{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:13:34Z","timestamp":1783721614451,"version":"3.55.0"},"reference-count":89,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T00:00:00Z","timestamp":1644624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["APP1126795"],"award-info":[{"award-number":["APP1126795"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"name":"AISRF EMCR Fellowship by the Australian Academy of Science, and Australian Women Research Success Grant","award":["AWRSG 2020\/2021"],"award-info":[{"award-number":["AWRSG 2020\/2021"]}]},{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Changes in cell phenotype are thought to occur through the expression of groups of co-regulated genes within topologically associated domains (TADs). In this paper, we allocate genes expressed within the myometrium of the human uterus during the onset of term labour into TADs. Transformation of the myometrial cells of the uterus into a contractile phenotype during term human labour is the result of a complex interaction of different epigenomic and genomic layers. Recent work suggests that the transcription factor (TF) RELA lies at the top of this regulatory network. Using deep RNA sequencing (RNAseq) analysis of myometrial samples (n = 16) obtained at term from women undergoing caesarean section prior to or after the onset of labour, we have identified evidence for how other gene expression regulatory elements interact with TFs in the labour phenotype transition. Gene set enrichment analysis of our RNAseq data identified three modules of enriched genes (M1, M2 and M3), which in gene ontology studies are linked to matrix degradation, smooth muscle and immune gene signatures, respectively. These genes were predominantly located within chromosomal TADs suggesting co-regulation of expression. Our transcriptomic analysis also identified significant differences in the expression of long non-coding RNAs (lncRNA), microRNAs (miRNA) and TFs that were predicted to target genes within the TADs. Additionally, network analysis revealed 15 new lncRNA (MCM3AP-AS1, TUG1, MIR29B2CHG, HCG18, LINC00963, KCNQ1OT1, NEAT1, HELLPAR, SNHG16, NUTM2B-AS1, MALAT1, PSMA3-AS1, GABPB1-AS1, NORAD and NKILA) and 4 miRNA (mir-145, mir-223, mir-let-7a and mir-132) as top gene hubs with three TFs (NFKB1, RELA and ESR1) as master regulators. Together, these factors are likely to be involved in co-regulatory networks driving a myometrial transformation to generate an estrogen-sensitive phenotype. We conclude that lncRNA and miRNA targeting the estrogen receptor 1 and nuclear factor kappa B pathways play a key role in the initiation of human labour. For the first time, we perform an integrative analysis to present a multi-level genomic signature made of mRNA, non-coding RNA and TFs in the myometrium for spontaneous term labour.<\/jats:p>","DOI":"10.1093\/molehr\/gaac003","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T12:09:34Z","timestamp":1644235774000},"source":"Crossref","is-referenced-by-count":7,"title":["Transcriptomic analysis reveals myometrial topologically associated domains linked to the onset of human term labour"],"prefix":"10.1093","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0181-6258","authenticated-orcid":false,"given":"Sonika","family":"Tyagi","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Central Clinical School, Monash University and the Alfred Hospital, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eng-Cheng","family":"Chan","sequence":"additional","affiliation":[{"name":"Mothers and Babies Research Centre, HMRI University of Newcastle, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Barker","sequence":"additional","affiliation":[{"name":"University of Newcastle, Newcastle, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"McElduff","sequence":"additional","affiliation":[{"name":"University of Newcastle, Newcastle, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly A","family":"Taylor","sequence":"additional","affiliation":[{"name":"Mothers and Babies Research Centre, HMRI University of Newcastle, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Riveros","sequence":"additional","affiliation":[{"name":"University of Newcastle, Newcastle, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esha","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Biochemical Engineering, Indian Institute of Technology, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4720-0280","authenticated-orcid":false,"given":"Roger","family":"Smith","sequence":"additional","affiliation":[{"name":"Mothers and Babies Research Centre, HMRI University of Newcastle, NSW, Australia"},{"name":"University of Newcastle, Newcastle, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,12]]},"reference":[{"key":"2022031113101018600_gaac003-B1","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/biolre\/ioy040","article-title":"Integrated microRNA and mRNA network analysis of the human myometrial transcriptome in the transition from quiescence to labor","volume":"98","author":"Ackerman","year":"2018","journal-title":"Biol