{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T21:41:57Z","timestamp":1763415717292,"version":"3.41.2"},"reference-count":82,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T00:00:00Z","timestamp":1700784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Reproductive potential in women declines with age. The impact of ageing on embryo\u2013maternal interactions is still unclear. Rabbits were used as a reproductive model to investigate maternal age-related alterations in reproductive organs and embryos on Day 6 of pregnancy. Blood, ovaries, endometrium, and blastocysts from young (16\u201320\u2009weeks) and advanced maternal age phase (&amp;gt;108\u2009weeks, old) rabbits were analysed at the mRNA and protein levels to investigate the insulin-like growth factor (IGF) system, lipid metabolism, and stress defence system. Older rabbits had lower numbers of embryos at Day 6 of pregnancy. Plasma insulin and IGF levels were reduced, which was accompanied by paracrine regulation of IGFs and their receptors in ovaries and endometrium. Embryos adapted to hormonal changes as indicated by reduced embryonic IGF1 and 2 levels. Aged reproductive organs increased energy generation from the degradation of fatty acids, leading to higher oxidative stress. Stress markers, including catalase, superoxide dismutase 2, and receptor for advanced glycation end products were elevated in ovaries and endometrium from aged rabbits. Embryonic fatty acid uptake and \u03b2-oxidation were increased in both embryonic compartments (embryoblast and trophoblast) in old rabbits, associated with minor changes in the oxidative and glycative stress defence systems. In summary, the insulin\/IGF system, lipid metabolism, and stress defence were dysregulated in reproductive tissues of older rabbits, which is consistent with changes in embryonic metabolism and stress defence. These data highlight the crucial influence of maternal age on uterine adaptability and embryo development.<\/jats:p>","DOI":"10.1093\/molehr\/gaad040","type":"journal-article","created":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T03:22:39Z","timestamp":1700882559000},"source":"Crossref","is-referenced-by-count":6,"title":["Advanced maternal age leads to changes within the insulin\/IGF system and lipid metabolism in the reproductive tract and preimplantation embryo: insights from the rabbit model"],"prefix":"10.1093","volume":"29","author":[{"given":"Juliane","family":"Trohl","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine , Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2151-767X","authenticated-orcid":false,"given":"Maria","family":"Schindler","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine , Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Buske","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine , Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"de Nivelle","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine , Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Toto Nienguesso","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine , Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Navarrete Santos","sequence":"additional","affiliation":[{"name":"Department 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