{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T01:00:25Z","timestamp":1781312425857,"version":"3.54.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271702"],"award-info":[{"award-number":["82271702"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Nanjing Medical University Science and Technology Development Fund","award":["NMUB20240239"],"award-info":[{"award-number":["NMUB20240239"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endometriosis (EMs) is characterized by ectopic lesions that disrupt endometrial decidualization, a process frequently accompanied by aberrant collagen deposition and closely linked to clinical infertility. Extracellular vesicles (EVs) are key mediators of intercellular communication and contribute to the pathogenesis and progression of EMs. However, whether EVs promote type I collagen deposition in the eutopic endometrium through glycolytic reprogramming and subsequent non-histone lactylation remains unclear. This study reveals that PKM2-carrying EVs derived from ectopic endometrial stromal cells (designated EMs-EVs) are transported via the systemic circulation to eutopic endometrial stromal cells and are internalized. This process upregulates PKM2 in the eutopic endometrium, triggering glycolytic reprogramming and lactate accumulation. The increased lactate level induces lactylation at lysine 1520 (K1520la) of myosin heavy chain 10 (MYH10). This modification not only upregulates \u03b1-smooth muscle actin (\u03b1-SMA) but also enhances the binding between MYH10 and \u03b1-SMA: an interaction essential for conferring contractile properties to stress fibers. Consequently, these events promote type I collagen deposition and contribute to defective decidualization in the eutopic endometrium. Collectively, our findings demonstrated that EMs-EVs drive endometrial collagen deposition through PKM2-mediated glycolytic reprogramming and subsequent MYH10 K1520 lactylation, thereby deepening our understanding of the role of impaired decidualization in the development of endometriosis-associated infertility.<\/jats:p>","DOI":"10.1093\/molehr\/gaag028","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T11:42:14Z","timestamp":1778240534000},"source":"Crossref","is-referenced-by-count":0,"title":["Glycolytic reprogramming and MYH10 K1520 lactylation mediate eutopic endometrial collagen I deposition driven by PKM2-packaged ectopic endometrial extracellular vesicles"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2900-8964","authenticated-orcid":false,"given":"Liang","family":"Gao","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine and Obstetrics and Gynecology, Drum Tower Clinic Medical College of Nanjing Medical University , Nanjing,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, The Affiliated Taizhou People\u2019s Hospital of Nanjing Medical University , Taizhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8484-3440","authenticated-orcid":false,"given":"Shiming","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6703-8863","authenticated-orcid":false,"given":"Jingyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5599-9340","authenticated-orcid":false,"given":"Linhui","family":"Gao","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Kang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8900-2042","authenticated-orcid":false,"given":"Jidong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9303-3623","authenticated-orcid":false,"given":"Jianjun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine and Obstetrics and Gynecology, Drum Tower Clinic Medical College of Nanjing Medical University , Nanjing,","place":["China"]},{"name":"Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University , Nanjing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"2026061220434992400_gaag028-B1","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.3945\/jn.117.256404","article-title":"Proline precursors and collagen synthesis: biochemical challenges of nutrient supplementation and wound healing","volume":"147","author":"Albaugh","year":"2017","journal-title":"J Nutr"},{"key":"2026061220434992400_gaag028-B2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12964-021-00787-y","article-title":"Extracellular vesicles: mediators of intercellular communication in tissue injury and disease","volume":"19","author":"Berumen Sanchez","year":"2021","journal-title":"Cell Commun