{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:12:00Z","timestamp":1787501520919,"version":"build-2736575974"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Forschungsgemeinschaft","award":["544376111"],"award-info":[{"award-number":["544376111"]}]},{"name":"Forschungsgemeinschaft","award":["R01 HD 083273"],"award-info":[{"award-number":["R01 HD 083273"]}]},{"name":"Forschungsgemeinschaft","award":["R01 HD099090"],"award-info":[{"award-number":["R01 HD099090"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endometriosis is a chronic systemic disease affecting \u223c10\u201315% of women of reproductive age, often resulting in chronic pelvic pain and infertility. Despite its high prevalence, diagnosis is frequently delayed. tRNA-derived fragments (tRFs) are an emerging class of small non-coding RNAs that have been implicated in gene regulation and various pathological processes but remain understudied in endometriosis. This study aimed to characterize temporal changes in circulating tRF abundance after experimentally induced endometriosis in a baboon model. Endometriosis was induced in eight female baboons, and peripheral blood samples were collected at five time points post-inoculation. RNA was extracted from serum samples and sequenced to profile tRF abundance. Differential expression analysis was performed. Significant changes in tRFs were observed as early as 3 months after induction. A ranking based on log fold change and adjusted P-values revealed the 10 most significantly altered tRFs. These tRFs demonstrated consistent differential abundance throughout all time points. This is the first study to investigate circulating tRFs in endometriosis. Our longitudinal findings suggest that tRFs may serve as promising candidate biomarkers for endometriosis.<\/jats:p>","DOI":"10.1093\/molehr\/gaag032","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T11:42:52Z","timestamp":1779450172000},"source":"Crossref","is-referenced-by-count":1,"title":["Circulating transfer RNA-derived fragment abundance after experimental endometriosis induction in baboons"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7708-7995","authenticated-orcid":false,"given":"Hanna","family":"Surmann","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine , New Haven, CT,","place":["USA"]},{"name":"Department of Gynecology and Obstetrics, University of M\u00fcnster , M\u00fcnster,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4022-8910","authenticated-orcid":false,"given":"Ramanaiah","family":"Mamillapalli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine , New Haven, CT,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niraj","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University , Grand Rapids, MI,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0021-4319","authenticated-orcid":false,"given":"Gregory","family":"Burns","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University , Grand Rapids, MI,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asgerally T","family":"Fazleabas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University , Grand Rapids, MI,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1720-8310","authenticated-orcid":false,"given":"Hugh S","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine , New Haven, CT,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"2026061006121802500_gaag032-B1","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.3390\/cells11132028","article-title":"The role of the immune system in the development of endometriosis","volume":"11","author":"Abramiuk","year":"2022","journal-title":"Cells"},{"key":"2026061006121802500_gaag032-B2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1055\/s-0037-1603582","article-title":"The systemic effects of endometriosis","volume":"35","author":"Alderman","year":"2017","journal-title":"Semin Reprod Med"},{"key":"2026061006121802500_gaag032-B3","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1111\/j.1471-0528.2008.01878.x","article-title":"Can symptomatology help in the diagnosis of endometriosis? 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