{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:07:13Z","timestamp":1792786033207,"version":"4.5.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Development","award":["NIH R01 HD096266"],"award-info":[{"award-number":["NIH R01 HD096266"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Development","award":["NIH U01 HD104482"],"award-info":[{"award-number":["NIH U01 HD104482"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Uterine glands and, by inference, their secretions impact uterine receptivity, blastocyst implantation, stromal cell decidualization, and placental development. Changes in gland function across the menstrual cycle are primarily governed by the steroid hormones estrogen (E2) and progesterone (P4) but can also be influenced by extrinsic factors from the stroma. Using a human endometrial epithelial organoid system, transcriptome and proteome analyses identified distinct responses of the organoids to steroid hormones and prostaglandin E2 (PGE2). Notably, P4 and PGE2 modulated the basolateral secretion of organoid proteins, particularly cystatin C (CST3), serpin family A member 3 (SERPINA3), and stanniocalcin 1 (STC1). CST3, but not SERPINA3 or STC1, attenuated the in vitro stromal decidualization response to steroid hormones and PGE2. These findings provide evidence that uterine gland-derived factors impact stromal cell decidualization, which has implications for pregnancy establishment and fertility in women.<\/jats:p>","DOI":"10.1093\/molehr\/gaad007","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T18:46:07Z","timestamp":1675881967000},"source":"Crossref","is-referenced-by-count":35,"title":["Basolateral secretions of human endometrial epithelial organoids impact stromal cell decidualization"],"prefix":"10.1093","volume":"29","author":[{"given":"Harriet C","family":"Fitzgerald","sequence":"first","affiliation":[{"name":"Division of Animal Sciences, University of Missouri , Columbia, MO, USA"},{"name":"Present\u00a0address: The Ritchie Centre, Hudson Institute of Medical Research, Clayton, 3168 Victoria, Australia; Department of Obstetrics and Gynaecology, Monash University, Clayton, 3168 Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M","family":"Kelleher","sequence":"additional","affiliation":[{"name":"Division of Obstetrics, Gynecology and Women\u2019s Health, University of Missouri , Columbia, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaman","family":"Ranjit","sequence":"additional","affiliation":[{"name":"Division of Animal Sciences, University of Missouri , Columbia, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny J","family":"Schust","sequence":"additional","affiliation":[{"name":"Division of Obstetrics, Gynecology and Women\u2019s Health, University of Missouri , Columbia, MO, USA"},{"name":"Present\u00a0address: Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-766X","authenticated-orcid":false,"given":"Thomas E","family":"Spencer","sequence":"additional","affiliation":[{"name":"Division of Animal Sciences, University of Missouri , Columbia, MO, USA"},{"name":"Division of Obstetrics, Gynecology and Women\u2019s Health, University of Missouri , Columbia, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"key":"2023070517260743700_gaad007-B1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1042\/bj2680287","article-title":"Structure and expression of the human cystatin C gene","volume":"268","author":"Abrahamson","year":"1990","journal-title":"Biochem J"},{"key":"2023070517260743700_gaad007-B2","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1242\/dev.124.17.3415","article-title":"The expression and function of cystatin C and cathepsin B and cathepsin L during mouse embryo implantation and placentation","volume":"124","author":"Afonso","year":"1997","journal-title":"Development"},{"key":"2023070517260743700_gaad007-B3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1477-7827-10-49","article-title":"The effects of oxidative stress on female reproduction: a review","volume":"10","author":"Agarwal","year":"2012","journal-title":"Reprod Biol Endocrinol"},{"key":"2023070517260743700_gaad007-B4","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1210\/en.2009-0923","article-title":"The protein kinase A pathway-regulated transcriptome of endometrial stromal fibroblasts reveals compromised differentiation and persistent proliferative potential in endometriosis","volume":"151","author":"Aghajanova","year":"2010","journal-title":"Endocrinology"},{"key":"2023070517260743700_gaad007-B5","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1530\/jrf.0.0910301","article-title":"Paracrine interactions between platelet-activating factor and prostaglandins in hormonally-treated human luteal phase endometrium in vitro","volume":"91","author":"Alecozay","year":"1991","journal-title":"J Reprod Fertil"},{"key":"2023070517260743700_gaad007-B6","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.mce.2011.10.035","article-title":"Mechanisms