Signal"},{"key":"2026061220434992400_gaag028-B3","doi-asserted-by":"crossref","first-page":"103752","DOI":"10.1016\/j.autrev.2025.103752","article-title":"Endometriosis and autoimmunity","volume":"24","author":"Blanco","year":"2025","journal-title":"Autoimmun Rev"},{"key":"2026061220434992400_gaag028-B4","doi-asserted-by":"crossref","first-page":"1020827","DOI":"10.3389\/fendo.2022.1020827","article-title":"Endometriosis-associated infertility: from pathophysiology to tailored treatment","volume":"13","author":"Bonavina","year":"2022","journal-title":"Front Endocrinol"},{"key":"2026061220434992400_gaag028-B5","doi-asserted-by":"crossref","first-page":"101509","DOI":"10.1016\/j.redox.2020.101509","article-title":"Mitochondria dysfunction and metabolic reprogramming as drivers of idiopathic pulmonary fibrosis","volume":"33","author":"Bueno","year":"2020","journal-title":"Redox Biol"},{"key":"2026061220434992400_gaag028-B6","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.jmig.2021.02.007","article-title":"Impact of surgery for deep infiltrative endometriosis before in vitro fertilization: a systematic review and meta-analysis","volume":"28","author":"Casals","year":"2021","journal-title":"J Minim Invasive Gynecol"},{"key":"2026061220434992400_gaag028-B7","doi-asserted-by":"crossref","first-page":"1435177","DOI":"10.3389\/fendo.2024.1435177","article-title":"Molecular mechanism of aberrant decidualization in adenomyosis leading to reduced endometrial receptivity","volume":"15","author":"Dai","year":"2024","journal-title":"Front Endocrinol"},{"key":"2026061220434992400_gaag028-B8","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.cell.2020.08.049","article-title":"Lactate elicits ER-mitochondrial Mg(2+) dynamics to integrate cellular metabolism","volume":"183","author":"Daw","year":"2020","journal-title":"Cell"},{"key":"2026061220434992400_gaag028-B9","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s13048-024-01480-7","article-title":"Extracellular vesicles and their content in the context of polycystic ovarian syndrome and endometriosis: a review","volume":"17","author":"Duval","year":"2024","journal-title":"J Ovarian Res"},{"key":"2026061220434992400_gaag028-B10","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12958-021-00816-y","article-title":"HOX cluster and their cofactors showed an altered expression pattern in eutopic and ectopic endometriosis tissues","volume":"19","author":"Esfandiari","year":"2021","journal-title":"Reprod Biol Endocrinol"},{"key":"2026061220434992400_gaag028-B11","doi-asserted-by":"crossref","first-page":"eaaw5473","DOI":"10.1126\/science.aaw5473","article-title":"Metabolic reprogramming and cancer progression","volume":"368","author":"Faubert","year":"2020","journal-title":"Science"},{"key":"2026061220434992400_gaag028-B12","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1161\/CIRCRESAHA.120.316958","article-title":"Myofibroblasts and fibrosis: mitochondrial and metabolic control of cellular differentiation","volume":"127","author":"Gibb","year":"2020","journal-title":"Circ Res"},{"key":"2026061220434992400_gaag028-B13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.matbio.2024.07.003","article-title":"Metabolic control of collagen synthesis","volume":"133","author":"Guillard","year":"2024","journal-title":"Matrix Biol"},{"key":"2026061220434992400_gaag028-B14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00441-016-2358-1","article-title":"Exosomes derived from endometriotic stromal cells have enhanced angiogenic effects in vitro","volume":"365","author":"Harp","year":"2016","journal-title":"Cell Tissue Res"},{"key":"2026061220434992400_gaag028-B15","doi-asserted-by":"crossref","first-page":"4249","DOI":"10.1242\/dev.151282","article-title":"Tension, contraction and tissue morphogenesis","volume":"144","author":"Heer","year":"2017","journal-title":"Development"},{"key":"2026061220434992400_gaag028-B16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00018-012-1002-9","article-title":"Nonmuscle myosin-2: mix and match","volume":"70","author":"Heissler","year":"2013","journal-title":"Cell Mol Life Sci"},{"key":"2026061220434992400_gaag028-B17","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1083\/jcb.200201049","article-title":"The NH2-terminal peptide of alpha-smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo","volume":"157","author":"Hinz","year":"2002","journal-title":"J Cell