"Blood"},{"key":"2021070802585911900_gaab024-B76","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1210\/en.2014-1566","article-title":"Progesterone receptor transcriptome and cistrome in decidualized human endometrial stromal cells","volume":"156","author":"Mazur","year":"2015","journal-title":"Endocrinology"},{"key":"2021070802585911900_gaab024-B77","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mce.2008.04.003","article-title":"New insights into the classical and non-classical actions of estrogen: evidence from estrogen receptor knock out and knock in mice","volume":"290","author":"McDevitt","year":"2008","journal-title":"Mol Cell Endocrinol"},{"key":"2021070802585911900_gaab024-B78","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1210\/jc.2007-0077","article-title":"Nuclear progesterone receptors in the human pregnancy myometrium: evidence that parturition involves functional progesterone withdrawal mediated by increased expression of progesterone receptor-A","volume":"92","author":"Merlino","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2021070802585911900_gaab024-B79","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1210\/jcem.87.6.8609","article-title":"Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium","volume":"87","author":"Mesiano","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2021070802585911900_gaab024-B80","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12916-016-0632-4","article-title":"Modeling hormonal and inflammatory contributions to preterm and term labor using uterine temporal transcriptomics","volume":"14","author":"Migale","year":"2016","journal-title":"BMC Med"},{"key":"2021070802585911900_gaab024-B81","doi-asserted-by":"crossref","first-page":"R525","DOI":"10.1152\/ajpregu.00153.2009","article-title":"Are animal models relevant to key aspects of human parturition?","volume":"297","author":"Mitchell","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2021070802585911900_gaab024-B82","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1095\/biolreprod67.1.240","article-title":"Differential expression of activator protein-1 transcription factors in pregnant rat myometrium","volume":"67","author":"Mitchell","year":"2002","journal-title":"Biol Reprod"},{"key":"2021070802585911900_gaab024-B83","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1210\/en.2004-1066","article-title":"Differential activation of the connexin 43 promoter by dimers of activator protein-1 transcription factors in myometrial cells","volume":"146","author":"Mitchell","year":"2005","journal-title":"Endocrinology"},{"key":"2021070802585911900_gaab024-B84","doi-asserted-by":"crossref","first-page":"E439","DOI":"10.1152\/ajpendo.00275.2003","article-title":"Mechanical stretch and progesterone differentially regulate activator protein-1 transcription factors in primary rat myometrial smooth muscle cells","volume":"287","author":"Mitchell","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2021070802585911900_gaab024-B85","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1101\/gr.210930.116","article-title":"Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genes","volume":"27","author":"Moorthy","year":"2017","journal-title":"Genome Res"},{"key":"2021070802585911900_gaab024-B86","author":"Nadeem","year":"2019"},{"key":"2021070802585911900_gaab024-B87","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/jcmm.13335","article-title":"Differential expression of myometrial AP-1 proteins during gestation and labour","volume":"22","author":"Nadeem","year":"2018","journal-title":"J Cell Mol Med"},{"key":"2021070802585911900_gaab024-B88","doi-asserted-by":"crossref","first-page":"11565","DOI":"10.1038\/ncomms11565","article-title":"Molecular evidence of functional progesterone withdrawal in human myometrium","volume":"7","author":"Nadeem","year":"2016","journal-title":"Nat Commun"},{"key":"2021070802585911900_gaab024-B89","doi-asserted-by":"crossref","first-page":"13357","DOI":"10.1038\/s41598-017-13488-9","article-title":"Progesterone via its type-A receptor promotes myometrial gap junction coupling","volume":"7","author":"Nadeem","year":"2017","journal-title":"Sci Rep"},{"key":"2021070802585911900_gaab024-B90","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/0092-8674(88)90146-8","article-title":"DNA binding activities of three murine Jun proteins: stimulation by Fos","volume":"55","author":"Nakabeppu","year":"1988","journal-title":"Cell"},{"key":"2021070802585911900_gaab024-B91","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1073\/pnas.75.4.2044","article-title":"Opposing effects of estradiol and progesterone on oxytocin receptors in rabbit uterus","volume":"75","author":"Nissenson","year":"1978","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021070802585911900_gaab024-B92","doi-asserted-by":"crossref","first-page":"C1530","DOI":"10.1152\/ajpcell.00607.2001","article-title":"Mitogen-activated protein kinases mediate stretch-induced c-fos mRNA expression in myometrial smooth muscle cells","volume":"283","author":"Oldenhof","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"key":"2021070802585911900_gaab024-B93","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0092-8674(92)90145-3","article-title":"Mechanism