{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:31:54Z","timestamp":1792027914193,"version":"4.4.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Jiangsu Provincial Natural Science Foundation of China","award":["BK20211006"],"award-info":[{"award-number":["BK20211006"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271653"],"award-info":[{"award-number":["82271653"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471663"],"award-info":[{"award-number":["82471663"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Endometriosis is a chronic inflammatory disorder in which immune cells, specifically macrophages, play a pivotal yet incompletely understood role. Aberrations within the eutopic endometrium are implicated in the initiation and progression of endometriosis. In this study, we reported a notable increase in the proportion of a distinct S100A9+ macrophage subpopulation undergoing ferroptosis in the eutopic endometrium of endometriosis patients compared with normal endometrium, as evidenced by single-cell RNA sequencing and experimental validation. Furthermore, we confirmed that Ammonium iron (III) citrate-treated macrophages upregulate S100A9 through the NF-\u03baB pathway in vitro. Subsequent cell function experiments and endometriosis mouse models revealed that S100A9 promotes the development of endometriosis by facilitating angiogenesis. Notably, the S100A9 inhibitor Tasquinimod effectively reduced angiogenesis and thereby reduced ectopic lesions in mice. These results indicated that S100A9+ macrophages represent a potential therapeutic target for endometriosis.<\/jats:p>","DOI":"10.1093\/molehr\/gaaf027","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T20:20:07Z","timestamp":1749586807000},"source":"Crossref","is-referenced-by-count":5,"title":["Eutopic macrophages facilitate endometriosis progression via ferroptosis-mediated release of S100A9"],"prefix":"10.1093","volume":"31","author":[{"given":"Chunying","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panmei","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichen","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6456-3435","authenticated-orcid":false,"given":"Guangfeng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine , Nanjing,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0600-2176","authenticated-orcid":false,"given":"Qiao","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine , Nanjing,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"2025063012262044400_gaaf027-B1","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.3390\/cells11132028","article-title":"The role of the immune system in the development of endometriosis","volume":"11","author":"Abramiuk","year":"2022","journal-title":"Cells"},{"key":"2025063012262044400_gaaf027-B2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1158\/0008-5472.CAN-23-4036","article-title":"Macrophages under the influence of tumor mesothelin weaken host defenses against pancreatic cancer metastasis","volume":"84","author":"Alewine","year":"2024","journal-title":"Cancer Res"},{"key":"2025063012262044400_gaaf027-B3","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.3390\/ijms22105196","article-title":"Endometriosis and cancer: exploring the role of macrophages","volume":"22","author":"Artemova","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025063012262044400_gaaf027-B4","doi-asserted-by":"crossref","first-page":"547","DOI":"10.2353\/ajpath.2009.081011","article-title":"Macrophages are alternatively activated in patients with endometriosis and required for growth and vascularization of lesions in a mouse model of disease","volume":"175","author":"Bacci","year":"2009","journal-title":"Am J Pathol"},{"key":"2025063012262044400_gaaf027-B5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3892\/mmr.2024.13167","article-title":"Angiogenesis signaling in endometriosis: molecules, diagnosis and treatment (review)","volume":"29","author":"Bo","year":"2024","journal-title":"Mol Med Rep"},{"key":"2025063012262044400_gaaf027-B6","doi-asserted-by":"crossref","first-page":"e13636","DOI":"10.1111\/cpr.13636","article-title":"Advances in the study of S100A9 in cardiovascular diseases","volume":"57","author":"Chen","year":"2024","journal-title":"Cell