Biol"},{"key":"2026061220434992400_gaag028-B18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.yexcr.2019.03.027","article-title":"Mechanical regulation of myofibroblast phenoconversion and collagen contraction","volume":"379","author":"Hinz","year":"2019","journal-title":"Exp Cell Res"},{"key":"2026061220434992400_gaag028-B19","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.fertnstert.2019.09.031","article-title":"Interventions for endometriosis-related infertility: a systematic review and network meta-analysis","volume":"113","author":"Hodgson","year":"2020","journal-title":"Fertil Steril"},{"key":"2026061220434992400_gaag028-B20","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.cell.2019.11.033","article-title":"SnapShot: endometriosis","volume":"179","author":"Horne","year":"2019","journal-title":"Cell"},{"key":"2026061220434992400_gaag028-B21","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/brv.13135","article-title":"Unlocking the multifaceted molecular functions and diverse disease implications of lactylation","volume":"100","author":"Jing","year":"2025","journal-title":"Biol Rev Camb Philos Soc"},{"key":"2026061220434992400_gaag028-B22","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1021\/acs.jproteome.5b00965","article-title":"Deep quantitative proteomics reveals extensive metabolic reprogramming and cancer-like changes of ectopic endometriotic stromal cells","volume":"15","author":"Kasvandik","year":"2016","journal-title":"J Proteome Res"},{"key":"2026061220434992400_gaag028-B23","doi-asserted-by":"crossref","first-page":"eadn5228","DOI":"10.1126\/sciadv.adn5228","article-title":"Glycolysis in hepatic stellate cells coordinates fibrogenic extracellular vesicle release spatially to amplify liver fibrosis","volume":"10","author":"Khanal","year":"2024","journal-title":"Sci Adv"},{"key":"2026061220434992400_gaag028-B24","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3390\/ph18060813","article-title":"Warburg-like metabolic reprogramming in endometriosis: from molecular mechanisms to therapeutic approaches","volume":"18","author":"Kim","year":"2025","journal-title":"Pharmaceuticals"},{"key":"2026061220434992400_gaag028-B25","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1038\/s41467-018-06833-7","article-title":"Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease","volume":"9","author":"Kim","year":"2018","journal-title":"Nat Commun"},{"key":"2026061220434992400_gaag028-B26","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ejogrb.2020.12.044","article-title":"Revisiting estrogen-dependent signaling pathways in endometriosis: potential targets for non-hormonal therapeutics","volume":"258","author":"Kobayashi","year":"2021","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2026061220434992400_gaag028-B27","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41467-024-55577-0","article-title":"The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment","volume":"16","author":"Lan","year":"2025","journal-title":"Nat Commun"},{"key":"2026061220434992400_gaag028-B28","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12943-024-02008-9","article-title":"Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma","volume":"23","author":"Li","year":"2024","journal-title":"Mol Cancer"},{"key":"2026061220434992400_gaag028-B29","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/s41586-024-07992-y","article-title":"AARS1 and AARS2 sense L-lactate to regulate cGAS as global lysine lactyltransferases","volume":"634","author":"Li","year":"2024","journal-title":"Nature"},{"key":"2026061220434992400_gaag028-B30","doi-asserted-by":"crossref","first-page":"116982","DOI":"10.1016\/j.biopha.2024.116982","article-title":"Advances in the interaction of glycolytic reprogramming with lactylation","volume":"177","author":"Li","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"2026061220434992400_gaag028-B31","doi-asserted-by":"crossref","first-page":"e08220","DOI":"10.1002\/advs.202408220","article-title":"Elevated histone lactylation mediates ferroptosis resistance in endometriosis through the METTL3-regulated HIF1A\/HMOX1 signaling pathway","volume":"12","author":"Liang","year":"2025","journal-title":"Adv Sci"},{"key":"2026061220434992400_gaag028-B32","doi-asserted-by":"crossref","first-page":"e70813","DOI":"10.1096\/fj.202500614R","article-title":"AlkB homolog 5 regulates hexokinase 2-mediated glycolysis and participates in the progression of