of specificity in the Fos-Jun oncoprotein heterodimer","volume":"68","author":"O\u2019Shea","year":"1992","journal-title":"Cell"},{"key":"2021070802585911900_gaab024-B94","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/molehr\/gag001","article-title":"Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term","volume":"9","author":"Osman","year":"2003","journal-title":"Mol Hum Reprod"},{"key":"2021070802585911900_gaab024-B95","doi-asserted-by":"crossref","first-page":"10696","DOI":"10.1074\/jbc.273.17.10696","article-title":"Progesterone regulates transcription of the p21 WAF1 cyclindependent kinase inhibitor gene through Sp1 and CBP\/p300","volume":"273","author":"Owen","year":"1998","journal-title":"J Biol Chem"},{"key":"2021070802585911900_gaab024-B96","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1210\/jc.2014-2846","article-title":"Prolonged pregnancy in women is associated with attenuated myometrial expression of progesterone receptor co-regulator Kr\u00fcppel-like factor 9","volume":"100","author":"Pabona","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"2021070802585911900_gaab024-B97","doi-asserted-by":"crossref","first-page":"e12494","DOI":"10.1097\/MD.0000000000012494","article-title":"Interaction between NF-\u03baB and AP-1 and their intracellular localization at labor in human late pregnant myometrial cells in vivo and in vitro","volume":"97","author":"Peng","year":"2018","journal-title":"Medicine"},{"key":"2021070802585911900_gaab024-B98","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1210\/endo.133.1.8391423","article-title":"Regulation of transcripts encoding the myometrial gap junction protein, connexin-43, by estrogen and progesterone","volume":"133","author":"Petrocelli","year":"1993","journal-title":"Endocrinology"},{"key":"2021070802585911900_gaab024-B99","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1210\/jc.2004-1962","article-title":"Regulation of expression of the chorionic gonadotropin\/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases","volume":"90","author":"Phillips","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2021070802585911900_gaab024-B100","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/molehr\/7.9.875","article-title":"Interactions between progesterone receptor isoforms in myometrial cells in human labour","volume":"7","author":"Pieber","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"2021070802585911900_gaab024-B101","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1210\/me.2004-0302","article-title":"Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20\u03b1-hydroxysteroid dehydrogenase","volume":"19","author":"Piekorz","year":"2005","journal-title":"Mol Endocrinol"},{"key":"2021070802585911900_gaab024-B102","doi-asserted-by":"crossref","first-page":"E640","DOI":"10.1152\/ajpendo.00063.2010","article-title":"SK3 channel expression during pregnancy is regulated through estrogen and Sp factor-mediated transcriptional control of the KCNN3 gene","volume":"299","author":"Pierce","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2021070802585911900_gaab024-B103","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1530\/REP-15-0258","article-title":"Specific inhibition of c-Jun N-terminal kinase delays preterm labour and reduces mortality","volume":"150","author":"Pirianov","year":"2015","journal-title":"Reproduction"},{"key":"2021070802585911900_gaab024-B104","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1172\/JCI114110","article-title":"Mithramycin blocks protein binding and function of the SV40 early promoter","volume":"83","author":"Ray","year":"1989","journal-title":"J Clin Invest"},{"key":"2021070802585911900_gaab024-B105","doi-asserted-by":"crossref","first-page":"a023069","DOI":"10.1101\/cshperspect.a023069","article-title":"Molecular regulation of parturition: a myometrial perspective","volume":"5","author":"Renthal","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2021070802585911900_gaab024-B106","doi-asserted-by":"crossref","first-page":"re1","DOI":"10.1126\/stke.1999.5.re1","article-title":"The NF-\u03baB activation pathway: a paradigm in information transfer from membrane to nucleus","volume":"1999","author":"Rothwarf","year":"1999","journal-title":"Sci STKE"},{"key":"2021070802585911900_gaab024-B107","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0002-9378(11)91699-8","article-title":"Studies of connexin 43 and cell-to-cell coupling in cultured human uterine smooth muscle","volume":"167","author":"Sakai","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"2021070802585911900_gaab024-B108","doi-asserted-by":"crossref","first-page":"5872","DOI":"10.1210\/en.2008-0602","article-title":"Systematic expression analysis and antibody screening do not support the existence of naturally occurring progesterone receptor (PR)-C, PR-M, or other truncated PR isoforms","volume":"149","author":"Samalecos","year":"2008","journal-title":"Endocrinology"},{"key":"2021070802585911900_gaab024-B109","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nature11279","article-title":"The long-range