{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:52:23Z","timestamp":1781758343784,"version":"3.54.5"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":128,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Program","doi-asserted-by":"crossref","award":["EO1 W81XWH1910364"],"award-info":[{"award-number":["EO1 W81XWH1910364"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Health and Medical Research Council of Australia Investigator Grants","award":["1173882"],"award-info":[{"award-number":["1173882"]}]},{"name":"National Health and Medical Research Council of Australia Investigator Grants","award":["1177194"],"award-info":[{"award-number":["1177194"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The human endometrium is a complex, dynamic, and poorly understood tissue involving monthly cyclical regeneration likely from adult stem\/progenitor cells. This regeneration is associated with reproductive pathologies, such as endometriosis and adenomyosis. Endometrial epithelial cells have rates of mutations that are higher than expected for non-malignant tissue. Many of these mutations occur in known cancer-driver genes and can be inherited by endometriosis or adenomyosis lesions. The impact of these mutations on endometrial function and their contribution to endometrial pathologies is unclear. This gap in knowledge is partly due to the lack of suitable in vitro models for studying their effects on endometrial epithelial function. In this manuscript, we present a narrative review of the mutation landscape of the endometrium, their potential means of acquisition, and methods to study their consequences. Cataloguing and studying the role of somatic mutations will help us to understand their contribution to endometrial disease. Identifying their molecular and functional consequences will improve diagnostics, facilitate targeted treatment, and provide a step towards the personalization of treatment for endometrial pathologies.<\/jats:p>","DOI":"10.1093\/molehr\/gaag027","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:36:48Z","timestamp":1778153808000},"source":"Crossref","is-referenced-by-count":0,"title":["Somatic mutations in endometrial epithelium: biological insights and emerging\n                    <i>in vitro<\/i>\n                    models"],"prefix":"10.1093","volume":"32","author":[{"given":"Sugarniya","family":"Subramaniam","sequence":"first","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, St Lucia , Brisbane, QLD,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3590-2077","authenticated-orcid":false,"given":"Caroline E","family":"Gargett","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research , Clayton, VIC,","place":["Australia"]},{"name":"Department of Obstetrics and Gynaecology, Monash University , Clayton, VIC,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1776-8377","authenticated-orcid":false,"given":"Harriet C","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research , Clayton, VIC,","place":["Australia"]},{"name":"Department of Obstetrics and Gynaecology, Monash University , Clayton, VIC,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4140-8139","authenticated-orcid":false,"given":"Grant W","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, St Lucia 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