of endometrial progesterone resistance","volume":"358","author":"Al-Sabbagh","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"2023070517260743700_gaad007-B7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41418-020-0565-5","article-title":"Organoid systems to study the human female reproductive tract and pregnancy","volume":"28","author":"Alzamil","year":"2021","journal-title":"Cell Death Differ"},{"key":"2023070517260743700_gaad007-B8","doi-asserted-by":"crossref","first-page":"14700","DOI":"10.1073\/pnas.0702305104","article-title":"R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6","volume":"104","author":"Binnerts","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023070517260743700_gaad007-B9","doi-asserted-by":"crossref","first-page":"33811","DOI":"10.1038\/srep33811","article-title":"Compartmentalized gene expression profiling of receptive endometrium reveals progesterone regulated ENPP3 is differentially expressed and secreted in glycosylated form","volume":"6","author":"Boggavarapu","year":"2016","journal-title":"Sci Rep"},{"key":"2023070517260743700_gaad007-B10","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1242\/dev.148478","article-title":"Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability","volume":"144","author":"Boretto","year":"2017","journal-title":"Development"},{"key":"2023070517260743700_gaad007-B11","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1210\/jcem.87.6.8563","article-title":"Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy","volume":"87","author":"Burton","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2023070517260743700_gaad007-B12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0300-483X(98)00150-4","article-title":"Metallothionein in radiation exposure: its induction and protective role","volume":"132","author":"Cai","year":"1999","journal-title":"Toxicology"},{"key":"2023070517260743700_gaad007-B13","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.fertnstert.2013.06.007","article-title":"Coculturing human endometrial epithelial cells and stromal fibroblasts alters cell-specific gene expression and cytokine production","volume":"100","author":"Chen","year":"2013","journal-title":"Fertil Steril"},{"key":"2023070517260743700_gaad007-B14","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1071\/RD17257","article-title":"Expression of ENPP3 in human cyclic endometrium: a novel molecule involved in embryo implantation","volume":"30","author":"Chen","year":"2018","journal-title":"Reprod Fertil Dev"},{"key":"2023070517260743700_gaad007-B15","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.4049\/jimmunol.172.7.4245","article-title":"IFN-\u03b3 stimulates the expression of a novel secretoglobin that regulates chemotactic cell migration and invasion","volume":"172","author":"Choi","year":"2004","journal-title":"J Immunol"},{"key":"2023070517260743700_gaad007-B16","doi-asserted-by":"crossref","first-page":"6535","DOI":"10.1073\/pnas.94.12.6535","article-title":"Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium","volume":"94","author":"Cooke","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023070517260743700_gaad007-B17","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.2353\/ajpath.2010.100026","article-title":"Olfactomedin-4 regulation by estrogen in the human endometrium requires epidermal growth factor signaling","volume":"177","author":"Dassen","year":"2010","journal-title":"Am J Pathol"},{"key":"2023070517260743700_gaad007-B18","doi-asserted-by":"crossref","first-page":"23952","DOI":"10.1073\/pnas.2014272117","article-title":"Sexually dimorphic effects of forkhead box a2 (FOXA2) and uterine glands on decidualization and fetoplacental development","volume":"117","author":"Dhakal","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023070517260743700_gaad007-B19","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/jcmm.12232","article-title":"Oestrogen receptor-mediated expression of Olfactomedin 4 regulates the progression of endometrial adenocarcinoma","volume":"18","author":"Duan","year":"2014","journal-title":"J Cell Mol Med"},{"key":"2023070517260743700_gaad007-B20","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrendo.2016.116","article-title":"Fertile ground: human endometrial programming and lessons in health and disease","volume":"12","author":"Evans","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"2023070517260743700_gaad007-B21","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1095\/biolreprod.106.053058","article-title":"Autocrine prolactin inhibits human uterine decidualization: a novel role for prolactin","volume":"76","author":"Eyal","year":"2007","journal-title":"Biol Reprod"},{"key":"2023070517260743700_gaad007-B22","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1093\/humrep\/deh806","article-title":"Secretion of cytokines and chemokines by polarized human