interaction landscape of gene promoters","volume":"489","author":"Sanyal","year":"2012","journal-title":"Nature"},{"key":"2021070802585911900_gaab024-B110","doi-asserted-by":"crossref","first-page":"E44","DOI":"10.9778\/cmajo.20170128","article-title":"The Canadian Preterm Birth Network: a study protocol for improving outcomes for preterm infants and their families","volume":"6","author":"Shah","year":"2018","journal-title":"CMAJ Open"},{"key":"2021070802585911900_gaab024-B111","doi-asserted-by":"crossref","first-page":"e3000710","DOI":"10.1371\/journal.pbio.3000710","article-title":"The pregnant myometrium is epigenetically activated at contractility-driving gene loci prior to the onset of labor in mice","volume":"18","author":"Shchuka","year":"2020","journal-title":"PLoS Biol"},{"key":"2021070802585911900_gaab024-B112","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/1933719112446084","article-title":"Physiologic uterine inflammation and labor onset: integration of endocrine and mechanical signals","volume":"20","author":"Shynlova","year":"2013","journal-title":"Reprod Sci Thousand Sci"},{"key":"2021070802585911900_gaab024-B113","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1095\/biolreprod.103.023648","article-title":"Progesterone and gravidity differentially regulate expression of extracellular matrix components in the pregnant rat myometrium","volume":"70","author":"Shynlova","year":"2004","journal-title":"Biol Reprod"},{"key":"2021070802585911900_gaab024-B115","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1582-4934.2012.01650.x","article-title":"Myometrial immune cells contribute to term parturition, preterm labour and post-partum involution in mice","volume":"17","author":"Shynlova","year":"2013","journal-title":"J Cell Mol Med"},{"key":"2021070802585911900_gaab024-B116","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1095\/biolreprod.105.040006","article-title":"Expression and localization of alpha-smooth muscle and gamma-actins in the pregnant rat myometrium","volume":"73","author":"Shynlova","year":"2005","journal-title":"Biol Reprod"},{"issue":"Suppl 1","key":"2021070802585911900_gaab024-B117","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.ejogrb.2009.02.044","article-title":"Integration of endocrine and mechanical signals in the regulation of myometrial functions during pregnancy and labour","volume":"144","author":"Shynlova","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2021070802585911900_gaab024-B118","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/molehr\/gah021","article-title":"Mechanical stretch activates type 2 cyclooxygenase via activator protein-1 transcription factor in human myometrial cells","volume":"10","author":"Sooranna","year":"2004","journal-title":"Mol Hum Reprod"},{"key":"2021070802585911900_gaab024-B119","first-page":"1","article-title":"Myometrial transcriptional signatures of human parturition","volume":"10","author":"Stanfield","year":"2019","journal-title":"Front Genet"},{"key":"2021070802585911900_gaab024-B120","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1126\/science.277.5326.681","article-title":"Failure of parturition in mice lacking the prostaglandin F receptor","volume":"277","author":"Sugimoto","year":"1997","journal-title":"Science"},{"key":"2021070802585911900_gaab024-B121","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein\u2013protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2021070802585911900_gaab024-B122","doi-asserted-by":"crossref","first-page":"E719","DOI":"10.1210\/jc.2011-3251","article-title":"Progesterone receptor-A and -B have opposite effects on proinflammatory gene expression in human myometrial cells: implications for progesterone actions in human pregnancy and parturition","volume":"97","author":"Tan","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2021070802585911900_gaab024-B123","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1210\/jc.2004-0277","article-title":"Mechanical stretch up-regulates the human oxytocin receptor in primary human uterine myocytes","volume":"90","author":"Terzidou","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2021070802585911900_gaab024-B124","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/humrep\/14.1.229","article-title":"Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process","volume":"14","author":"Thomson","year":"1999","journal-title":"Hum Reprod Oxf Engl"},{"key":"2021070802585911900_gaab024-B125","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S1097-2765(02)00781-5","article-title":"Looping and interaction between hypersensitive sites in the active beta-globin locus","volume":"10","author":"Tolhuis","year":"2002","journal-title":"Mol Cell"},{"key":"2021070802585911900_gaab024-B126","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1089\/104454903770238102","article-title":"Progesterone receptor (hPR) upregulates the fibronectin promoter activity in human decidual fibroblasts","volume":"22","author":"Tseng","year":"2003","journal-title":"DNA Cell Biol"},{"key":"2021070802585911900_gaab024-B127","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1210\/endo.141.1.7236","article-title":"Uterine