Prolif"},{"key":"2025063012262044400_gaaf027-B7","doi-asserted-by":"crossref","first-page":"188891","DOI":"10.1016\/j.bbcan.2023.188891","article-title":"S100A8 and S100A9 in cancer","volume":"1878","author":"Chen","year":"2023","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"2025063012262044400_gaaf027-B8","doi-asserted-by":"crossref","first-page":"e23507","DOI":"10.1016\/j.heliyon.2023.e23507","article-title":"The application of approaches in detecting ferroptosis","volume":"10","author":"Chen","year":"2024","journal-title":"Heliyon"},{"key":"2025063012262044400_gaaf027-B9","doi-asserted-by":"crossref","first-page":"5005136","DOI":"10.1155\/2021\/5005136","article-title":"Ferroptosis mediated by lipid reactive oxygen species: a possible causal link of neuroinflammation to neurological disorders","volume":"2021","author":"Cheng","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"2025063012262044400_gaaf027-B10","doi-asserted-by":"crossref","first-page":"856316","DOI":"10.3389\/fgwh.2022.856316","article-title":"Endometriosis-associated angiogenesis and anti-angiogenic therapy for endometriosis","volume":"3","author":"Chung","year":"2022","journal-title":"Front Glob Womens Health"},{"key":"2025063012262044400_gaaf027-B11","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1158\/2326-6066.CIR-17-0192","article-title":"Extracellular S100A9 protein in bone marrow supports multiple myeloma survival by stimulating angiogenesis and cytokine secretion","volume":"5","author":"De Veirman","year":"2017","journal-title":"Cancer Immunol Res"},{"key":"2025063012262044400_gaaf027-B12","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.autrev.2012.01.005","article-title":"Is there an association between autoimmunity and endometriosis?","volume":"11","author":"Eisenberg","year":"2012","journal-title":"Autoimmunity Reviews"},{"key":"2025063012262044400_gaaf027-B13","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1189\/jlb.0306170","article-title":"S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules","volume":"81","author":"Foell","year":"2007","journal-title":"J Leukoc Biol"},{"key":"2025063012262044400_gaaf027-B14","doi-asserted-by":"crossref","first-page":"11210","DOI":"10.1096\/fj.201900797R","article-title":"Macrophage-derived insulin-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associated with endometriosis","volume":"33","author":"Forster","year":"2019","journal-title":"FASEB J"},{"key":"2025063012262044400_gaaf027-B15","doi-asserted-by":"crossref","first-page":"110540","DOI":"10.1016\/j.intimp.2023.110540","article-title":"Neutrophils regulate tumor angiogenesis in oral squamous cell carcinoma and the role of Chemerin","volume":"121","author":"Gao","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"2025063012262044400_gaaf027-B16","doi-asserted-by":"crossref","first-page":"e13204","DOI":"10.1097\/MD.0000000000013204","article-title":"Efficacy of tasquinimod in men with metastatic castration-resistant prostate cancer","volume":"97","author":"Gong","year":"2018","journal-title":"Medicine"},{"key":"2025063012262044400_gaaf027-B17","first-page":"151","article-title":"Retrograde menstruation in healthy women and in patients with endometriosis","volume":"64","author":"Halme","year":"1984","journal-title":"Obstet Gynecol"},{"key":"2025063012262044400_gaaf027-B18","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/humupd\/4.5.736","article-title":"Angiogenesis: a new theory for endometriosis","volume":"4","author":"Healy","year":"1998","journal-title":"Hum Reprod Update"},{"key":"2025063012262044400_gaaf027-B19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fendo.2020.00007","article-title":"Endometriosis-associated macrophages: origin, phenotype, and function","volume":"11","author":"Hogg","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2025063012262044400_gaaf027-B20","doi-asserted-by":"crossref","first-page":"e070750","DOI":"10.1136\/bmj-2022-070750","article-title":"Pathophysiology, diagnosis, and management of endometriosis","volume":"379","author":"Horne","year":"2022","journal-title":"BMJ"},{"key":"2025063012262044400_gaaf027-B21","doi-asserted-by":"crossref","first-page":"1307748","DOI":"10.3389\/fimmu.2024.1307748","article-title":"Deconvolution of synovial myeloid cell subsets across pathotypes and role of COL3A1+ macrophages in rheumatoid