{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T18:53:47Z","timestamp":1775242427654,"version":"3.50.1"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000912","name":"March of Dimes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pre-implantation embryo movement is crucial to pregnancy success, but the role of ovarian hormones in modulating embryo movement is not understood. We ascertain the effects of altered hormonal environment on embryo location using two delayed implantation mouse models: natural lactational diapause (ND); and artificially induced diapause (AD), a laboratory version of ND generated by ovary removal and provision of supplemental progesterone (P4). Previously, we showed that embryos in a natural pregnancy (NP) first display unidirectional clustered movement, followed by bidirectional scattering and spacing movement. In the ND model, we discovered that embryos are present as clusters near the oviductal\u2013uterine junction for \u223c24 h longer than NP, followed by locations consistent with a unidirectional scattering and spacing movement. Intriguingly, the AD model resembles embryo location in NP and not ND. When measuring serum hormone levels, unlike the popular paradigm of reduced estrogen (E2) levels in diapause, we observed that E2 levels are comparable across NP, ND and AD. P4 levels are reduced in ND and highly increased in AD when compared to NP. Further, exogenous administration of E2 or P4 modifies embryo location during the unidirectional phase, while E2 treatment also affects embryo location in the bidirectional phase. Taken together, our data suggest that embryo movement can be modulated by both P4 and E2. Understanding natural hormonal adaptation in diapause provides an opportunity to determine key players that regulate embryo location, thus impacting implantation success. This knowledge can be leveraged to understand pregnancy survival and implantation success in hormonally altered conditions in the clinic.<\/jats:p>","DOI":"10.1093\/molehr\/gaac043","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T18:47:15Z","timestamp":1672253235000},"source":"Crossref","is-referenced-by-count":14,"title":["Pre-implantation mouse embryo movement under hormonally altered conditions"],"prefix":"10.1093","volume":"29","author":[{"given":"Hannah","family":"Lufkin","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University , East Lansing, MI, USA"},{"name":"Institute for Quantitative Health Science and Engineering, Michigan State University , East Lansing, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Flores","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University , East Lansing, MI, USA"},{"name":"Institute for Quantitative Health Science and Engineering, Michigan State University , East Lansing, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Raider","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University , East Lansing, MI, USA"},{"name":"Institute for Quantitative Health Science and Engineering, Michigan State University , East Lansing, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj","family":"Madhavan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University , East Lansing, MI, USA"},{"name":"Institute for Quantitative Health Science and Engineering, Michigan State University , East Lansing, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeline","family":"Dawson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University , East Lansing, MI, USA"},{"name":"Institute for Quantitative Health Science and Engineering, Michigan State University , East Lansing, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Coronel","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University , East Lansing, MI, USA"},{"name":"Institute for Quantitative Health Science and Engineering, Michigan State University , East Lansing, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhruv","family":"Sharma","sequence":"additional","affiliation":[{"name":"Center for Statistical Training & Consulting, Michigan State University , East Lansing, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5051-6724","authenticated-orcid":false,"given":"Ripla","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University , East Lansing, MI, USA"},{"name":"Institute for Quantitative Health Science and Engineering, Michigan State University , East Lansing, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"2023050913375716600_gaac043-B1","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1242\/dev.144386","article-title":"Insights from imaging the implanting embryo and the uterine environment in three dimensions","volume":"143","author":"Arora","year":"2016","journal-title":"Development"},{"key":"2023050913375716600_gaac043-B2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40104-015-0048-6","article-title":"Early pregnancy in the horse revisited\u2014does exception prove the rule?","volume":"6","author":"Aurich","year":"2015","journal-title":"J Anim Sci Biotechnol"},{"key":"2023050913375716600_gaac043-B3","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/aja.1000980305","article-title":"Rabbit blastocyst distribution","volume":"98","author":"Boving","year":"1956","journal-title":"Am J Anat"},{"key":"2023050913375716600_gaac043-B4","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/01.gco.0000233947.97543.c4","article-title":"Uterine contractility and embryo implantation","volume":"18","author":"Bulletti","year":"2006","journal-title":"Curr