expression of prostaglandin H2 synthase in late pregnancy and during parturition in prostaglandin F receptor-deficient mice","volume":"141","author":"Tsuboi","year":"2000","journal-title":"Endocrinology"},{"key":"2021070802585911900_gaab024-B128","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1477-7827-8-8","article-title":"Nuclear factor-kappa B localization and function within intrauterine tissues from term and preterm labor and cultured fetal membranes","volume":"8","author":"Vora","year":"2010","journal-title":"Reprod Biol Endocrinol"},{"key":"2021070802585911900_gaab024-B129","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.1093\/nar\/gkq537","article-title":"The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function","volume":"38","author":"Warde-Farley","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"2021070802585911900_gaab024-B130","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1210\/mend-4-12-1833","article-title":"5\u2032-Heterogeneity in human progesterone receptor transcripts predicts a new amino-terminal truncated \u201cC\u201d-receptor and unique A-receptor messages","volume":"4","author":"Wei","year":"1990","journal-title":"Mol Endocrinol"},{"key":"2021070802585911900_gaab024-B131","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0960-0760(97)00044-7","article-title":"An N-terminally truncated third progesterone receptor protein, PRC, forms heterodimers with PRB but interferes in PRB-DNA binding","volume":"62","author":"Wei","year":"1997","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2021070802585911900_gaab024-B132","first-page":"4421","article-title":"Endocrinology of parturition","volume":"85","author":"Weiss","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"2021070802585911900_gaab024-B133","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/emboj.2009.88","article-title":"ChIP-Seq of ER\u03b1 and RNA polymerase II defines genes differentially responding to ligands","volume":"28","author":"Welboren","year":"2009","journal-title":"EMBO J"},{"key":"2021070802585911900_gaab024-B134","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1530\/JOE-11-0358","article-title":"Estrogen receptor (ER) expression and function in the pregnant human myometrium: estradiol via ER\u03b1 activates ERK1\/2 signaling in term myometrium","volume":"212","author":"Welsh","year":"2012","journal-title":"J Endocrinol"},{"key":"2021070802585911900_gaab024-B135","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1096\/fj.201902654R","article-title":"Dynamic transcriptome, accessible genome, and PGR cistrome profiles in the human myometrium","volume":"34","author":"Wu","year":"2020","journal-title":"FASEB J"},{"key":"2021070802585911900_gaab024-B136","first-page":"171","volume-title":"Curr Top Dev Biol","author":"Wu","year":"2017"},{"key":"2021070802585911900_gaab024-B137","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1210\/endo.138.9.5394","article-title":"Regulation of prostaglandin endoperoxide H synthase 1 and 2 by estradiol and progesterone in nonpregnant ovine myometrium and endometrium in vivo","volume":"138","author":"Wu","year":"1997","journal-title":"Endocrinology"},{"key":"2021070802585911900_gaab024-B138","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1071-55760300116-3","article-title":"The role of leukocyte traffic and activation in parturition","volume":"10","author":"Yellon","year":"2003","journal-title":"J Soc Gynecol Investig"},{"key":"2021070802585911900_gaab024-B139","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1095\/biolreprod.107.065821","article-title":"Delayed parturition and altered myometrial progesterone receptor isoform A expression in mice null for Kr\u00fcppel-like factor 9","volume":"78","author":"Zeng","year":"2008","journal-title":"Biol Reprod"},{"key":"2021070802585911900_gaab024-B140","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s12967-014-0222-1","article-title":"Down-regulation of Sp1 suppresses cell proliferation, clonogenicity and the expressions of stem cell markers in nasopharyngeal carcinoma","volume":"12","author":"Zhang","year":"2014","journal-title":"J Transl Med"}],"container-title":["Molecular Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/molehr\/advance-article-pdf\/doi\/10.1093\/molehr\/gaab024\/36925442\/gaab024.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/molehr\/article-pdf\/27\/5\/gaab024\/37940712\/gaab024.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/molehr\/article-pdf\/27\/5\/gaab024\/37940712\/gaab024.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T08:56:14Z","timestamp":1671785774000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molehr\/article\/doi\/10.1093\/molehr\/gaab024\/6212651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,6]]},"references-count":139,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5,8]]}},"URL":"https:\/\/doi.org\/10.1093\/molehr\/gaab024","relation":{},"ISSN":["1360-9947","1460-2407"],"issn-type":[{"value":"1360-9947","type":"print"},{"value":"1460-2407","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,5,1]]},"published":{"date-parts":[[2021,4,6]]},"article-number":"gaab024"}}