{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T15:01:55Z","timestamp":1772290915582,"version":"3.50.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":40,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Fundamental Research Program of Shanxi Province","award":["202303021221247"],"award-info":[{"award-number":["202303021221247"]}]},{"name":"Fundamental Research Program of Shanxi Province","award":["202403021212267"],"award-info":[{"award-number":["202403021212267"]}]},{"name":"Taiyuan 2024 \u201cSix First Batch\u201d Healthcare Talent Development","award":["Y2024001"],"award-info":[{"award-number":["Y2024001"]}]},{"name":"Research Seed Fund Project of Peking University First Hospital Taiyuan Hospital","award":["202519"],"award-info":[{"award-number":["202519"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ovulatory disorders are a major cause of infertility. Studies have shown that the renin\u2013angiotensin system (RAS) plays a vital role in the female reproductive system. The angiotensin II type 1 receptor (AT1R), an important mediator of the RAS, may induce anovulation when activated. Previous studies have shown that the levels of AT1R autoantibody (AT1-AA) are significantly higher in the serum of infertile women and are negatively correlated with the oocyte maturation rate. However, systematic understanding of the changes of AT1-AA associated with female ovulatory dysfunction remains limited. In this study, participants were divided into three groups: healthy controls, tubal obstruction group, and ovulatory disorders group. The levels of AT1-AA in serum and follicular fluid were determined using ELISA. The results showed that AT1-AA levels were elevated in both serum and follicular fluid of the ovulatory disorders group compared to the tubal obstruction group. The levels of AT1-AA were negatively correlated with high-quality embryos in the ovulatory disorders group. Follicular fluid AT1-AA levels were an independent risk factor for developing ovulatory disorders. Furthermore, AT1-AA impeded mouse oocyte maturation in vitro, and this effect was suppressed by the second extracellular loop peptide of AT1R. Our findings indicate that follicular fluid AT1-AA is associated with ovulatory disorders and impaired oocyte maturation.<\/jats:p>","DOI":"10.1093\/molehr\/gaag003","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:35:00Z","timestamp":1770122100000},"source":"Crossref","is-referenced-by-count":0,"title":["Angiotensin II type 1 receptor autoantibody (AT1-AA) is involved in ovulatory disorders: AT1-AA impairs spindle and chromosome organization"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0185-1759","authenticated-orcid":false,"given":"Yao","family":"Chen","sequence":"first","affiliation":[{"name":"Reproductive Center, Taiyuan Central Hospital of Shanxi Medical University , Taiyuan,","place":["China"]},{"name":"Shanxi Key Laboratory of Reproductive Immunology and Genetics , Taiyuan,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui-Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Reproductive Center, Taiyuan Central Hospital of Shanxi Medical University , Taiyuan,","place":["China"]},{"name":"Shanxi Key Laboratory of Reproductive Immunology and Genetics , Taiyuan,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Reproductive Center, Taiyuan Central Hospital of Shanxi Medical University , Taiyuan,","place":["China"]},{"name":"Shanxi Key Laboratory of Reproductive Immunology and Genetics , Taiyuan,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Min","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive Center, Taiyuan Central Hospital of Shanxi Medical University , Taiyuan,","place":["China"]},{"name":"Shanxi Key Laboratory of Reproductive Immunology and Genetics , Taiyuan,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Na","family":"Yu","sequence":"additional","affiliation":[{"name":"Reproductive Center, Taiyuan Central Hospital of Shanxi Medical University , Taiyuan,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De","family":"Song","sequence":"additional","affiliation":[{"name":"Reproductive Center, Taiyuan Central Hospital of Shanxi Medical University , Taiyuan,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui-Xia","family":"Guo","sequence":"additional","affiliation":[{"name":"Reproductive Center, Taiyuan Central Hospital of Shanxi Medical University , Taiyuan,","place":["China"]},{"name":"Shanxi Key Laboratory of Reproductive Immunology and Genetics , Taiyuan,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Ren","sequence":"additional","affiliation":[{"name":"Reproductive Center, Taiyuan Central Hospital of Shanxi Medical University , Taiyuan,","place":["China"]},{"name":"Shanxi Key Laboratory of Reproductive Immunology and Genetics , Taiyuan,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Nuo","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive Center, Taiyuan Central Hospital of Shanxi Medical University , Taiyuan,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hui","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Fenyang College of Shanxi Medical University , 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