epithelial cells from the female reproductive tract","volume":"20","author":"Fahey","year":"2005","journal-title":"Hum Reprod"},{"key":"2023070517260743700_gaad007-B23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1095\/biolreprod.113.107631","article-title":"Endometrial glands are essential for blastocyst implantation and decidualization in the mouse uterus","volume":"88","author":"Filant","year":"2013","journal-title":"Biol Reprod"},{"key":"2023070517260743700_gaad007-B24","doi-asserted-by":"crossref","first-page":"23132","DOI":"10.1073\/pnas.1915389116","article-title":"Self-renewing endometrial epithelial organoids of the human uterus","volume":"116","author":"Fitzgerald","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023070517260743700_gaad007-B25","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1093\/biolre\/ioy063","article-title":"Idiopathic infertility in women is associated with distinct changes in proliferative phase uterine fluid proteins","volume":"98","author":"Fitzgerald","year":"2018","journal-title":"Biol Reprod"},{"key":"2023070517260743700_gaad007-B26","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/biolre\/ioaa183","article-title":"In vitro models of the human endometrium: evolution and application for women's health","volume":"104","author":"Fitzgerald","year":"2021","journal-title":"Biol Reprod"},{"key":"2023070517260743700_gaad007-B27","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1210\/endo.134.1.7506205","article-title":"Prostaglandin E2 enhances human endometrial stromal cell differentiation","volume":"134","author":"Frank","year":"1994","journal-title":"Endocrinology"},{"key":"2023070517260743700_gaad007-B28","doi-asserted-by":"crossref","first-page":"E8468","DOI":"10.1073\/pnas.1706546114","article-title":"Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology","volume":"114","author":"Garrido-Gomez","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023070517260743700_gaad007-B29","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1677\/joe.0.1780357","article-title":"Cyclic AMP and progesterone receptor cross-talk in human endometrium: a decidualizing affair","volume":"178","author":"Gellersen","year":"2003","journal-title":"J Endocrinol"},{"key":"2023070517260743700_gaad007-B30","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/toxsci\/55.1.223","article-title":"Metallothionein-null mice are more sensitive than wild-type mice to liver injury induced by repeated exposure to cadmium","volume":"55","author":"Habeebu","year":"2000","journal-title":"Toxicol Sci"},{"key":"2023070517260743700_gaad007-B31","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1477-7827-2-58","article-title":"Endometrial glands as a source of nutrients, growth factors and cytokines during the first trimester of human pregnancy: a morphological and immunohistochemical study","volume":"2","author":"Hempstock","year":"2004","journal-title":"Reprod Biol Endocrinol"},{"key":"2023070517260743700_gaad007-B32","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1186\/1479-7364-5-6-691","article-title":"Update of the human secretoglobin (SCGB) gene superfamily and an example of \u2018evolutionary bloom\u2019 of androgen-binding protein genes within the mouse Scgb gene superfamily","volume":"5","author":"Jackson","year":"2011","journal-title":"Hum Genomics"},{"key":"2023070517260743700_gaad007-B33","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1210\/endo.143.6.8885","article-title":"Global gene profiling in human endometrium during the window of implantation","volume":"143","author":"Kao","year":"2002","journal-title":"Endocrinology"},{"key":"2023070517260743700_gaad007-B34","doi-asserted-by":"crossref","first-page":"8543","DOI":"10.1096\/fj.201900013R","article-title":"Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium","volume":"33","author":"Kelleher","year":"2019","journal-title":"FASEB J"},{"key":"2023070517260743700_gaad007-B35","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1210\/er.2018-00281","article-title":"Uterine glands: developmental biology and functional roles in pregnancy","volume":"40","author":"Kelleher","year":"2019","journal-title":"Endocr Rev"},{"key":"2023070517260743700_gaad007-B36","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1210\/er.2018-00281","article-title":"Uterine glands: developmental biology and functional roles in pregnancy","volume":"40","author":"Kelleher","year":"2019","journal-title":"Endocr Rev"},{"key":"2023070517260743700_gaad007-B37","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1038\/s41467-018-04848-8","article-title":"Uterine glands coordinate on-time embryo implantation and impact endometrial decidualization for pregnancy success","volume":"9","author":"Kelleher","year":"2018","journal-title":"Nat Commun"},{"key":"2023070517260743700_gaad007-B38","doi-asserted-by":"crossref","first-page":"E1018","DOI":"10.1073\/pnas.1618433114","article-title":"Forkhead