arthritis remission","volume":"15","author":"Hu","year":"2024","journal-title":"Front Immunol"},{"key":"2025063012262044400_gaaf027-B22","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/cei\/uxad029","article-title":"Single-cell transcriptome analysis reveals endometrial immune microenvironment in minimal\/mild endometriosis","volume":"212","author":"Huang","year":"2023","journal-title":"Clin Exp Immunol"},{"key":"2025063012262044400_gaaf027-B23","doi-asserted-by":"crossref","first-page":"e34207","DOI":"10.1371\/journal.pone.0034207","article-title":"S100A9 interaction with TLR4 promotes tumor growth","volume":"7","author":"K\u00e4llberg","year":"2012","journal-title":"PLoS One"},{"key":"2025063012262044400_gaaf027-B24","doi-asserted-by":"crossref","first-page":"306","DOI":"10.5114\/reum.2016.64907","article-title":"Calprotectin in rheumatic diseases: a review","volume":"54","author":"Kope\u0107-M\u0119drek","year":"2016","journal-title":"Rheumatology"},{"key":"2025063012262044400_gaaf027-B25","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.bbrc.2012.05.162","article-title":"S100A8 and S100A9 are messengers in the crosstalk between epidermis and dermis modulating a psoriatic milieu in human skin","volume":"423","author":"Lee","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"2025063012262044400_gaaf027-B26","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1042\/BJ20090465","article-title":"A novel p53 target gene, S100A9, induces p53-dependent cellular apoptosis and mediates the p53 apoptosis pathway","volume":"422","author":"Li","year":"2009","journal-title":"Biochem J"},{"key":"2025063012262044400_gaaf027-B27","doi-asserted-by":"crossref","first-page":"248574","DOI":"10.1155\/2012\/248574","article-title":"Low concentration of S100A8\/9 promotes angiogenesis-related activity of vascular endothelial cells: bridges among inflammation, angiogenesis, and tumorigenesis?","volume":"2012","author":"Li","year":"2012","journal-title":"Mediators Inflamm"},{"key":"2025063012262044400_gaaf027-B28","first-page":"2225","article-title":"S100A proteins in the pathogenesis of experimental corneal neovascularization","volume":"16","author":"Li","year":"2010","journal-title":"Mol Vis"},{"key":"2025063012262044400_gaaf027-B29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41420-022-00821-z","article-title":"Endometrial stromal cell ferroptosis promotes angiogenesis in endometriosis","volume":"8","author":"Li","year":"2022","journal-title":"Cell Death Discov"},{"key":"2025063012262044400_gaaf027-B30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10238-024-01454-5","article-title":"Integrative single-cell and bulk transcriptome analyses identify a distinct pro-tumor macrophage signature that has a major prognostic impact on glioblastomas","volume":"24","author":"Li","year":"2024","journal-title":"Clin Exp Med"},{"key":"2025063012262044400_gaaf027-B31","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/humrep\/deaa363","article-title":"Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis","volume":"36","author":"Li","year":"2021","journal-title":"Hum Reprod"},{"key":"2025063012262044400_gaaf027-B32","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/s41589-022-01033-3","article-title":"Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability","volume":"18","author":"Li","year":"2022","journal-title":"Nat Chem Biol"},{"key":"2025063012262044400_gaaf027-B33","first-page":"Ra92","article-title":"Is abnormal eutopic endometrium the cause of endometriosis? The role of eutopic endometrium in pathogenesis of endometriosis","volume":"17","author":"Liu","year":"2011","journal-title":"Med Sci Monit"},{"key":"2025063012262044400_gaaf027-B34","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/s41423-021-00636-5","article-title":"Placenta-derived IL-32\u03b2 activates neutrophils to promote preeclampsia development","volume":"18","author":"Liu","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"2025063012262044400_gaaf027-B35","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41419-023-06045-y","article-title":"The diversified role of mitochondria in ferroptosis in cancer","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Disease"},{"key":"2025063012262044400_gaaf027-B36","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/j.fertnstert.2008.02.103","article-title":"Iron