{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T23:30:42Z","timestamp":1768606242245,"version":"3.49.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Magee Womens Research Institute and Foundation"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R21 HD110826"],"award-info":[{"award-number":["R21 HD110826"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"the National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG080590-01"],"award-info":[{"award-number":["R01AG080590-01"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endometriosis (EM) is a debilitating disease involving the growth of endometrial glands and stroma outside the uterus. To further our understanding of epigenomic dysregulation in EM and search for disease biomarkers, we performed a comprehensive evaluation of DNA methylation in eutopic endometrium (EE) and EM lesions. We undertook deconvolution analysis of DNA methylation data previously generated from endometrial aspirate biopsies obtained from 637 EM cases and 347 controls using microarray-based DNA methylation analysis. We further analyzed DNA methylation in EM lesions and paired EE samples via solution phase hybridization and DNA sequencing. For analysis of microarray data, we used a reference-free approach (BCconf) to recover latent factors and found high correlation with EM status, suggesting EE cell proportions vary between EM cases and controls. Deconvolution revealed that epithelial cells (P-value\u2009=\u20099.1\u2009\u00d7\u200910\u22123) and fibroblasts (P-value\u2009=\u20090.022) were reduced in EM cases. Deconvolution of the sequencing data identified differences between EM lesions and EE of cases and controls, including vascular endothelial cells (false discovery rate [FDR]-adjusted P-value\u2009=\u20096.1\u2009\u00d7\u200910\u22123; more abundant in EM lesions), natural killer cells (FDR-adjusted P-value\u2009=\u20090.031; less abundant in EM lesions) and ovarian\/endometrial epithelium (FDR-adjusted P-value\u2009=\u20093.2\u2009\u00d7\u200910\u22123). We detected significant differences in cell type proportion between EE samples of cases and controls. Improved reference data for deconvolution to inform more intelligent region targeting approaches will provide further insight into the molecular phenotype of EM and may inform novel approaches for minimally invasive detection.<\/jats:p>","DOI":"10.1093\/molehr\/gaaf061","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T12:54:26Z","timestamp":1766148866000},"source":"Crossref","is-referenced-by-count":0,"title":["Deconvolution of DNA methylation data reveals cell type-specific epigenomic signatures in endometriosis and eutopic endometrium"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6638-7772","authenticated-orcid":false,"given":"Yucheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Statistics, University of Pittsburgh , Pittsburgh, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A","family":"Shaw","sequence":"additional","affiliation":[{"name":"Magee-Womens Research Institute , Pittsburgh, PA,","place":["USA"]},{"name":"Signature Diagnostics , Pittsburgh, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1019-9431","authenticated-orcid":false,"given":"Camille K","family":"Boufford","sequence":"additional","affiliation":[{"name":"Magee-Womens Research Institute , Pittsburgh, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley C","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh , Pittsburgh, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4336-5010","authenticated-orcid":false,"given":"Elizabeth","family":"Lewis","sequence":"additional","affiliation":[{"name":"Magee-Womens Research Institute , Pittsburgh, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5744-4188","authenticated-orcid":false,"given":"Amanda","family":"Vallon","sequence":"additional","affiliation":[{"name":"Magee-Womens Research Institute , Pittsburgh, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Tavares Naief","sequence":"additional","affiliation":[{"name":"Magee-Womens Research Institute , Pittsburgh, PA,","place":["USA"]},{"name":"Signature Diagnostics , Pittsburgh, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Ednie","sequence":"additional","affiliation":[{"name":"Magee-Womens Research Institute , Pittsburgh, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9494-9024","authenticated-orcid":false,"given":"Laken","family":"Ritzert","sequence":"additional","affiliation":[{"name":"Magee-Womens Research Institute , Pittsburgh, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1928-3234","authenticated-orcid":false,"given":"Francis R G","family":"Amrit","sequence":"additional","affiliation":[{"name":"Signature Diagnostics , Pittsburgh, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9872-0249","authenticated-orcid":false,"given":"Nicole M","family":"Donnellan","sequence":"additional","affiliation":[{"name":"Magee-Womens Research Institute , Pittsburgh, PA,","place":["USA"]},{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh , Pittsburgh, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9644-771X","authenticated-orcid":false,"given":"Tianjiao","family":"Chu","sequence":"additional","affiliation":[{"name":"Magee-Womens Research Institute , Pittsburgh, PA,","place":["USA"]},{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh , Pittsburgh, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2096-8257","authenticated-orcid":false,"given":"Chris G","family":"McKennan","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Pittsburgh , Pittsburgh, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4354-1125","authenticated-orcid":false,"given":"David G","family":"Peters","sequence":"additional","affiliation":[{"name":"Magee-Womens Research Institute , Pittsburgh, PA,","place":["USA"]},{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh , Pittsburgh, PA,","place":["USA"]},{"name":"Department of Human Genetics, University of Pittsburgh , Pittsburgh, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"2026011607121324300_gaaf061-B1","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1093\/hmg\/ddl253","article-title":"Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder","volume":"15","author":"Abdolmaleky","year":"2006","journal-title":"Hum Mol Genet"},{"key":"2026011607121324300_gaaf061-B2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s13059-024-03306-7","article-title":"sciMET-cap: high-throughput single-cell methylation analysis with a reduced sequencing burden","volume":"25","author":"Acharya","year":"2024","journal-title":"Genome Biol"},{"key":"2026011607121324300_gaaf061-B3","doi-asserted-by":"crossref","first-page":"R87","DOI":"10.1186\/gb-2012-13-10-r87","article-title":"methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles","volume":"13","author":"Akalin","year":"2012","journal-title":"Genome Biol"},{"key":"2026011607121324300_gaaf061-B4","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nbt.1533","article-title":"Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells","volume":"27","author":"Ball","year":"2009","journal-title":"Nat Biotechnol"},{"key":"2026011607121324300_gaaf061-B5","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/pd.3853","article-title":"Discovery of epigenetic biomarkers for the noninvasive diagnosis of fetal disease","volume":"32","author":"Bunce","year":"2012","journal-title":"Prenat Diagn"},{"key":"2026011607121324300_gaaf061-B6","doi-asserted-by":"crossref","first-page":"5413","DOI":"10.1523\/JNEUROSCI.2730-19.2020","article-title":"Modular and distinct plexin-A4\/FARP2\/Rac1 signaling controls dendrite morphogenesis","volume":"40","author":"Danelon","year":"2020","journal-title":"J Neurosci"},{"key":"2026011607121324300_gaaf061-B7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3389\/fphys.2012.00097","article-title":"Nerve-cancer interactions in the stromal biology of pancreatic cancer","volume":"3","author":"Demir","year":"2012","journal-title":"Front Physiol"},{"key":"2026011607121324300_gaaf061-B8","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.bpj.2015.08.012","article-title":"Claudin-11 tight junctions in myelin are a barrier to diffusion and lack strong adhesive properties","volume":"109","author":"Denninger","year":"2015","journal-title":"Biophys J"},{"key":"2026011607121324300_gaaf061-B9","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1186\/1471-2105-11-587","article-title":"Comparison of beta-value and M-value methods for quantifying methylation levels by microarray analysis","volume":"11","author":"Du","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"2026011607121324300_gaaf061-B10","doi-asserted-by":"crossref","first-page":"e1004158","DOI":"10.1371\/journal.pgen.1004158","article-title":"Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis","volume":"10","author":"Dyson","year":"2014","journal-title":"PLoS Genet"},{"key":"2026011607121324300_gaaf061-B11","doi-asserted-by":"crossref","first-page":"e1002732","DOI":"10.1080\/2162402X.2014.1002732","article-title":"Chronic inflammation in endometriosis