box a2 (FOXA2) is essential for uterine function and fertility","volume":"114","author":"Kelleher","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023070517260743700_gaad007-B39","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.fertnstert.2005.08.046","article-title":"Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity","volume":"85","author":"Klemmt","year":"2006","journal-title":"Fertil Steril"},{"key":"2023070517260743700_gaad007-B40","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/humrep\/17.1.213","article-title":"Concentration of leukaemia inhibitory factor (LIF) in uterine flushing fluid is highly predictive of embryo implantation","volume":"17","author":"L\u00e9d\u00e9e-Bataille","year":"2002","journal-title":"Hum Reprod"},{"key":"2023070517260743700_gaad007-B41","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12958-018-0327-0","article-title":"Expression of cystatin C in the female reproductive tract and its effect on human sperm capacitation","volume":"16","author":"Lee","year":"2018","journal-title":"Reprod Biol Endocrinol"},{"key":"2023070517260743700_gaad007-B42","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0015-0282(16)58140-0","article-title":"Endometrial progesterone receptors and markers of uterine receptivity in the window of implantation","volume":"65","author":"Lessey","year":"1996","journal-title":"Fertil Steril"},{"key":"2023070517260743700_gaad007-B43","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1126\/science.1197454","article-title":"The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2","volume":"331","author":"Li","year":"2011","journal-title":"Science"},{"key":"2023070517260743700_gaad007-B44","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.toxlet.2015.01.010","article-title":"Zinc treatment prevents type 1 diabetes-induced hepatic oxidative damage, endoplasmic reticulum stress, and cell death, and even prevents possible steatohepatitis in the OVE26 mouse model: Important role of metallothionein","volume":"233","author":"Liang","year":"2015","journal-title":"Toxicol Lett"},{"key":"2023070517260743700_gaad007-B45","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/stem.2222","article-title":"Loss of endometrial plasticity in recurrent pregnancy loss","volume":"34","author":"Lucas","year":"2016","journal-title":"Stem Cells"},{"key":"2023070517260743700_gaad007-B46","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s42003-020-0763-1","article-title":"Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window","volume":"3","author":"Lucas","year":"2020","journal-title":"Commun Biol"},{"key":"2023070517260743700_gaad007-B47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.114.122846","article-title":"The human endometrium as a sensor of embryo quality","volume":"91","author":"Macklon","year":"2014","journal-title":"Biol Reprod"},{"key":"2023070517260743700_gaad007-B48","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1210\/jcem.86.9.7856","article-title":"Expression, localization, and signaling of PGE2 and EP2\/EP4 receptors in human nonpregnant endometrium across the menstrual cycle","volume":"86","author":"Milne","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2023070517260743700_gaad007-B49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jtemb.2014.04.008","article-title":"Pro-inflammatory effects of metals in persons and animals exposed to tobacco smoke","volume":"29","author":"Milnerowicz","year":"2015","journal-title":"J Trace Elem Med Biol"},{"key":"2023070517260743700_gaad007-B50","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/molehr\/gax023","article-title":"Deregulation of the endometrial stromal cell secretome precedes embryo implantation failure","volume":"23","author":"Peter Durairaj","year":"2017","journal-title":"Mol Hum Reprod"},{"key":"2023070517260743700_gaad007-B51","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.bbrc.2006.08.054","article-title":"Expression of Cystatin C in the rat endometrium during the peri-implantation period","volume":"349","author":"Quinn","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"2023070517260743700_gaad007-B52","doi-asserted-by":"crossref","first-page":"R85","DOI":"10.1530\/RAF-21-0023","article-title":"Organoids to model the endometrium: implantation and beyond","volume":"2","author":"Rawlings","year":"2021","journal-title":"Reprod Fertil"},{"key":"2023070517260743700_gaad007-B53","doi-asserted-by":"crossref","first-page":"e10287","DOI":"10.1371\/journal.pone.0010287","article-title":"Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss","volume":"5","author":"Salker","year":"2010","journal-title":"PLoS One"},{"key":"2023070517260743700_gaad007-B54","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1093\/humrep\/dey023","article-title":"Asynchronous and pathological windows of implantation: two causes of recurrent implantation failure","volume":"33","author":"Sebastian-Leon","year":"2018","journal-title":"Hum