Opin Obstet Gynecol"},{"key":"2023050913375716600_gaac043-B5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12958-015-0038-8","article-title":"Progesterone-mediated effects on gene expression and oocyte-cumulus complex transport in the mouse fallopian tube","volume":"13","author":"Bylander","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"key":"2023050913375716600_gaac043-B6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.semcdb.2014.05.005","article-title":"Cadence of procreation: orchestrating embryo-uterine interactions","volume":"34","author":"Cha","year":"2014","journal-title":"Semin Cell Dev Biol"},{"key":"2023050913375716600_gaac043-B7","doi-asserted-by":"crossref","first-page":"130035","DOI":"10.1098\/rsob.130035","article-title":"A new role for muscle segment homeobox genes in mammalian embryonic diapause","volume":"3","author":"Cha","year":"2013","journal-title":"Open Biol"},{"key":"2023050913375716600_gaac043-B8","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1749-6632.2001.tb03801.x","article-title":"Contractility of the nonpregnant uterus: the follicular phase","volume":"943","author":"de Ziegler","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"2023050913375716600_gaac043-B9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1095\/biolreprod.115.131110","article-title":"Deletion of lysophosphatidic acid receptor 3 (Lpar3) disrupts fine local balance of progesterone and estrogen signaling in mouse uterus during implantation","volume":"93","author":"Diao","year":"2015","journal-title":"Biol Reprod"},{"key":"2023050913375716600_gaac043-B10","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1095\/biolreprod59.3.571","article-title":"Luteotropic hormone receptors in the ovary of the mink (Mustela vison) during delayed implantation and early-postimplantation gestation","volume":"59","author":"Douglas","year":"1998","journal-title":"Biol Reprod"},{"key":"2023050913375716600_gaac043-B11","first-page":"57","article-title":"Effect of migration, distribution and spacing of pig embryos on pregnancy and fetal survival","volume":"33","author":"Dziuk","year":"1985","journal-title":"J Reprod Fertil Suppl"},{"key":"2023050913375716600_gaac043-B12","first-page":"323","article-title":"The reproductive tract of the female nine-banded armadillo","volume":"17","author":"Enders","year":"1959","journal-title":"Tex Rep Biol Med"},{"key":"2023050913375716600_gaac043-B13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/B978-0-12-382032-7.10002-5","article-title":"Reproductive anatomy and physiology","author":"Evans","year":"2011","journal-title":"Reprod Dev Toxicol"},{"key":"2023050913375716600_gaac043-B14","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1387\/ijdb.140074bm","article-title":"Embryonic diapause: development on hold","volume":"58","author":"Fenelon","year":"2014","journal-title":"Int J Dev Biol"},{"key":"2023050913375716600_gaac043-B15","doi-asserted-by":"crossref","DOI":"10.1242\/dev.193490","article-title":"Mechanical and signaling mechanisms that guide pre-implantation embryo movement","volume":"147","author":"Flores","year":"2020","journal-title":"Development"},{"key":"2023050913375716600_gaac043-B16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1095\/biolreprod.113.115337","article-title":"Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice","volume":"90","author":"Fu","year":"2014","journal-title":"Biol Reprod"},{"key":"2023050913375716600_gaac043-B17","doi-asserted-by":"crossref","first-page":"107631","DOI":"10.1016\/j.celrep.2020.107631","article-title":"In vivo cell fate tracing provides no evidence for mesenchymal to epithelial transition in adult fallopian tube and uterus","volume":"31","author":"Ghosh","year":"2020","journal-title":"Cell Rep"},{"key":"2023050913375716600_gaac043-B18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0015-0282(16)49099-0","article-title":"Failure of implantation in human in vitro fertilization and embryo transfer patients: the effects of altered progesterone\/estrogen ratios in humans and mice","volume":"45","author":"Gidley-Baird","year":"1986","journal-title":"Fertil Steril"},{"key":"2023050913375716600_gaac043-B19","doi-asserted-by":"crossref","first-page":"10326","DOI":"10.1073\/pnas.0402597101","article-title":"Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation","volume":"101","author":"Hamatani","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023050913375716600_gaac043-B20","doi-asserted-by":"crossref","first-page":"16621","DOI":"10.1073\/pnas.1900401116","article-title":"Blastocyst activation engenders transcriptome reprogram affecting X-chromosome reactivation and inflammatory trigger of implantation","volume":"116","author":"He","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023050913375716600_gaac043-B21","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/0093-691X(87)90059-8","article-title":"Role of progesterone in mobility, fixation, orientation, and survival of the equine embryonic vesicle","volume":"27","author":"Kastelic","year":"1987","journal-title":"Theriogenology"},{"key":"2023050913375716600_gaac043-B22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1530\/jrf.0.0580253","article-title":"Investigation of the influence of progesterone on mouse embryo transport by using antiprogestational steroids","volume":"58","author":"Kendle","year":"1980","journal-title":"J Reprod