Reprod"},{"key":"2022031113101018600_gaac003-B2","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/hmg\/ddq519","article-title":"miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock","volume":"20","author":"Alvarez-Saavedra","year":"2011","journal-title":"Hum Mol Genet"},{"key":"2022031113101018600_gaac003-B3","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.4161\/cc.9.21.13674","article-title":"The role of miR-31 and its target gene SATB2 in cancer-associated fibroblasts","volume":"9","author":"Aprelikova","year":"2010","journal-title":"Cell Cycle"},{"key":"2022031113101018600_gaac003-B4","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1210\/me.2003-0007","article-title":"Microarray analysis of uterine gene expression in mouse and human pregnancy","volume":"17","author":"Bethin","year":"2003","journal-title":"Mol Endocrinol"},{"key":"2022031113101018600_gaac003-B5","doi-asserted-by":"crossref","first-page":"D344","DOI":"10.1093\/nar\/gkaa977","article-title":"The InterPro protein families and domains database: 20 years on","volume":"49","author":"Blum","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2022031113101018600_gaac003-B6","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nrg.2016.147","article-title":"Erratum: organization and function of the 3D genome","volume":"17","author":"Bonev","year":"2016","journal-title":"Nat Rev Genet"},{"key":"2022031113101018600_gaac003-B7","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.1371\/journal.pmed.0030169","article-title":"Labor-associated gene expression in the human uterine fundus, lower segment, and cervix","volume":"3","author":"Bukowski","year":"2006","journal-title":"PLoS Med"},{"key":"2022031113101018600_gaac003-B8","doi-asserted-by":"crossref","first-page":"W523","DOI":"10.1093\/nar\/gkz410","article-title":"LnCompare: gene set feature analysis for human long non-coding RNAs","volume":"47","author":"Carlevaro-Fita","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2022031113101018600_gaac003-B9","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s42003-019-0741-7","article-title":"Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis","volume":"3","author":"Carlevaro-Fita","year":"2020","journal-title":"Commun Biol"},{"key":"2022031113101018600_gaac003-B10","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1210\/jcem.87.6.8439","article-title":"Human myometrial genes are differentially expressed in labor: a suppression subtractive hybridization study","volume":"87","author":"Chan","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2022031113101018600_gaac003-B11","doi-asserted-by":"crossref","first-page":"W244","DOI":"10.1093\/nar\/gkaa467","article-title":"miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology","volume":"48","author":"Chang","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2022031113101018600_gaac003-B12","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1093\/bioinformatics\/btt426","article-title":"Novel human lncRNA\u2013disease association inference based on lncRNA expression profiles","volume":"29","author":"Chen","year":"2013","journal-title":"Bioinformatics"},{"key":"2022031113101018600_gaac003-B13","doi-asserted-by":"crossref","first-page":"5861","DOI":"10.1038\/s41598-019-42166-1","article-title":"First trimester circulating microRNA biomarkers predictive of subsequent preterm delivery and cervical shortening","volume":"9","author":"Cook","year":"2019","journal-title":"Sci Rep"},{"key":"2022031113101018600_gaac003-B14","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1016\/j.febslet.2013.06.023","article-title":"MicroRNA-133b stimulates ovarian estradiol synthesis by targeting Foxl2","volume":"587","author":"Dai","year":"2013","journal-title":"FEBS Lett"},{"key":"2022031113101018600_gaac003-B15","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nature14222","article-title":"Chromatin architecture reorganization during stem cell differentiation","volume":"518","author":"Dixon","year":"2015","journal-title":"Nature"},{"key":"2022031113101018600_gaac003-B16","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature11082","article-title":"Topological domains in mammalian genomes identified by analysis of chromatin interactions","volume":"485","author":"Dixon","year":"2012","journal-title":"Nature"},{"key":"2022031113101018600_gaac003-B17","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1067\/mob.2002.119188","article-title":"Plasma corticotropin-releasing hormone and unconjugated estriol in human pregnancy: gestational patterns and ability to predict preterm delivery","volume":"186","author":"Ellis","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"2022031113101018600_gaac003-B18","doi-asserted-by":"crossref","first-page":"221.e1","DOI":"10.1016\/j.ajog.2013.12.043","article-title":"Distinct cervical microRNA profiles are present in women destined to have a preterm birth","volume":"210","author":"Elovitz","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"2022031113101018600_gaac003-B19","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.ajog.2004.12.021","article-title":"The use of