and endometriosis-associated ovarian cancer: New roles for the \u201cold\u201d complement pathway","volume":"4","author":"Edwards","year":"2015","journal-title":"Oncoimmunology"},{"key":"2026011607121324300_gaaf061-B12","first-page":"474","article-title":"HOXA10 DNA Methylation Level in the Endometrium Women with Endometriosis: A Systematic Review","volume":"12","author":"Elias","year":"2023","journal-title":"Biology (Basel)"},{"key":"2026011607121324300_gaaf061-B13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0889-8545(05)70302-8","article-title":"Epidemiology of endometriosis","volume":"24","author":"Eskenazi","year":"1997","journal-title":"Obstet Gynecol Clin North Am"},{"key":"2026011607121324300_gaaf061-B14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ajpath.2019.09.008","article-title":"Involvement of transcription factor 21 in the pathogenesis of fibrosis in endometriosis","volume":"190","author":"Ganieva","year":"2020","journal-title":"Am J Pathol"},{"key":"2026011607121324300_gaaf061-B15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/01443615.2019.1603217","article-title":"Diagnostic delay for superficial and deep endometriosis in the United Kingdom","volume":"40","author":"Ghai","year":"2020","journal-title":"J Obstet Gynaecol"},{"key":"2026011607121324300_gaaf061-B16","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/humrep\/17.3.777","article-title":"Embryotoxicity of peritoneal fluid in women with endometriosis. Its relation with cytokines and lymphocyte populations","volume":"17","author":"Gomez-Torres","year":"2002","journal-title":"Hum Reprod"},{"key":"2026011607121324300_gaaf061-B17","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s13148-020-00983-6","article-title":"Global hypermethylation of intestinal epithelial cells is a hallmark feature of neonatal surgical necrotizing enterocolitis","volume":"12","author":"Good","year":"2020","journal-title":"Clin Epigenetics"},{"key":"2026011607121324300_gaaf061-B18","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1016\/j.ajpath.2015.04.012","article-title":"Estradiol is a critical mediator of macrophage-nerve cross talk in peritoneal endometriosis","volume":"185","author":"Greaves","year":"2015","journal-title":"Am J Pathol"},{"key":"2026011607121324300_gaaf061-B19","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/GRF.0000000000000298","article-title":"A review of the epigenetic contributions to endometriosis","volume":"60","author":"Grimstad","year":"2017","journal-title":"Clin Obstet Gynecol"},{"key":"2026011607121324300_gaaf061-B20","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/oxfordjournals.humrep.a019270","article-title":"Delay in the diagnosis of endometriosis: a survey of women from the USA and the UK","volume":"11","author":"Hadfield","year":"1996","journal-title":"Hum Reprod"},{"key":"2026011607121324300_gaaf061-B21","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1523\/JNEUROSCI.3035-17.2018","article-title":"Combinatorial effects of alpha- and gamma-protocadherins on neuronal survival and dendritic self-avoidance","volume":"38","author":"Ing-Esteves","year":"2018","journal-title":"J Neurosci"},{"key":"2026011607121324300_gaaf061-B22","doi-asserted-by":"crossref","first-page":"e13078","DOI":"10.1111\/aji.13078","article-title":"GATA6 expression promoted by an active enhancer may become a molecular marker in endometriosis lesions","volume":"81","author":"Izawa","year":"2019","journal-title":"Am J Reprod Immunol"},{"key":"2026011607121324300_gaaf061-B23","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1186\/gb-2014-15-2-r31","article-title":"Accounting for cellular heterogeneity is critical in epigenome-wide association studies","volume":"15","author":"Jaffe","year":"2014","journal-title":"Genome Biol"},{"key":"2026011607121324300_gaaf061-B24","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1046\/j.1523-1747.2003.12487.x","article-title":"17Beta-estradiol enhances the production of nerve growth factor in THP-1-derived macrophages or peripheral blood monocyte-derived macrophages","volume":"121","author":"Kanda","year":"2003","journal-title":"J Invest Dermatol"},{"key":"2026011607121324300_gaaf061-B25","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1177\/1933719118802053","article-title":"Upregulation of fibroblast growth factors caused by heart and neural crest derivatives expressed 2 suppression in endometriotic cells: a possible therapeutic target in endometriosis","volume":"26","author":"Kato","year":"2019","journal-title":"Reprod