Reprod"},{"key":"2023070517260743700_gaad007-B55","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1210\/en.2010-0275","article-title":"The endometrial response to chorionic gonadotropin is blunted in a baboon model of endometriosis","volume":"151","author":"Sherwin","year":"2010","journal-title":"Endocrinology"},{"key":"2023070517260743700_gaad007-B56","doi-asserted-by":"crossref","first-page":"e2026804118","DOI":"10.1073\/pnas.2026804118","article-title":"Capture and metabolomic analysis of the human endometrial epithelial organoid secretome","volume":"118","author":"Simintiras","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023070517260743700_gaad007-B57","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0952-3278(88)90146-9","article-title":"The release of PGF2\u03b1 and PGE2 from separated cells of human endometrium and decidua","volume":"33","author":"Smith","year":"1988","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"2023070517260743700_gaad007-B58","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1095\/biolreprod.109.080929","article-title":"Cathepsin B, cathepsin L, and cystatin C in the porcine uterus and placenta: potential roles in endometrial\/placental remodeling and in fluid-phase transport of proteins secreted by uterine epithelia across placental areolae","volume":"82","author":"Song","year":"2010","journal-title":"Biol Reprod"},{"key":"2023070517260743700_gaad007-B59","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev-animal-020518-115321","article-title":"Development and function of uterine glands in domestic animals","volume":"7","author":"Spencer","year":"2019","journal-title":"Annu Rev Anim Biosci"},{"key":"2023070517260743700_gaad007-B60","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/biolre\/ioab183","article-title":"Single-cell analysis of prostaglandin E2-induced human decidual cell in vitro differentiation: a minimal ancestral deciduogenic signal","volume":"106","author":"Stadtmauer","year":"2022","journal-title":"Biol Reprod"},{"key":"2023070517260743700_gaad007-B61","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1210\/jc.2003-030494","article-title":"Identification, characterization, and regulation of the canonical Wnt signaling pathway in human endometrium","volume":"88","author":"Tulac","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"2023070517260743700_gaad007-B62","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1210\/jc.2005-0769","article-title":"Dickkopf-1, an inhibitor of Wnt signaling, is regulated by progesterone in human endometrial stromal cells","volume":"91","author":"Tulac","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"2023070517260743700_gaad007-B63","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/ncb3516","article-title":"Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium","volume":"19","author":"Turco","year":"2017","journal-title":"Nat Cell Biol"},{"key":"2023070517260743700_gaad007-B64","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1210\/en.2009-0389","article-title":"Increased mitogen-activated protein kinase kinase\/extracellularly regulated kinase activity in human endometrial stromal fibroblasts of women with endometriosis reduces 3',5'-cyclic adenosine 5'-monophosphate inhibition of cyclin D1","volume":"150","author":"Velarde","year":"2009","journal-title":"Endocrinology"},{"key":"2023070517260743700_gaad007-B65","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/s41591-020-1040-z","article-title":"Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle","volume":"26","author":"Wang","year":"2020","journal-title":"Nat Med"},{"key":"2023070517260743700_gaad007-B66","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1095\/biolreprod45.1.163","article-title":"Role of cyclic adenosine 3\u2032,5\u2032-monophosphate in mediating the effect of prostaglandin E2 on decidualization in vitro","volume":"45","author":"Yee","year":"1991","journal-title":"Biol Reprod"}],"container-title":["Molecular Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/molehr\/advance-article-pdf\/doi\/10.1093\/molehr\/gaad007\/49315715\/gaad007.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molehr\/article-pdf\/29\/4\/gaad007\/50825027\/gaad007.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molehr\/article-pdf\/29\/4\/gaad007\/50825027\/gaad007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T17:29:12Z","timestamp":1728840552000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molehr\/article\/doi\/10.1093\/molehr\/gaad007\/7055303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,23]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4,3]]}},"URL":"https:\/\/doi.org\/10.1093\/molehr\/gaad007","relation":{},"ISSN":["1460-2407"],"issn-type":[{"value":"1460-2407","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,4,1]]},"published":{"date-parts":[[2023,2,23]]},"article-number":"gaad007"}}