cDNA microarray to identify differentially expressed labor-associated genes within the human myometrium during labor","volume":"193","author":"Esplin","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"2022031113101018600_gaac003-B20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/nature19800","article-title":"Formation of new chromatin domains determines pathogenicity of genomic duplications","volume":"538","author":"Franke","year":"2016","journal-title":"Nature"},{"key":"2022031113101018600_gaac003-B21","doi-asserted-by":"crossref","first-page":"D766","DOI":"10.1093\/nar\/gky955","article-title":"GENCODE reference annotation for the human and mouse genomes","volume":"47","author":"Frankish","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2022031113101018600_gaac003-B22","first-page":"D58","article-title":"EnhancerAtlas 2.0: an updated resource with enhancer annotation in 586 tissue\/cell types across nine species","volume":"48","author":"Gao","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2022031113101018600_gaac003-B23","doi-asserted-by":"crossref","first-page":"e0215495","DOI":"10.1371\/journal.pone.0215495","article-title":"CiiiDER: a tool for predicting and analysing transcription factor binding sites","volume":"14","author":"Gearing","year":"2019","journal-title":"PLoS One"},{"key":"2022031113101018600_gaac003-B24","doi-asserted-by":"crossref","first-page":"25963","DOI":"10.18632\/oncotarget.15657","article-title":"MicroRNA regulation of progesterone receptor in breast cancer","volume":"8","author":"Gilam","year":"2017","journal-title":"Oncotarget"},{"key":"2022031113101018600_gaac003-B25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s43586-021-00018-1","article-title":"CLIP and complementary methods","volume":"1","author":"Hafner","year":"2021","journal-title":"Nat Rev Methods Primers"},{"key":"2022031113101018600_gaac003-B26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12884-016-0857-4","article-title":"Diagnosing onset of labor: a systematic review of definitions in the research literature","volume":"16","author":"Hanley","year":"2016","journal-title":"BMC Pregnancy Childbirth"},{"key":"2022031113101018600_gaac003-B27","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.molcel.2012.08.031","article-title":"Gene density, transcription, and insulators contribute to the partition of the Drosophila genome into physical domains","volume":"48","author":"Hou","year":"2012","journal-title":"Mol Cell"},{"key":"2022031113101018600_gaac003-B28","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/s41590-018-0207-y","article-title":"NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death","volume":"19","author":"Huang","year":"2018","journal-title":"Nat Immunol"},{"key":"2022031113101018600_gaac003-B29","doi-asserted-by":"crossref","first-page":"62520","DOI":"10.18632\/oncotarget.11528","article-title":"Long non-coding RNA NKILA inhibits migration and invasion of tongue squamous cell carcinoma cells via suppressing epithelial-mesenchymal transition","volume":"7","author":"Huang","year":"2016","journal-title":"Oncotarget"},{"key":"2022031113101018600_gaac003-B30","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1053\/plac.2002.0948","article-title":"Cytokines, Prostaglandins and parturition\u2014a review","volume":"24","author":"Keelan","year":"2003","journal-title":"Placenta"},{"key":"2022031113101018600_gaac003-B31","doi-asserted-by":"crossref","first-page":"D1284","DOI":"10.1093\/nar\/gkx1188","article-title":"JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework","volume":"46","author":"Khan","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2022031113101018600_gaac003-B32","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat Biotechnol"},{"key":"2022031113101018600_gaac003-B33","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4103\/2230-8210.107841","article-title":"Endocrinology of parturition","volume":"17","author":"Kota","year":"2013","journal-title":"Indian J Endocrinol Metab"},{"key":"2022031113101018600_gaac003-B34","doi-asserted-by":"crossref","first-page":"D155","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: from microRNA sequences to function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2022031113101018600_gaac003-B35","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1038\/leu.2014.133","article-title":"Notch and NF-kB signaling pathways regulate miR-223\/FBXW7 axis in T-cell acute lymphoblastic leukemia","volume":"28","author":"Kumar","year":"2014","journal-title":"Leukemia"},{"key":"2022031113101018600_gaac003-B36","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1534\/g3.112.003202","article-title":"oPOSSUM-3: advanced analysis of regulatory motif over-representation across genes or ChIP-Seq datasets","volume":"2","author":"Kwon","year":"2012","journal-title":"G3 (Bethesda)"},{"key":"2022031113101018600_gaac003-B37","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"voom: precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol"},{"key":"2022031113101018600_gaac003-B38","doi-asserted-by":"crossref","first-page":"D458","DOI":"10.1093\/nar\/gkaa937","article-title":"SMART: recent updates, new developments and status in 2020","volume":"49","author":"Letunic","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2022031113101018600_gaac003-B39","first-page":"2679","article-title":"Enhancer-gene rewiring in the pathogenesis of Quebec platelet disorder","volume":"136","author":"Liang","year":"2020","journal-title":"Blood"},{"key":"2022031113101018600_gaac003-B40","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"2022031113101018600_gaac003-B41","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkz114","article-title":"The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads","volume":"47","author":"Liao","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2022031113101018600_gaac003-B42","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1126\/science.1181369","article-title":"Comprehensive mapping of long-range interactions reveals folding principles of the human genome","volume":"326","author":"Lieberman-Aiden","year":"2009","journal-title":"Science"},{"key":"2022031113101018600_gaac003-B43","doi-asserted-by":"crossref","first-page":"D189","DOI":"10.1093\/nar\/gkz804","article-title":"RNAInter in 2020: RNA interactome repository with increased coverage and annotation","volume":"48","author":"Lin","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2022031113101018600_gaac003-B44","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.ccell.2015.02.004","article-title":"A cytoplasmic NF-\u03baB interacting long noncoding RNA blocks I\u03baB phosphorylation and suppresses breast cancer metastasis","volume":"27","author":"Liu","year":"2015","journal-title":"Cancer Cell"},{"key":"2022031113101018600_gaac003-B45","doi-asserted-by":"crossref","first-page":"e0121256","DOI":"10.1371\/journal.pone.0121256","article-title":"Let-7 miRNAs modulate the activation of NF-\u03baB by targeting TNFAIP3 and are involved in the pathogenesis of lupus nephritis","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"key":"2022031113101018600_gaac003-B46","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13048-015-0162-2","article-title":"MicroRNAs in ovarian function and disorders","volume":"8","author":"Li","year":"2015","journal-title":"J Ovarian Res"},{"key":"2022031113101018600_gaac003-B47","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/biolre\/iox186","article-title":"Delineating differential regulatory signatures of the human transcriptome in the choriodecidua and myometrium at term labor","volume":"98","author":"Lui","year":"2018","journal-title":"Biol Reprod"},{"key":"2022031113101018600_gaac003-B48","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.cell.2015.04.004","article-title":"Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions","volume":"161","author":"Lupi\u00e1\u00f1ez","year":"2015","journal-title":"Cell"},{"key":"2022031113101018600_gaac003-B49","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nm0595-460","article-title":"A placental clock controlling the length of human pregnancy","volume":"1","author":"McLean","year":"1995","journal-title":"Nat Med"},{"key":"2022031113101018600_gaac003-B50","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.celrep.2019.02.003","article-title":"Cell-type-specific gene expression profiling in adult mouse brain reveals normal and disease-state signatures","volume":"26","author":"Merienne","year":"2019","journal-title":"Cell Rep"},{"key":"2022031113101018600_gaac003-B51","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1210\/jcem.87.6.8609","article-title":"Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium","volume":"87","author":"Mesiano","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2022031113101018600_gaac003-B52","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1515\/jpm.2010.097","article-title":"Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term","volume":"38","author":"Mittal","year":"2010","journal-title":"J Perinat Med"},{"key":"2022031113101018600_gaac003-B53","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat Genet"},{"key":"2022031113101018600_gaac003-B54","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12957-017-1127-2","article-title":"Identification and interaction analysis of key genes and microRNAs in hepatocellular carcinoma by bioinformatics analysis","volume":"15","author":"Mou","year":"2017","journal-title":"World J Surg Oncol"},{"key":"2022031113101018600_gaac003-B55","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13072-019-0317-2","article-title":"The distributions of protein coding genes within chromatin domains in relation to human disease","volume":"12","author":"Muro","year":"2019","journal-title":"Epigenetics Chromatin"},{"key":"2022031113101018600_gaac003-B56","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.jbiomech.2015.02.065","article-title":"The mechanical role of the cervix in pregnancy","volume":"48","author":"Myers","year":"2015","journal-title":"J