{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:09:46Z","timestamp":1753877386663,"version":"3.41.2"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"JSPS KAKENHI","award":["19K09779","21K09447","22K09570"],"award-info":[{"award-number":["19K09779","21K09447","22K09570"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Preterm birth is a serious pregnancy complication that affects neonatal mortality, morbidity, and long-term neurological prognosis. Predicting spontaneous preterm delivery (PTD) is important for its management. While excluding the risk of PTD is important, identifying women at high risk of PTD is imperative for medical intervention. Currently used PTD prediction parameters in clinical practice have shown high negative predictive values, but low positive predictive values. We focused on sulfated and sialylated glycocalyx changes in the uterus and vagina prior to the onset of parturition and explored the potential of electrophysiological detection of these changes as a PTD prediction parameter with a high positive predictive value. In vivo local vaginal bioelectrical impedance (VZ) was measured using two different mouse PTD models. PTD was induced in ICR mice through the subcutaneous injection of mifepristone or local intrauterine injection of lipopolysaccharide (LPS). The PTD rates were 100% and 60% post-administration of mifepristone (16\u201320\u2009h, n\u2009=\u20094) and LPS (12\u201324\u2009h, n\u2009=\u200920), respectively. The local VZ values (15 and 10\u2009h after mifepristone or LPS treatment, respectively) were significantly lower in the PTD group than in the non-PTD group. Receiver operator characteristic (ROC) curve analysis of VZ at 125\u2009kHz as a predictor of PTD showed an area under the ROC curve of 1.00 and 0.77 and positive predictive values of 1.00 and 0.86, for the mifepristone and LPS models, respectively, suggesting that local VZ value can predict PTD. Histological examination of the LPS-treated model 6\u2009h post-treatment revealed increased expression of sulfomucins and\/or sulfated proteoglycans and sialomucins in the cervical epithelium, cervical stroma and vaginal stroma. In conclusion, local VZ values can determine sulfated and sialylated glycocalyx alterations within the uterus and vagina and might be a useful PTD prediction parameter.<\/jats:p>","DOI":"10.1093\/molehr\/gaae021","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T20:50:45Z","timestamp":1717447845000},"source":"Crossref","is-referenced-by-count":0,"title":["Local vaginal bioelectrical impedance can predict preterm delivery in mice"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4158-5474","authenticated-orcid":false,"given":"Reina","family":"Komatsu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Osaka University Graduate School of Medicine , Suita, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1439-0375","authenticated-orcid":false,"given":"Hitomi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Osaka University Graduate School of Medicine , Suita, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Hosono","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Engineering, Osaka Electro-Communication University , Shijyo-nawate, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Osaka University Graduate School of Medicine , Suita, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn J P","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester , Manchester, UK"},{"name":"Manchester Academic Health Sciences Centre, St Mary's Hospital , Manchester, UK"},{"name":"Maternal and Fetal Health Research Centre, St Mary\u2019s Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre , Manchester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8777-9261","authenticated-orcid":false,"given":"John D","family":"Aplin","sequence":"additional","affiliation":[{"name":"Division of Developmental Biology and Medicine, Maternal and Fetal Health Research Centre, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester , Manchester, UK"},{"name":"Manchester Academic Health Sciences Centre, St Mary's Hospital , Manchester, UK"},{"name":"Maternal and Fetal 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