Sci"},{"key":"2026011607121324300_gaaf061-B26","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.cgh.2018.05.004","article-title":"Analysis of DNA methylation at specific loci in stool samples detects colorectal cancer and high-grade dysplasia in patients with inflammatory bowel disease","volume":"17","author":"Kisiel","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2026011607121324300_gaaf061-B27","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.3892\/mmr.2016.4925","article-title":"DNA methylation in endometriosis (review)","volume":"13","author":"Koukoura","year":"2016","journal-title":"Mol Med Rep"},{"key":"2026011607121324300_gaaf061-B28","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1093\/bioinformatics\/btr167","article-title":"Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications","volume":"27","author":"Krueger","year":"2011","journal-title":"Bioinformatics"},{"key":"2026011607121324300_gaaf061-B29","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/humupd\/dmy001","article-title":"Basic mechanisms of vascularization in endometriosis and their clinical implications","volume":"24","author":"Laschke","year":"2018","journal-title":"Hum Reprod Update"},{"key":"2026011607121324300_gaaf061-B30","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/humupd\/dmr023","article-title":"Vasculogenesis: a new piece of the endometriosis puzzle","volume":"17","author":"Laschke","year":"2011","journal-title":"Hum Reprod Update"},{"key":"2026011607121324300_gaaf061-B31","doi-asserted-by":"crossref","first-page":"E1826","DOI":"10.1073\/pnas.1519286113","article-title":"Identification of tissue-specific cell death using methylation patterns of circulating DNA","volume":"113","author":"Lehmann-Werman","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026011607121324300_gaaf061-B32","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mce.2016.01.012","article-title":"Potential role of estrogen in maintaining the imbalanced sympathetic and sensory innervation in endometriosis","volume":"424","author":"Liang","year":"2016","journal-title":"Mol Cell Endocrinol"},{"key":"2026011607121324300_gaaf061-B33","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12958-018-0441-z","article-title":"Villainous role of estrogen in macrophage-nerve interaction in endometriosis","volume":"16","author":"Liang","year":"2018","journal-title":"Reprod Biol Endocrinol"},{"key":"2026011607121324300_gaaf061-B34","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1177\/1933719116670036","article-title":"Silencing of SRA1 regulates ER expression and attenuates the growth of stromal cells in ovarian endometriosis","volume":"24","author":"Lin","year":"2017","journal-title":"Reprod Sci"},{"key":"2026011607121324300_gaaf061-B35","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.3390\/jpm13091284","article-title":"Spatiotemporal Trends and Age\u2013Period\u2013Cohort Analysis for the Burden of Endometriosis-Related Infertility: An Analysis of the Global Burden of Disease Study 2019","volume":"13","author":"Liu","year":"2023","journal-title":"J Pers Med"},{"key":"2026011607121324300_gaaf061-B36","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.14336\/AD.2018.1028","article-title":"TNFalpha-induced up-regulation of Ascl2 affects the differentiation and proliferation of neural stem cells","volume":"10","author":"Liu","year":"2019","journal-title":"Aging Dis"},{"key":"2026011607121324300_gaaf061-B37","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41586-022-05580-6","article-title":"A DNA methylation atlas of normal human cell types","volume":"613","author":"Loyfer","year":"2023","journal-title":"Nature"},{"key":"2026011607121324300_gaaf061-B38","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/biomet\/asz037","article-title":"Accounting for unobserved covariates with varying degrees of estimability in high-dimensional biological data","volume":"106","author":"McKennan","year":"2019","journal-title":"Biometrika"},{"key":"2026011607121324300_gaaf061-B39","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/01621459.2020.1769635","article-title":"Estimating and accounting for unobserved covariates in high-dimensional correlated data","volume":"117","author":"McKennan","year":"2022","journal-title":"J Am Stat Assoc"},{"key":"2026011607121324300_gaaf061-B40","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/GRF.0b013e3181db7bde","article-title":"Epidemiology of endometriosis: an assessment of risk factors","volume":"53","author":"McLeod","year":"2010","journal-title":"Clin