Biomech"},{"key":"2022031113101018600_gaac003-B57","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1126\/science.1262088","article-title":"CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation","volume":"347","author":"Narendra","year":"2015","journal-title":"Science"},{"key":"2022031113101018600_gaac003-B58","doi-asserted-by":"crossref","first-page":"D980","DOI":"10.1093\/nar\/gkv1094","article-title":"Lnc2Cancer: a manually curated database of experimentally supported lncRNAs associated with various human cancers","volume":"44","author":"Ning","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2022031113101018600_gaac003-B59","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nature11049","article-title":"Spatial partitioning of the regulatory landscape of the X-inactivation centre","volume":"485","author":"Nora","year":"2012","journal-title":"Nature"},{"key":"2022031113101018600_gaac003-B60","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2217\/epi.13.55","article-title":"Epigenetic role of miRNAs in normal and leukemic hematopoiesis","volume":"5","author":"Pagano","year":"2013","journal-title":"Epigenomics"},{"key":"2022031113101018600_gaac003-B61","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.cell.2013.04.053","article-title":"Architectural protein subclasses shape 3D organization of genomes during lineage commitment","volume":"153","author":"Phillips-Cremins","year":"2013","journal-title":"Cell"},{"key":"2022031113101018600_gaac003-B62","doi-asserted-by":"crossref","first-page":"589697","DOI":"10.3389\/fgene.2020.589697","article-title":"Evolution of genome-organizing long non-coding RNAs in metazoans","volume":"11","author":"Ram\u00edrez-Colmenero","year":"2020","journal-title":"Front Genet"},{"key":"2022031113101018600_gaac003-B63","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.cell.2014.11.021","article-title":"A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping","volume":"159","author":"Rao","year":"2014","journal-title":"Cell"},{"key":"2022031113101018600_gaac003-B64","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41596-018-0103-9","article-title":"Pathway enrichment analysis and visualization of omics data using g:Profiler, GSEA, Cytoscape and EnrichmentMap","volume":"14","author":"Reimand","year":"2019","journal-title":"Nat Protoc"},{"key":"2022031113101018600_gaac003-B65","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"2022031113101018600_gaac003-B66","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.3109\/14767058.2013.860963","article-title":"Transcriptome interrogation of human myometrium identifies differentially expressed sense-antisense pairs of protein-coding and long non-coding RNA genes in spontaneous labor at term","volume":"27","author":"Romero","year":"2014","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2022031113101018600_gaac003-B67","doi-asserted-by":"crossref","first-page":"e276","DOI":"10.1371\/journal.pmed.0030276","article-title":"Insights into the physiology of childbirth using transcriptomics","volume":"3","author":"Romero","year":"2006","journal-title":"PLoS Med"},{"key":"2022031113101018600_gaac003-B68","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12859-018-2053-1","article-title":"CEMiTool: a Bioconductor package for performing comprehensive modular co-expression analyses","volume":"19","author":"Russo","year":"2018","journal-title":"BMC Bioinformatics"},{"key":"2022031113101018600_gaac003-B69","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1158\/0008-5472.CAN-10-2345","article-title":"MicroRNAs miR-199a-5p and \u22123p target the Brm subunit of SWI\/SNF to generate a double-negative feedback loop in a variety of human cancers","volume":"71","author":"Sakurai","year":"2011","journal-title":"Cancer Res"},{"key":"2022031113101018600_gaac003-B70","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","article-title":"A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?","volume":"146","author":"Salmena","year":"2011","journal-title":"Cell"},{"key":"2022031113101018600_gaac003-B71","doi-asserted-by":"crossref","first-page":"D91","DOI":"10.1093\/nar\/gkh012","article-title":"JASPAR: an open-access database for eukaryotic transcription factor binding profiles","volume":"32","author":"Sandelin","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"2022031113101018600_gaac003-B72","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.cell.2012.01.010","article-title":"Three-dimensional folding and functional organization principles of the Drosophila genome","volume":"148","author":"Sexton","year":"2012","journal-title":"Cell"},{"key":"2022031113101018600_gaac003-B73","doi-asserted-by":"crossref","first-page":"e0155413","DOI":"10.1371\/journal.pone.0155413","article-title":"Transcription analysis of the myometrium of labouring and non-labouring women","volume":"11","author":"Sharp","year":"2016","journal-title":"PLoS One"},{"key":"2022031113101018600_gaac003-B74","doi-asserted-by":"crossref","first-page":"319fs51","DOI":"10.1126\/scitranslmed.aad9788","article-title":"Reapplying the uterine brake in preterm labor","volume":"7","author":"Smith","year":"2015","journal-title":"Sci Transl Med"},{"key":"2022031113101018600_gaac003-B75","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ebiom.2018.12.012","article-title":"Do