endometriosis","volume":"39","author":"Liu","year":"2025","journal-title":"FASEB J"},{"key":"2026061220434992400_gaag028-B33","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1186\/s13287-020-01990-3","article-title":"si-SNHG5-FOXF2 inhibits TGF-beta1-induced fibrosis in human primary endometrial stromal cells by the Wnt\/beta-catenin signalling pathway","volume":"11","author":"Liu","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"2026061220434992400_gaag028-B34","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1242\/jcs.180927","article-title":"The inner workings of stress fibers\u2009-\u2009from contractile machinery to focal adhesions and back","volume":"129","author":"Livne","year":"2016","journal-title":"J Cell Sci"},{"key":"2026061220434992400_gaag028-B35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12943-019-0965-7","article-title":"Extracellular vesicles-mediated intercellular communication: roles in the tumor microenvironment and anti-cancer drug resistance","volume":"18","author":"Maacha","year":"2019","journal-title":"Mol Cancer"},{"key":"2026061220434992400_gaag028-B36","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41590-021-00899-0","article-title":"Extracellular vesicles in immunomodulation and tumor progression","volume":"22","author":"Marar","year":"2021","journal-title":"Nat Immunol"},{"key":"2026061220434992400_gaag028-B37","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3389\/fendo.2018.00725","article-title":"Endometriosis is a cause of infertility. does reactive oxygen damage to gametes and embryos play a key role in the pathogenesis of infertility caused by endometriosis?","volume":"9","author":"Mate","year":"2018","journal-title":"Front Endocrinol"},{"key":"2026061220434992400_gaag028-B38","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1161\/CIRCRESAHA.123.321872","article-title":"Ketones and the heart: metabolic principles and therapeutic implications","volume":"132","author":"Matsuura","year":"2023","journal-title":"Circ Res"},{"key":"2026061220434992400_gaag028-B39","doi-asserted-by":"crossref","first-page":"15321","DOI":"10.1038\/ncomms15321","article-title":"YAP regulates cell mechanics by controlling focal adhesion assembly","volume":"8","author":"Nardone","year":"2017","journal-title":"Nat Commun"},{"key":"2026061220434992400_gaag028-B40","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1093\/humrep\/dead216","article-title":"The role of small extracellular vesicle-miRNAs in endometriosis","volume":"38","author":"Nazri","year":"2023","journal-title":"Hum Reprod"},{"key":"2026061220434992400_gaag028-B41","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.3390\/ijms21114092","article-title":"Endometrial decidualization: the primary driver of pregnancy health","volume":"21","author":"Ng","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2026061220434992400_gaag028-B42","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s43556-025-00275-6","article-title":"Histone and non-histone lactylation: molecular mechanisms, biological functions, diseases, and therapeutic targets","volume":"6","author":"Peng","year":"2025","journal-title":"Mol Biomed"},{"key":"2026061220434992400_gaag028-B43","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.cmet.2023.06.013","article-title":"Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis","volume":"35","author":"Rho","year":"2023","journal-title":"Cell Metab"},{"key":"2026061220434992400_gaag028-B44","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/abbs\/gmz146","article-title":"Regulatory mechanisms of endometrial decidualization and pregnancy-related diseases","volume":"52","author":"Sang","year":"2020","journal-title":"Acta Biochim Biophys Sin"},{"key":"2026061220434992400_gaag028-B45","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/molehr\/gay049","article-title":"Macrophages alternatively activated by endometriosis-exosomes contribute to the development of lesions in mice","volume":"25","author":"Sun","year":"2019","journal-title":"Mol Hum Reprod"},{"key":"2026061220434992400_gaag028-B46","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0140-6736(21)00389-5","article-title":"Endometriosis is a chronic systemic disease: clinical challenges and novel innovations","volume":"397","author":"Taylor","year":"2021","journal-title":"Lancet"},{"key":"2026061220434992400_gaag028-B47","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrm809","article-title":"Myofibroblasts