Obstet Gynecol"},{"key":"2026011607121324300_gaaf061-B41","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.fertnstert.2006.11.200","article-title":"Peritoneal fluid macrophages in endometriosis: correlation between the expression of estrogen receptors and inflammation","volume":"90","author":"Montagna","year":"2008","journal-title":"Fertil Steril"},{"key":"2026011607121324300_gaaf061-B42","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.jaci.2020.07.005","article-title":"Epigenetic landscape links upper airway microbiota in infancy with allergic rhinitis at 6 years of age","volume":"146","author":"Morin","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"2026011607121324300_gaaf061-B43","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.jaci.2022.12.828","article-title":"A functional genomics pipeline to identify high-value asthma and allergy CpGs in the human methylome","volume":"151","author":"Morin","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"2026011607121324300_gaaf061-B44","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/humupd\/dmu021","article-title":"Peripheral changes in endometriosis-associated pain","volume":"20","author":"Morotti","year":"2014","journal-title":"Hum Reprod Update"},{"key":"2026011607121324300_gaaf061-B45","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/s42003-023-05070-z","article-title":"Global endometrial DNA methylation analysis reveals insights into mQTL regulation and associated endometriosis disease risk and endometrial function","volume":"6","author":"Mortlock","year":"2023","journal-title":"Commun Biol"},{"key":"2026011607121324300_gaaf061-B46","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.ygyno.2019.12.023","article-title":"Analysis of DNA methylation in endometrial biopsies to predict risk of endometrial cancer","volume":"156","author":"Multinu","year":"2020","journal-title":"Gynecol Oncol"},{"key":"2026011607121324300_gaaf061-B47","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.stem.2019.12.011","article-title":"Ascl2-dependent cell dedifferentiation drives regeneration of ablated intestinal stem cells","volume":"26","author":"Murata","year":"2020","journal-title":"Cell Stem Cell"},{"key":"2026011607121324300_gaaf061-B48","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.fertnstert.2011.05.090","article-title":"Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries","volume":"96","author":"Nnoaham","year":"2011","journal-title":"Fertil Steril"},{"key":"2026011607121324300_gaaf061-B49","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.3390\/jcm8091468","article-title":"NK Cells as Potential Targets for Immunotherapy in Endometriosis","volume":"8","author":"\u015acie\u017cy\u0144ska","year":"2019","journal-title":"J Clin Med"},{"key":"2026011607121324300_gaaf061-B50","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41586-018-0703-0","article-title":"Sensitive tumour detection and classification using plasma cell-free DNA methylomes","volume":"563","author":"Shen","year":"2018","journal-title":"Nature"},{"key":"2026011607121324300_gaaf061-B51","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.23031","article-title":"Foxd4 is essential for establishing neural cell fate and for neuronal differentiation","volume":"55","author":"Sherman","year":"2017","journal-title":"Genesis"},{"key":"2026011607121324300_gaaf061-B52","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1186\/s13104-018-3836-1","article-title":"Methylation analysis of HOXA10 regulatory elements in patients with endometriosis","volume":"11","author":"Signorile","year":"2018","journal-title":"BMC Res Notes"},{"key":"2026011607121324300_gaaf061-B53","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1073\/pnas.0510171102","article-title":"Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer","volume":"103","author":"Smith","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026011607121324300_gaaf061-B54","doi-asserted-by":"crossref","first-page":"12469","DOI":"10.1073\/pnas.0805012105","article-title":"Normal ovarian surface epithelial label-retaining cells exhibit stem\/progenitor cell characteristics","volume":"105","author":"Szotek","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026011607121324300_gaaf061-B55","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s11626-016-0056-7","article-title":"Induction of specific neuron types by overexpression of single transcription