estrogen receptor variants explain the enigma of human birth?","volume":"39","author":"Smith","year":"2019","journal-title":"EBioMedicine"},{"key":"2022031113101018600_gaac003-B76","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.tem.2012.05.002","article-title":"Recent advances in understanding the endocrinology of human birth","volume":"23","author":"Smith","year":"2012","journal-title":"Trends Endocrinol Metab"},{"key":"2022031113101018600_gaac003-B77","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1113\/EP088155","article-title":"Sharpey-Schafer Lecture 2019: from retroviruses to human birth","volume":"105","author":"Smith","year":"2020","journal-title":"Exp Physiol"},{"key":"2022031113101018600_gaac003-B78","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1210\/jc.2008-2257","article-title":"Patterns of plasma corticotropin-releasing hormone, progesterone, estradiol, and estriol change and the onset of human labor","volume":"94","author":"Smith","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"2022031113101018600_gaac003-B79","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1210\/en.2012-2262","article-title":"Mammalian labor: variations on a theme by amniota","volume":"154","author":"Smith","year":"2013","journal-title":"Endocrinology"},{"key":"2022031113101018600_gaac003-B80","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/cdd.2009.117","article-title":"miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-\u03b1 in human breast cancer cells","volume":"17","author":"Spizzo","year":"2010","journal-title":"Cell Death Differ"},{"key":"2022031113101018600_gaac003-B81","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fgene.2019.00185","article-title":"Myometrial transcriptional signatures of human parturition","volume":"10","author":"Stanfield","year":"2019","journal-title":"Front Genet"},{"key":"2022031113101018600_gaac003-B82","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022031113101018600_gaac003-B83","doi-asserted-by":"crossref","first-page":"e0199029","DOI":"10.1371\/journal.pone.0199029","article-title":"Micro RNA clusters in maternal plasma are associated with preterm birth and infant outcomes","volume":"13","author":"Wommack","year":"2018","journal-title":"PLoS One"},{"key":"2022031113101018600_gaac003-B84","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12958-015-0095-z","article-title":"MicroRNA-132 promotes estradiol synthesis in ovarian granulosa cells via translational repression of Nurr1","volume":"13","author":"Wu","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"key":"2022031113101018600_gaac003-B85","doi-asserted-by":"crossref","first-page":"D202","DOI":"10.1093\/nar\/gkq1056","article-title":"starBase: a database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data","volume":"39","author":"Yang","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"2022031113101018600_gaac003-B86","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature13994","article-title":"Enhancer-core-promoter specificity separates developmental and housekeeping gene regulation","volume":"518","author":"Zabidi","year":"2015","journal-title":"Nature"},{"key":"2022031113101018600_gaac003-B87","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.4161\/cc.21468","article-title":"Transcriptional targeting by microRNA-polycomb complexes: a novel route in cell fate determination","volume":"11","author":"Zardo","year":"2012","journal-title":"Cell Cycle"},{"key":"2022031113101018600_gaac003-B88","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1677\/joe.0.181r001","article-title":"Corticotropin-releasing hormone stimulates NF-kappaB in human epidermal keratinocytes","volume":"181","author":"Zbytek","year":"2004","journal-title":"J Endocrinol"},{"key":"2022031113101018600_gaac003-B89","doi-asserted-by":"crossref","first-page":"Article17","DOI":"10.2202\/1544-6115.1128","article-title":"A general framework for weighted gene co-expression network analysis","volume":"4","author":"Zhang","year":"2005","journal-title":"Stat Appl Genet Mol Biol"}],"container-title":["Molecular Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/molehr\/advance-article-pdf\/doi\/10.1093\/molehr\/gaac003\/42503078\/gaac003.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molehr\/article-pdf\/28\/3\/gaac003\/42830035\/gaac003.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molehr\/article-pdf\/28\/3\/gaac003\/42830035\/gaac003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T13:11:41Z","timestamp":1647004301000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molehr\/article\/doi\/10.1093\/molehr\/gaac003\/6527642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,12]]},"references-count":89,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3,8]]}},"URL":"https:\/\/doi.org\/10.1093\/molehr\/gaac003","relation":{},"ISSN":["1360-9947","1460-2407"],"issn-type":[{"value":"1360-9947","type":"print"},{"value":"1460-2407","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,3,1]]},"published":{"date-parts":[[2022,2,12]]},"article-number":"gaac003"}}