storage is significantly increased in peritoneal macrophages of endometriosis patients and correlates with iron overload in peritoneal fluid","volume":"91","author":"Lousse","year":"2009","journal-title":"Fertil Steril"},{"key":"2025063012262044400_gaaf027-B37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13578-021-00637-x","article-title":"Single-cell transcriptomic analysis of endometriosis provides insights into fibroblast fates and immune cell heterogeneity","volume":"11","author":"Ma","year":"2021","journal-title":"Cell Biosci"},{"key":"2025063012262044400_gaaf027-B38","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1471-4914(03)00051-0","article-title":"Pathogenesis of endometriosis: natural immunity dysfunction or autoimmune disease?","volume":"9","author":"Matarese","year":"2003","journal-title":"Trends Mol Med"},{"key":"2025063012262044400_gaaf027-B39","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cytogfr.2021.10.004","article-title":"S100A8\/A9 in COVID-19 pathogenesis: Impact on clinical outcomes","volume":"63","author":"Mellett","year":"2022","journal-title":"Cytokine Growth Factor Rev"},{"key":"2025063012262044400_gaaf027-B40","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1161\/CIRCRESAHA.116.309194","article-title":"Abandoning M1\/M2 for a network model of macrophage function","volume":"119","author":"Nahrendorf","year":"2016","journal-title":"Circulation Research"},{"key":"2025063012262044400_gaaf027-B41","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/hep.23099","article-title":"S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis","volume":"50","author":"N\u00e9meth","year":"2009","journal-title":"Hepatology"},{"key":"2025063012262044400_gaaf027-B42","doi-asserted-by":"crossref","first-page":"e37421","DOI":"10.1097\/MD.0000000000037421","article-title":"Ferroptosis and oxidative stress in endometriosis: a systematic review of the literature","volume":"103","author":"Ni","year":"2024","journal-title":"Medicine (Baltimore)"},{"key":"2025063012262044400_gaaf027-B43","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1476-4598-9-107","article-title":"Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors","volume":"9","author":"Olsson","year":"2010","journal-title":"Mol Cancer"},{"key":"2025063012262044400_gaaf027-B44","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/s41598-020-79578-3","article-title":"CD206+\u2009macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model","volume":"11","author":"Ono","year":"2021","journal-title":"Sci Rep"},{"key":"2025063012262044400_gaaf027-B45","doi-asserted-by":"crossref","first-page":"770472","DOI":"10.3389\/fncel.2021.770472","article-title":"Role of RAGE and its ligands on inflammatory responses to brain tumors","volume":"15","author":"Otazu","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"2025063012262044400_gaaf027-B46","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.3390\/cells12091318","article-title":"Vascularisation in deep endometriosis: a systematic review with narrative outcomes","volume":"12","author":"Powell","year":"2023","journal-title":"Cells"},{"key":"2025063012262044400_gaaf027-B47","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41418-018-0173-9","article-title":"Ferroptosis and necroinflammation, a yet poorly explored link","volume":"26","author":"Proneth","year":"2019","journal-title":"Cell Death Differ"},{"key":"2025063012262044400_gaaf027-B48","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.7150\/thno.91180","article-title":"Single-cell RNA sequencing reveals S100a9(hi) macrophages promote the transition from acute inflammation to fibrotic remodeling after myocardial ischemia\u2013reperfusion","volume":"14","author":"Shen","year":"2024","journal-title":"Theranostics"},{"key":"2025063012262044400_gaaf027-B49","doi-asserted-by":"crossref","first-page":"10554","DOI":"10.3390\/ijms221910554","article-title":"Endometriosis: epidemiology, classification, pathogenesis, treatment and genetics (review of literature)","volume":"22","author":"Smolarz","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025063012262044400_gaaf027-B50","doi-asserted-by":"crossref","first-page":"179515","DOI":"10.1155\/2014\/179515","article-title":"Theories on the pathogenesis of