Fertil"},{"key":"2023050913375716600_gaac043-B23","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1093\/humrep\/deab184","article-title":"Analysis of serum and endometrial progesterone in determining endometrial receptivity","volume":"36","author":"Labarta","year":"2021","journal-title":"Hum Reprod"},{"key":"2023050913375716600_gaac043-B24","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2307\/2529876","article-title":"Random-effects models for longitudinal data","volume":"38","author":"Laird","year":"1982","journal-title":"Biometrics"},{"key":"2023050913375716600_gaac043-B25","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0093-691X(85)90169-4","article-title":"Mobility of the conceptus and uterine contractions in the mare","volume":"24","author":"Leith","year":"1985","journal-title":"Theriogenology"},{"key":"2023050913375716600_gaac043-B26","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/s41598-017-18643-w","article-title":"The high concentration of progesterone is harmful for endometrial receptivity and decidualization","volume":"8","author":"Liang","year":"2018","journal-title":"Sci Rep"},{"key":"2023050913375716600_gaac043-B27","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1530\/rep.1.00444","article-title":"Embryonic diapause and its regulation","volume":"128","author":"Lopes","year":"2004","journal-title":"Reproduction"},{"key":"2023050913375716600_gaac043-B28","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1073\/pnas.0530162100","article-title":"Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation","volume":"100","author":"Ma","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023050913375716600_gaac043-B29","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1095\/biolreprod62.5.1193","article-title":"Distribution and activation of uterine mononuclear phagocytes in peripartum endometrium and myometrium of the mouse","volume":"62","author":"Mackler","year":"2000","journal-title":"Biol Reprod"},{"key":"2023050913375716600_gaac043-B30","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1530\/jrf.0.0120391","article-title":"Frequency and extent of delayed implantation in lactating rats and mice","volume":"12","author":"Mantalenakis","year":"1966","journal-title":"J Reprod Fertil"},{"key":"2023050913375716600_gaac043-B31","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1530\/jrf.0.0410297","article-title":"Evidence for a preimplantation rise in oestradiol-17beta levels on day 4 of pregnancy in the mouse","volume":"41","author":"McCormack","year":"1974","journal-title":"J Reprod Fertil"},{"key":"2023050913375716600_gaac043-B32","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1095\/biolreprod39.2.340","article-title":"Restricted conceptus mobility results in failure of pregnancy maintenance in mares","volume":"39","author":"McDowell","year":"1988","journal-title":"Biol Reprod"},{"key":"2023050913375716600_gaac043-B33","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1677\/joe.0.0420453","article-title":"A study of balstocysts during delay and subsequent implantation in lactating mice","volume":"42","author":"McLaren","year":"1968","journal-title":"J Endocrinol"},{"key":"2023050913375716600_gaac043-B34","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1677\/joe.0.0500515","article-title":"Blastocysts in the mouse uterus: the effect of ovariectomy, progesterone and oestrogen","volume":"50","author":"McLaren","year":"1971","journal-title":"J Endocrinol"},{"key":"2023050913375716600_gaac043-B35","first-page":"11","article-title":"Delayed implantation in mustelids, with special emphasis on the spotted skunk","volume":"29","author":"Mead","year":"1981","journal-title":"J Reprod Fertil Suppl"},{"key":"2023050913375716600_gaac043-B36","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/jez.1402660611","article-title":"Embryonic diapause in vertebrates","volume":"266","author":"Mead","year":"1993","journal-title":"J Exp Zool"},{"key":"2023050913375716600_gaac043-B37","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1530\/jrf.0.0390187","article-title":"The morphology of blastocyst implantation","volume":"39","author":"Nilsson","year":"1974","journal-title":"J Reprod Fertil"},{"key":"2023050913375716600_gaac043-B38","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1258\/002367781780893858","article-title":"Concurrent lactation and reproductive performance in CFLP mice mated post partum","volume":"15","author":"Norris","year":"1981","journal-title":"Lab Anim"},{"key":"2023050913375716600_gaac043-B39","doi-asserted-by":"crossref","first-page":"10159","DOI":"10.1073\/pnas.90.21.10159","article-title":"Blastocyst's state of activity determines the \"window\" of implantation in the receptive mouse uterus","volume":"90","author":"Paria","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023050913375716600_gaac043-B40","author":"Pinheiro","year":"2022"},{"key":"2023050913375716600_gaac043-B41","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1095\/biolreprod27.3.575","article-title":"Intrauterine migration of the porcine embryo: influence of estradiol-17 beta and histamine","volume":"27","author":"Pope","year":"1982","journal-title":"Biol Reprod"},{"key":"2023050913375716600_gaac043-B42","first-page":"85","article-title":"[CONTROL OF NIDATION IN MAMMALS]","volume":"54","author":"Psychoyos","year":"1965","journal-title":"Arch Anat Microsc Morphol Exp"},{"key":"2023050913375716600_gaac043-B43","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0083-6729(08)60999-1","article-title":"Hormonal