{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:52:15Z","timestamp":1780581135652,"version":"3.54.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2702500"],"award-info":[{"award-number":["2022YFC2702500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82022028"],"award-info":[{"award-number":["82022028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171627"],"award-info":[{"award-number":["82171627"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371643"],"award-info":[{"award-number":["82371643"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82288102"],"award-info":[{"award-number":["82288102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease, which leads to serious impairment of reproductive health in women of child-bearing age. Anovulation or oligo-ovulation is a common clinical manifestation of PCOS patients. A disturbance of the ovarian immune microenvironment contributes to the disorders of follicle development and ovulation; however, the underlying mechanism remains unclear. Here we demonstrated the protective effect of immune factor interleukin-22 (IL-22) on PCOS follicle development and ovulation. Follicular IL-22 levels were significantly lower in PCOS patients than in the control group and were positively correlated with oocyte fertilization rate and high-quality embryo rate. Additionally, IL-22 evidently improved follicle development in vitro and promoted ovulation-related gene expression, which was disrupted by the depletion of interleukin-22 receptor 1 (IL-22R1) or inhibition of STAT3 in granulosa cells. This indicates that IL-22 acts through IL-22R1 and the STAT3 signaling pathway to promote follicle development and ovulation in PCOS. In summary, this study has elucidated the vital role of the ovarian immune microenvironment in follicle development and ovulation. Application of IL-22 may provide new insights into the treatment of PCOS patients.<\/jats:p>","DOI":"10.1093\/molehr\/gaae037","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T16:42:12Z","timestamp":1729269732000},"source":"Crossref","is-referenced-by-count":5,"title":["Interleukin-22 improves ovulation in polycystic ovary syndrome via STAT3 signaling"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1859-001X","authenticated-orcid":false,"given":"Baoying","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University Third Hospital , Beijing,","place":["China"]},{"name":"National Clinical Research Center for Obstetrics and Gynaecology, Peking University Third Hospital , Beijing,","place":["China"]},{"name":"Ministry of Education, Key Laboratory of Assisted Reproduction (Peking University) , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University Third Hospital , Beijing,","place":["China"]},{"name":"National Clinical Research Center for Obstetrics and Gynaecology, Peking University Third Hospital , Beijing,","place":["China"]},{"name":"Ministry of Education, Key Laboratory of Assisted Reproduction (Peking University) , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University Third Hospital , Beijing,","place":["China"]},{"name":"National Clinical Research Center for Obstetrics and Gynaecology, Peking University Third Hospital , Beijing,","place":["China"]},{"name":"Ministry of Education, Key Laboratory of Assisted Reproduction (Peking University) , Beijing,","place":["China"]},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyu","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University Third Hospital , Beijing,","place":["China"]},{"name":"National Clinical Research Center for Obstetrics and Gynaecology, Peking University Third Hospital , Beijing,","place":["China"]},{"name":"Ministry of Education, Key Laboratory of Assisted Reproduction (Peking University) , Beijing,","place":["China"]},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1967-2416","authenticated-orcid":false,"given":"Yanli","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Peking University Third Hospital , Beijing,","place":["China"]},{"name":"National Clinical Research Center for Obstetrics and Gynaecology, Peking University Third Hospital , Beijing,","place":["China"]},{"name":"Ministry of Education, Key Laboratory of Assisted Reproduction (Peking University) , Beijing,","place":["China"]},{"name":"Institute of Advanced Clinical Medicine, Peking University , Beijing,","place":["China"]},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"key":"2024103104385141900_gaae037-B1","doi-asserted-by":"crossref","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"Azziz","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2024103104385141900_gaae037-B2","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.1002\/jcp.30305","article-title":"TGF-\u03b21 stimulates aromatase expression and estradiol production through SMAD2 and ERK1\/2 signaling pathways in human granulosa-lutein cells","volume":"236","author":"Cheng","year":"2021","journal-title":"J Cell Physiol"},{"key":"2024103104385141900_gaae037-B3","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1095\/biolreprod.106.057471","article-title":"Oocyte-secreted factor activation of SMAD 2\/3 signaling enables initiation of mouse cumulus cell expansion","volume":"76","author":"Dragovic","year":"2007","journal-title":"Biol Reprod"},{"key":"2024103104385141900_gaae037-B4","doi-asserted-by":"crossref","first-page":"e2476","DOI":"10.1038\/cddis.2016.379","article-title":"TGF-\u03b2 signaling controls FSHR signaling-reduced ovarian granulosa cell apoptosis through the SMAD4\/miR-143 axis","volume":"7","author":"Du","year":"2016","journal-title":"Cell Death Dis"},{"key":"2024103104385141900_gaae037-B5","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment","volume":"14","author":"Escobar-Morreale","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"2024103104385141900_gaae037-B6","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.218123","article-title":"Nuclear exclusion of SMAD2\/3 in granulosa cells is associated with primordial follicle activation in the mouse 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