{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T19:37:29Z","timestamp":1782761849706,"version":"3.54.5"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001512"],"award-info":[{"award-number":["82001512"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease that affects women of reproductive age. It is also a significant cause of infertility. Circular RNAs have been found to have a crucial role in the development and progression of reproductive system diseases. In this study, we focused on circ_BECN1 and aimed to investigate its role and mechanism in PCOS, providing a foundation for early diagnosis and treatment of this condition. Our findings revealed an upregulation of circ_BECN1 expression in the ovarian granulosa cells (GCs) of PCOS patients. Additionally, the silencing of circ_BECN1 resulted in inhibited proliferation and enhanced apoptosis of the human ovarian granulosa-like tumor cell line (KGN), therefore implicating circ_BECN1 in the cell cycle process. Through a dual-luciferase reporting assay, we determined that circ_BECN1 acts as a sponge for miR-619-5p and that Rab5b is the target gene of miR-619-5p. Moreover, the expression of Rab5b was found to be upregulated in the ovarian tissue of PCOS patients. Knocking down circ_BECN1 resulted in decreased Rab5b expression, which was then restored by using a miR-619-5p inhibitor. Additionally, rescue experiments demonstrated that overexpressing Rab5b reversed the effects of circ_BECN1 knockdown on cell proliferation and apoptosis in KGN cells. In summary, our findings indicate that circ_BECN1 is upregulated in PCOS GCs and promotes cell growth and cell cycle progression, and reduces cell apoptosis by modulating the miR-619-5p\/Rab5b axis. Therefore, circ_BECN1 may serve as a potential therapeutic target for PCOS treatment.<\/jats:p>","DOI":"10.1093\/molehr\/gaad036","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T14:39:08Z","timestamp":1698331148000},"source":"Crossref","is-referenced-by-count":11,"title":["hsa_circRNA_BECN1 acts as a ceRNA to promote polycystic ovary syndrome progression by sponging the miR-619-5p\/Rab5b axis"],"prefix":"10.1093","volume":"29","author":[{"given":"Hairui","family":"Fan","sequence":"first","affiliation":[{"name":"Key Laboratory for Animal Genetics, Breeding, Reproduction and Molecular Design, College of Animal Science and Technology, Yangzhou University , Yangzhou, China"},{"name":"College of Veterinary Medicine, Yangzhou University , Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Clinical Medical College, Yangzhou University , Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Zhang","sequence":"additional","affiliation":[{"name":"California Excellent Fertility (CEF) , Anaheim, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Northern Jiangsu People\u2019s Hospital, Yangzhou University , Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Northern Jiangsu People\u2019s Hospital, Yangzhou University , Yangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongmin","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Northern Jiangsu People\u2019s Hospital, Yangzhou University , Yangzhou, 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