control of ovoimplantation","volume":"31","author":"Psychoyos","year":"1973","journal-title":"Vitam Horm"},{"key":"2023050913375716600_gaac043-B44","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1387\/ijdb.140059mr","article-title":"Embryo-endometrial interactions during early development after embryonic diapause in the marsupial tammar wallaby","volume":"58","author":"Renfree","year":"2014","journal-title":"Int J Dev Biol"},{"key":"2023050913375716600_gaac043-B45","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1530\/jrf.0.0240423","article-title":"The timing and variation of pre-implantation events in the mouse","volume":"24","author":"Restall","year":"1971","journal-title":"J Reprod Fertil"},{"key":"2023050913375716600_gaac043-B46","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0010-7824(87)90007-2","article-title":"The effect of RU486 on transport, development and implantation of mouse embryos","volume":"36","author":"Roblero","year":"1987","journal-title":"Contraception"},{"key":"2023050913375716600_gaac043-B47","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-81-322-1115-0_8","volume-title":"Human Embryo Transfer","author":"Sebag-Peyrelevade","year":"2015"},{"key":"2023050913375716600_gaac043-B48","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4141\/cjas73-010","article-title":"INTRAUTERINE MIGRATION OF PIG EMBRYOS IN LITTERS WITHOUT LOSSES","volume":"53","author":"Sittmann","year":"1973","journal-title":"Can J Anim Sci"},{"key":"2023050913375716600_gaac043-B49","author":"R Development Core Team","year":"2014"},{"key":"2023050913375716600_gaac043-B50","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/S0015-0282(01)01786-1","article-title":"Is there evidence for preferential delivery of ovarian estradiol to the endometrium?","volume":"75","author":"Tourgeman","year":"2001","journal-title":"Fertil Steril"},{"key":"2023050913375716600_gaac043-B51","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1292\/jvms1939.51.613","article-title":"Evidence for transuterine migration of embryos in the domestic cat","volume":"51","author":"Tsutsui","year":"1989","journal-title":"Nihon Juigaku Zasshi"},{"key":"2023050913375716600_gaac043-B52","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1292\/jvms.64.1117","article-title":"Factors affecting transuterine migration of canine embryos","volume":"64","author":"Tsutsui","year":"2002","journal-title":"J Vet Med Sci"},{"key":"2023050913375716600_gaac043-B53","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.repbio.2013.09.007","article-title":"Mouse models to study polycystic ovary syndrome: a possible link between metabolism and ovarian function?","volume":"14","author":"van Houten","year":"2014","journal-title":"Reprod Biol"},{"key":"2023050913375716600_gaac043-B54","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nrg1808","article-title":"Roadmap to embryo implantation: clues from mouse models","volume":"7","author":"Wang","year":"2006","journal-title":"Nat Rev Genet"},{"key":"2023050913375716600_gaac043-B55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/joe.0.0130001","article-title":"Endocrine studies on delayed implantation in lactating mice","volume":"13","author":"Whitten","year":"1955","journal-title":"J Endocrinol"},{"key":"2023050913375716600_gaac043-B56","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1677\/joe.0.0160435","article-title":"Endocrine studies on delayed implantation in lactating mice; role of the pituitary in implantation","volume":"16","author":"Whitten","year":"1958","journal-title":"J Endocrinol"},{"key":"2023050913375716600_gaac043-B57","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1095\/biolreprod.114.117929","article-title":"Role of uterine contraction in regeneration of the murine postpartum endometrium","volume":"91","author":"Yoshii","year":"2014","journal-title":"Biol Reprod"},{"key":"2023050913375716600_gaac043-B58","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1530\/jrf.0.0020035","article-title":"Effect of local application of ovarian hormones on the delay in implantation in lactating rats","volume":"2","author":"Yoshinaga","year":"1961","journal-title":"J Reprod Fertil"},{"key":"2023050913375716600_gaac043-B59","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1530\/jrf.0.0120593","article-title":"Delayed implantation in the spayed, progesterone treated adult mouse","volume":"12","author":"Yoshinaga","year":"1966","journal-title":"J Reprod Fertil"}],"container-title":["Molecular Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/molehr\/advance-article-pdf\/doi\/10.1093\/molehr\/gaac043\/48443154\/gaac043.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molehr\/article-pdf\/29\/2\/gaac043\/50257307\/gaac043.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molehr\/article-pdf\/29\/2\/gaac043\/50257307\/gaac043.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T23:57:37Z","timestamp":1728604657000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molehr\/article\/doi\/10.1093\/molehr\/gaac043\/6965029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,1,31]]}},"URL":"https:\/\/doi.org\/10.1093\/molehr\/gaac043","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.11.19.469319","asserted-by":"object"}]},"ISSN":["1460-2407"],"issn-type":[{"value":"1460-2407","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,2]]},"published":{"date-parts":[[2022,12,29]]},"article-number":"gaac043"}}