{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T04:13:24Z","timestamp":1774671204330,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T00:00:00Z","timestamp":1706918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170920"],"award-info":[{"award-number":["32170920"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Preterm birth (PTB) is a major problem affecting perinatal health, directly increasing the mortality risk of mother and infant that often results from the breakdown of the maternal\u2013fetal immune balance. Increasing evidence shows the essential role of mucosal-associated invariant T (MAIT) cells to balance antibacterial function and immune tolerance function during pregnancy. However, the phenotype and function of placental MAIT cells and their specific mechanisms in PTB remain unclear. Here, we report that MAIT cells in placentas from PTBs show increased activation levels and decreased IFN-\u03b3 secretion capacity compared with those from normal pregnancies. Moreover, our data indicate gravidity is a factor affecting placental MAIT cells during pregnancies. Multi-omics analysis indicated aberrant immune activation and abnormal increase of lipids and lipid-like metabolites in the PTB placental microenvironment. Moreover, the proportion and activation of MAIT cells were positively correlated with the abnormal increase of lipids and lipid-like metabolites. Together, our work revealed that abnormal activation and impaired function of MAIT cells may be related to abnormal elevation of lipids and lipid-like metabolites in PTB.<\/jats:p>","DOI":"10.1093\/molehr\/gaae006","type":"journal-article","created":{"date-parts":[[2024,2,4]],"date-time":"2024-02-04T05:15:13Z","timestamp":1707023713000},"source":"Crossref","is-referenced-by-count":2,"title":["Dysregulation of mucosal-associated invariant T cells correlates with altered placental microenvironment in preterm birth"],"prefix":"10.1093","volume":"30","author":[{"given":"Mi","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoquan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiongwen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1790-4981","authenticated-orcid":false,"given":"Min","family":"Xiong","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2625-2137","authenticated-orcid":false,"given":"Xiufang","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, 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