factors","volume":"52","author":"Teratani-Ota","year":"2016","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"2026011607121324300_gaaf061-B56","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1093\/humrep\/del260","article-title":"Nerve fibres in peritoneal endometriosis","volume":"21","author":"Tokushige","year":"2006","journal-title":"Hum Reprod"},{"key":"2026011607121324300_gaaf061-B57","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.cell.2009.01.031","article-title":"Transcription factor achaete scute-like 2 controls intestinal stem cell fate","volume":"136","author":"van der Flier","year":"2009","journal-title":"Cell"},{"key":"2026011607121324300_gaaf061-B58","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1007\/s00018-007-6526-z","article-title":"Epigenetic mechanisms in the context of complex diseases","volume":"64","author":"van Vliet","year":"2007","journal-title":"Cell Mol Life Sci"},{"key":"2026011607121324300_gaaf061-B59","doi-asserted-by":"crossref","first-page":"e2016517118","DOI":"10.1073\/pnas.2016517118","article-title":"ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development","volume":"118","author":"Varberg","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026011607121324300_gaaf061-B60","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1093\/humupd\/dmae023","article-title":"The role of fibrosis in endometriosis: a systematic review","volume":"30","author":"Vissers","year":"2024","journal-title":"Hum Reprod Update"},{"key":"2026011607121324300_gaaf061-B61","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ajog.2005.01.034","article-title":"Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis","volume":"193","author":"Wu","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"2026011607121324300_gaaf061-B62","doi-asserted-by":"crossref","first-page":"454","DOI":"10.5468\/ogs.21114","article-title":"Detection of nerve fibers in the eutopic endometrium of women with endometriosis, uterine fibroids and adenomyosis","volume":"64","author":"Yadav","year":"2021","journal-title":"Obstet Gynecol Sci"},{"key":"2026011607121324300_gaaf061-B63","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.3390\/ijms25063362","article-title":"An Estrogen\u2013NK Cells Regulatory Axis in Endometriosis, Related Infertility, and Miscarriage","volume":"25","author":"Yang","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026011607121324300_gaaf061-B64","doi-asserted-by":"crossref","first-page":"e0170859","DOI":"10.1371\/journal.pone.0170859","article-title":"Epigenetic alterations affecting transcription factors and signaling pathways in stromal cells of endometriosis","volume":"12","author":"Yotova","year":"2017","journal-title":"PLoS One"},{"key":"2026011607121324300_gaaf061-B65","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.1093\/hmg\/ddv196","article-title":"Increased burden of de novo predicted deleterious variants in complex congenital diaphragmatic hernia","volume":"24","author":"Yu","year":"2015","journal-title":"Hum Mol Genet"},{"key":"2026011607121324300_gaaf061-B66","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.2147\/JPR.S453148","article-title":"Distribution of nerve fibers in abdominal wall endometriosis and their clinical significance","volume":"17","author":"Zhang","year":"2024","journal-title":"J Pain Res"},{"key":"2026011607121324300_gaaf061-B67","doi-asserted-by":"crossref","first-page":"1198243","DOI":"10.3389\/fnins.2023.1198243","article-title":"Hierarchical deconvolution for extensive cell type resolution in the human brain using DNA methylation","volume":"17","author":"Zhang","year":"2023","journal-title":"Front Neurosci"}],"container-title":["Molecular Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/molehr\/advance-article-pdf\/doi\/10.1093\/molehr\/gaaf061\/66117896\/gaaf061.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molehr\/article-pdf\/32\/1\/gaaf061\/66117896\/gaaf061.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molehr\/article-pdf\/32\/1\/gaaf061\/66117896\/gaaf061.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:12:26Z","timestamp":1768565546000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molehr\/article\/doi\/10.1093\/molehr\/gaaf061\/8403091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,23]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,7]]}},"URL":"https:\/\/doi.org\/10.1093\/molehr\/gaaf061","relation":{},"ISSN":["1360-9947","1460-2407"],"issn-type":[{"value":"1360-9947","type":"print"},{"value":"1460-2407","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2025,12,23]]},"article-number":"gaaf061"}}