endometriosis","volume":"2014","author":"Sourial","year":"2014","journal-title":"Int J Reprod Med"},{"key":"2025063012262044400_gaaf027-B51","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"2025063012262044400_gaaf027-B52","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.molmed.2018.07.004","article-title":"The immunopathophysiology of endometriosis","volume":"24","author":"Symons","year":"2018","journal-title":"Trends Mol Med"},{"key":"2025063012262044400_gaaf027-B53","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/s41419-020-2347-x","article-title":"Frataxin deficiency induces lipid accumulation and affects thermogenesis in brown adipose tissue","volume":"11","author":"Turchi","year":"2020","journal-title":"Cell Death Disease"},{"key":"2025063012262044400_gaaf027-B54","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-pathmechdis-012419-032654","article-title":"The origin and pathogenesis of endometriosis","volume":"15","author":"Wang","year":"2020","journal-title":"Annu Rev Pathol"},{"key":"2025063012262044400_gaaf027-B55","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1210\/en.2005-0790","article-title":"Neutrophils and macrophages promote angiogenesis in the early stage of endometriosis in a mouse model","volume":"147","author":"Wing","year":"2006","journal-title":"Endocrinology"},{"key":"2025063012262044400_gaaf027-B56","doi-asserted-by":"crossref","first-page":"110319","DOI":"10.1016\/j.ygeno.2022.110319","article-title":"Human umbilical cord mesenchymal stem cell-derived extracellular vesicles loaded with miR-223 ameliorate myocardial infarction through P53\/S100A9 axis","volume":"114","author":"Yang","year":"2022","journal-title":"Genomics"},{"key":"2025063012262044400_gaaf027-B57","doi-asserted-by":"crossref","first-page":"e068950","DOI":"10.1136\/bmj-2021-068950","article-title":"Endometriosis","volume":"379","author":"Ye","year":"2022","journal-title":"BMJ"},{"key":"2025063012262044400_gaaf027-B58","doi-asserted-by":"crossref","first-page":"6189","DOI":"10.3390\/cimb44120422","article-title":"Baicalein relieves ferroptosis-mediated phagocytosis inhibition of macrophages in ovarian endometriosis","volume":"44","author":"Yi","year":"2022","journal-title":"Curr Issues Mol Biol"},{"key":"2025063012262044400_gaaf027-B59","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41419-024-06807-2","article-title":"Advances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases","volume":"15","author":"Zeng","year":"2024","journal-title":"Cell Death Dis"},{"key":"2025063012262044400_gaaf027-B60","doi-asserted-by":"crossref","first-page":"e007441","DOI":"10.1136\/jitc-2023-007441","article-title":"C1q+ tumor-associated macrophages contribute to immunosuppression through fatty acid metabolic reprogramming in malignant pleural effusion","volume":"11","author":"Zhang","year":"2023","journal-title":"J Immunother Cancer"},{"key":"2025063012262044400_gaaf027-B61","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1056\/NEJMra1810764","article-title":"Endometriosis","volume":"382","author":"Zondervan","year":"2020","journal-title":"N Engl J Med"},{"key":"2025063012262044400_gaaf027-B62","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13578-021-00613-5","article-title":"Cell subtypes and immune dysfunction in peritoneal fluid of endometriosis revealed by single-cell RNA-sequencing","volume":"11","author":"Zou","year":"2021","journal-title":"Cell Biosci"}],"container-title":["Molecular Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/molehr\/advance-article-pdf\/doi\/10.1093\/molehr\/gaaf027\/63464937\/gaaf027.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molehr\/article-pdf\/31\/2\/gaaf027\/63464937\/gaaf027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molehr\/article-pdf\/31\/2\/gaaf027\/63464937\/gaaf027.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T16:26:38Z","timestamp":1751300798000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molehr\/article\/doi\/10.1093\/molehr\/gaaf027\/8160022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4,3]]}},"URL":"https:\/\/doi.org\/10.1093\/molehr\/gaaf027","relation":{},"ISSN":["1460-2407"],"issn-type":[{"value":"1460-2407","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025]]},"published":{"date-parts":[[2025]]},"article-number":"gaaf027"}}