and mechano-regulation of connective tissue remodelling","volume":"3","author":"Tomasek","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026061220434992400_gaag028-B48","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/s41556-018-0142-z","article-title":"YAP\/TAZ upstream signals and downstream responses","volume":"20","author":"Totaro","year":"2018","journal-title":"Nat Cell Biol"},{"key":"2026061220434992400_gaag028-B49","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1210\/jc.2009-0207","article-title":"Decidualization attenuates the contractility of eutopic and ectopic endometrial stromal cells: implications for hormone therapy of endometriosis","volume":"94","author":"Tsuno","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"2026061220434992400_gaag028-B50","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12958-021-00770-9","article-title":"HSF1 promotes endometriosis development and glycolysis by up-regulating PFKFB3 expression","volume":"19","author":"Wang","year":"2021","journal-title":"Reprod Biol Endocrinol"},{"key":"2026061220434992400_gaag028-B51","doi-asserted-by":"crossref","first-page":"C500","DOI":"10.1152\/ajpcell.00493.2024","article-title":"Histone lactylation-mediated overexpression of RASD2 promotes endometriosis progression via upregulating the SUMOylation of CTPS1","volume":"328","author":"Wang","year":"2025","journal-title":"Am J Physiol Cell Physiol"},{"key":"2026061220434992400_gaag028-B52","doi-asserted-by":"crossref","first-page":"e240018","DOI":"10.1530\/REP-24-0018","article-title":"Highly expressed lncRNA H19 in endometriosis promotes aerobic glycolysis and histone lactylation","volume":"168","author":"Wen","year":"2024","journal-title":"Reproduction"},{"key":"2026061220434992400_gaag028-B53","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.jconrel.2023.11.057","article-title":"Extracellular vesicles and their engineering strategies, delivery systems, and biomedical applications","volume":"365","author":"Yang","year":"2024","journal-title":"J Control Release"},{"key":"2026061220434992400_gaag028-B54","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1210\/jc.2014-1026","article-title":"Transforming growth factor-beta induced Warburg-like metabolic reprogramming may underpin the development of peritoneal endometriosis","volume":"99","author":"Young","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2026061220434992400_gaag028-B55","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"2026061220434992400_gaag028-B56","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/molehr\/gaaa026","article-title":"Human chorionic gonadotropin improves endometrial receptivity by increasing the expression of homeobox A10","volume":"26","author":"Zhu","year":"2020","journal-title":"Mol Hum Reprod"},{"key":"2026061220434992400_gaag028-B57","doi-asserted-by":"crossref","first-page":"111523","DOI":"10.1016\/j.cellsig.2024.111523","article-title":"Extracellular vesicle-packaged PKM2 from endometriotic stromal cells promotes endometrial collagen I deposition by inhibiting autophagy in endometriosis","volume":"127","author":"Zhu","year":"2025","journal-title":"Cell Signal"},{"key":"2026061220434992400_gaag028-B58","doi-asserted-by":"crossref","first-page":"gaae066","DOI":"10.1093\/molehr\/gaae042","article-title":"Ectopic endometrial stromal cell-derived extracellular vesicles encapsulating microRNA-25-3p induce endometrial collagen I deposition impairing decidualization in endometriosis","volume":"30","author":"Zhu","year":"2024","journal-title":"Mol Hum Reprod"}],"container-title":["Molecular Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/molehr\/advance-article-pdf\/doi\/10.1093\/molehr\/gaag028\/68268813\/gaag028.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molehr\/article-pdf\/32\/2\/gaag028\/68268813\/gaag028.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molehr\/article-pdf\/32\/2\/gaag028\/68268813\/gaag028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:44:00Z","timestamp":1781311440000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molehr\/article\/doi\/10.1093\/molehr\/gaag028\/8675991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4,11]]}},"URL":"https:\/\/doi.org\/10.1093\/molehr\/gaag028","relation":{},"ISSN":["1360-9947","1460-2407"],"issn-type":[{"value":"1360-9947","type":"print"},{"value":"1460-2407","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"gaag028"}}